Neill R Graff-Radford

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Influence of comorbidities in idiopathic normal pressure hydrocephalus - research and clinical care. A report of the ISHCSF task force on comorbidities in INPH
    Jan Malm
    Department of Clinical Neuroscience, Umea University, Umea, 901 85, Sweden
    Fluids Barriers CNS 10:22. 2013
  2. doi request reprint Do systolic BP and pulse pressure relate to ventricular enlargement?
    N R Graff-Radford
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Eur J Neurol 20:720-4. 2013
  3. ncbi request reprint A cost effective method of identifying and recruiting persons over 80 free of dementia or mild cognitive impairment
    Neill R Graff-Radford
    Department of Neurology, Biostatistics Unit at Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    Alzheimer Dis Assoc Disord 20:101-4. 2006
  4. ncbi request reprint Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease
    Neill R Graff-Radford
    Department of Neuroscience, Mayo College of Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Arch Neurol 64:354-62. 2007
  5. pmc Can aerobic exercise protect against dementia?
    Neill R Graff-Radford
    Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Alzheimers Res Ther 3:6. 2011
  6. pmc Replication of CLU, CR1, and PICALM associations with alzheimer disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Birdsall Building, Jacksonville, FL 32224, USA
    Arch Neurol 67:961-4. 2010
  7. pmc C9ORF72 repeat expansions in cases with previously identified pathogenic mutations
    Marka van Blitterswijk
    From the Departments of Neuroscience M v B, M C B, M D H, M E M, N J R, P E B, T R, B M, P E A A, K F B, L P, D W D, R R and Neurology Z K W, K B B, N R G R, Mayo Clinic, Jacksonville, FL Proteomics Unit and NeuroBioGen Lab Memory Clinic R G, L B, G B, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy Department of Clinical Neurological Sciences E F, M J S, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada Division of Neurology G Y R H, and Department of Pathology and Laboratory Medicine I R M, University of British Columbia, Vancouver, Canada Department of Neurology B J K, D S K, R C P, Healthcare Hawkes Bay
    Neurology 81:1332-41. 2013
  8. pmc Novel late-onset Alzheimer disease loci variants associate with brain gene expression
    Mariet Allen
    Department of Neuroscience, Biostatistics Unit, Mayo Clinic Florida, Jacksonville, FL, USA
    Neurology 79:221-8. 2012
  9. pmc Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72
    Bradley F Boeve
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Brain 135:765-83. 2012
  10. pmc Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort study
    Marka van Blitterswijk
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Lancet Neurol 12:978-88. 2013

Detail Information

Publications93

  1. pmc Influence of comorbidities in idiopathic normal pressure hydrocephalus - research and clinical care. A report of the ISHCSF task force on comorbidities in INPH
    Jan Malm
    Department of Clinical Neuroscience, Umea University, Umea, 901 85, Sweden
    Fluids Barriers CNS 10:22. 2013
    ..Future INPH research should focus on the contribution of comorbidity to overall morbidity, mortality and long-term outcomes. ..
  2. doi request reprint Do systolic BP and pulse pressure relate to ventricular enlargement?
    N R Graff-Radford
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Eur J Neurol 20:720-4. 2013
    ..Observations in laboratory animals suggest intraventricular pulse pressure (systolic-diastolic) may play a role in ventricular enlargement...
  3. ncbi request reprint A cost effective method of identifying and recruiting persons over 80 free of dementia or mild cognitive impairment
    Neill R Graff-Radford
    Department of Neurology, Biostatistics Unit at Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    Alzheimer Dis Assoc Disord 20:101-4. 2006
    ..Hearing loss present in 50% did not influence TICS-m or CDR performance. Using stringent entry criteria and the telephone CDR, this method accurately identified normal elderly persons...
  4. ncbi request reprint Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease
    Neill R Graff-Radford
    Department of Neuroscience, Mayo College of Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Arch Neurol 64:354-62. 2007
    ..To develop preventive therapy for Alzheimer disease (AD), it is essential to develop AD-related biomarkers that identify at-risk individuals in the same way that cholesterol levels identify persons at risk for heart disease...
  5. pmc Can aerobic exercise protect against dementia?
    Neill R Graff-Radford
    Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Alzheimers Res Ther 3:6. 2011
    ....
  6. pmc Replication of CLU, CR1, and PICALM associations with alzheimer disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Birdsall Building, Jacksonville, FL 32224, USA
    Arch Neurol 67:961-4. 2010
    ..To test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease...
  7. pmc C9ORF72 repeat expansions in cases with previously identified pathogenic mutations
    Marka van Blitterswijk
    From the Departments of Neuroscience M v B, M C B, M D H, M E M, N J R, P E B, T R, B M, P E A A, K F B, L P, D W D, R R and Neurology Z K W, K B B, N R G R, Mayo Clinic, Jacksonville, FL Proteomics Unit and NeuroBioGen Lab Memory Clinic R G, L B, G B, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy Department of Clinical Neurological Sciences E F, M J S, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada Division of Neurology G Y R H, and Department of Pathology and Laboratory Medicine I R M, University of British Columbia, Vancouver, Canada Department of Neurology B J K, D S K, R C P, Healthcare Hawkes Bay
    Neurology 81:1332-41. 2013
    ....
  8. pmc Novel late-onset Alzheimer disease loci variants associate with brain gene expression
    Mariet Allen
    Department of Neuroscience, Biostatistics Unit, Mayo Clinic Florida, Jacksonville, FL, USA
    Neurology 79:221-8. 2012
    ..Single nucleotide polymorphisms that influence gene expression (eSNPs) constitute an important class of functional variants. We therefore investigated the influence of the novel LOAD risk loci on human brain gene expression...
  9. pmc Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72
    Bradley F Boeve
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Brain 135:765-83. 2012
    ..While variability exists, most cases with this mutation have a characteristic spectrum of demographic, clinical, neuropsychological, neuroimaging and especially neuropathological findings...
  10. pmc Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort study
    Marka van Blitterswijk
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Lancet Neurol 12:978-88. 2013
    ..We assessed whether expansion size is associated with disease severity or phenotype...
  11. pmc Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology
    Fanggeng Zou
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
    PLoS ONE 8:e64802. 2013
    ..These findings support the hypothesis that Gab2 may protect neurons against LOAD but due to significant population heterogeneity, it is still unclear whether this protection is detectable at the genetic level...
  12. pmc Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
    Mariet Allen
    Mayo Clinic Florida, Department of Neuroscience, Jacksonville, FL, USA
    Mol Neurodegener 7:13. 2012
    ..4,617 controls) and PD (678 PDs vs. 712 controls) for association with disease risk (case-controls), age-at-diagnosis (cases) and brain gene expression levels (autopsied subjects)...
  13. pmc Clinical and neuropathologic heterogeneity of c9FTD/ALS associated with hexanucleotide repeat expansion in C9ORF72
    Melissa E Murray
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Acta Neuropathol 122:673-90. 2011
    ..Further studies are needed to address the molecular mechanism of clinical and pathological heterogeneity of c9FTD/ALS due to mutations in C9ORF72...
  14. pmc Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
    Mariely DeJesus-Hernandez
    Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL 32224, USA
    Neuron 72:245-56. 2011
    ..Our findings indicate that repeat expansion in C9ORF72 is a major cause of both FTD and ALS...
  15. ncbi request reprint Mayo's Older African Americans Normative Studies: norms for Boston Naming Test, Controlled Oral Word Association, Category Fluency, Animal Naming, Token Test, WRAT-3 Reading, Trail Making Test, Stroop Test, and Judgment of Line Orientation
    John A Lucas
    Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL 32224, USA
    Clin Neuropsychol 19:243-69. 2005
    ..These data should enhance interpretation of individual test performances and facilitate analysis of neuropsychological profile patterns in older African American patients who present for dementia evaluations...
  16. doi request reprint Enhancing recovery after acute ischemic stroke with donepezil as an adjuvant therapy to standard medical care: results of a phase IIA clinical trial
    Kevin M Barrett
    Department of Neurology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    J Stroke Cerebrovasc Dis 20:177-82. 2011
    ..Our aim was to assess the safety, tolerability, and efficacy signal of early donepezil administration with regard to enhancing recovery in a diverse acute ischemic stroke population...
  17. pmc Polysomnographic findings in dementia with Lewy bodies
    Winnie C Pao
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Neurologist 19:1-6. 2013
    ..We sought to characterize the polysomnographic (PSG) findings in a series of DLB patients with sleep-related complaints...
  18. pmc Neuropathologically defined subtypes of Alzheimer's disease differ significantly from neurofibrillary tangle-predominant dementia
    Nicholas J Janocko
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Acta Neuropathol 124:681-92. 2012
    ....
  19. pmc An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology
    Christian Wider
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    J Neurol Neurosurg Psychiatry 83:424-9. 2012
    ..The study investigates the effects of genetic factors on the pathology of Alzheimer's disease (AD) and Lewy body (LB) diseases, including Parkinson's disease and dementia with Lewy bodies...
  20. pmc Diagnostic validity of age and education corrections for the Mini-Mental State Examination in older African Americans
    Otto Pedraza
    Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Am Geriatr Soc 60:328-31. 2012
    ....
  21. pmc Robust and expanded norms for the Dementia Rating Scale
    Otto Pedraza
    Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL 32224, USA
    Arch Clin Neuropsychol 25:347-58. 2010
    ..The current study presents a reappraisal of the original MOANS DRS norms, provides robust and expanded norms based on a sample of 894 adults age 55 and over, and critically evaluates the benefits of robust norming...
  22. ncbi request reprint Mayo's Older African Americans Normative Studies: normative data for commonly used clinical neuropsychological measures
    John A Lucas
    Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL 32224, USA
    Clin Neuropsychol 19:162-83. 2005
    ..In most cases, the use of MOAANS norms should improve diagnostic accuracy in dementia evaluations of African American elders...
  23. ncbi request reprint Mayo's Older African Americans Normative Studies: WMS-R norms for African American elders
    John A Lucas
    Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL 32224, USA
    Clin Neuropsychol 19:189-213. 2005
    ..We anticipate that these data will enhance the diagnostic utility and clinical interpretation of WMS-R performance in older African Americans...
  24. ncbi request reprint Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    J Neuropathol Exp Neurol 66:142-51. 2007
    ..On the other hand, there is no histopathologic feature or combination of features that is pathognomonic. Neuronal intranuclear inclusions are virtually always present, but they can be detected in PGRN(-) cases...
  25. ncbi request reprint Neuropsychological differentiation of dementia with Lewy bodies from normal aging and Alzheimer's disease
    Tanis J Ferman
    The Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL 32224, USA
    Clin Neuropsychol 20:623-36. 2006
    ..These finding extend prior research suggesting a cognitive profile that can aid in the clinical diagnosis of DLB. Early attention and visual perceptual disturbance suggests DLB, while early impairment in memory and naming suggests AD...
  26. ncbi request reprint Mayo's Older African American Normative Studies: Auditory Verbal Learning Test norms for African American elders
    Tanis J Ferman
    Department of Psychiatry and Psychology, Mayo Foundation, Jacksonville, FL 32224, USA
    Clin Neuropsychol 19:214-28. 2005
    ....
  27. pmc Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype
    Nicola J Rutherford
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Aging 33:2950.e5-7. 2012
    ..No meaningful association between the repeat length of the normal alleles of the GGGGCC repeat in C9ORF72 and disease phenotype or age at onset was observed in C9ORF72 mutation carriers or nonmutation carriers...
  28. pmc Replication of BIN1 association with Alzheimer's disease and evaluation of genetic interactions
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    J Alzheimers Dis 24:751-8. 2011
    ..In summary, we provide additional evidence for the variant near BIN1 (rs744373) as a LOAD risk modifier, but our results indicate that the effect of EXOC3L2 independent of APOE ε4 should be studied further...
  29. pmc Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease
    Olivia Belbin
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Hum Genet 129:273-82. 2011
    ..Overall, this large, independent follow-up study for 15 of the top LOAD candidate genes provides support for GAB2 and LOC651924 (6q24.1) as risk modifiers of LOAD and novel associations between PGBD1 and EBF3 with age-at-onset...
  30. ncbi request reprint Dementia with Lewy bodies may present as dementia and REM sleep behavior disorder without parkinsonism or hallucinations
    Tanis J Ferman
    Department of Psychiatry and Psychology, Mayo Clinic and Foundation, Jacksonville, Florida 32224, USA
    J Int Neuropsychol Soc 8:907-14. 2002
    ..This provides further evidence in support of including RBD as one of the core diagnostic features of DLB...
  31. pmc MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies
    Melissa E Murray
    From the Department of Neuroscience M E M, A M L, B N D, D W D, Psychiatry and Psychology T J F, and Neurology N R G R, Mayo Clinic, Jacksonville, FL and Department of Neurology B F B, D S K, M H S, R C P, Biomedical Statistics S A P, T G L, Radiology M L S, J L G, G M P, P V, C R J, K K, Nuclear Medicine V J L, Psychology G E S, Laboratory Medicine and Pathology J E P, and Center for Sleep Medicine M H S, Mayo Clinic, Rochester, MN
    Neurology 81:1681-9. 2013
    ..To determine structural MRI and digital microscopic characteristics of REM sleep behavior disorder in individuals with low-, intermediate-, and high-likelihood dementia with Lewy bodies (DLB) at autopsy...
  32. pmc Pathogenicity of exonic indels in fused in sarcoma in amyotrophic lateral sclerosis
    Nicola J Rutherford
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Aging 33:424.e23-4. 2012
    ..Gly475del) was identified, however in vitro studies did not reveal abnormal localization of p.Gly475del mutant FUS. These findings suggest that not all exonic indels in FUS cause disease...
  33. pmc TARDBP mutations in Parkinson's disease
    Sruti Rayaprolu
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Parkinsonism Relat Disord 19:312-5. 2013
    ..Our findings widen the phenotypic presentation for the TDP-43 p.N267S substitution and support a possible role for rare TDP-43 mutations presenting with Parkinson's disease...
  34. pmc Clinicopathologic variability of the GRN A9D mutation, including amyotrophic lateral sclerosis
    Ashley Cannon
    Departments of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Neurology 80:1771-7. 2013
    ..We examined the clinical and pathologic phenotypes of GRN mutation carriers with the pathogenic A9D (g.26C>A) missense mutation...
  35. pmc Evaluation of the role of SNCA variants in survival without neurological disease
    Michael G Heckman
    Biostatistics Unit, Mayo Clinic, Jacksonville, Florida, United States of America
    PLoS ONE 7:e42877. 2012
    ..This exploratory study examined whether SNCA variants may also promote successful aging as defined by survival without neurological disease...
  36. pmc Corticospinal tract degeneration associated with TDP-43 type C pathology and semantic dementia
    Keith A Josephs
    Behavioural Neurology, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Brain 136:455-70. 2013
    ....
  37. pmc Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations
    Jannet Kocerha
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    BMC Genomics 12:527. 2011
    ..Here we examine the role of miRNAs in FTLD patients with TAR DNA-binding protein 43 pathology (FTLD-TDP) caused by genetic mutations in the progranulin (PGRN) gene...
  38. pmc Association of common KIBRA variants with episodic memory and AD risk
    Jeremy D Burgess
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Aging 32:557.e1-9. 2011
    ..06) but not cerebellum. These results suggest a modest role for KIBRA as a cognition and AD risk gene, and also highlight the multifactorial complexity of its genetic associations...
  39. ncbi request reprint Reliable change on the Dementia Rating Scale
    Otto Pedraza
    Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Int Neuropsychol Soc 13:716-20. 2007
    ..In addition, preliminary cross-validation was performed in a clinical comparison sample of another 22 older adults. The findings are discussed in the context of potential clinical and research applications...
  40. pmc Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort
    Bradley F Boeve
    Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Sleep Med 12:445-53. 2011
    ..To validate a questionnaire focused on rapid eye movement sleep (REM) sleep behavior disorder (RBD) among participants in an aging and dementia cohort...
  41. pmc TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
    Sruti Rayaprolu
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Mol Neurodegener 8:19. 2013
    ..With this in mind we set out to assess the genetic association of the Alzheimer's disease-related risk variant in TREM2 (rs75932628, p.R47H) with other related neurodegenerative disorders...
  42. pmc Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Mol Neurodegener 6:54. 2011
    ..abstract:..
  43. pmc Patterns of brain atrophy in clinical variants of frontotemporal lobar degeneration
    Po H Lu
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Dement Geriatr Cogn Disord 35:34-50. 2013
    ..Using magnetic resonance imaging (MRI), tensor-based morphometry (TBM) was used to determine distinct patterns of atrophy between these three clinical groups...
  44. doi request reprint Effect of leuprolide on serum amyloid-β peptide levels and memory in patients with prostate cancer with biochemical recurrence
    Winston W Tan
    Division of Hematology, Oncology, Cancer Center, GU Oncology, Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Urology 81:150-4. 2013
    ..To investigate whether prostate cancer patients receiving leuprolide demonstrated objective cognitive decline accompanied by a change in plasma levels of amyloid-β...
  45. pmc Reliable change on the Boston naming test
    Bonnie C Sachs
    Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, Florida, USA
    J Int Neuropsychol Soc 18:375-8. 2012
    ..These findings may help clinicians and researchers to characterize with greater precision the temporal changes in confrontation naming ability...
  46. ncbi request reprint Longitudinal tracking of FTLD: toward developing clinical trial methodology
    David S Knopman
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Alzheimer Dis Assoc Disord 21:S58-63. 2007
    ..In addition, a multicenter trial is described in which some aspects of diagnosis and longitudinal measurement in the frontotemporal lobar degenerations are being specifically explored...
  47. ncbi request reprint A brief report on WAIS-R normative data collection in Mayo's Older African Americans Normative Studies
    John A Lucas
    Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL 32224, USA
    Clin Neuropsychol 19:184-8. 2005
    ..As such, WAIS-R normative estimates are not presented here. Interested readers who wish to obtain a full set of MOAANS WAIS-R norms, however, are invited to contact the authors for these data...
  48. pmc Ataxin-2 repeat-length variation and neurodegeneration
    Owen A Ross
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Hum Mol Genet 20:3207-12. 2011
    ....
  49. pmc Neuropathological features of corticobasal degeneration presenting as corticobasal syndrome or Richardson syndrome
    Naomi Kouri
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Brain 134:3264-75. 2011
    ..Atrophy of anterior corpus callosum may be a potential neuroimaging marker to differentiate corticobasal degeneration from progressive supranuclear palsy in patients with Richardson syndrome...
  50. doi request reprint Frontotemporal lobar degeneration with ubiquitin-positive, but TDP-43-negative inclusions
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Acta Neuropathol 116:159-67. 2008
    ..The findings raise the possibly of an as yet identified protein that may play a pathogenic role in tau-negative FTLD...
  51. pmc Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis
    Nicola J Rutherford
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America
    PLoS Genet 4:e1000193. 2008
    ....
  52. ncbi request reprint Differences in tau and apolipoprotein E polymorphism frequencies in sporadic frontotemporal lobar degeneration syndromes
    Rodney A Short
    4500 San Pablo Rd, Mayo Clinic, Jacksonville, FL 32224, USA
    Arch Neurol 59:611-5. 2002
    ..Furthermore, the apolipoprotein epsilon4 allele (APOE epsilon4) may be associated with Pick disease...
  53. pmc Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    Nat Genet 41:192-8. 2009
    ..0 x 10(-7)) and 1.26 (95% CI = 1.05-1.51) for female heterozygotes (P = 0.01) compared to female noncarriers. For male hemizygotes (P = 0.07) compared to male noncarriers, the odds ratio was 1.18 (95% CI = 0.99-1.41)...
  54. pmc Hippocampal sclerosis in the elderly: genetic and pathologic findings, some mimicking Alzheimer disease clinically
    Winnie C Pao
    Department of Neurology, Mayo Clinic, Jacksonville, FL, USA
    Alzheimer Dis Assoc Disord 25:364-8. 2011
    ..Hippocampal sclerosis (HpScl) in the elderly is often associated with neurodegeneration...
  55. pmc Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants
    Fanggeng Zou
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA
    PLoS Genet 8:e1002707. 2012
    ..Our findings have implications for the design and interpretation of eGWAS in general and the use of brain expression quantitative trait loci in the study of human disease genetics...
  56. pmc Association and heterogeneity at the GAPDH locus in Alzheimer's disease
    Mariet Allen
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neurobiol Aging 33:203.e25-33. 2012
    ..The most promising rs3741916 variant is unlikely to be functional given opposing effects in different series. Identification of functional variant(s) in this region likely awaits deep sequencing...
  57. pmc Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study
    Melissa E Murray
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Lancet Neurol 10:785-96. 2011
    ..We aimed to compare clinical and neuropathological features between typical and atypical AD cases...
  58. pmc Early onset familial Alzheimer Disease with spastic paraparesis, dysarthria, and seizures and N135S mutation in PSEN1
    Leslie A Rudzinski
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Alzheimer Dis Assoc Disord 22:299-307. 2008
    ....
  59. doi request reprint Profilin-1 mutations are rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia
    Marka van Blitterswijk
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Amyotroph Lateral Scler Frontotemporal Degener 14:463-9. 2013
    ..In conclusion, the p.E117G variant appears to represent a benign polymorphism. PFN1 mutations, in general, are rare in ALS and FTLD-TDP patients...
  60. pmc Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies
    Tanis J Ferman
    From the Departments of Psychiatry and Psychology T J F, O P, Pathology D W D, M E M, and Neurology N R G R, Z W, J V G, R U, Mayo Clinic, Jacksonville, FL and Departments of Psychiatry and Psychology G E S, Radiology K K, Neurology B F B, D S K, R C P, Health Sciences Research V S P, J A, and Laboratory Medicine and Pathology J P, Mayo Clinic, Rochester, MN
    Neurology 81:2032-8. 2013
    ..To determine the rate of progression of mild cognitive impairment (MCI) to dementia with Lewy bodies (DLB)...
  61. pmc CSF1R mutations link POLD and HDLS as a single disease entity
    Alexandra M Nicholson
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Neurology 80:1033-40. 2013
    ..Recently, we reported that mutations in the colony-stimulating factor 1 receptor (CSF1R) gene cause HDLS. In this study, we determined whether CSF1R mutations are also a cause of POLD...
  62. pmc Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Am J Hum Genet 87:890-7. 2010
    ..This finding opens avenues for future research into GRN biology and the pathophysiology of neurodegenerative diseases...
  63. pmc Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
    PLoS ONE 5:e8764. 2010
    ..The insulin-degrading enzyme gene (IDE) is a strong functional and positional candidate for late onset Alzheimer's disease (LOAD)...
  64. pmc Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL FL 32224, USA
    Hum Mol Genet 17:3631-42. 2008
    ..Translational regulation by miRNAs may represent a common mechanism underlying complex neurodegenerative disorders...
  65. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
    ..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
  66. pmc Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members
    NiCole Finch
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain 132:583-91. 2009
    ..We propose that plasma GRN levels could be used as a reliable and inexpensive tool to identify all GRN mutation carriers in early-onset dementia populations and asymptomatic at-risk individuals...
  67. pmc Differential item functioning of the Boston Naming Test in cognitively normal African American and Caucasian older adults
    Otto Pedraza
    Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Int Neuropsychol Soc 15:758-68. 2009
    ..These findings afford a finer characterization of the psychometric properties of the BNT and expand our understanding of between-group performance...
  68. pmc Validation of the neuropathologic criteria of the third consortium for dementia with Lewy bodies for prospectively diagnosed cases
    Hiroshige Fujishiro
    Department of Pathology and Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Neuropathol Exp Neurol 67:649-56. 2008
    ....
  69. pmc C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease
    Matthew Harms
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    JAMA Neurol 70:736-41. 2013
    ..Hexanucleotide repeat expansions in the chromosome 9 open reading frame 72 (C9orf72) gene underlie a significant fraction of frontotemporal dementia and amyotrophic lateral sclerosis...
  70. pmc Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 86:876-84. 2011
    ..Exercise should not be overlooked as an important therapeutic strategy...
  71. pmc Development of methodology for conducting clinical trials in frontotemporal lobar degeneration
    David S Knopman
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Brain 131:2957-68. 2008
    ..There are several candidate outcome measures -- including the FTLD-CDR and the cognitive composites -- that could be used in clinical trials across the spectrum of FTLD...
  72. pmc Prominent phenotypic variability associated with mutations in Progranulin
    Brendan J Kelley
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurobiol Aging 30:739-51. 2009
    ..Some kindreds with PGRN mutations exhibited lateralized topography of degeneration across all affected individuals...
  73. ncbi request reprint Neuropsychiatric features in 36 pathologically confirmed cases of corticobasal degeneration
    Yonas E Geda
    Department of Psychiatry, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    J Neuropsychiatry Clin Neurosci 19:77-80. 2007
    ..No patient experienced visual hallucinations. If confirmed by a prospective study, the absence of visual hallucinations may help to distinguish corticobasal syndrome from other parkinsonian syndromes...
  74. ncbi request reprint Apolipoprotein E and intellectual achievement
    Richard J Caselli
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA
    J Am Geriatr Soc 50:49-54. 2002
    ..To determine whether apolipoprotein E (apo E) genotype influences intellectual achievement in cognitively normal individuals...
  75. ncbi request reprint Normal pressure hydrocephalus
    Neill R Graff-Radford
    Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Neurol Clin 25:809-32, vii-viii. 2007
    ....
  76. doi request reprint Mayo Acute Stroke Trial for Enhancing Recovery (MASTER) protocol
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 19:299-310. 2010
    ..There is no definitively proven pharmacologic technique to accelerate recovery from stroke. The short-term goal of this study is to develop donepezil hydrochloride as pharmacotherapy for enhancing stroke recovery...
  77. pmc Voxelwise genome-wide association study (vGWAS)
    Jason L Stein
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
    Neuroimage 53:1160-74. 2010
    ..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure...
  78. ncbi request reprint Normal pressure hydrocephalus and large head size
    Thomas A Krefft
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Alzheimer Dis Assoc Disord 18:35-7. 2004
    ..To determine if patients with normal pressure hydrocephalus (NPH) have larger head size than normal controls...
  79. ncbi request reprint Frontotemporal dementia
    Neill R Graff-Radford
    Department of Neurology, Mayo College of Medicine, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    Semin Neurol 27:48-57. 2007
    ..In contrast, FTD with Pick bodies is rare. Although there are strategies to help patients and their families, there is no known treatment for the disease...
  80. pmc Sex-dependent association of a common low-density lipoprotein receptor polymorphism with RNA splicing efficiency in the brain and Alzheimer's disease
    Fanggeng Zou
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Hum Mol Genet 17:929-35. 2008
    ..49, 95% confidence interval (CI) of 1.13-1.97, uncorrected P = 0.005], but not in females. In summary, these studies identify a functional apoE receptor SNP that is associated with AD in a sex-dependent fashion...
  81. pmc TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
    Catalina Amador-Ortiz
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Ann Neurol 61:435-45. 2007
    ....
  82. ncbi request reprint The ability to pun may be retained in Alzheimer disease
    David B Hawkins
    Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Neurocase 13:50-4. 2007
    ..Acknowledging and focusing on the remaining positive attributes of a person with AD can be helpful to both family members and professionals...
  83. ncbi request reprint Familial primary progressive aphasia
    Thomas A Krefft
    Department of Neurology, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    Alzheimer Dis Assoc Disord 17:106-12. 2003
    ..DNA analysis of the proband did not detect any known mutation in tau exons 1-5, 7, or 9-13. To our knowledge, this is the first family presenting with hereditary aphasia in which typical PPA occurs in all affected members...
  84. pmc High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
    Paul S Aisen
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Dr, M C 0949, La Jolla, CA 92093, USA
    JAMA 300:1774-83. 2008
    ..Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline...
  85. ncbi request reprint Serum creatinine levels correlate with plasma amyloid Beta protein
    Zoe Arvanitakis
    Rush University, Chicago, Illinois, USA
    Alzheimer Dis Assoc Disord 16:187-90. 2002
    ..01), accounting for 7.3% and 3.1% of shared variance, respectively. Significant associations were also present in NC and AD groups separately. These results indicate that it may be useful to consider Cr levels when measuring plasma Abeta...
  86. pmc Detecting dementia with the mini-mental state examination in highly educated individuals
    Sid E O'Bryant
    Department of Neuropsychiatry and Behavioral Science, Texas Tech University Health Sciences Center, 3601 4th St, STOP 8321, Lubbock, TX 79430, USA
    Arch Neurol 65:963-7. 2008
    ..To evaluate the utility of Mini-Mental State Examination (MMSE) scores in detecting cognitive dysfunction in a sample of highly educated individuals...
  87. ncbi request reprint Cognitive asymmetries associated with apolipoprotein E genotype in patients with Alzheimer's disease
    Michael J Finton
    The Wallace Kettering Neuroscience Institute, Kettering, Ohio, USA
    J Int Neuropsychol Soc 9:751-9. 2003
    ..The epsilon4 allele may thus be associated with a specific neurocognitive phenotype among patients with AD, with the overall pattern of cognitive asymmetry dependent upon epsilon4 dose...
  88. ncbi request reprint Mayo's Older African American Normative Studies: norms for the Mattis Dementia Rating Scale
    Laurie M Rilling
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Clin Neuropsychol 19:229-42. 2005
    ..These norms should help improve interpretation of DRS performance in African Americans and allow for greater diagnostic accuracy in patients with early cognitive decline...
  89. ncbi request reprint Discrepancies between self-reported years of education and estimated reading level among elderly community-dwelling African-Americans: Analysis of the MOAANS data
    Sid E O'Bryant
    Department of Neuropsychiatry and Behavioral Science, Texas Tech University Health Science Center, Lubbock, TX 79430, USA
    Arch Clin Neuropsychol 22:327-32. 2007
    ..South), parental education and literacy, and percentage of segregation in schooling. Implications of these results are discussed, as are areas for further inquiry...
  90. ncbi request reprint Mayo's older African American normative studies: confirmatory factor analysis of a core battery
    Otto Pedraza
    Department of Clinical and Health Psychology and McKnight Brain Institute, University of Florida, Gainesville, Florida, USA
    J Int Neuropsychol Soc 11:184-91. 2005
    ....
  91. ncbi request reprint Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families
    Marsel Mesulam
    Cognitive Neurology and Alzheimer s Disease Center and Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Arch Neurol 64:43-7. 2007
    ..Primary progressive aphasia (PPA) is a language-based dementia characterized by fluent or nonfluent language disorder as its principal feature...
  92. ncbi request reprint Association between apolipoprotein E genotype and Alzheimer disease in African American subjects
    Neill R Graff-Radford
    Genetics Program L 320, Boston University School of Medicine, 715 Albany St, Boston, MA 02118, USA
    Arch Neurol 59:594-600. 2002
    ..The association between Alzheimer disease (AD) and genotypes at the apolipoprotein E (APOE) locus has been confirmed in numerous populations worldwide, but appears to be inconsistent in African American subjects...
  93. ncbi request reprint Different patterns of magnetic resonance imaging atrophy for frontotemporal lobar degeneration syndromes
    Rodney A Short
    Arch Neurol 62:1106-10. 2005
    ..Frontotemporal lobar degeneration (FTLD) is an uncommon degenerative dementia that presents with focal cognitive and behavioral deficits...