Ellen Goode

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Risk of ovarian cancer and inherited variants in relapse-associated genes
    Abraham Peedicayil
    Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 5:e8884. 2010
  2. pmc Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22
    Mine S Cicek
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 7:e38175. 2012
  3. pmc The ratios of CD8+ T cells to CD4+CD25+ FOXP3+ and FOXP3- T cells correlate with poor clinical outcome in human serous ovarian cancer
    Claudia C Preston
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e80063. 2013
  4. pmc Germline copy number variation and ovarian cancer survival
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic Rochester, MN, USA
    Front Genet 3:142. 2012
  5. pmc Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome
    Kristin L White
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Cancer Epidemiol Biomarkers Prev 22:987-92. 2013
  6. pmc Inherited variants in regulatory T cell genes and outcome of ovarian cancer
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e53903. 2013
  7. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
  8. pmc Single versus multiple imputation for genotypic data
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    BMC Proc 3:S7. 2009
  9. pmc The genetics of gene expression: comparison of linkage scans using two phenotype normalization methods
    Mariza de Andrade
    Division of Biostatistics, Mayo Clinic College of Medicine, 200 First Street Southwest, Harwick 7, Rochester, Minnesota 55905, USA
    BMC Proc 1:S151. 2007
  10. pmc Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules
    Wen Liu Mares
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    BMC Proc 1:S126. 2007

Detail Information

Publications51

  1. pmc Risk of ovarian cancer and inherited variants in relapse-associated genes
    Abraham Peedicayil
    Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 5:e8884. 2010
    ..We previously identified a panel of genes associated with outcome of ovarian cancer. The purpose of the current study was to assess whether variants in these genes correlated with ovarian cancer risk...
  2. pmc Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22
    Mine S Cicek
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 7:e38175. 2012
    ..02, α = 0.51, 132.52 cM, rs1319036). These previously unreported linkage peaks demonstrate the continued utility of family-based data in complex traits and suggest that new CRC risk alleles remain to be elucidated...
  3. pmc The ratios of CD8+ T cells to CD4+CD25+ FOXP3+ and FOXP3- T cells correlate with poor clinical outcome in human serous ovarian cancer
    Claudia C Preston
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e80063. 2013
    ..Thus, immunotherapy strategies that modify the ratio of CD4(+)CD25(+)FOXP3(+) Tregs or CD4(+)CD25(+)FOXP3(-) T cells to CD8(+) effector cells may be useful in improving outcomes in ovarian cancer. ..
  4. pmc Germline copy number variation and ovarian cancer survival
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic Rochester, MN, USA
    Front Genet 3:142. 2012
    ..40). Although CNVs that were not well-covered by the Illumina 610 quad array merit investigation, these data suggest no association between inherited CNVs and survival after ovarian cancer...
  5. pmc Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome
    Kristin L White
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Cancer Epidemiol Biomarkers Prev 22:987-92. 2013
    ....
  6. pmc Inherited variants in regulatory T cell genes and outcome of ovarian cancer
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e53903. 2013
    ..1×10(-4)) among all cases combined. As the products of these genes are known to affect induction, trafficking, or immunosuppressive function of Tregs, these results suggest the need for follow-up phenotypic studies...
  7. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  8. pmc Single versus multiple imputation for genotypic data
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    BMC Proc 3:S7. 2009
    ..This limited study involving four regions indicates that, contrary to expectations, multiple imputations may not be necessary...
  9. pmc The genetics of gene expression: comparison of linkage scans using two phenotype normalization methods
    Mariza de Andrade
    Division of Biostatistics, Mayo Clinic College of Medicine, 200 First Street Southwest, Harwick 7, Rochester, Minnesota 55905, USA
    BMC Proc 1:S151. 2007
    ..In summary, we conclude, as have other published reports, that normalization methods play an important role in the linkage results, and that some significant linkage signals might be due to a specific normalization method...
  10. pmc Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules
    Wen Liu Mares
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    BMC Proc 1:S126. 2007
    ..We conclude that variation in the genes encoding p50 and c-Rel may play a role in NF-kappaB-related transcription of FAS, IRF1, and CD40...
  11. pmc Linkage analysis using principal components of gene expression data
    Elizabeth J Atkinson
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, Minnesota 55905, USA
    BMC Proc 1:S79. 2007
    ....
  12. pmc Assessment of genotype imputation methods
    Joanna M Biernacka
    Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 USA
    BMC Proc 3:S5. 2009
    ..However, in both situations, none of the imputation-based tests provide the same level of evidence of association as the complete data at SNPs strongly associated with disease...
  13. pmc The role of parametric linkage methods in complex trait analyses using microsatellites
    Michael D Badzioch
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington, USA
    BMC Genet 6:S48. 2005
    ..05) by a model-free approach. We conclude that parametric methods, using even over-simplified models of complex phenotypes, may complement nonparametric methods and decrease false positives...
  14. pmc Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer
    Kristin L White
    Mayo Clinic College of Medicine, Rochester, MN, USA
    BMC Cancer 9:170. 2009
    ..Inhibitors of kappaB (IkappaB) prevent NF-kappaB activation by sequestering NF-kappaB proteins in the cytoplasm until IkappaB proteins are phosphorylated and degraded...
  15. ncbi Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps
    Ellen L Goode
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center Seattle, WA, USA
    Carcinogenesis 28:328-41. 2007
    ....
  16. pmc Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:935-44. 2009
    ..These results exemplify the utility of imputation in candidate gene studies and lend evidence to a role of cell cycle genes in ovarian cancer etiology, suggest a reduced set of SNPs to target in additional cases and controls...
  17. pmc Assessment of hepatocyte growth factor in ovarian cancer mortality
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 20:1638-48. 2011
    ..Invasive ovarian cancer is a significant cause of gynecologic cancer mortality...
  18. pmc Comparison of tagging single-nucleotide polymorphism methods in association analyses
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    BMC Proc 1:S6. 2007
    ..e., whether a SNP or haplotype is responsible); unfortunately, this is often unknown at the time of SNP selection. Additional evaluations using empirical and simulated data are needed...
  19. ncbi Assessment and implications of linkage disequilibrium in genome-wide single-nucleotide polymorphism and microsatellite panels
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Genet Epidemiol 29:S72-6. 2005
    ..As ease of genotyping continues to increase, study design and SNP selection for linkage and association studies (including genome-wide association studies) will be improved with consideration of LD in the particular populations studied...
  20. ncbi Heritability of longitudinal measures of body mass index and lipid and lipoprotein levels in aging twins
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester Minnesota 55905, USA
    Twin Res Hum Genet 10:703-11. 2007
    ..In summary, longitudinal analyses of twin data indicate that genetic factors do not account for a significant proportion of the variation in age-related changes of BMI or lipid and lipoprotein levels...
  21. pmc No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
    Ellen L Goode
    Health Sciences Research, Mayo Clinic College of Medicine, Rochester, USA
    BMC Cancer 9:312. 2009
    ..No studies of ovarian cancer have been reported to date...
  22. pmc Bias of allele-sharing linkage statistics in the presence of intermarker linkage disequilibrium
    Ellen L Goode
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    BMC Genet 6:S82. 2005
    ..Methods to address LD in a high-throughput manner are needed for efficient, robust genomic scans with dense SNPs...
  23. pmc Inherited determinants of ovarian cancer survival
    Ellen L Goode
    Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Cancer Res 16:995-1007. 2010
    ....
  24. pmc Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer
    Xianshu Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Stabile 2 42, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 17:2101-8. 2008
    ....
  25. pmc A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Nat Genet 42:874-9. 2010
    ..Analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development...
  26. ncbi Polymorphisms in PTGS1 (=COX-1) and risk of colorectal polyps
    Cornelia M Ulrich
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:889-93. 2004
    ..These preliminary findings require confirmation in larger studies of colorectal neoplasia...
  27. ncbi Oligogenic segregation analysis of hereditary prostate cancer pedigrees: evidence for multiple loci affecting age at onset
    Erin M Conlon
    Division of Medical Genetics, Department of Medicine, University of Washington, Box 357720, Seattle, WA 98195 7720, USA
    Int J Cancer 105:630-5. 2003
    ..Our findings for the number of QTLs contributing to HPC and the variance contribution of these QTLs will be instructive in mapping and identifying these genes...
  28. pmc Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer
    Kristin L White
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Twin Res Hum Genet 13:43-56. 2010
    ..10). These results indicate that the SNPs studied here are not related to risk of this gynecologic malignancy and that the site-specific nature of 8q24.21.a associations may not include ovarian cancer...
  29. pmc Bayesian mixture models for the incorporation of prior knowledge to inform genetic association studies
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Genet Epidemiol 34:418-26. 2010
    ..We illustrate the use of this method through a genome-wide linkage study of colorectal cancer, and a genome-wide association study of colorectal polyps...
  30. ncbi Methionine synthase D919G polymorphism, folate metabolism, and colorectal adenoma risk
    Ellen L Goode
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:157-62. 2004
    ..These findings add to what is known about the complexities of genetic variations in one-carbon-metabolizing enzymes in relation to colorectal carcinogenesis...
  31. pmc Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk
    Robert R McWilliams
    Division of Medical Oncology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Cancer Res 68:4928-35. 2008
    ..78; 95% CI, 1.28-6.04) or D711D (OR, 2.19; 95% CI, 1.01-4.73). No other significant differences in risk were identified. Minor alleles in DNA repair genes XPF/ERCC4 and XPD/ERCC2 were associated with altered risk for pancreatic cancer...
  32. pmc Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer
    Abraham Peedicayil
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Gynecol Oncol 114:260-4. 2009
    ..We now examine the hypothesis that inherited alterations in TCEAL7 play a role in the etiology of ovarian cancer...
  33. ncbi Genomic scan of 254 hereditary prostate cancer families
    Marta Janer
    Institute for Systems Biology, Seattle, Washington, USA
    Prostate 57:309-19. 2003
    ..These analyses support the existence of multiple HPC loci, whose presence may be best identified by analyses of large, including pooled, datasets which consider locus heterogeneity...
  34. pmc Genetic variation in the one-carbon transfer pathway and ovarian cancer risk
    Linda E Kelemen
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 68:2498-506. 2008
    ..Interventions with modifiable factors such as multivitamin intake may reduce risk...
  35. pmc ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study
    Jennifer A Doherty
    Program in Epidemiology M4 C308, Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 19:245-50. 2010
    ..These data provide suggestive evidence that the rs2295190 T allele, or another allele in linkage disequilibrium with it, may be associated with increased risk of invasive ovarian cancer...
  36. ncbi Polymorphisms in DNA repair genes and associations with cancer risk
    Ellen L Goode
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Epidemiol Biomarkers Prev 11:1513-30. 2002
    ..Such studies may benefit from analysis of multiple genes or polymorphisms and from the consideration of relevant exposures that may influence the likelihood of cancer in the presence of reduced DNA repair capacity...
  37. pmc Multiple genome-wide analyses of smoking behavior in the Framingham Heart Study
    Ellen L Goode
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    BMC Genet 4:S102. 2003
    ....
  38. pmc Performance of amplified DNA in an Illumina GoldenGate BeadArray assay
    Julie M Cunningham
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 17:1781-9. 2008
    ..We recommend that biological SNP characteristics, notably distance to telomere and GC content (<50% GC recommended), as well as Illumina-provided metrics be considered in the creation of GoldenGate assays using MDA WGA DNA...
  39. ncbi Age-related lobular involution and risk of breast cancer
    Tia R Milanese
    Mayo Medical School, Rochester, MN 55905, USA
    J Natl Cancer Inst 98:1600-7. 2006
    ..As women age, the lobules in their breasts undergo involution or regression. We investigated whether lobular involution in women with benign breast disease was associated with subsequent breast cancer risk...
  40. pmc Functional folate receptor alpha is elevated in the blood of ovarian cancer patients
    Eati Basal
    Department of Immunology, Mayo Clinic, Rochester, MN, USA
    PLoS ONE 4:e6292. 2009
    ..In the current study, the goal was to determine whether ovarian cancer patients (n = 30) had elevated serum levels of a fully functional intact FRalpha compared to matched healthy controls (n = 30)...
  41. ncbi Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, NOR4411A, Los Angeles, CA 90089 9175, USA
    Cancer Res 67:11128-32. 2007
    ..These data suggest that common variants may play important roles in the risk of CRC...
  42. pmc Association of single nucleotide polymorphisms in glycosylation genes with risk of epithelial ovarian cancer
    Thomas A Sellers
    Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Cancer Epidemiol Biomarkers Prev 17:397-404. 2008
    ..10 frequency; odds ratio, 0.07; P = 0.01) compared with the most common haplotype (0.39 frequency). These results suggest that genetic polymorphisms in the glycoslyation process may be novel risk factors for ovarian cancer...
  43. ncbi Genetic analysis workshop 13: Summary of analyses of alcohol and cigarette use phenotypes in the Framingham Heart Study
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 25:S90-7. 2003
    ..quantitative traits, and consideration of transformations and covariates...
  44. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment...
  45. ncbi Effect of germ-line genetic variation on breast cancer survival in a population-based study
    Ellen L Goode
    Cancer Research United Kingdom Genetic Epidemiology Group, Strangeways Research Laboratories, University of Cambridge, Wort s Causeway, Cambridge CB1 8RN, United Kingdom
    Cancer Res 62:3052-7. 2002
    ..However, our results demonstrate the potential of the analysis of germ-line variation to provide insight into the biological determinants of response to treatment and prognosis in breast cancer...
  46. pmc Consortium analysis of 7 candidate SNPs for ovarian cancer
    Susan J Ramus
    Translational Research Laboratory, University College London EGA Institute for Women s Health, London, United Kingdom
    Int J Cancer 123:380-8. 2008
    ..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach...
  47. ncbi A common coding variant in CASP8 is associated with breast cancer risk
    Angela Cox
    Sheffield University Medical School, Sheffield S10 2RX, UK
    Nat Genet 39:352-8. 2007
    ..02-1.13) and 1.16 (95% c.i.: 1.08-1.25), respectively; P(trend) = 2.8 x 10(-5)). These results demonstrate that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies...
  48. ncbi Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer
    Simon A Gayther
    Translational Research Laboratories, University College London, London, United Kingdom
    Cancer Res 67:3027-35. 2007
    ..This study highlights the need for multicenter collaborations for genetic association studies...
  49. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach...
  50. ncbi Genome-wide association analyses of expression phenotypes
    Gary K Chen
    Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Genet Epidemiol 31:S7-S11. 2007
    ..Finally, for datasets with small sample sizes but a large number of features like the Genetic Analysis Workshop 15 dataset, machine learning approaches may be more practical than traditional parametric approaches...

Research Grants6

  1. GENETIC LINKAGE IN COLORECTAL CANCER FAMILES
    Ellen Goode; Fiscal Year: 2007
    ..A key future aim is to combine these families with those of other CRC linkage studies in the US and UK to amass an extensive resource with further increased power to understand CRC genetic susceptibility. ..
  2. Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology
    Ellen Goode; Fiscal Year: 2007
    ....
  3. Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology
    Ellen Goode; Fiscal Year: 2009
    ....
  4. Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer Etiology
    Ellen L Goode; Fiscal Year: 2010
    ....