CLIFFORD ROBERT JACK
Affiliation: Mayo Clinic
- Jack C, Lowe V, Weigand S, Wiste H, Senjem M, Knopman D, et al. Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain. 2009;132:1355-65 pubmed publisher..This model implies a complimentary role for MRI and PIB imaging in Alzheimer's disease, with each reflecting one of the major pathologies, amyloid dysmetabolism and neurodegeneration. ..
- Jack C, Wiste H, Weigand S, Therneau T, Knopman D, Lowe V, et al. Age-specific and sex-specific prevalence of cerebral β-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50-95 years: a cross-sectional study. Lancet Neurol. 2017;16:435-444 pubmed publisher..National Institute on Aging (part of the US National Institutes of Health), the Alexander Family Professorship of Alzheimer's Disease Research, the Mayo Clinic, and the GHR Foundation. ..
- Jack C, Wiste H, Weigand S, Rocca W, Knopman D, Mielke M, et al. Age-specific population frequencies of cerebral Î²-amyloidosis and neurodegeneration among people with normal cognitive function aged 50-89 years: a cross-sectional study. Lancet Neurol. 2014;13:997-1005 pubmed publisher..US National Institute on Aging and Alexander Family Professorship of Alzheimer's Disease Research. ..
- Jack C, Holtzman D. Biomarker modeling of Alzheimer's disease. Neuron. 2013;80:1347-58 pubmed publisher..In this Review, we discuss several time-dependent models of AD that take into consideration varying age of onset (early versus late) and the influence of aging and co-occurring brain pathologies that commonly arise in the elderly. ..
- Jack C, Wiste H, Lesnick T, Weigand S, Knopman D, Vemuri P, et al. Brain ?-amyloid load approaches a plateau. Neurology. 2013;80:890-6 pubmed publisher..5-2.5 is approximately 15 years. This roughly 15-year interval where the slope of the amyloid SUVR vs time curve is greatest and roughly linear represents a large therapeutic window for secondary preventive interventions. ..
- Jack C, Albert M, Knopman D, McKhann G, Sperling R, Carrillo M, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011;7:257-62 pubmed publisher..However, the recommendations of the preclinical AD workgroup are intended purely for research purposes. ..
- Aisen P, Cummings J, Jack C, Morris J, Sperling R, FrÃ¶lich L, et al. On the path to 2025: understanding the Alzheimer's disease continuum. Alzheimers Res Ther. 2017;9:60 pubmed publisher..While the pathophysiology of AD has still not been elucidated completely, there is ample evidence to support researchers and clinicians embracing the view of a disease continuum in their study, diagnosis, and management of the disease. ..
- Marks M, Alexander A, Matsumoto J, Matsumoto J, Morris J, Petersen R, et al. Creating three dimensional models of Alzheimer's disease. 3D Print Med. 2017;3:13 pubmed publisher..Our explicated workflow can create effective models of Alzheimer's brains that can be used in patient education, medical education, and policy forums. ..