JAMES FOWLER GREENLEAF

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc In vivo thyroid vibro-acoustography: a pilot study
    Azra Alizad
    Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    BMC Med Imaging 13:12. 2013
  2. ncbi request reprint Selected methods for imaging elastic properties of biological tissues
    James F Greenleaf
    Basic Ultrasound Research Laboratory, Department of Physiology and Biophysics, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    Annu Rev Biomed Eng 5:57-78. 2003
  3. doi request reprint Measurement of tissue mechanical properties with shear wave dispersion ultrasound vibrometry (SDUV)
    James F Greenleaf
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905 USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4411-4. 2009
  4. doi request reprint Shearwave dispersion ultrasound vibrometry applied to in vivo myocardium
    Cristina Pislaru
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:2891-4. 2009
  5. doi request reprint Ex Vivo measurements of myocardial viscoelasticity using Shearwave Dispersion Ultrasound Vibrometry (SDUV)
    Ivan Nenadic
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA nenadic ivan mayo edu
    Conf Proc IEEE Eng Med Biol Soc 2009:2895-8. 2009
  6. ncbi request reprint Quantifying elasticity and viscosity from measurement of shear wave speed dispersion
    Shigao Chen
    Basic Ultrasound Research Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Acoust Soc Am 115:2781-5. 2004
  7. pmc Shearwave dispersion ultrasound vibrometry (SDUV) for measuring tissue elasticity and viscosity
    Shigao Chen
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 56:55-62. 2009
  8. ncbi request reprint Characterization of reperfused infarcted myocardium from high-frequency intracardiac ultrasound imaging using homodyned K distribution
    Xiaohui Hao
    Department of Physiology and Biophysics, Mayo Foundation, Rochester, MN 55905, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 49:1530-42. 2002
  9. ncbi request reprint Imaging mass lesions by vibro-acoustography: modeling and experiments
    Azra Alizad
    Department of Physiology and Biomedical Engineering, Ultrasound Research Laboratory, Rochester, MN 55905, USA
    IEEE Trans Med Imaging 23:1087-93. 2004
  10. ncbi request reprint Measuring the phase of vibration of spheres in a viscoelastic medium as an image contrast modality
    Matthew W Urban
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Acoust Soc Am 118:3465-72. 2005

Research Grants

  1. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 1993
  2. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2005
  3. ARTERIAL PROPERTIES FROM STIMULATED ACOUSTICAL EMISSION
    James Greenleaf; Fiscal Year: 2007
  4. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2009
  5. ARTERIAL PROPERTIES FROM STIMULATED ACOUSTICAL EMISSION
    James Greenleaf; Fiscal Year: 2009
  6. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2009
  7. ARTERIAL PROPERTIES FROM STIMULATED ACOUSTICAL EMISSION
    James Greenleaf; Fiscal Year: 2003
  8. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2001
  9. ARTERIAL PROPERTIES FROM STIMULATED ACOUSTICAL EMISSION
    JAMES FOWLER GREENLEAF; Fiscal Year: 2010

Detail Information

Publications64

  1. pmc In vivo thyroid vibro-acoustography: a pilot study
    Azra Alizad
    Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    BMC Med Imaging 13:12. 2013
    ..The purpose of this study was to evaluate the utility of a noninvasive ultrasound-based method, vibro-acoustography (VA), for thyroid imaging and determine the feasibility and challenges of VA in detecting nodules in thyroid...
  2. ncbi request reprint Selected methods for imaging elastic properties of biological tissues
    James F Greenleaf
    Basic Ultrasound Research Laboratory, Department of Physiology and Biophysics, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    Annu Rev Biomed Eng 5:57-78. 2003
    ..Nevertheless, such estimates may add a great deal of information not currently available to the current field of medical imaging...
  3. doi request reprint Measurement of tissue mechanical properties with shear wave dispersion ultrasound vibrometry (SDUV)
    James F Greenleaf
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905 USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4411-4. 2009
    ..An example application of the method is described to measure material properties in bovine tissue...
  4. doi request reprint Shearwave dispersion ultrasound vibrometry applied to in vivo myocardium
    Cristina Pislaru
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:2891-4. 2009
    ..The method was applied to estimate viscoelastic properties of the myocardium during diastole and systole...
  5. doi request reprint Ex Vivo measurements of myocardial viscoelasticity using Shearwave Dispersion Ultrasound Vibrometry (SDUV)
    Ivan Nenadic
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA nenadic ivan mayo edu
    Conf Proc IEEE Eng Med Biol Soc 2009:2895-8. 2009
    ..An anti-symmetric Lamb wave model was fit to the shear wave dispersion curves in four orthogonal directions to obtain elastic and viscous moduli...
  6. ncbi request reprint Quantifying elasticity and viscosity from measurement of shear wave speed dispersion
    Shigao Chen
    Basic Ultrasound Research Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Acoust Soc Am 115:2781-5. 2004
    ..Experiments in gelatin phantoms show promising results validated by an independent method. Practical considerations and challenges in possible medical applications are discussed...
  7. pmc Shearwave dispersion ultrasound vibrometry (SDUV) for measuring tissue elasticity and viscosity
    Shigao Chen
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 56:55-62. 2009
    ..Feasibility of this pulse sequence is demonstrated by in vivo SDUV measurements in swine liver using a dual transducer prototype simulating the operation of a single array transducer...
  8. ncbi request reprint Characterization of reperfused infarcted myocardium from high-frequency intracardiac ultrasound imaging using homodyned K distribution
    Xiaohui Hao
    Department of Physiology and Biophysics, Mayo Foundation, Rochester, MN 55905, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 49:1530-42. 2002
    ..We conclude that the homodyned K distribution may characterize normal and reperfused infarcted myocardium using high-frequency intracardiac ultrasound images...
  9. ncbi request reprint Imaging mass lesions by vibro-acoustography: modeling and experiments
    Azra Alizad
    Department of Physiology and Biomedical Engineering, Ultrasound Research Laboratory, Rochester, MN 55905, USA
    IEEE Trans Med Imaging 23:1087-93. 2004
    ..Resulting images show lesions with enhanced boundary and often with distinctive textures relative to their background. The results suggest that vibro-acoustography maybe a clinically useful imaging modality for detection of mass lesions...
  10. ncbi request reprint Measuring the phase of vibration of spheres in a viscoelastic medium as an image contrast modality
    Matthew W Urban
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Acoust Soc Am 118:3465-72. 2005
    ..With phase measurements and images, it is demonstrated that predictable image contrast exists for spheres of different density embedded in a viscoelastic medium...
  11. ncbi request reprint Noninvasive measurement of aortic aneurysm sac tension with vibrometry
    Geza Mozes
    Division of Vascular Surgery, Mayo Clinic, Mayo Medical School, Rochester, MN 55905, USA
    J Vasc Surg 42:963-71. 2005
    ..By measuring the change in wave velocity, it is possible to detect the change in tensile stress and calculate the pressure through the vibrated surface. We tested this concept in an in vitro aneurysm model...
  12. ncbi request reprint Multifrequency vibro-acoustography
    Matthew W Urban
    Ultrasound Research Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    IEEE Trans Med Imaging 25:1284-95. 2006
    ..This method holds the potential for a large gain of information with no increase in scanning time compared to conventional vibro-acoustography systems...
  13. ncbi request reprint Measurement of wave velocity in arterial walls with ultrasound transducers
    Xiaoming Zhang
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ultrasound Med Biol 32:1655-60. 2006
    ..Local wave velocity more than a few millimeters can be measured, which is not possible with the PWV method...
  14. pmc Air-coupled ultrasound stimulated optical vibrometry for resonance analysis of rubber tubes
    Xiaoming Zhang
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55095, USA
    Ultrasonics 49:26-30. 2009
    ..It may also be helpful to better understand the coupling effects of the surrounding tissue and interior blood on the vessel wall by measuring the resonance of the vessel in vitro and in vivo...
  15. pmc In vivo vibroacoustography of large peripheral arteries
    Cristina Pislaru
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Invest Radiol 43:243-52. 2008
    ..This study tested the feasibility of using vibroacoustography to distinguish between normal and calcified femoral arteries in a pig model...
  16. ncbi request reprint Phase aberration correction using ultrasound radiation force and vibrometry optimization
    Matthew W Urban
    Ultrasound Research Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street, Rochester, MN 55905, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:1142-53. 2007
    ..By maximizing the radiation force-induced vibration of scatterers in the focal region, the resolution of the ultrasound beam can be recovered after aberration defocusing...
  17. doi request reprint Estimation of tissue's elasticity with surface wave speed
    Xiaoming Zhang
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Acoust Soc Am 122:2522-5. 2007
    ..The surface wave fields are measured with a laser vibrometer. It shows that the surface wave speed can be used for inversely estimating tissue's elastic properties based on tissue's surface measurement...
  18. doi request reprint Harmonic pulsed excitation and motion detection of a vibrating reflective target
    Matthew W Urban
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Acoust Soc Am 123:519-33. 2008
    ..The parameterized numerical and experimental analyses provide insight into how to optimize acquisition parameters to minimize measurement errors...
  19. ncbi request reprint Vibration mode imaging
    Xiaoming Zhang
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    IEEE Trans Med Imaging 26:843-52. 2007
    ..However, the image of the artery can be improved if the vibration of the artery is measured directly. Imaging of the structure in the gelatin or tissue can be enhanced by small bubbles and contrast agents...
  20. ncbi request reprint Harmonic vibro-acoustography
    Shigao Chen
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:1346-51. 2007
    ..Applications of this technique include imaging the nonlinearity of the object and selective detection of microbubbles for perfusion imaging. The impact of microbubble destruction during the imaging process also is discussed...
  21. pmc Prostate cryotherapy monitoring using vibroacoustography: preliminary results of an ex vivo study and technical feasibility
    Farid G Mitri
    Department of Physiology and Biomedical Engineering, Ultrasound Research Laboratory, Mayo Clinic, Rochester, MN 55905, USA
    IEEE Trans Biomed Eng 55:2584-92. 2008
    ..These results provide substantial motivation to further investigate VA as a potential modality to monitor prostate cryotherapy intraoperatively...
  22. pmc Image features in medical vibro-acoustography: in vitro and in vivo results
    Azra Alizad
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, MN 55905, USA
    Ultrasonics 48:559-62. 2008
    ..It is concluded that vibro-acoustography offers features that may be valuable for diagnostic purposes...
  23. doi request reprint Modal analysis of ultrasound radiation force generated shear waves on arteries
    Miguel Bernal
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:2585-8. 2010
    ..This work shows the feasibility of our method for the study and characterization of propagating modes in the arterial wall. Future studies include developing a Lamb wave model for cylindrical viscoelastic structures to fit our data...
  24. doi request reprint Lamb wave Shearwave dispersion ultrasound Vibrometry (SDUV) validation study
    Ivan Nenadic
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:45-8. 2010
    ..Elasticity and viscosity of urethane and gelatin obtained using the Lamb wave SDUV and embedded sphere methods agree within one standard deviation...
  25. doi request reprint Quantitative assessment of scleroderma by surface wave technique
    Xiaoming Zhang
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Med Eng Phys 33:31-7. 2011
    ..Statistical analyses suggest that there are significant differences of viscoelasticity between scleroderma patients and healthy subjects. Scleroderma can be effectively and quantitatively evaluated based on human skin viscoelasticity...
  26. pmc Modulation of ultrasound to produce multifrequency radiation force
    Matthew W Urban
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Acoust Soc Am 127:1228-38. 2010
    ..Modulating ultrasound is a very flexible technique to produce radiation force with multiple frequency components that can be used for various applications...
  27. pmc Thermal safety of vibro-acoustography using a confocal transducer
    Shigao Chen
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ultrasound Med Biol 36:343-9. 2010
    ..05 degrees C for all three attenuation coefficients evaluated: 0.3, 0.5 and 0.7 dB/cm/MHz. Transducer self-heating during a single VA scan measured by a thermocouple is less than 0.27 degrees C...
  28. doi request reprint Liver elasticity and viscosity quantification using shearwave dispersion ultrasound vibrometry (SDUV)
    Shigao Chen
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:2252-5. 2009
    ..Feasibility of this pulse sequence is demonstrated by in vivo SDUV measurements in porcine liver using a dual transducer prototype...
  29. ncbi request reprint Myocardial contractility by strain echocardiography: comparison with physiological measurements in an in vitro model
    Theodore P Abraham
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Heart Circ Physiol 285:H2599-604. 2003
    ..There was no bias with SR measurements during hypoxia or with epsilon measurements. SE closely tracks standard physiological parameters of regional contractile function, such as SV and delta L, under conditions of varying afterload...
  30. doi request reprint Evaluation of biaxial mechanical properties of soft tubes and arteries using sonometry
    Miguel Bernal
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:2835-8. 2009
    ..The technique we propose has a potential for the non destructive study of soft material cylindrical shapes and can be use to study the mechanical properties of vessels...
  31. pmc Error in estimates of tissue material properties from shear wave dispersion ultrasound vibrometry
    Matthew W Urban
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 56:748-58. 2009
    ..5 microm. The model provides a basis to explore different parameters related to implementation of the SDUV method. The experiment confirmed conclusions made by the model, and the results can be used for optimization of SDUV...
  32. ncbi request reprint Optimization of ultrasound radiation force source for shear wave dispersion measurements
    Matthew W Urban
    Dept of Physio and Biomedical Eng, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905
    J Acoust Soc Am 125:2552. 2009
    ..This work was supported in part by Grant EB002167 from NIH.]...
  33. ncbi request reprint Difference frequency and its harmonic emitted by microbubbles under dual frequency excitation
    Shigao Chen
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Ultrasonics 44:e123-6. 2006
    ..In conclusion, harmonic acoustic emission is present for microbubbles. It is very sensitive to the size of the bubble and may be used for selective detection of microbubbles...
  34. ncbi request reprint Estimation of complex arterial elastic modulus from ring resonance excited by ultrasound radiation force
    Xiaoming Zhang
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Ultrasonics 44:e169-72. 2006
    ..Experiments were carried out on a porcine artery embedded in gelatin. The estimation only requires the diameter of the artery, but does not need the thickness of the artery which is difficult to measure with accuracy and precision...
  35. ncbi request reprint Vibro-acoustic tissue mammography
    Mostafa Fatemi
    Basic Ultrasound Research Laboratory, Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    IEEE Trans Med Imaging 21:1-8. 2002
    ..Resulting vibro-acoustographic images show microcalcifications with high contrast with respect to the background soft tissue. Structures such as dense sclerotic tissue do not seem to interfere with detection of microcalcifications...
  36. ncbi request reprint Rapid quantitative assessment of myocardial perfusion: spectral analysis of myocardial contrast echocardiographic images
    Richard Y Bae
    Division of Cardiovascular Diseases and Internal Medicine and the Department of Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Am Soc Echocardiogr 15:63-8. 2002
    ....
  37. ncbi request reprint Ultrasound strain imaging of altered myocardial stiffness: stunned versus infarcted reperfused myocardium
    Cristina Pislaru
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Ultrasound Research Lab, 200 First St SW, Rochester, Minn 55905, USA
    Circulation 109:2905-10. 2004
    ..In this study we evaluate the diastolic deformation of ischemic/reperfused myocardium and relate this deformation to tissue elastic properties...
  38. ncbi request reprint Linear arrays for vibro-acoustography: a numerical simulation study
    Glauber T Silva
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 1st St SW, Rochester, MN 55905, USA
    Ultrason Imaging 26:1-17. 2004
    ..It is concluded that linear array transducers can produce acceptable spatial resolution for clinical applications...
  39. ncbi request reprint Comparison of stress field forming methods for vibro-acoustography
    Shigao Chen
    Basic Ultrasound Research Laboratory, Department of Physiology and Biophysics, Mayo Clinic, Rochester, MN 55905, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 51:313-21. 2004
    ..The measured velocity profiles match the theory. The theory and experimental technique may be useful in future transducer design for vibro-acoustography...
  40. ncbi request reprint Performance of vibro-acoustography in detecting microcalcifications in excised human breast tissue: a study of 74 tissue samples
    Azra Alizad
    Department of Physiology and Biomedical Engineering, Ultrasound Research Laboratory, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    IEEE Trans Med Imaging 23:307-12. 2004
    ..The results indicate that in most cases micro-calcifications can be detected by vibro-acoustography. Further development of vibro-acoustography may lead to a novel-imaging tool for in vivo detection of microcalcifications...
  41. ncbi request reprint Application of vibro-acoustography for detection of calcified arteries in breast tissue
    Azra Alizad
    Department of Physiology and Biophysics, Ultrasound Research Laboratory, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Ultrasound Med 23:267-73. 2004
    ..In this study, we examined the application of vibro-acoustography in detecting calcified arteries in breast tissue...
  42. ncbi request reprint Measurement of the ultrasound backscatter signal from three seed types as a function of incidence angle: application to permanent prostate brachytherapy
    Brian J Davis
    Division of Radiation Oncology, Department of Physiology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 57:1174-82. 2003
    ..To measure the relative ultrasound backscatter of different seed types as a function of seed orientation and to evaluate the corresponding images of these seeds...
  43. ncbi request reprint Detection of calcium deposits on heart valve leaflets by vibro-acoustography: an in vitro study
    Azra Alizad
    Basic Ultrasound Research, Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Am Soc Echocardiogr 15:1391-5. 2002
    ..The method is tested on excised human heart valve tissues. Resulting images clearly show calcium deposits with high contrast and are in agreement with the corresponding radiographs of the specimens...
  44. ncbi request reprint Higher myocardial strain rates during isovolumic relaxation phase than during ejection characterize acutely ischemic myocardium
    Cristina Pislaru
    Department of Physiology and Biophysics, Rochester, Minnesota, USA
    J Am Coll Cardiol 40:1487-94. 2002
    ..The aim of this study was to define an index that can differentiate normal from ischemic myocardial segments that exhibit postsystolic shortening (PSS)...
  45. ncbi request reprint Remote measurement of material properties from radiation force induced vibration of an embedded sphere
    Shigao Chen
    Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Acoust Soc Am 112:884-9. 2002
    ..These experimental results are used to verify the model. This method can be used to estimate the material properties of the medium (e.g., shear modulus) surrounding the sphere...
  46. ncbi request reprint Distinctive changes in end-diastolic wall thickness and postsystolic thickening in viable and infarcted myocardium
    Cristina Pislaru
    Mayo Clinic College of Medicine, Ultrasound Research Laboratory, Rochester, MN 55905, USA
    J Am Soc Echocardiogr 17:855-62. 2004
    ....
  47. ncbi request reprint Potential applications of vibro-acoustography in breast imaging
    Azra Alizad
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905, USA
    Technol Cancer Res Treat 4:151-8. 2005
    ..In addition, we will briefly discuss our recent results of in vivo breast vibro-acoustography. Future developments and potential impact of vibro-acoustography in breast imaging are also discussed...
  48. ncbi request reprint Vibrational characteristics of bone fracture and fracture repair: application to excised rat femur
    Azra Alizad
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Biomech Eng 128:300-8. 2006
    ..This change in mechanical properties of a bone should result in a change of the resonant frequencies of that bone. A vibrational method for bone evaluation has been introduced...
  49. ncbi request reprint Noninvasive generation and measurement of propagating waves in arterial walls
    Xiaoming Zhang
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW Rochester, Minnesota 55905, USA
    J Acoust Soc Am 119:1238-43. 2006
    ....
  50. ncbi request reprint Critical issues in breast imaging by vibro-acoustography
    Azra Alizad
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200, 1st St SW Rochester, MN 55905, USA
    Ultrasonics 44:e217-20. 2006
    ....
  51. ncbi request reprint Measurement of dynamic and static radiation force on a sphere
    Shigao Chen
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 71:056618. 2005
    ..T. Silva, Phys. Rev. E 71, 056617 (2005)]...
  52. ncbi request reprint Noninvasive method for estimation of complex elastic modulus of arterial vessels
    Xiaoming Zhang
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 52:642-52. 2005
    ..The measured wave velocity is about 3 m/s at 100 Hz and 6.5 m/s at 500 Hz. The real part of complex elastic modulus of the artery is estimated to be 300 kPa...
  53. ncbi request reprint Characteristics of the audio sound generated by ultrasound imaging systems
    Mostafa Fatemi
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Acoust Soc Am 117:1448-55. 2005
    ..These findings suggest that fetuses may become exposed to a high-intensity audio sound during maternal ultrasound examinations. Therefore, contrary to common beliefs, ultrasound may not be considered a passive tool in fetal imaging...
  54. ncbi request reprint Generation of a torsion wave and measuring its propagation velocity in the circumferential direction of arterial wall
    Xiaoming Zhang
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Ultrasonics 44:e165-8. 2006
    ..The elastic modulus of the artery can be calculated from the torsion wave velocity without the knowledge of the thickness of the artery, which is difficult to measure with accuracy...
  55. ncbi request reprint Evaluating the dynamic performance of a fibre optic pressure microsensor
    Shigao Chen
    Department of Physiology and Biomedical Engineering Mayo Clinic College of Medicine, Rochester, MN, USA
    Physiol Meas 26:N13-9. 2005
    ..The output of the fibre optic system used shows a constant time delay (0.13 s) for all frequencies tested. Experiments suggest that, with current sensor design, its immersion in degassed water prior to use ensures a reliable performance...
  56. ncbi request reprint Spectral normalization for ultrasonic contrast microbubble detection
    Shigao Chen
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ultrason Imaging 26:150-62. 2004
    ..A simplified model is used to illustrate the usefulness of these two parameters. Experiments show that both parameters improve detection of microbubbles and that HSFR performs better than HFR...
  57. doi request reprint In vitro renal cortex elasticity and viscosity measurements with Shearwave Dispersion Ultrasound Vibrometry (SDUV) on swine kidney
    Carolina Amador
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4428-31. 2009
    ..The purpose of this study was to evaluate the feasibility of SDUV for in vitro measurements of renal cortex elasticity and viscosity in the kidney...
  58. ncbi request reprint Calcium signaling is required for ultrasound-stimulated aggrecan synthesis by rat chondrocytes
    Javad Parvizi
    Department of Orthopaedics, Mayo Clinic, Rochester, MN 55905, USA
    J Orthop Res 20:51-7. 2002
    ..These results imply that ultrasound-stimulated synthesis of cell matrix proteoglycan, associated with accelerated fracture healing, is mediated by intracellular calcium signaling...
  59. ncbi request reprint Nitric oxide and prostacyclin in ultrasonic vasodilatation of the canine internal mammary artery
    Ayako Maruo
    Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann Thorac Surg 77:126-32. 2004
    ..Investigators recently demonstrated increased free blood flow from radial artery free grafts harvested using ultrasonic technology. We investigated the mechanism underlying this phenomenon...
  60. ncbi request reprint Detection of tissue harmonic motion induced by ultrasonic radiation force using pulse-echo ultrasound and Kalman filter
    Yi Zheng
    Saint Cloud State University, St Cloud, MN, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:290-300. 2007
    ....
  61. ncbi request reprint Stress field forming of sector array transducers for vibro-acoustography
    Glauber T Silva
    Universidade Federal de Alagoas, Instituto de Computação, Maceio, Alagoas, Brazil
    IEEE Trans Ultrason Ferroelectr Freq Control 52:1943-51. 2005
    ..Results show that the measured PSF is in good agreement with the theoretical predications. Vibro-acoustography images of a breast-phantom by both transducers are presented and discussed...
  62. ncbi request reprint Fetal ultrasound: mechanical effects
    Melvin E Stratmeyer
    Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, 9200 Corporate Blvd, HFZ 120, Rockville, MD 20850 USA
    J Ultrasound Med 27:597-605; quiz 606-9. 2008
    ..However, low-intensity pulsed ultrasound effects reported in humans and animal models indicate a need for further investigation of potentially adverse developmental effects...
  63. ncbi request reprint The stiffening of arteries by the tissue-mimicking gelatin
    Xiaoming Zhang
    IEEE Trans Ultrason Ferroelectr Freq Control 53:1534-9. 2006
    ..It is found that the tissue-mimicking gelatin significantly stiffens the rubber tube and the artery if they are embedded in gelatin...

Research Grants34

  1. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 1993
    ....
  2. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2005
    ..7cc) regions in the myocardium. When VAE, validated in this program, is combined with the ICE catheter in a future clinical instrument, highly localized stress, strain and perfusion could be estimated within the mvocardium. ..
  3. ARTERIAL PROPERTIES FROM STIMULATED ACOUSTICAL EMISSION
    James Greenleaf; Fiscal Year: 2007
    ..Successful completion of this program will result in new noninvasive methods to assess arterial stiffness and other material properties with fast and accurate measurements applicable to the conscious human. ..
  4. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2009
    ....
  5. ARTERIAL PROPERTIES FROM STIMULATED ACOUSTICAL EMISSION
    James Greenleaf; Fiscal Year: 2009
    ....
  6. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2009
    ....
  7. ARTERIAL PROPERTIES FROM STIMULATED ACOUSTICAL EMISSION
    James Greenleaf; Fiscal Year: 2003
    ..Successful completion of this program will result in USAE methods that are immediately applicable to clinical studies. ..
  8. MULTIDIMENSIONAL HEART IMAGING WITH ULTRASOUND
    James Greenleaf; Fiscal Year: 2001
    ....
  9. ARTERIAL PROPERTIES FROM STIMULATED ACOUSTICAL EMISSION
    JAMES FOWLER GREENLEAF; Fiscal Year: 2010
    ....