Michael Hutton

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease
    Hanno M Roder
    Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Expert Opin Ther Targets 11:435-42. 2007
  2. pmc Progranulin in frontotemporal lobar degeneration and neuroinflammation
    Zeshan Ahmed
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    J Neuroinflammation 4:7. 2007
  3. pmc Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, MD, USA
    BMC Neurol 6:44. 2006
  4. ncbi The presenilins and Alzheimer's disease
    M Hutton
    Neurogenetics Laboratory, The Mayo Clinic Jacksonville, FL 32224, USA
    Hum Mol Genet 6:1639-46. 1997
  5. ncbi Analysis of tauopathies with transgenic mice
    M Hutton
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, USA
    Trends Mol Med 7:467-70. 2001
  6. ncbi Molecular genetics of chromosome 17 tauopathies
    M Hutton
    Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Ann N Y Acad Sci 920:63-73. 2000
  7. ncbi Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17
    M Hutton
    Mayo Clinic Jacksonville, Florida 32224, USA
    Nature 393:702-5. 1998
  8. ncbi Progressive white matter pathology in the spinal cord of transgenic mice expressing mutant (P301L) human tau
    Wen Lang Lin
    Mayo Clinic College of Medicine, Jacksonville, Florida, 32224, USA
    J Neurocytol 34:397-410. 2005
  9. ncbi Phosphorylated p38MAPK specific antibodies cross-react with sarkosyl-insoluble hyperphosphorylated tau proteins
    Naruhiko Sahara
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA
    J Neurochem 90:829-38. 2004
  10. ncbi Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau
    Wen Lang Lin
    Mayo Clinic, Jacksonville, Florida 32224, USA
    J Neurocytol 32:1091-105. 2003

Research Grants

  1. Tau and Neurodegeneration II: A therapeutic target
    Michael Hutton; Fiscal Year: 2007
  2. Amyloid and tau pathology in a transgenic model
    Michael Hutton; Fiscal Year: 2006
  3. Tangle Formation in P301L Transgenic Mice
    Michael Hutton; Fiscal Year: 2005
  4. The genetics of chromosome 17q21-linked tau-negative FTD
    Michael Hutton; Fiscal Year: 2006

Detail Information

Publications50

  1. ncbi Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease
    Hanno M Roder
    Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Expert Opin Ther Targets 11:435-42. 2007
    ..In this review, the authors discuss some of the main therapeutic ideas presently advanced in the field and their molecular rationales...
  2. pmc Progranulin in frontotemporal lobar degeneration and neuroinflammation
    Zeshan Ahmed
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    J Neuroinflammation 4:7. 2007
    ....
  3. pmc Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, MD, USA
    BMC Neurol 6:44. 2006
    ..A new locus for amyotrophic lateral sclerosis--frontotemporal dementia (ALS-FTD) has recently been ascribed to chromosome 9p...
  4. ncbi The presenilins and Alzheimer's disease
    M Hutton
    Neurogenetics Laboratory, The Mayo Clinic Jacksonville, FL 32224, USA
    Hum Mol Genet 6:1639-46. 1997
    ....
  5. ncbi Analysis of tauopathies with transgenic mice
    M Hutton
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, USA
    Trends Mol Med 7:467-70. 2001
    ..Recent progress in the development of transgenic mouse models of human tauopathy is allowing these questions to be addressed...
  6. ncbi Molecular genetics of chromosome 17 tauopathies
    M Hutton
    Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Ann N Y Acad Sci 920:63-73. 2000
    ....
  7. ncbi Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17
    M Hutton
    Mayo Clinic Jacksonville, Florida 32224, USA
    Nature 393:702-5. 1998
    ..The increase in exon 10+ messenger RNA will increase the proportion of Tau containing four microtubule-binding repeats, which is consistent with the neuropathology described in several families with FTDP-17...
  8. ncbi Progressive white matter pathology in the spinal cord of transgenic mice expressing mutant (P301L) human tau
    Wen Lang Lin
    Mayo Clinic College of Medicine, Jacksonville, Florida, 32224, USA
    J Neurocytol 34:397-410. 2005
    ..The progressive axonal pathology is most consistent with a dying-back process caused by abnormal accumulation of tau in upstream neurons, while vacuolar myelinopathy may be a secondary manifestation of neuroinflammation...
  9. ncbi Phosphorylated p38MAPK specific antibodies cross-react with sarkosyl-insoluble hyperphosphorylated tau proteins
    Naruhiko Sahara
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA
    J Neurochem 90:829-38. 2004
    ..Together, the results indicate that the cross-reactivity of antiactive-p38MAPK antibody with phosphorylated tau is responsible for the immunolabeling of tau-positive inclusion...
  10. ncbi Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau
    Wen Lang Lin
    Mayo Clinic, Jacksonville, Florida 32224, USA
    J Neurocytol 32:1091-105. 2003
    ..These P301L transgenic mice exhibit many features common to human tauopathies, making them a valuable model to study the pathogenesis of these uncommon disorders...
  11. pmc The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
    Chad A Dickey
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
    J Clin Invest 117:648-58. 2007
    ....
  12. ncbi Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene
    Nilufer Ertekin-Taner
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Hum Mol Genet 14:447-60. 2005
    ..PLAU_1 is a plausible pathogenic mutation that could act by increasing Abeta42, but additional biological experiments are required to show this definitively...
  13. pmc Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice
    Takashi Ishizawa
    Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32225, USA
    Am J Pathol 163:1057-67. 2003
    ....
  14. ncbi Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species
    Chad A Dickey
    Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    J Neurosci 26:6985-96. 2006
    ..Based on these findings, we propose that polyubiquitination of tau by CHIP may facilitate the formation of insoluble filamentous tau lesions...
  15. ncbi Presenilin 1 mutation in an african american family presenting with atypical Alzheimer dementia
    Gregory A Rippon
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Arch Neurol 60:884-8. 2003
    ..Mutations in 3 genes (presenilin 1 and 2 and amyloid precursor protein) are associated with presenile AD. Presenilin 1 gene mutations have not been described in African Americans...
  16. ncbi A novel tau mutation in exon 9 (1260V) causes a four-repeat tauopathy
    Andrew Grover
    Laboratory of Neurogenetics, Neuroscience Department, Mayo Clinic, Jacksonville, FL 32224, USA
    Exp Neurol 184:131-40. 2003
    ....
  17. ncbi The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy
    Marion Hogg
    Neurogenetics Laboratory, Mayo Clinic Jacksonville, Jacksonville, Florida, USA
    Acta Neuropathol 106:323-36. 2003
    ..In addition, the results of the RD3 and ET3 immunostains clearly explain for the first time the presence of both 3R and 4R tau isoforms in preparations of insoluble tau from some Pick's disease cases...
  18. ncbi A decade of modeling Alzheimer's disease in transgenic mice
    Eileen McGowan
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Trends Genet 22:281-9. 2006
    ..The relationship between these lesions, neurodegeneration and development of the clinical syndrome will be explored...
  19. ncbi The genetics of frontotemporal dementia
    Kristoffer Haugarvoll
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neurol Clin 25:697-715, vi. 2007
    ..The clinical and neuropathologic features of frontotemporal dementia with parkinsonism linked to chromosome 17 and the nature of the mutations in the progranulin and microtubule-associated protein tau genes are emphasized...
  20. ncbi Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease
    Todd E Golde
    Mayo Clinic College of Medicine, Department of Neuroscience, Mayo Clinic Jacksonville 4500 San Pablo Rd, Jacksonville, Florida 32224, USA
    Curr Alzheimer Res 3:421-30. 2006
    ....
  21. ncbi Clinical features and disease haplotypes of individuals with the N279K tau gene mutation: a comparison of the pallidopontonigral degeneration kindred and a French family
    Yoshio Tsuboi
    Department of Neurology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Arch Neurol 59:943-50. 2002
    ..An N279K missense mutation in exon 10 of the tau gene reported in an American family with pallidopontonigral degeneration (PPND family) was recently found in members of a French kindred with dementia and supranuclear palsy...
  22. ncbi Clearing tau pathology with Abeta immunotherapy--reversible and irreversible stages revealed
    Michael Hutton
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neuron 43:293-4. 2004
    ..This result supports a primary role for Abeta in AD etiology...
  23. doi Progranulin gene mutation with an unusual clinical and neuropathologic presentation
    Christian Wider
    Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA
    Mov Disord 23:1168-73. 2008
    ..This study further expands the clinical and pathological spectrum of PGRN mutations, and suggests the diagnosis could be missed in some individuals with atypical presentations...
  24. pmc Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation
    Wen Lang Lin
    Mayo Clinic, Jacksonville, Florida, USA
    Am J Pathol 162:213-8. 2003
    ..Given similarities of the lesions in the mice to human neuronal and glial inclusions, these transgenic mice appear to be a valuable model to study pathogenesis of the neurodegenerative tauopathies...
  25. pmc Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
    Nilufer Ertekin-Taner
    Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Hum Mol Genet 12:3133-43. 2003
    ..These findings indicate that VR22 has variant(s) which influence Abeta42 and contribute to the previously reported linkage for plasma Abeta42 in LOAD families...
  26. ncbi HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites
    Chad A Dickey
    Mayo Clinic Jacksonville, College of Medicine, Jacksonville, Florida, USA
    FASEB J 20:753-5. 2006
    ....
  27. ncbi Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study
    Bradley F Boeve
    Department of Neurology, Mayo Clinic Rochester, MN 55905, USA
    Brain 129:3103-14. 2006
    ..These findings suggest that the insR352 PSEN1 is not pathogenic, and the IVS1+1G-->A mutation in PGRN causes FTDP associated with FTLD-U pathology and represents a new class of neurodegenerative disease--the 'hypoprogranulinopathies'...
  28. ncbi Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment
    Richard J Caselli
    Department of Neurology, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    Arch Neurol 64:1306-11. 2007
    ..These changes could represent presymptomatic disease in some, despite their youth...
  29. ncbi Progressive supranuclear palsy: pathology and genetics
    Dennis W Dickson
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Brain Pathol 17:74-82. 2007
    ..Imaging studies suggest that there may be sensitive and specific means to differentiate PSP from other parkinsonian disorders, but identification of a diagnostic biomarker is still elusive...
  30. ncbi The effect of tau genotype on clinical features in FTDP-17
    Yasuhiko Baba
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Parkinsonism Relat Disord 11:205-8. 2005
    ..7; 95% confidence interval, 1.4-98.7; P=0.008). Our results suggest that tau genotype does not influence the disease course. However, it may predispose to a specific clinical sign in the early stage of FTDP-17...
  31. pmc Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL FL 32224, USA
    Hum Mol Genet 17:3631-42. 2008
    ..Translational regulation by miRNAs may represent a common mechanism underlying complex neurodegenerative disorders...
  32. pmc Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates
    Irving E Vega
    Department of Neuroscience, Mayo Clinic College of Medicine, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Brain Res Mol Brain Res 138:135-44. 2005
    ..The results suggest that tyrosine phosphorylation is as important as phosphorylation of other residues in tauopathy...
  33. pmc Early onset familial Alzheimer Disease with spastic paraparesis, dysarthria, and seizures and N135S mutation in PSEN1
    Leslie A Rudzinski
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Alzheimer Dis Assoc Disord 22:299-307. 2008
    ....
  34. ncbi Atypical progressive supranuclear palsy with corticospinal tract degeneration
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    J Neuropathol Exp Neurol 65:396-405. 2006
    ..The clinicopathologic features of these 12 cases expand the spectrum of 4R tauopathies...
  35. ncbi Hereditary diffuse leukoencephalopathy with spheroids: clinical, pathologic and genetic studies of a new kindred
    Yasuhiko Baba
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Acta Neuropathol 111:300-11. 2006
    ..Immunohistochemistry for APP and alphaB-crystallin demonstrates distinctive neurodegeneration in cerebral axons and perikarya...
  36. ncbi A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch
    Zareen Amtul
    Department of Neuroscience and Pharmacology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Neurobiol Dis 9:269-73. 2002
    ..The distinct clinical phenotype associated with this mutation suggests that chronic partial inhibition of gamma-secretase activity may result in neurodegeneration...
  37. ncbi Clinical-pathologic study of biomarkers in FTDP-17 (PPND family with N279K tau mutation)
    Zoe Arvanitakis
    Department of Neurology, Mayo Clinic, Jacksonville, FL, USA
    Parkinsonism Relat Disord 13:230-9. 2007
    ..Autopsy of six affected subjects showed frontotemporal degeneration with extensive tauopathy. Further studies of FTDP-17 patients are needed to replicate these findings...
  38. ncbi Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    J Neuropathol Exp Neurol 66:142-51. 2007
    ..On the other hand, there is no histopathologic feature or combination of features that is pathognomonic. Neuronal intranuclear inclusions are virtually always present, but they can be detected in PGRN(-) cases...
  39. pmc TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
    Catalina Amador-Ortiz
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Ann Neurol 61:435-45. 2007
    ....
  40. pmc Voxel-based morphometry in frontotemporal lobar degeneration with ubiquitin-positive inclusions with and without progranulin mutations
    Jennifer L Whitwell
    Division of Behavioral Neurology, Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 64:371-6. 2007
    ..Mutations in the progranulin gene (PGRN) have recently been identified as a cause of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) in some families...
  41. pmc Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging
    Zeshan Ahmed
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
    Am J Pathol 177:311-24. 2010
    ..Our data suggests that PGRN plays a key role in maintaining neuronal function during aging and supports the notion that PGRN is a trophic factor essential for long-term neuronal survival...
  42. ncbi Heredofamilial brain calcinosis syndrome
    Yasuhiko Baba
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Fla 32224, USA
    Mayo Clin Proc 80:641-51. 2005
    ..We review conditions associated with heredofamilial BCS in which brain calcinosis is nearly uniformly present because such information may be Important to the clinician pursuing an investigative strategy...
  43. ncbi Neurofibrillary tangle-related synaptic alterations of spinal motor neurons of P301L tau transgenic mice
    Omi Katsuse
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neurosci Lett 409:95-9. 2006
    ..In addition, synaptic boutons were detached from NFT-bearing neurons with the resulting space occupied by astrocytic processes, suggesting that astrocytes may be involved in the observed synaptic alterations...
  44. ncbi Association between apolipoprotein E genotype and Alzheimer disease in African American subjects
    Neill R Graff-Radford
    Genetics Program L 320, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Arch Neurol 59:594-600. 2002
    ..The association between Alzheimer disease (AD) and genotypes at the apolipoprotein E (APOE) locus has been confirmed in numerous populations worldwide, but appears to be inconsistent in African American subjects...
  45. ncbi High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy
    Rosa Rademakers
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Belgium
    Hum Mol Genet 14:3281-92. 2005
    ..Thus, risk variants on different H1 htSNP haplotypes and protective variants on H2 contribute to population risk for PSP...
  46. pmc APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway
    Sigrid B Sando
    Department of Neuroscience, Norwegian University of Science and Technology, NTNU, Trondheim, Norway
    BMC Neurol 8:9. 2008
    ....
  47. pmc GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers
    Eric M Reiman
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
    Neuron 54:713-20. 2007
    ..Our findings suggest that GAB2 modifies LOAD risk in APOE epsilon4 carriers and influences Alzheimer's neuropathology...
  48. ncbi Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center and Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Arch Neurol 64:43-7. 2007
    ..Primary progressive aphasia (PPA) is a language-based dementia characterized by fluent or nonfluent language disorder as its principal feature...
  49. pmc Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies
    John V Pearson
    Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
    Am J Hum Genet 80:126-39. 2007
    ....
  50. ncbi Haplotype-phenotype correlations in kindreds with the N279K mutation in the tau gene
    Bryan K Woodruff
    Arch Neurol 61:1327; author reply 1327. 2004

Research Grants10

  1. Tau and Neurodegeneration II: A therapeutic target
    Michael Hutton; Fiscal Year: 2007
    ..Project 3 will study the impact of the chaperone Hsp70 and its co-chaperone CHIP on tau pathogenesis whilst Project 4, will examine the impact of tau phosphorylation on pathology and neurodegeneration...
  2. Amyloid and tau pathology in a transgenic model
    Michael Hutton; Fiscal Year: 2006
    ..abstract_text> ..
  3. Tangle Formation in P301L Transgenic Mice
    Michael Hutton; Fiscal Year: 2005
    ....
  4. The genetics of chromosome 17q21-linked tau-negative FTD
    Michael Hutton; Fiscal Year: 2006
    ..The identification of this gene will be a crucial step towards understanding the etiology of FTD as well as determining how this disease relates to MND. ..