John Heit


Affiliation: Mayo Clinic
Country: USA


  1. Heit J, Lahr B, Ashrani A, Petterson T, Bailey K. Predictors of venous thromboembolism recurrence, adjusted for treatments and interim exposures: a population-based case-cohort study. Thromb Res. 2015;136:298-307 pubmed publisher
    ..Baseline and interim exposures can stratify VTE recurrence risk and may be useful for directing secondary prophylaxis. ..
  2. Atkinson E, Eckel Passow J, Wang A, Greenberg A, Scott C, Pankratz V, et al. The association of copy number variation and percent mammographic density. BMC Res Notes. 2015;8:297 pubmed publisher
    ..Even so, the proximity of the identified CNV regions to loci known to be associated with breast cancer risk suggests further investigation and potentially shared genetic mechanisms underlying the PD and breast cancer association. ..
  3. Heit J. The epidemiology of venous thromboembolism in the community: implications for prevention and management. J Thromb Thrombolysis. 2006;21:23-9 pubmed
    ..Better individual risk stratification is needed in order to modify exposures and target primary and secondary prophylaxis to the person who would benefit most. ..
  4. Heit J, Lahr B, Petterson T, Bailey K, Ashrani A, Melton L. Heparin and warfarin anticoagulation intensity as predictors of recurrence after deep vein thrombosis or pulmonary embolism: a population-based cohort study. Blood. 2011;118:4992-9 pubmed publisher
    ..In summary, lower-intensity heparin and standard-intensity warfarin anticoagulation are effective in preventing VTE recurrence. ..
  5. Barsoum M, Cohoon K, Roger V, Mehta R, Hodge D, Bailey K, et al. Are myocardial infarction and venous thromboembolism associated? Population-based case-control and cohort studies. Thromb Res. 2014;134:593-8 pubmed publisher
    ..In both univariate and multivariate analyses, VTE (overall or idiopathic) was not a predictor of MI. MI is not an independent risk factor for VTE, and VTE is not a predictor of MI. ..
  6. Petterson T, Marks R, Ashrani A, Bailey K, Heit J. Risk of site-specific cancer in incident venous thromboembolism: a population-based study. Thromb Res. 2015;135:472-8 pubmed publisher
    ..001). Adjusting for age and sex, pancreatic, brain, other digestive cancers, and lymphoma had significantly higher RRs than the grouped comparison cancers. Incident VTE risk can be stratified by cancer site. ..
  7. Kumar R, Rodriguez V, Matsumoto J, Khan S, Weaver A, McBane R, et al. Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: a cohort study. Thromb Res. 2015;135:347-51 pubmed publisher
    ..Number of thrombosed vein segments at diagnosis and time duration between incident DVT and survey completion were independent predictors of PTS. ..
  8. Cohoon K, Leibson C, Ransom J, Ashrani A, Petterson T, Long K, et al. Costs of venous thromboembolism associated with hospitalization for medical illness. Am J Manag Care. 2015;21:e255-63 pubmed
    ..VTE during or after recent hospitalization for medical illness contributes a substantial economic burden. ..
  9. Heit J. Predicting the risk of venous thromboembolism recurrence. Am J Hematol. 2012;87 Suppl 1:S63-7 pubmed publisher
    ..The appropriateness of secondary prophylaxis should be continuously reevaluated, and the prophylaxis stopped if the benefit no longer exceeds the risk. ..

More Information


  1. Heit J, Spencer F, White R. The epidemiology of venous thromboembolism. J Thromb Thrombolysis. 2016;41:3-14 pubmed publisher
    ..Although independent VTE risk factors and predictors of VTE recurrence have been identified, and effective primary and secondary prophylaxis is available, the occurrence of VTE seems to be relatively constant, or even increasing. ..
  2. Cohoon K, Ransom J, Leibson C, Ashrani A, Petterson T, Long K, et al. Direct Medical Costs Attributable to Cancer-Associated Venous Thromboembolism: A Population-Based Longitudinal Study. Am J Med. 2016;129:1000.e15-25 pubmed publisher
    ..Venous thromboembolism-attributable costs among patients with active cancer contribute a substantial economic burden and are highest from index to 3 months, but may persist for up to 5 years. ..
  3. Heit J, Armasu S, McCauley B, Kullo I, Sicotte H, Pathak J, et al. Identification of unique venous thromboembolism-susceptibility variants in African-Americans. Thromb Haemost. 2017;117:758-768 pubmed publisher
  4. Cohoon K, Leibson C, Ransom J, Ashrani A, Park M, Petterson T, et al. Direct medical costs attributable to venous thromboembolism among persons hospitalized for major operation: a population-based longitudinal study. Surgery. 2015;157:423-31 pubmed publisher
    ..VTE during or after recent hospitalization for major operation contributes a substantial economic burden; VTE-attributable costs are greatest in the initial 3 months but persist for up to 5 years. ..
  5. Heit J, ASHRANI A, Crusan D, McBane R, Petterson T, Bailey K. Reasons for the persistent incidence of venous thromboembolism. Thromb Haemost. 2017;117:390-400 pubmed publisher
    ..Increasing surgery PAR suggests that concurrent efforts to prevent VTE may have been insufficient. ..
  6. Heit J, Armasu S, Asmann Y, Cunningham J, Matsumoto M, Petterson T, et al. A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q. J Thromb Haemost. 2012;10:1521-31 pubmed publisher
    ..0 and 1.51 for minor allele frequencies=0.05 and 0.5, respectively (?=1×10(-8); 1% VTE prevalence). Apart from F5 rs6025, ABO rs8176719, rs2519093 and F2 rs1799963, additional common and high VTE-risk SNPs among whites are unlikely. ..
  7. de Andrade M, Armasu S, McCauley B, Petterson T, Heit J. Identification of Genetic Interaction with Risk Factors Using a Time-To-Event Model. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..We showed that the time-to-event model is a useful approach for identifying potential hazard-modification of the genetic variants when the event of interest (VTE) occurs due to a risk factor (pre- or post-partum). ..