Michael Heckman

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint LRRK2 exonic variants and risk of multiple system atrophy
    Michael G Heckman
    From the Section of Biostatistics M G H, N N D and Departments of Neuroscience A I S O, S R, K O, M E M, D W D, O A R and Neurology S F, W P C, R J U, Z K W, Mayo Clinic, Jacksonville, FL Department of Molecular Neuroscience L S, A s, H H, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK Department of Medical Genetics M J F, University of British Columbia, Vancouver, Canada Laboratory of Neurogenetics A B S, National Institute on Aging, Bethesda, MD Institute of Genetic Medicine P F C, M J K, Newcastle University, Central Parkway, Newcastle upon Tyne Neuropathology Unit S M G, Department of Medicine, Imperial College London Queen Square Brain Bank for Neurological Disorders J L H, K A, Department of Molecular Neuroscience, UCL Institute of Neurology, University College London Clinical and Cognitive Sciences Research Group D M A M, Institute of Brain, Behavior and Mental Health, Tel Aviv University
    Neurology 83:2256-61. 2014
  2. ncbi request reprint Analysis of COQ2 gene in multiple system atrophy
    Kotaro Ogaki
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Mol Neurodegener 9:44. 2014
  3. ncbi request reprint Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene
    Marka van Blitterswijk
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Mol Neurodegener 9:38. 2014
  4. pmc Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants
    Michael G Heckman
    Section of Biostatistics, Mayo Clinic, Jacksonville, FL, USA Electronic address
    Neurobiol Aging 35:266.e5-14. 2014
  5. pmc Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke
    M G Heckman
    Biostatistics Unit, Mayo Clinic, Jacksonville, FL 32224, USA
    Eur J Neurol 20:300-8. 2013
  6. ncbi request reprint Evaluation of MDM2, p16, and p53 staining levels as biomarkers of biochemical recurrence following salvage radiation therapy for recurrent prostate cancer
    Michael G Heckman
    Biostatistics Unit, Mayo Clinic Florida, Jacksonville, Florida 32224, USA
    Prostate 72:1757-66. 2012
  7. pmc Evaluation of the role of SNCA variants in survival without neurological disease
    Michael G Heckman
    Biostatistics Unit, Mayo Clinic, Jacksonville, Florida, United States of America
    PLoS ONE 7:e42877. 2012
  8. pmc In vivo silencing of alpha-synuclein using naked siRNA
    Jada Lewis
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Mol Neurodegener 3:19. 2008

Collaborators

Detail Information

Publications8

  1. ncbi request reprint LRRK2 exonic variants and risk of multiple system atrophy
    Michael G Heckman
    From the Section of Biostatistics M G H, N N D and Departments of Neuroscience A I S O, S R, K O, M E M, D W D, O A R and Neurology S F, W P C, R J U, Z K W, Mayo Clinic, Jacksonville, FL Department of Molecular Neuroscience L S, A s, H H, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK Department of Medical Genetics M J F, University of British Columbia, Vancouver, Canada Laboratory of Neurogenetics A B S, National Institute on Aging, Bethesda, MD Institute of Genetic Medicine P F C, M J K, Newcastle University, Central Parkway, Newcastle upon Tyne Neuropathology Unit S M G, Department of Medicine, Imperial College London Queen Square Brain Bank for Neurological Disorders J L H, K A, Department of Molecular Neuroscience, UCL Institute of Neurology, University College London Clinical and Cognitive Sciences Research Group D M A M, Institute of Brain, Behavior and Mental Health, Tel Aviv University
    Neurology 83:2256-61. 2014
    ..The aim of this study was to evaluate the association between common exonic variants in the leucine-rich repeat kinase 2 (LRRK2) gene and risk of multiple system atrophy (MSA)...
  2. ncbi request reprint Analysis of COQ2 gene in multiple system atrophy
    Kotaro Ogaki
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Mol Neurodegener 9:44. 2014
    ....
  3. ncbi request reprint Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene
    Marka van Blitterswijk
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Mol Neurodegener 9:38. 2014
    ..Substantial phenotypic heterogeneity has been described in patients with these expansions. We set out to identify genetic modifiers of disease risk, age at onset, and survival after onset that may contribute to this clinical variability...
  4. pmc Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants
    Michael G Heckman
    Section of Biostatistics, Mayo Clinic, Jacksonville, FL, USA Electronic address
    Neurobiol Aging 35:266.e5-14. 2014
    ..R1398H genotypes. Our results indicate that the association of LRRK2 p.R1398H with Parkinson's disease is independent of SNCA and MAPT variants, and vice versa, in Caucasian and Asian populations...
  5. pmc Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke
    M G Heckman
    Biostatistics Unit, Mayo Clinic, Jacksonville, FL 32224, USA
    Eur J Neurol 20:300-8. 2013
    ..This study evaluated whether genetic risk factors for CAD and MI also affect susceptibility to ischaemic stroke in Caucasians and African Americans...
  6. ncbi request reprint Evaluation of MDM2, p16, and p53 staining levels as biomarkers of biochemical recurrence following salvage radiation therapy for recurrent prostate cancer
    Michael G Heckman
    Biostatistics Unit, Mayo Clinic Florida, Jacksonville, Florida 32224, USA
    Prostate 72:1757-66. 2012
    ..Herein, we provide the first evaluation of the ability of staining levels of the tumor based biomarkers MDM2, p16, and p53 to aid in prediction of biochemical recurrence (BCR) among men undergoing SRT for recurrent prostate cancer...
  7. pmc Evaluation of the role of SNCA variants in survival without neurological disease
    Michael G Heckman
    Biostatistics Unit, Mayo Clinic, Jacksonville, Florida, United States of America
    PLoS ONE 7:e42877. 2012
    ..This exploratory study examined whether SNCA variants may also promote successful aging as defined by survival without neurological disease...
  8. pmc In vivo silencing of alpha-synuclein using naked siRNA
    Jada Lewis
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Mol Neurodegener 3:19. 2008
    ..Genetic variability in SNCA contributes to risk of idiopathic Parkinson's disease (PD), possibly as a result of overexpression. SNCA downregulation is therefore a valid therapeutic target for PD...