R M Jacobson

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Independence of measles-specific humoral and cellular immune responses to vaccination
    Robert M Jacobson
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905 0001, USA
    Hum Immunol 73:474-9. 2012
  2. ncbi request reprint A taxonomy of reasoning flaws in the anti-vaccine movement
    Robert M Jacobson
    Vaccine Research Group, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 0001, United States
    Vaccine 25:3146-52. 2007
  3. ncbi request reprint Meta-analyses in vaccinology
    Robert M Jacobson
    Vaccine Research Group, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 0001, United States
    Vaccine 25:3153-9. 2007
  4. ncbi request reprint The pneumococcal conjugate vaccine
    R M Jacobson
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Minerva Pediatr 54:295-303. 2002
  5. ncbi request reprint The challenge of vaccine safety
    Robert M Jacobson
    Mayo Vaccine Research Group, The Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905 0001, USA
    Semin Pediatr Infect Dis 13:215-20. 2002
  6. ncbi request reprint The association of class I HLA alleles and antibody levels after a single dose of measles vaccine
    Robert M Jacobson
    Department of Pediatric and Adolescent MedicineMayo Clinic, Rochester, MN 55903, USA
    Hum Immunol 64:103-9. 2003
  7. ncbi request reprint Studies of twins in vaccinology
    Robert M Jacobson
    Vaccine Research Group, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 0001, United States
    Vaccine 25:3160-4. 2007
  8. ncbi request reprint The genetic basis for measles vaccine failure
    R M Jacobson
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905 0001, USA
    Acta Paediatr Suppl 93:43-6; discussion 46-7. 2004
  9. pmc An update on childhood and adolescent vaccines
    Robert M Jacobson
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:457-9; quiz 460. 2009
  10. ncbi request reprint Vaccine safety
    Robert M Jacobson
    Mayo Clinic Vaccine Research Group, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Immunol Allergy Clin North Am 23:589-603. 2003

Detail Information

Publications107 found, 100 shown here

  1. pmc Independence of measles-specific humoral and cellular immune responses to vaccination
    Robert M Jacobson
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905 0001, USA
    Hum Immunol 73:474-9. 2012
    ..As researchers pursue novel measles vaccine and measles vaccine delivery systems, they must not infer that humoral responses predict cellular responses...
  2. ncbi request reprint A taxonomy of reasoning flaws in the anti-vaccine movement
    Robert M Jacobson
    Vaccine Research Group, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 0001, United States
    Vaccine 25:3146-52. 2007
    ..The claims illustrate the breadth of reasoning flaws while providing a basis for anticipating and correcting them...
  3. ncbi request reprint Meta-analyses in vaccinology
    Robert M Jacobson
    Vaccine Research Group, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 0001, United States
    Vaccine 25:3153-9. 2007
    ....
  4. ncbi request reprint The pneumococcal conjugate vaccine
    R M Jacobson
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Minerva Pediatr 54:295-303. 2002
    ..Follow-up studies should address important questions regarding the use of pneumococcal conjugate vaccine and other age groups...
  5. ncbi request reprint The challenge of vaccine safety
    Robert M Jacobson
    Mayo Vaccine Research Group, The Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905 0001, USA
    Semin Pediatr Infect Dis 13:215-20. 2002
    ....
  6. ncbi request reprint The association of class I HLA alleles and antibody levels after a single dose of measles vaccine
    Robert M Jacobson
    Department of Pediatric and Adolescent MedicineMayo Clinic, Rochester, MN 55903, USA
    Hum Immunol 64:103-9. 2003
    ....
  7. ncbi request reprint Studies of twins in vaccinology
    Robert M Jacobson
    Vaccine Research Group, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 0001, United States
    Vaccine 25:3160-4. 2007
    ..We examine three of these studies in detail to illustrate important opportunities and limitations of twins studies in vaccinology...
  8. ncbi request reprint The genetic basis for measles vaccine failure
    R M Jacobson
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905 0001, USA
    Acta Paediatr Suppl 93:43-6; discussion 46-7. 2004
    ....
  9. pmc An update on childhood and adolescent vaccines
    Robert M Jacobson
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:457-9; quiz 460. 2009
    ..This article discusses some of the important changes that should be of concern to the practitioner...
  10. ncbi request reprint Vaccine safety
    Robert M Jacobson
    Mayo Clinic Vaccine Research Group, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Immunol Allergy Clin North Am 23:589-603. 2003
    ....
  11. ncbi request reprint The overall safety profile of currently available vaccines directed against infectious diseases
    Robert M Jacobson
    Mayo Building E931, Mayo Clinic, 200 First Street Southwest, Rochester, Minnesota 55905 0001, USA
    Expert Opin Drug Saf 2:215-23. 2003
    ....
  12. ncbi request reprint Why is evidence-based medicine so harsh on vaccines? An exploration of the method and its natural biases
    Robert M Jacobson
    Vaccine Research Group, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 0001, United States
    Vaccine 25:3165-9. 2007
    ..In this review, we examine the criticisms and consider the shortcomings in the field of vaccinology as well as in the methodology of evidence-based medicine...
  13. ncbi request reprint Promises and pitfalls of meta-analysis in vaccine research
    R M Jacobson
    Mayo Vaccine Research Group, Department of Pediatric and Adolescent Medicine, Rochester, MN 55905 0001, USA
    Vaccine 17:1628-34. 1999
    ..Three classical concerns revolve around the issue of publication bias, data dredging and individual study variability. Additionally, vaccine meta-analyses suffer concerns particular to the field of vaccine research...
  14. ncbi request reprint The current status of the rotavirus vaccine
    R M Jacobson
    Mayo Vaccine Research Group, Department of Pediatric and Adolescent Medicine, Rochester, MN 55905 0001, USA
    Vaccine 17:1690-9. 1999
    ..Immunity, furthermore, appears to be serotype-specific. Early attempts to develop a vaccine focused on animal forms of rotavirus. More recent efforts have created human-animal reassortants that have been far more successful...
  15. pmc Testing vaccines in pediatric research subjects
    Robert M Jacobson
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, United States
    Vaccine 27:3291-4. 2009
    ..Better understanding of the restrictions in pediatric research, the use of placebos, the attitude of parents, and the concerns with remuneration can better equip the vaccine researcher in pursuing successful studies in children...
  16. ncbi request reprint Adverse events and vaccination-the lack of power and predictability of infrequent events in pre-licensure study
    R M Jacobson
    Department of Pediatric and Adolescent Medicine, Vaccine Research Group, Mayo Clinic Baldwin 3B, Rochester, MN 55905 0001, USA
    Vaccine 19:2428-33. 2001
    ..For that reason, we must depend upon the modern post-licensure surveillance programs that we already have in place...
  17. ncbi request reprint Making vaccines more acceptable--methods to prevent and minimize pain and other common adverse events associated with vaccines
    R M Jacobson
    Department of Pediatric and Adolescent Medicine, Mayo ClinicRochester, MN 55905, USA
    Vaccine 19:2418-27. 2001
    ..Other measures to prevent or rapidly treat other common adverse events have been shown effective and should be considered as well...
  18. pmc Human leukocyte antigen associations with humoral and cellular immunity following a second dose of measles-containing vaccine: persistence, dampening, and extinction of associations found after a first dose
    Robert M Jacobson
    Mayo Clinic, 200 First St SW, Rochester, MN 55905 0001, USA
    Vaccine 29:7982-91. 2011
    ..Future studies of HLA associations should consider both the effect of dose and the role that subsequent doses might play on genetic associations found with the response to a first dose...
  19. ncbi request reprint Sample sizes and negative studies in clinical vaccine research
    Robert M Jacobson
    Vaccine Research Group, Mayo Clinic, Rochester, MN 55905 0001, USA
    Vaccine 23:2318-21. 2005
    ..The implications of the calculations have far-reaching effects upon elements of feasibility such as the expense of the study, the ability to recruit adequate numbers, and even whether the study will be done at all...
  20. ncbi request reprint Studies of equivalence in clinical vaccine research
    Robert M Jacobson
    Vaccine Research Group, Mayo Clinic, Mayo Building 9W37b, 200 First Street Southwest, Rochester, MN 55905 0001, USA
    Vaccine 23:2315-7. 2005
    ..In fact, the feasibility issues may prevent the study being undertaken at all...
  21. pmc HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3349-58. 2009
    ....
  22. pmc Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses
    Richard B Kennedy
    Mayo Clinic, Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, USA
    Hum Immunol 71:128-35. 2010
    ..We also show that homozygosity within different HLA class I and class II loci is correlated with variations (but not necessarily decreases) in interleukin (IL)-2, IL-5, and IL-10 secretion after rubella virus stimulation...
  23. pmc Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population
    N Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Tissue Antigens 72:211-20. 2008
    ..Our study identifies specific SNPs in innate immune response genes that may play a role in modulating antibody responses to measles vaccination and/or infection in Somali subjects...
  24. ncbi request reprint Associations between human leukocyte antigen (HLA) alleles and very high levels of measles antibody following vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 22:1914-20. 2004
    ..These data increase our understanding of measles vaccine-induced immune response and will be useful for future mechanistic work on measles virus antigen processing and presentation in seronegative and hyperseropositive individuals...
  25. ncbi request reprint Correlations between measles, mumps, and rubella serum antibody levels in Olmsted County school children
    J L St Sauver
    Department of Health Sciences Research, Guggenheim 611C, Mayo Clinic, 200 First Street S.W, Rochester, MN 55905, USA
    Vaccine 19:1363-8. 2001
    ..Therefore, our results support the current policy of continuing to administer the trivalent MMR vaccine even when only a single low antibody titer is observed...
  26. ncbi request reprint The contribution of HLA class I antigens in immune status following two doses of rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Hum Immunol 65:1506-15. 2004
    ..These data may facilitate our understanding of immune response variation in a genetically outbred heterogeneous population...
  27. pmc Influence of host genetic variation on rubella-specific T cell cytokine responses following rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3359-66. 2009
    ....
  28. pmc Relationship between HLA polymorphisms and gamma interferon and interleukin-10 cytokine production in healthy individuals after rubella vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Vaccine Immunol 14:115-22. 2007
    ....
  29. pmc Correlations among measles virus-specific antibody, lymphoproliferation and Th1/Th2 cytokine responses following measles-mumps-rubella-II (MMR-II) vaccination
    N Dhiman
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Exp Immunol 142:498-504. 2005
    ..Further examination of the determinants of Th1 versus Th2 skewing of the immune response and long-term follow-up is needed...
  30. ncbi request reprint Lack of association between transporter associated with antigen processing (TAP) and HLA-DM gene polymorphisms and antibody levels following measles vaccination
    N Dhiman
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, 611C Guggenheim Building, 200 First Street SW, Rochester, MN 55905, USA
    Eur J Immunogenet 30:195-200. 2003
    ..87) or DM (DMA, P = 0.42; DMB, P = 0.71) homozygosity and seronegativity to measles vaccine in this study group. Our study suggests that TAP and DM gene polymorphisms do not influence antibody levels post measles vaccination...
  31. ncbi request reprint Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics
    G A Poland
    Mayo Vaccine Research Group and the Program in Translational Immunovirology and Biodefense, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Pharmacol Ther 82:653-64. 2007
    ..e., is the individual at risk for the outcome for which the vaccine is being administered?)...
  32. ncbi request reprint Inter-operator variation in ELISPOT analysis of measles virus-specific IFN-gamma-secreting T cells
    J E Ryan
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Scand J Clin Lab Invest 65:681-9. 2005
    ..001). This demonstrates the importance of using a common ELISPOT reader and operator, among other parameters, to quantify the number of spots when a large volume of plates are being scanned and analyzed...
  33. pmc SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine
    Neelam Dhiman
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Guggenheim 611C, 200 First Street SW, Rochester, MN 55905, USA
    Immunogenetics 62:197-210. 2010
    ..Identification of such "genetic fingerprints" may predict the outcome of vaccine response and inform new vaccine strategies...
  34. ncbi request reprint Extinction of the human leukocyte antigen homozygosity effect after two doses of the measles-mumps-rubella vaccine
    Jennifer L St Sauver
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA
    Hum Immunol 66:788-98. 2005
    ..However, children who are HLA homozygous may be less protected against mumps compared with children who are heterozygous...
  35. pmc Human leukocyte antigen and cytokine receptor gene polymorphisms associated with heterogeneous immune responses to mumps viral vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pediatrics 121:e1091-9. 2008
    ..We set out to assess whether HLA and cytokine gene polymorphisms are associated with variations in the immune response to mumps viral vaccine...
  36. ncbi request reprint Measles antibody seroprevalence rates among immunized Inuit, Innu and Caucasian subjects
    G A Poland
    Mayo Vaccine Research Group, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA
    Vaccine 17:1525-31. 1999
    ..The determination of these sources of variability may lead to the development of more efficacious vaccines or delivery strategies...
  37. ncbi request reprint Immunologic significance of HLA class I genes in measles virus-specific IFN-gamma and IL-4 cytokine immune responses
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Immunogenetics 57:828-36. 2005
    ..Understanding the genetic factors that influence variations in cytokine secretion following measles vaccination will provide insight into the factors that influence both cell-mediated and humoral immunity to measles...
  38. ncbi request reprint Differential HLA gene expression in measles vaccine seropositive and seronegative subjects: a pilot study
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    Scand J Infect Dis 35:332-6. 2003
    ..These results suggest an association between antibody response and differential HLA gene activation and may explain one potential mechanism underlying measles vaccine non-response...
  39. pmc Replication of rubella vaccine population genetic studies: validation of HLA genotype and humoral response associations
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:6926-31. 2009
    ....
  40. doi request reprint An assessment of the association between childhood asthma and HLA DRB1*03 using extended haplotype analysis
    N A Hanchard
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Tissue Antigens 76:491-4. 2010
    ..Our results suggest that the role of the HLA DRB1*03 in asthma susceptibility is independent of ancestral-haplotype-mediated linkage disequilibrium...
  41. ncbi request reprint Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    J Infect Dis 195:21-9. 2007
    ..Cytokines are key regulators of measles vaccine humoral and cellular immunity. Single-nucleotide polymorphisms (SNPs) that are associated with differences in cytokine levels should also influence measles vaccine-induced immunity...
  42. ncbi request reprint Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Infect Dis 193:655-63. 2006
    ..002). Better characterization of such HLA profiles could inform and improve the design of novel epitope-rich vaccines and help to predict protective immune responses at the individual and population level...
  43. pmc 2'-5'-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine
    Iana H Haralambieva
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, USA
    Hum Immunol 71:383-91. 2010
    ..Our results suggest that innate immunity and OAS genetic variations are likely involved in modulating the magnitude and quality of the adaptive immune responses to live attenuated rubella vaccine...
  44. pmc Frequency of measles virus-specific CD4+ and CD8+ T cells in subjects seronegative or highly seropositive for measles vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Diagn Lab Immunol 10:411-6. 2003
    ..These differences agree in directionality with the observed antibody response phenotype...
  45. pmc Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Guggenheim 611C, Rochester, MN 55905, USA
    Hum Genet 127:207-21. 2010
    ..This is the first paper to present evidence that polymorphisms in the TLR, vitamin A, vitamin D receptor, and innate immunity genes can influence adaptive cytokine responses to rubella vaccination...
  46. ncbi request reprint Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Infect Dis 191:515-9. 2005
    ..This study of HLA class II-restricted humoral and cellular immune responses to rubella provides significant insight into mechanisms of vaccine response and new vaccine development...
  47. pmc Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Guggenheim 611C, 200 First Street SW, Rochester, MN 55905, USA
    Vaccine 26:1731-6. 2008
    ..These data contribute to understanding the immunogenetic mechanisms underlying variations in the immune response to measles vaccine...
  48. ncbi request reprint HLA class II alleles and measles virus-specific cytokine immune response following two doses of measles vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Guggenheim 611C, 200 1st Street SW, Rochester, MN 55905, USA
    Immunogenetics 56:798-807. 2005
    ..These data suggest that IFN-gamma and IL-4 cytokine responses to measles may be genetically restricted in part by HLA class II genes, which in turn can restrict the cellular immune response to measles vaccine...
  49. ncbi request reprint Understanding those who do not understand: a brief review of the anti-vaccine movement
    G A Poland
    Mayo Vaccine Research Group, Clinical Pharmacology Unit and Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 19:2440-5. 2001
    ..This paper will examine the current anti-vaccine movement and provide current examples. Finally, a review of suggestions for dealing with the anti-vaccine movement will be presented...
  50. ncbi request reprint Childhood asthma and human leukocyte antigen type
    Y J Juhn
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Tissue Antigens 69:38-46. 2007
    ..However, the HLA class II gene does not explain the influences of family history of asthma or atopy on development of asthma. The mechanism underlying the association between asthma and HLA genes needs to be elucidated...
  51. ncbi request reprint Association of parental vaccination reports with measles, mumps, and rubella protective antibody levels: comparison of Somali immigrant, Hispanic migrant, and US children in Rochester, Minn
    SauverJenniferL St
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 77:241-5. 2002
    ..To compare measles, mumps, and rubella antibody levels in Somali immigrant, Hispanic migrant, and US children in Rochester, Minn, and to determine whether parental vaccination reports predict seropositivity...
  52. ncbi request reprint Cytokine production patterns and antibody response to measles vaccine
    Inna G Ovsyannikova
    Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 21:3946-53. 2003
    ..There was no correlation between cytokine production by PBMC supernatants after PHA stimulation and circulating levels of plasma cytokines. No relationship was found between any specific cytokine level and measles antibody level...
  53. doi request reprint Timeliness of diagnosis of asthma in children and its predictors
    W E Molis
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Allergy 63:1529-35. 2008
    ..There is a paucity of literature using medical records to evaluate the timeliness of asthma diagnosis in children and the predictors associated with timeliness of asthma diagnosis...
  54. ncbi request reprint Identification of an association between HLA class II alleles and low antibody levels after measles immunization
    G A Poland
    Department of Internal Medicine, Mayo Vaccine Research Group, Mayo Clinic and Foundation, 611C Guggenheim Building, 200 First Street, SW, Rochester, MN 55905, USA
    Vaccine 20:430-8. 2001
    ..These findings are crucial in designing both measles eradication by the use of vaccine, and future vaccines to be used in genetically heterozygous populations...
  55. ncbi request reprint Rotavirus vaccination
    K A Bjur
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905 0001, USA
    Minerva Pediatr 61:515-21. 2009
    ..This review will focus on the nature and epidemiology of the virus and on the history of rotavirus vaccine, its availability and current recommendations about its administration...
  56. pmc Increased risk of serious pneumococcal disease in patients with atopic conditions other than asthma
    Ji A Jung
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 125:217-21. 2010
    ..We reported an increased risk of serious pneumococcal disease (SPD) among patients with asthma. It is not known whether this is true for patients with other atopic conditions...
  57. ncbi request reprint Variations in measles vaccine-specific humoral immunity by polymorphisms in SLAM and CD46 measles virus receptors
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, Minn, USA
    J Allergy Clin Immunol 120:666-72. 2007
    ..Measles infection requires 2 cellular receptors, signaling lymphocyte activation molecule (SLAM) and CD46. Known and novel single nucleotide polymorphisms (SNPs) in SLAM and CD46 genes might influence the immune response to measles vaccine...
  58. pmc Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity
    Pritish K Tosh
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    Viral Immunol 22:451-6. 2009
    ..We were unable to find any significant correlation between cytokine production after in-vitro rubella stimulation and serum antibody titers...
  59. ncbi request reprint HLA supertypes and immune responses to measles-mumps-rubella viral vaccine: findings and implications for vaccine design
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Vaccine 25:3090-100. 2007
    ..This information may be of significant value in the engineering of potential epitope-based vaccines that are recognized by T cells restricted by human HLA supertype alleles...
  60. ncbi request reprint Influenza vaccines: a review and rationale for use in developed and underdeveloped countries
    G A Poland
    Mayo Vaccine Research Group, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 19:2216-20. 2001
    ..Recommendations for the use of the influenza vaccine in various countries and guidelines for influenza vaccine use worldwide will be proposed...
  61. ncbi request reprint Selective antibody immune deficiency in a patient with Smith-Lemli-Opitz syndrome
    D Babovic-Vuksanovic
    Department of Medical Genetics, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Inherit Metab Dis 28:181-6. 2005
    ..Early recognition and appropriate therapeutic interventions may decrease the severity of infections, prevent potentially fatal infections, and eventually improve the quality of life in these patients...
  62. pmc Vaccine immunogenetics: bedside to bench to population
    Gregory A Poland
    Mayo Vaccine Research Group, The Program in Translational Immunovirology and Biodefense, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Vaccine 26:6183-8. 2008
    ..Such information may provide further understanding of genetic restrictions that influence the generation of protective immune responses to vaccines, and eventually the development of new vaccines...
  63. pmc Increased risk of serious pneumococcal disease in patients with asthma
    Young J Juhn
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Allergy Clin Immunol 122:719-23. 2008
    ..Individuals with asthma have been reported to be at increased risk of invasive pneumococcal disease (IPD). These findings need to be confirmed in a different population-based study setting...
  64. pmc Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity
    Inna G Ovsyannikova
    Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 5:e11806. 2010
    ..Apart from HLA, little is known about the effect of this extended genetic region on HLA haplotypic backgrounds as applied to immune responses...
  65. pmc The social, political, ethical, and economic aspects of biodefense vaccines
    Gregory A Poland
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:D23-7. 2009
    ..In this article we define bioterrorism as the deliberate use of naturally occurring or bioengineered microorganisms in order to cause harm to people, animals, or plants...
  66. pmc Personalized vaccines: the emerging field of vaccinomics
    Gregory A Poland
    Mayo Clinic College of Medicine, Mayo Vaccine Research Group, Program in TranslationalImmunovirology and Biodefense, Mayo Clinic, Rochester, Minnesota 55905, USA
    Expert Opin Biol Ther 8:1659-67. 2008
    ..This paper reviews the basis and logic of personalized vaccines, and describes recent advances in the field...
  67. pmc Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees
    Neelam Dhiman
    Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Cytokine 50:24-9. 2010
    ..These results suggest an immune-deviation or "skewing" from Th1/Th2 cytokine patterns towards a predominant inflammatory response upon in vitro rubella virus stimulation...
  68. pmc Immunogenetics of seasonal influenza vaccine response
    Gregory A Poland
    Mayo Vaccine Research Group, The Program in Translational Immunovirology and Biodefense, Mayo Clinic, 611C Guggenheim Building, 200 First Street, SW, Rochester, MN 55905, USA
    Vaccine 26:D35-40. 2008
    ..Finally, we propose that a better understanding of vaccine immunogenetics offers insight towards the development of better influenza vaccines...
  69. pmc Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Infect Dis 201:207-13. 2010
    ..Genetic polymorphisms play an important role in rubella vaccine-induced immunity...
  70. pmc Application of pharmacogenomics to vaccines
    Gregory A Poland
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Pharmacogenomics 10:837-52. 2009
    ..Additional benefits from vaccinomic studies include the development of personalized vaccines, the development of novel vaccines and the development of novel vaccine adjuvants...
  71. ncbi request reprint Hepatitis B DNA vaccine induces protective antibody responses in human non-responders to conventional vaccination
    Scott T Rottinghaus
    Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 21:4604-8. 2003
    ..This study provides evidence in humans for protective immunogenicity of a particle-mediated DNA vaccine in subjects who have responded suboptimally to conventional vaccination...
  72. pmc Trends affecting the future of vaccine development and delivery: the role of demographics, regulatory science, the anti-vaccine movement, and vaccinomics
    Gregory A Poland
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3240-4. 2009
    ..These issues have been under-valued, under-discussed, and in some cases, ignored. We hope that discussion of these issues will result in changes in how we develop, and how we communicate those developments, to the public...
  73. ncbi request reprint A reexamination of the feasibility of the administration of routine childhood vaccines in emergency departments in the era of electronic vaccine registries
    Jennifer J Olson
    Department of Pediatric and Adolescent Medicine, Division of Pediatric Emergency Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905 0001, USA
    Pediatr Emerg Care 21:565-7. 2005
    ..To determine if electronic vaccine records facilitate successful routine childhood vaccination in the emergency department (ED)...
  74. ncbi request reprint Requiring influenza vaccination for health care workers: seven truths we must accept
    Gregory A Poland
    Mayo Vaccine Research Group, 611 C Guggenheim Building, 200 First Street, SW, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 23:2251-5. 2005
    ..High rates of health care worker immunization will benefit patients, health care workers, their families and employers, and the communities within which they work and live...
  75. ncbi request reprint Human leukocyte antigen polymorphisms: variable humoral immune responses to viral vaccines
    Inna G Ovsyannikova
    Department of Internal Medicine, Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Expert Rev Vaccines 5:33-43. 2006
    ..These associations not only explain why vaccine-induced humoral immune responses vary among individuals and between populations, but these variations may also hold the key to the development of future generations of vaccines...
  76. ncbi request reprint Clinical practice: prevention of hepatitis B with the hepatitis B vaccine
    Gregory A Poland
    Mayo Vaccine Research Group, Program in Translational Immunovirology and Biodefense, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 351:2832-8. 2004
  77. ncbi request reprint HLA homozygosity does not adversely affect measles vaccine-induced cytokine responses
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Virology 364:87-94. 2007
    ..01). Our results suggest that HLA homozygosity showed no disadvantage for measles-specific cytokine responses and instead was associated with increased IFN-gamma levels...
  78. ncbi request reprint Immunosenescence: role and measurement in influenza vaccine response among the elderly
    Paul V Targonski
    Vaccine Research Group, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 0001, United States
    Vaccine 25:3066-9. 2007
    ..We briefly review immunosenescence with a focus on replicative senescence in cytotoxic T cells and recent clinical studies examining its association with influenza and infectious disease outcomes...
  79. ncbi request reprint Avian and pandemic influenza: an overview
    Gregory A Poland
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Vaccine 25:3057-61. 2007
    ..This brief overview will review basic virologic, immunologic and epidemiologic information relevant to understanding and preparing for this threat. In particular, the role of avian influenza vaccines will be reviewed...
  80. ncbi request reprint Interleukin-4 induced by measles virus and measles-derived peptides as measured by IL-4 receptor-blocking ELISA
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Immunol Methods 287:217-25. 2004
    ..We propose that the IL-4 receptor-blocking assay is an easy-to-adapt technique for screening antigen-specific immune responses in large-scale population-based studies...
  81. ncbi request reprint Correlates of lymphoproliferative responses to measles, mumps, and rubella (MMR) virus vaccines following MMR-II vaccination in healthy children
    Neelam Dhiman
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, 611C Guggenheim Building, 200 First Street SW, Rochester, MN 55905, USA
    Clin Immunol 115:154-61. 2005
    ..This study demonstrates recall CMI post-MMR-II vaccination with significant intraclass correlation among the CMI responses to the three vaccine components...
  82. ncbi request reprint Severity of childhood asthma and human leukocyte antigens type
    Young J Juhn
    Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Asthma 44:163-8. 2007
    ..Because of limited statistical power, our study findings are subject to further investigation...
  83. ncbi request reprint Associations between measles antibody levels and the protein structure of class II human leukocyte antigens
    Jennifer L St Sauver
    Department of Health Sciences Research, Mayo Clinic and Foundation, Mayo Vaccine Research Group, Rochester, MN 55905, USA
    Hum Immunol 64:696-707. 2003
    ..Our data suggest that specific DQA and DQB amino acid variations are associated with measles seronegativity after vaccination...
  84. pmc Score tests for association between traits and haplotypes when linkage phase is ambiguous
    Daniel J Schaid
    Department of Health Sciences Research, Mayo Clinic Foundation, Rochester, MN 55905, USA
    Am J Hum Genet 70:425-34. 2002
    ..Limited simulations are also presented to demonstrate the validity of our methods, as well as to provide guidelines on how our methods could be used...
  85. ncbi request reprint Associations between human leukocyte antigen homozygosity and antibody levels to measles vaccine
    Jennifer L St Sauver
    Section of Clinical Epidemiology, Department of Health Sciences Research, Vaccine Research Group, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    J Infect Dis 185:1545-9. 2002
    ..These results suggest that lack of HLA diversity may limit the range of peptides that can be presented to antibody-producing cells, potentially resulting in a decreased immune response to viral infections...
  86. doi request reprint Effectiveness of inactivated influenza vaccine in children less than 5 years of age over multiple influenza seasons: a case-control study
    Avni Y Joshi
    Mayo Graduate School of Medicine, Mayo Clinic, Rochester, MN, United States
    Vaccine 27:4457-61. 2009
    ..This trend continued in the partially vaccinated group (Odds Ratio: 0.27, 95% Confidence Interval: 0.07-0.97) but the protection provided maybe suboptimal...
  87. ncbi request reprint Immunogenicity and reactogenicity of a novel vaccine for human papillomavirus 16: a 2-year randomized controlled clinical trial
    Gregory A Poland
    Division of General Internal Medicine, Mayo Vaccine Research Group, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 80:601-10. 2005
    ..To evaluate the immunogenicity, reactogenicity, and tolerability of a prototype human papillomavirus (HPV) 16 viruslike particle (VLP) vaccine directed against the L1 capsid protein...
  88. doi request reprint A program of anticipatory guidance for the prevention of emergency department visits for ear pain
    Deborah B McWilliams
    Division of Community Pediatric and Adolescent Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905 0001, USA
    Arch Pediatr Adolesc Med 162:151-6. 2008
    ..To test whether well-child care visit anticipatory guidance can safely reduce emergency department (ED) visits...
  89. ncbi request reprint Population-based prevalence of repeated group A beta-hemolytic streptococcal pharyngitis episodes
    Jennifer L St Sauver
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 81:1172-6. 2006
    ..To define the population-based 3-year period prevalence of repeated group A beta-hemolytic streptococcal (GABHS) pharyngitis episodes in children between 4 and 15 years of age...
  90. pmc Human leukocyte antigen and interleukin 2, 10 and 12p40 cytokine responses to measles: is there evidence of the HLA effect?
    Inna G Ovsyannikova
    Mayo Clinic Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cytokine 36:173-9. 2006
    ..These novel findings suggest that HLA class II genes may influence the level of cytokine production in the adaptive immune responses to measles vaccine...
  91. doi request reprint Health care worker pertussis immunization requirements and patient safety
    Gregory A Poland
    Mayo Clinic Vaccine Research Group, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Infect Control 36:390-1. 2008
  92. ncbi request reprint Childhood asthma and measles vaccine response
    Young J Juhn
    Division of Pediatric and Adolescent Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Allergy Asthma Immunol 97:469-76. 2006
    ..Asthmatic patients have a TH2-predominant milieu that is associated with humoral immunity. However, little is known about whether humoral immune responses to viral antigens differ between asthmatic and nonasthmatic children...
  93. ncbi request reprint Effect of differing immunization policies on circulating measles antibody levels in US and Canadian children
    Gregory A Poland
    Mayo Vaccine Research Group, Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 77:446-52. 2002
    ..To examine the effect of differing age-at-immunization policies on measles antibody levels in US children immunized at the age of 15 months compared with Canadian children immunized at the age of 12 months...
  94. ncbi request reprint High frequency of HLA-A*0103 allele in a Somali population
    G A Poland
    Mayo Vaccine Research Group, Rochester, MN 55905, USA
    Hum Immunol 62:197-200. 2001
    ..Lastly, this is the first identification of this allele in the homozygous state...
  95. ncbi request reprint The prevention of Lyme disease with vaccine
    G A Poland
    Department of Internal Medicine and Mayo Vaccine Research Group, 611C Guggenheim Building, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vaccine 19:2303-8. 2001
    ..Only mild or moderate, transient vaccine-associated adverse events have been reported after immunization. The vaccine is a safe and effective method of preventing Lyme disease...
  96. ncbi request reprint Teaching numeracy to physicians-in-training. Quantitative analysis for evidence-based medicine
    Robert M Jacobson
    Department of Pediatric and Adolescent Medicine, College of Medicine at Mayo Clinic, USA
    Minn Med 90:37-8, 46. 2007
    ..Since 2001, Mayo Clinic has been teaching its residents in pediatric and adolescent medicine the skills required for EBM. This article describes the 5 steps involved in practicing EBM, focusing on the interpretation of study results...
  97. ncbi request reprint Assessing participation bias in a population-based study of measles-mumps-rubella vaccine immunity in children and adolescents aged 12-18
    Jennifer L St Sauver
    Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA
    Paediatr Perinat Epidemiol 21:376-84. 2007
    ..However, special efforts may be necessary to improve research participation among children who are infrequent users of the health care systems of interest...
  98. pmc Effect of multiple freeze-thaw cycles on detection of measles, mumps, and rubella virus antibodies
    Norman A Pinsky
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Diagn Lab Immunol 10:19-21. 2003
    ....
  99. ncbi request reprint Comparison of fingerstick versus venipuncture for antibody testing of measles and rubella
    Norman A Pinsky
    Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minnesota, 55905, USA
    Scand J Infect Dis 35:107-9. 2003
    ..There was no significant difference in antibody levels from blood obtained by either method...
  100. doi request reprint Characterization of the duration from onset of asthma symptoms to asthma disease
    Molly Martyn
    Mayo Medical School, Rochester, Minnesota 55905, USA
    Ann Allergy Asthma Immunol 100:589-95. 2008
    ..Little is known about factors associated with progression of childhood asthma from onset of symptoms to index date determined by medical records...
  101. ncbi request reprint Seroprevalence of antibody to varicella among Somali refugees
    Lana J Nysse
    Mayo Vaccine Research Group, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 82:175-80. 2007
    ..To determine the seroprevalence of varicella antibody among recent Somali refugees living in Olmsted County, Minnesota, and to estimate the risk of varicella-zoster virus (VZV) infection in this group...