Research Topics
| L C HartmannSummaryAffiliation: Mayo Clinic Country: USA Publications
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Detail Information
Publications
Mammary involution and breast cancer risk: transgenic models and clinical studiesDerek C Radisky
Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA
J Mammary Gland Biol Neoplasia 14:181-91. 2009..By contrast, new human studies show that completion of lobular involution protects against subsequent breast cancer incidence...- Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancerKristin L White
Mayo Clinic College of Medicine, Rochester, MN, USA
BMC Cancer 9:170. 2009..Inhibitors of kappaB (IkappaB) prevent NF-kappaB activation by sequestering NF-kappaB proteins in the cytoplasm until IkappaB proteins are phosphorylated and degraded... - Unrealistic expectationsLynn C Hartmann
J Clin Oncol 23:4231-2; discussion 4233-4. 2005 - Gene expression profiles predict early relapse in ovarian cancer after platinum-paclitaxel chemotherapyLynn C Hartmann
Mayo Clinic Cancer Center, 200 First Street Southwest, Rochester, MN 55905, USA
Clin Cancer Res 11:2149-55. 2005..We hypothesized that differences in gene expression before treatment could distinguish patients with short versus long time to recurrence after administration of platinum-paclitaxel combination chemotherapy... - Management of cancer pain. Safe, adequate analgesia to improve quality of lifeL C Hartmann
Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
Postgrad Med 107:267-72, 275-6. 2000.... - Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriersL C Hartmann
Division of Medical Oncology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
J Natl Cancer Inst 93:1633-7. 2001..We examined the association between bilateral prophylactic mastectomy and breast cancer risk in women at high risk for breast cancer who also had mutations in BRCA1 and BRCA2 genes... - Genetic analysis of early- versus late-stage ovarian tumorsV Shridhar
Department of Experimental Pathology, Division of Laboratory Medicine, The Mayo Clinic and Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA
Cancer Res 61:5895-904. 2001..However, differences observed at the genomic level suggest differences between the early- and late-stage tumors and provide support for a progression model for ovarian cancer development... - Efficacy of contralateral prophylactic mastectomy in women with a personal and family history of breast cancerS K McDonnell
Division of Medical Oncology, Mayo Clinic Cancer Center, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
J Clin Oncol 19:3938-43. 2001..6% to 99.5%). CONCLUSION: The incidence of contralateral breast cancer seems to be reduced significantly after contralateral prophylactic mastectomy in women with a personal and family history of breast cancer... - Cigarette smoking increases risk for breast cancer in high-risk breast cancer familiesF J Couch
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer Epidemiol Biomarkers Prev 10:327-32. 2001..8-3.2). These results suggest that smoking may increase risk for breast cancer in families with multiple cases of breast or ovarian cancer, especially those with the strongest apparent familial predisposition... - Association of Peutz-Jeghers-like mucocutaneous pigmentation with breast and gynecologic carcinomas in womenL A Boardman
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
Medicine (Baltimore) 79:293-8. 2000..In particular, the relative risk for cancer in females with IMMP was significantly increased, as is true in females with PJS. However, LKB1 mutations did not contribute to the development of IMMP in the patients tested... - Phase I trial of autologous hematopoietic SCT with escalating doses of topotecan combined with CY and carboplatin in patients with relapsed or persistent ovarian or primary peritoneal carcinomaM R Litzow
Division of Hematology, Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Bone Marrow Transplant 45:490-7. 2010..04). Topotecan can safely be dose escalated to 4.5 mg/m(2)/d in combination with CY, carboplatin and AHSCT. This trial is registered at ClinicalTrials.gov as NCT00652691... - Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancerV Shridhar
Division of Experimental Pathology, Mayo Clinic Foundation, 200 First Street SW, Rochester, MN 55905, USA
Cancer Res 61:4258-65. 2001.... - Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable mannerR Rattan
Department of Experimental Pathology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
J Cell Mol Med 15:166-78. 2011..Collectively, these results provide evidence on the role of metformin as an anti-proliferative therapeutic that can act through both AMPK-dependent as well as AMPK-independent pathways... - Breast cancer prevention trialsD J Rhodes
Division of General Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Curr Oncol Rep 2:558-65. 2000..Until the results of this trial are available, it is premature to use raloxifene for primary breast cancer prevention... - T-cell immunity to the folate receptor alpha is prevalent in women with breast or ovarian cancerKeith L Knutson
Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Clin Oncol 24:4254-61. 2006..A candidate antigen is the folate receptor alpha (FRalpha), which is overexpressed in breast and ovarian cancers. Our goal in this study was to attain a better understanding of the extent of endogenous FRalpha immunity... - Serine protease HtrA1 modulates chemotherapy-induced cytotoxicityJeremy Chien
Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA, Medical Oncology Unit and Department of Histopathology, San Salvatore Hospital, Pesaro, Italy
J Clin Invest 116:1994-2004. 2006.... - An analysis of breast cancer risk in women with single, multiple, and atypical papillomaJason T Lewis
Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Surg Pathol 30:665-72. 2006..The presence of papilloma in, or associated with, atypia does not modify the risk connotation of ADH/ALH overall. MP constitutes a proliferative breast disease subset having unique clinical and biologic behavior... - Independent test set performance in the prediction of early relapse in ovarian cancer with gene expression profilesFrank De Smet
Clin Cancer Res 11:7958-9; author reply 7959. 2005 - Satisfaction after contralateral prophylactic mastectomy: the significance of mastectomy type, reconstructive complications, and body appearanceMarlene H Frost
Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA
J Clin Oncol 23:7849-56. 2005..The purpose of this research is to evaluate women's long-term satisfaction with CPM, factors influencing satisfaction, and psychological and social function after CPM... - Benign breast disease and the risk of breast cancerLynn C Hartmann
Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
N Engl J Med 353:229-37. 2005..CONCLUSIONS: Risk factors for breast cancer after the diagnosis of benign breast disease include the histologic classification of a benign breast lesion and a family history of breast cancer... - The use of a tropism-modified measles virus in folate receptor-targeted virotherapy of ovarian cancerKosei Hasegawa
Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Cancer Res 12:6170-8. 2006..and i.p.). CONCLUSIONS: A FR-exclusive ovarian cancer targeted oncolytic virus was generated and shown to be therapeutically effective, thus introducing a new modality for FR targeting and a candidate measles virus for clinical testing... - Age-related lobular involution and risk of breast cancerTia R Milanese
Mayo Medical School, Rochester, MN 55905, USA
J Natl Cancer Inst 98:1600-7. 2006..003). CONCLUSIONS: In this large cohort of women with benign breast disease, lobular involution was associated with reduced risk of breast cancer. Aberrant involution may be a biologically important phenomenon in breast cancer biology... - Benign breast disease: emerging findings in a diverse populationLynn C Hartmann
Breast J 13:113-4. 2007 - An HLA-DR-degenerate epitope pool detects insulin-like growth factor binding protein 2-specific immunity in patients with cancerKimberly R Kalli
Departments of Oncology, Immunology, and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
Cancer Res 68:4893-901. 2008..All four peptides are naturally processed and presented to CD4 T-cells. The degenerate pool of peptides covers nearly 80% of patients and may be useful for augmenting CD4 T-cell immunity in patients undergoing immunization... - Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancerDaniel W Visscher
Department of Surgical Pathology, University of Michigan, Ann Arbor, MI, USA
J Natl Cancer Inst 100:421-7. 2008..Atypical hyperplasia in breast tissue, although benign, is associated with a high risk of breast cancer. We investigated whether COX-2 overexpression in atypical hyperplasia is associated with the risk of subsequent breast cancer... - Breast cancer risk in women with radial scars in benign breast biopsiesJena C Berg
Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Breast Cancer Res Treat 108:167-74. 2008..We studied the relative risk of radial scar lesions in a large cohort of patients with benign breast disease (BBD)... - Folate receptor overexpression is associated with poor outcome in breast cancerLynn C Hartmann
Division of Medical Oncology, Mayo Clinic Cancer Center and Mayo Clinic College of Medicine, Rochester, MN
Int J Cancer 121:938-42. 2007..001. Our work requires validation in a larger cohort, but supports the possibility of using folate receptor-targeted approaches in the management of breast cancer... - Folate receptor alpha as a tumor target in epithelial ovarian cancerKimberly R Kalli
Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Gynecol Oncol 108:619-26. 2008..The goal of this study is to improve historical data that lack specific information about FRalpha expression in rare histological subtypes, primary disease versus metastatic foci, and recurrent disease... - Immunomagnetic diffractometry for detection of diagnostic serum markersGhanashyam Acharya
Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, USA
J Am Chem Soc 129:15824-9. 2007..With this approach, a detection sensitivity of 700 fM (20 pg/mL) was achieved. The potential use of this approach in clinical diagnostics was demonstrated by measuring FR concentration in blood samples obtained from cancer patients... - Molecular pathogenesis and therapeutic targets in epithelial ovarian cancerJeremy R Chien
Department of Experimental Pathology, Mayo Clinic, Rochester, Minnesota, USA
J Cell Biochem 102:1117-29. 2007..Finally, we will discuss advances and new challenges in the development of mouse model systems to investigate EOC precursor lesions, progression, metastasis, and chemoresistance... - Stratification of breast cancer risk in women with atypia: a Mayo cohort studyAmy C Degnim
Division of General Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Clin Oncol 25:2671-7. 2007..Atypical hyperplasia is a well-recognized risk factor for breast cancer, conveying an approximately four-fold increased risk. Data regarding long-term absolute risk and factors for risk stratification are needed... - Elevated fibroblast growth factor 23 in women with malignant ovarian tumorsPeter J Tebben
Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Mayo Clin Proc 80:745-51. 2005..The presence of elevated FGF23 concentrations in patients with an ovarian mass should suggest advanced-stage disease... - Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancerJeremy Chien
Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic Foundation, 200 First Street, SW Rochester, MN 55905, USA
Oncogene 24:5089-100. 2005..These data implicate TCEAL7 as a cell death regulatory protein that is frequently inactivated in ovarian cancers, and suggest that it may function as a tumor suppressor... - Stories of breast cancer through artJulie A Ponto
Women s Cancer Program, Mayo Clinic Cancer Center, Rochester, MN, USA
Oncol Nurs Forum 30:1007-13. 2003..To describe the use of an art exhibit, created in response to breast cancer survivor stories, and additional supplementary activities to increase cancer awareness and provide support to those with cancer... - Reoperations after prophylactic mastectomy with or without implant reconstructionSara M Zion
New York Presbyterian Hospital, Weill Cornell Medical Center, New York, New York, USA
Cancer 98:2152-60. 2003..Most of the reoperations were implant related. Reoperations were fairly uncommon after prophylactic mastectomy without reconstruction... - Microsatellite instability in hereditary and sporadic breast cancersCamilo Adem
1Division of Laboratory Genetics, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
Int J Cancer 107:580-2. 2003..Mismatch repair gene mutations may be secondary random events in breast cancer progression... - Current status of prophylactic mastectomyKarthik Ghosh
Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Oncology (Williston Park) 16:1319-25; discussion 1325, 1329-30, 1332. 2002..It is also imperative that the woman be informed of alternative options for management, including chemoprevention, close surveillance, and prophylactic oophorectomy... - Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancerJanos L Tanyi
Departments of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 9:3534-45. 2003..Thus, the LPA-rich environment of the ovarian cancer cell in vivo and the subsequent effects of cellular pathophysiology may be a consequence of both increased LPA production and decreased LPA metabolism by ovarian cancer cells... - Long-term survival of patients with advanced/recurrent carcinoma of cervix and vagina after neoadjuvant treatment with methotrexate, vinblastine, doxorubicin, and cisplatin with or without the addition of molgramostim, and review of the literatureHarry J Long
Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Am J Clin Oncol 25:547-51. 2002..Its progression-free survival and overall survival rates appear promising. These results need to be confirmed within a large randomized phase III clinical trial... - Risk of breast cancer and breast cancer characteristics in women treated with supradiaphragmatic radiation for Hodgkin lymphoma: Mayo Clinic experienceDietlind L Wahner-Roedler
Division of Area General Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
Mayo Clin Proc 78:708-15. 2003..To evaluate the overall risk of breast cancer and breast cancer characteristics in women given supradiaphragmatic radiation therapy for Hodgkin lymphoma... - Her-2/neu expression in ovarian cancer: pre- and postexposure to platinum chemotherapyPrema P Peethambaram
Mayo Clinic, Rochester, MN 55905, USA
Gynecol Oncol 89:99-104. 2003..Our objective was to determine if the level of Her-2/neu expression in advanced ovarian cancer changed after platinum-based chemotherapy... - Pathologic characteristics of breast parenchyma in patients with hereditary breast carcinoma, including BRCA1 and BRCA2 mutation carriersCamilo Adem
Division of Laboratory Genetics, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
Cancer 97:1-11. 2003..This increased progression rate should be taken into account when considering the surveillance of asymptomatic women... - Heterogeneous role of caspase-8 in fenretinide-induced apoptosis in epithelial ovarian carcinoma cell linesKimberly R Kalli
Endocrine Research Unit, Joseph 5 194, Mayo Clinic and Foundation, 200 First Street S W, Rochester, MN 55905, USA
Mol Pharmacol 64:1434-43. 2003..These results indicate that synthetic retinoids can use caspase-8 as an initiating caspase, but they also indicate unexpected heterogeneity in caspase activation pathways among closely related cell lines... - Long-term follow-up of women with ovarian cancer after positive second-look laparotomySean C Dowdy
Gynecologic Surgery, Mayo Clinic, Rochester, MN 55905, USA
Gynecol Oncol 91:563-8. 2003..g., P32 or WART) influenced survival. Rather, low-grade disease and low tumor burdens following cytoreduction were associated with improved survival on multivariate analysis... - High-dose samarium-153 ethylene diamine tetramethylene phosphonate: low toxicity of skeletal irradiation in patients with osteosarcoma and bone metastasesPeter M Anderson
Department of Pediatrics, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
J Clin Oncol 20:189-96. 2002..Because the dose-limiting toxicity of (153)Sm-EDTMP is thrombocytopenia, a dose-escalation trial using peripheral-blood progenitor cells (PBPCs) or marrow support was conducted to treat metastatic bone cancer... - Bilateral oophorectomy and breast cancer risk reduction among women with a family historyJanet E Olson
Health Science Research, Mayo Foundation, Rochester, MN 55905, USA
Cancer Detect Prev 28:357-60. 2004..We investigated whether removal of the ovaries is an appropriate risk reduction option for women at elevated risk of breast cancer based on family history of breast cancer... - Surgical risk reduction: prophylactic salpingo-oophorectomy and prophylactic mastectomySean C Dowdy
Department of Obstetrics and Gynecology, Division of Gynecologic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Am J Obstet Gynecol 191:1113-23. 2004..We also present data about the frequency of use and psychosocial impact of prophylactic surgery in this typically young group of women. Finally, we provide general treatment guidelines for the practicing clinician... - Pathophysiology and palliation of inoperable bowel obstruction in patients with ovarian cancerAminah Jatoi
Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Support Oncol 2:323-34; discussion 334-7. 2004..This review discusses the general approach to patients with ovarian cancer and inoperable malignant bowel obstruction, with an emphasis on such palliative strategies... - Multimodal therapy including neoadjuvant methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) for stage IIB to IV cervical cancerSean C Dowdy
Section of Gynecologic Surgery, Mayo Clinic, Rochester, MN 55905, USA
Am J Obstet Gynecol 186:1167-73. 2002..Compared with historic control subjects, multimodal treatment may be associated with improved rates of pelvic control... - ERBB2, TBX2, RPS6KB1, and MYC alterations in breast tissues of BRCA1 and BRCA2 mutation carriersCamilo Adem
Division of Laboratory Genetics, Mayo Clinic and Foundation, Rochester, Minnesota, USA
Genes Chromosomes Cancer 41:1-11. 2004.... - Prophylactic mastectomy for BRCA1/2 carriers: progress and more questionsLynn C Hartmann
J Clin Oncol 22:981-3. 2004 - MR elastography of breast cancer: preliminary resultsAlexia L McKnight
Department of Radiology, Mayo Clinic, 200 First St, S.W, Rochester, MN 55905, USA
AJR Am J Roentgenol 178:1411-7. 2002..Further research is needed to evaluate the potential applications of MR elastography, such as detecting breast carcinoma and characterizing suspicious breast lesions... - Intraperitoneal therapy of ovarian cancer using an engineered measles virusKah Whye Peng
Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer Res 62:4656-62. 2002..Trackable recombinant measles viruses warrant further investigation for therapy of ovarian cancer... - Quantitation of circulating tumor cells in blood samples from ovarian and prostate cancer patients using tumor-specific fluorescent ligandsWei He
Department of Chemistry, Purdue University, West Lafayette, IN 47906, USA
Int J Cancer 123:1968-73. 2008..Use of tumor-specific fluorescent ligands to label CTCs in peripheral blood can provide a simple, accurate and sensitive method for determining the number of cancer cells circulating in the bloodstream... - Relative weight at age 12 and risk of postmenopausal breast cancerAditya Bardia
Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 17:374-8. 2008.... - Selective estrogen-receptor modulators -- mechanisms of action and application to clinical practiceB Lawrence Riggs
Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
N Engl J Med 348:618-29. 2003 - In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometryWei He
Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
Proc Natl Acad Sci U S A 104:11760-5. 2007.... - Current management strategies for ovarian cancerGiovanni D Aletti
Division of Gynecologic Surgery, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Mayo Clin Proc 82:751-70. 2007..In this review, we provide an overview of ovarian cancer with particular emphasis on recent advances in operative management and systemic therapies... - Recreational physical activity and risk of postmenopausal breast cancer based on hormone receptor statusAditya Bardia
Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Arch Intern Med 166:2478-83. 2006..If confirmed in additional studies, these results would suggest that additional mechanisms, besides an effect on body mass, may account for observed protective effects of physical activity in reducing breast cancer... - Helping people cope with bereavement: an opportunity for health care providers to link Web-based resources across MinnesotaAminah Jatoi
Department of Oncology, Mayo Clinic, Rochester, USA
Minn Med 89:42-4. 2006..It also suggests a need for health care institutions across the state to share information about their particular resources via the Internet with health care providers and patients... - Estrogen bioactivation, genetic polymorphisms, and ovarian cancerThomas A Sellers
Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33602, USA
Cancer Epidemiol Biomarkers Prev 14:2536-43. 2005..015). Although preliminary, this study provides some support for the hypothesis that low-penetrance susceptibility alleles may influence risk of epithelial ovarian cancer... - Breast biopsy utilization: a population-based studyKarthik Ghosh
Division of General Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
Arch Intern Med 165:1593-8. 2005..A multidisciplinary breast practice, along with established guidelines for breast biopsy, can ensure appropriate use of new technology and thereby improve patient care... - A piece of my mind. The octogenarian's planLynn C Hartmann
JAMA 293:15-6. 2005 - Association of single nucleotide polymorphisms in glycosylation genes with risk of epithelial ovarian cancerThomas A Sellers
Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Cancer Epidemiol Biomarkers Prev 17:397-404. 2008..10 frequency; odds ratio, 0.07; P = 0.01) compared with the most common haplotype (0.39 frequency). These results suggest that genetic polymorphisms in the glycoslyation process may be novel risk factors for ovarian cancer...
Research Grants
- PROPHYLCTIC MASTECTOMY IN HEREDITARY BREAST CANCERLynn Hartmann; Fiscal Year: 2002..We will also define short- and long-term complications following PM. ..
- Paul Calabresi Program in Clinical-Translational Research at Mayo ClinicLynn Hartmann; Fiscal Year: 2007....
- Risk Prediction for Breast Cancer: A Tissue-Based StrategyLynn Hartmann; Fiscal Year: 2009..We will combine tissue-based histologic and biomarker information, with standard risk factor data, from a large cohort of women with benign breast biopsies to craft a comprehensive risk prediction model for breast cancer. ..
- Risk Prediction for Breast Cancer: A Tissue-Based StrategyVernon Shane Pankratz; Fiscal Year: 2010..We will combine tissue-based histologic and biomarker information, with standard risk factor data, from a large cohort of women with benign breast biopsies to craft a comprehensive risk prediction model for breast cancer. ..