C Giannini

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Immunohistochemistry is highly sensitive and specific for detection of BRAF V600E mutation in pleomorphic xanthoastrocytoma
    Cristiane M Ida
    Departments of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Acta Neuropathol Commun 1:20. 2013
  2. doi request reprint Primary central nervous system vasculitis: pathology and mechanisms
    Caterina Giannini
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
    Acta Neuropathol 123:759-72. 2012
  3. doi request reprint Maintaining clinical tissue archives and supporting human research: challenges and solutions
    Caterina Giannini
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Arch Pathol Lab Med 135:347-53. 2011
  4. ncbi request reprint Analysis of p53 mutation and expression in pleomorphic xanthoastrocytoma
    C Giannini
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Neurogenetics 3:159-62. 2001
  5. ncbi request reprint Immunophenotype of pleomorphic xanthoastrocytoma
    Caterina Giannini
    Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Surg Pathol 26:479-85. 2002
  6. ncbi request reprint Choristoma of the optic nerve: case report
    Caterina Giannini
    Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurgery 50:1125-8. 2002
  7. doi request reprint Anaplastic oligodendroglial tumors: refining the correlation among histopathology, 1p 19q deletion and clinical outcome in Intergroup Radiation Therapy Oncology Group Trial 9402
    Caterina Giannini
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Brain Pathol 18:360-9. 2008
  8. ncbi request reprint Oligodendroglial tumors: diagnostic and molecular pathology
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Semin Diagn Pathol 27:136-45. 2010
  9. pmc Intracranial low-grade gliomas in adults: 30-year experience with long-term follow-up at Mayo Clinic
    David A Schomas
    Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Neuro Oncol 11:437-45. 2009
  10. ncbi request reprint The prognostic impact of histology and 1p/19q status in anaplastic oligodendroglial tumors
    J Matthew McDonald
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 104:1468-77. 2005

Detail Information

Publications95

  1. ncbi request reprint Immunohistochemistry is highly sensitive and specific for detection of BRAF V600E mutation in pleomorphic xanthoastrocytoma
    Cristiane M Ida
    Departments of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Acta Neuropathol Commun 1:20. 2013
    ..BRAF V600E mutation status was assessed by allele-specific polymerase chain reaction (PCR) with fragment analysis...
  2. doi request reprint Primary central nervous system vasculitis: pathology and mechanisms
    Caterina Giannini
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
    Acta Neuropathol 123:759-72. 2012
    ....
  3. doi request reprint Maintaining clinical tissue archives and supporting human research: challenges and solutions
    Caterina Giannini
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Arch Pathol Lab Med 135:347-53. 2011
    ..Conflicts may arise between pathologists who are responsible for overseeing and preserving the tissues and investigators who need these materials for research purposes...
  4. ncbi request reprint Analysis of p53 mutation and expression in pleomorphic xanthoastrocytoma
    C Giannini
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Neurogenetics 3:159-62. 2001
    ..Consequently, our findings suggest that the genetic events that underlie PXA formation differ from those involved in diffuse astrocytoma...
  5. ncbi request reprint Immunophenotype of pleomorphic xanthoastrocytoma
    Caterina Giannini
    Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Surg Pathol 26:479-85. 2002
    ..We found no evidence that the former is a precursor of the latter...
  6. ncbi request reprint Choristoma of the optic nerve: case report
    Caterina Giannini
    Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurgery 50:1125-8. 2002
    ..Optic nerve choristoma is a rare lesion composed of adipose tissue and smooth muscle involving the optic nerve. Few cases have been reported...
  7. doi request reprint Anaplastic oligodendroglial tumors: refining the correlation among histopathology, 1p 19q deletion and clinical outcome in Intergroup Radiation Therapy Oncology Group Trial 9402
    Caterina Giannini
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Brain Pathol 18:360-9. 2008
    ..3 years in RT group. These findings suggest that classic oligodendroglial morphology combined with 1p 19q deletion may in the future be predictive of chemotherapeutic response and survival...
  8. ncbi request reprint Oligodendroglial tumors: diagnostic and molecular pathology
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Semin Diagn Pathol 27:136-45. 2010
    ....
  9. pmc Intracranial low-grade gliomas in adults: 30-year experience with long-term follow-up at Mayo Clinic
    David A Schomas
    Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Neuro Oncol 11:437-45. 2009
    ..Postoperative RT was associated with improved OS and PFS and is recommended for patients after subtotal resection or biopsy...
  10. ncbi request reprint The prognostic impact of histology and 1p/19q status in anaplastic oligodendroglial tumors
    J Matthew McDonald
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 104:1468-77. 2005
    ..The authors sought to determine whether histology was an equivalent or superior predictor of outcome compared with 1p/19q status in 131 patients with AO tumors...
  11. ncbi request reprint Solitary fibrous tumor of the cerebellopontine angle with salivary gland heterotopia: a unique presentation
    Fausto Rodriguez
    Department of Pathology, Mayo Foundation, Rochester, Minnesota 55902, USA
    Am J Surg Pathol 28:139-42. 2004
    ..The presence of a myoepithelial cell layer, surrounding some of the acini and highlighted by the smooth muscle actin immunostain, strengthened this interpretation...
  12. pmc Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts
    Brett L Carlson
    Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Int J Radiat Oncol Biol Phys 75:212-9. 2009
    ..In this study, the efficacy of TMZ/RT was tested with a panel of 20 primary GBM xenografts...
  13. pmc Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme
    Caterina Giannini
    Departments of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Neuro Oncol 7:164-76. 2005
    ..The fact that such studies were carried out by using an invasive tumor model in an anatomically appropriate context should ensure a rigorous preclinical assessment of agent efficacy...
  14. pmc PTEN loss does not predict for response to RAD001 (Everolimus) in a glioblastoma orthotopic xenograft test panel
    Lin Yang
    Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA
    Clin Cancer Res 14:3993-4001. 2008
    ....
  15. ncbi request reprint Central neurocytoma: management recommendations based on a 35-year experience
    James L Leenstra
    Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 67:1145-54. 2007
    ..METHODS AND MATErials: The data from 45 patients with central neurocytomas diagnosed between 1971 and 2003 were retrospectively evaluated. Various combinations of surgery, radiotherapy (RT), and chemotherapy had been used for treatment...
  16. pmc Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model
    Gaspar J Kitange
    Department of Radiation Oncology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Neurooncol 92:23-31. 2009
    ..These data highlight one potential limitation of the evaluation of MGMT methylation by MS-PCR assay and suggest that more detailed evaluation of methylation at individual CpG sites relative to TMZ response may be worth pursuing...
  17. doi request reprint Sporadic adult-onset leukoencephalopathy with neuroaxonal spheroids mimicking cerebral MS
    B M Keegan
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 70:1128-33. 2008
    ..The authors present clinical, radiologic, and pathologic features of adult-onset, sporadic cases mimicking cerebral-type progressive MS...
  18. doi request reprint Primary central nervous system lymphoma can be histologically diagnosed after previous corticosteroid use: a pilot study to determine whether corticosteroids prevent the diagnosis of primary central nervous system lymphoma
    Alyx B Porter
    Department of Neurology, Mayo Clinic Rochester, Rochester MN, USA
    Ann Neurol 63:662-7. 2008
    ..0). The majority of PCNSL patients who received corticosteroids before diagnosis did not experience significant radiographic change or require second biopsy for diagnosis...
  19. doi request reprint Retrospective review of adjuvant chemotherapy for esthesioneuroblastoma
    Alyx B Porter
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Neurooncol 90:201-4. 2008
    ..Prior reviews have found efficacy of chemotherapy for high grade tumors in the advanced setting. However, little information is available regarding chemotherapy in the adjuvant setting...
  20. doi request reprint Allergic reaction to a bovine dural substitute following spinal cord untethering. Case report
    Andrew B Foy
    Department of Neurologic Surgery, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Neurosurg Pediatr 1:167-9. 2008
    ..Her clinical symptoms and laboratory values all improved after surgery. To the authors' knowledge this is the first reported case of an allergic reaction to bovine-based dural substitutes...
  21. pmc Gliomas in neurofibromatosis type 1: a clinicopathologic study of 100 patients
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Neuropathol Exp Neurol 67:240-9. 2008
    ..Classic PA and LGSI are the most common, and most have favorable prognoses. By contrast, DAs are more aggressive, similar to those that arise sporadically...
  22. ncbi request reprint Ganglioglioma in the cerebellopontine angle in a child. Case report and review of the literature
    Brian D Milligan
    Department of Neurologic Surgery, Mayo Clinic, St Mary s Hospital, Rochester, Minnesota 55905, USA
    J Neurosurg 107:292-6. 2007
    ..Although it occurs rarely, ganglioglioma should be included in the differential diagnosis of a posterior fossa mass in a child or young adult...
  23. ncbi request reprint Acute cerebellitis presenting as tumor. Report of two cases
    Nelly Amador
    Departments of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Neurosurg 107:57-61. 2007
    ..The literature is reviewed and therapy considerations are emphasized...
  24. pmc Neurosarcoidosis presenting as a cerebellar mass
    Gautam Kumar
    Department of Internal Medicine, Mayo Clinic, 200 2nd Street SW, Rochester, MN 55905, USA
    J Gen Intern Med 22:1373-6. 2007
    ..Suboccipital craniotomy and biopsy revealed noncaseating granulomas suggestive of sarcoidosis. He was initially treated with steroids and later switched to Infliximab. On follow-up 5 months later, symptoms and imaging had improved...
  25. pmc Interphase cytogenetics for 1p19q and t(1;19)(q10;p10) may distinguish prognostically relevant subgroups in extraventricular neurocytoma
    Fausto J Rodriguez
    Department of Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Brain Pathol 19:623-9. 2009
    ..5 to 5.5 years after first resection. These results suggest that 1p19q loss and t(1;19) occur in a subset of EVN, and may be associated with aggressive histology in these tumors...
  26. doi request reprint Immunoglobulin derived depositions in the nervous system: novel mass spectrometry application for protein characterization in formalin-fixed tissues
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Research Center, Mayo Clinic, Rochester, MN 55905, USA
    Lab Invest 88:1024-37. 2008
    ..LC-MS/MS represents a novel application for characterization of these deposits and is of diagnostic utility in addition to standard immunohistochemical analyses...
  27. pmc Epithelial and pseudoepithelial differentiation in glioblastoma and gliosarcoma: a comparative morphologic and molecular genetic study
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer 113:2779-89. 2008
    ..Glioblastomas exhibit a remarkable tendency toward morphologic diversity. Although rare, pseudoepithelial components (adenoid or epithelioid) or true epithelial differentiation may occur, posing a significant diagnostic challenge...
  28. pmc Phase II study of subcutaneous octreotide in adults with recurrent or progressive meningioma and meningeal hemangiopericytoma
    Derek R Johnson
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neuro Oncol 13:530-5. 2011
    ..Octreotide was well-tolerated but failed to produce objective tumor response, although 2 patients experienced prolonged stability of previously progressive tumors...
  29. pmc Combination of temsirolimus (CCI-779) with chemoradiation in newly diagnosed glioblastoma multiforme (GBM) (NCCTG trial N027D) is associated with increased infectious risks
    Jann N Sarkaria
    Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Clin Cancer Res 16:5573-80. 2010
    ..The mammalian target of rapamycin (mTOR) functions within the phosphoinositide 3-kinase/Akt signaling pathway as a critical modulator of cell survival...
  30. doi request reprint Pleomorphic xanthoastrocytoma in children and adolescents
    Amulya A Nageswara Rao
    Division of Pediatric Hematology Oncology, Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Pediatr Blood Cancer 55:290-4. 2010
    ..The superficial location of the tumor facilitates gross total resection (GTR) thus conferring a relatively favorable outcome with a reported 10-year overall survival (OS) of 70%...
  31. pmc Expression of CD74 in high grade gliomas: a potential role in temozolomide resistance
    Gaspar J Kitange
    Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA
    J Neurooncol 100:177-86. 2010
    ..Collectively, these findings suggest that CD74 is expressed in a subset of high grade gliomas and may contribute to TMZ resistance...
  32. pmc Phase II NCCTG trial of RT + irinotecan and adjuvant BCNU plus irinotecan for newly diagnosed GBM
    Kurt A Jaeckle
    Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Neurooncol 99:73-80. 2010
    ..This regimen was not significantly active and radiosensitization was not observed. Non-EIAC patients with UGT1A1*28 variant alleles appear particularly sensitive to toxicity from irinotecan...
  33. ncbi request reprint Anaplasia in pilocytic astrocytoma predicts aggressive behavior
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Surg Pathol 34:147-60. 2010
    ..In summary, PA with anaplastic features exhibits a spectrum of morphologies and is associated with decreased survival when compared with typical PA...
  34. pmc Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study
    Evanthia Galanis
    Mayo Clinic, Gonda 10 141, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Clin Oncol 27:2052-8. 2009
    ..Vorinostat, a histone deacetylase inhibitor, represents a rational therapeutic target in glioblastoma multiforme (GBM)...
  35. pmc Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neuropathol Exp Neurol 67:1194-204. 2008
    ..In summary, we have identified a molecular signature that distinguishes NF1-PA from S-PA and found that ALDH1L1 underexpression is associated with aggressive histology and/or biologic behavior...
  36. pmc Rapidly progressive neurodegenerative dementias
    Keith A Josephs
    Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 66:201-7. 2009
    ..Neurodegenerative dementias are typically characterized by an insidious onset and a relatively slowly progressive course. Less common are patients with a rapidly progressive course to death...
  37. pmc Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177
    Paul D Brown
    Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Clin Oncol 26:5603-9. 2008
    ..Erlotinib, a selective EGFR inhibitor, was combined with temozolomide (TMZ) and radiotherapy (RT) in a phase I/II trial...
  38. pmc Ectopic low-grade adrenocortical carcinoma in the spinal region: immunohistochemical and molecular cytogenetic study of a pediatric case
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 33:142-8. 2009
    ..This report demonstrates that ectopic adrenocortical tumors in the nervous system may exhibit clinicopathologic and cytogenetic features suggestive of adrenocortical carcinoma...
  39. ncbi request reprint Histopathologic grading of adult medulloblastomas
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer 109:2557-65. 2007
    ..Histopathologic evaluation of the degree and extent of anaplasia is a useful prognostic parameter in pediatric medulloblastomas. Whether the same applies to adult medulloblastomas is not known...
  40. ncbi request reprint Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade
    Jan C Buckner
    Division of Medical Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Neurooncol 84:279-86. 2007
    ..Anaplastic oligoastrocytomas (AOA) are relatively uncommon high-grade gliomas. While oligodendroglial elements are thought to be associated with better outcomes, the magnitude of the difference is not clear...
  41. ncbi request reprint A t(1;19)(q10;p10) mediates the combined deletions of 1p and 19q and predicts a better prognosis of patients with oligodendroglioma
    Robert B Jenkins
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 66:9852-61. 2006
    ..Like combined 1p/19q deletion, the 1;19 translocation is associated with superior OS and progression-free survival in low-grade glioma patients...
  42. ncbi request reprint Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response
    Jann N Sarkaria
    Department of Radiation Oncology, Laboratory Medicine and Pathology, and Biostatistics, Mayo Clinic, Rochester, Minnesota, USA
    Clin Cancer Res 12:2264-71. 2006
    ..The intent of the current study was to address this relationship using several EGFR-amplified glioblastoma xenografts in an orthotopic athymic mouse model...
  43. ncbi request reprint Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Central Cancer Treatment Group protocol N0177
    Sunil Krishnan
    Department of Radiation Oncology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Int J Radiat Oncol Biol Phys 65:1192-9. 2006
    ..To evaluate the toxicity and maximum tolerated dose (MTD) of erlotinib plus radiation therapy (RT) in patients with glioblastoma multiforme (GBM) in a multicenter phase I trial...
  44. ncbi request reprint Neurosarcoidosis mimicking meningioma
    Fausto Rodriguez
    Department of Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Arch Neurol 62:148-9. 2005
  45. ncbi request reprint Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study
    Bradley F Boeve
    Department of Neurology, Mayo Clinic Rochester, MN 55905, USA
    Brain 129:3103-14. 2006
    ..These findings suggest that the insR352 PSEN1 is not pathogenic, and the IVS1+1G-->A mutation in PGRN causes FTDP associated with FTLD-U pathology and represents a new class of neurodegenerative disease--the 'hypoprogranulinopathies'...
  46. ncbi request reprint Management of brain metastases from thyroid carcinoma: a study of 16 pathologically confirmed cases over 25 years
    Robert R McWilliams
    Division of Medical Oncology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer 98:356-62. 2003
    ..To help contribute to the management of this disease entity, the authors present herein what to their knowledge is the largest series reported to date in which all patients had biopsy proven confirmation of their brain metastases...
  47. pmc The relationship between six-month progression-free survival and 12-month overall survival end points for phase II trials in patients with glioblastoma multiforme
    Karla V Ballman
    Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neuro Oncol 9:29-38. 2007
    ..Finally, there was a strong association between progression-free survival status and overall survival. PFS6 seems to be a reasonable end point for phase II trials in patients with recurrent glioblastoma...
  48. ncbi request reprint Brainstem infarcts as an early manifestation of Streptococcus anginosus meningitis
    Sung B Lee
    Departments of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurocrit Care 3:157-60. 2005
    ..We present another case of brainstem infarction associated with meningitis caused by Streptococcus anginosus...
  49. ncbi request reprint Granular cell tumor of the sellar and suprasellar region: clinicopathologic study of 11 cases and literature review
    Aaron A Cohen-Gadol
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 78:567-73. 2003
    ..To report a series of cases of surgically resected granular cell tumors in an attempt to better characterize their clinical presentation, imaging features, and treatment outcomes with attention to previously published literature...
  50. ncbi request reprint Cerebral angiitis mimicking posterior leukoencephalopathy
    Eelco F M Wijdicks
    Neurology Critical Care Service, Department of Neurology, Saint Marys Hospital, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Neurol 250:444-8. 2003
    ..A cerebral angiogram and possibly brain biopsy to detect isolated angiitis should be considered in patients with posterior leukoencephalopathy of unknown etiology...
  51. ncbi request reprint Stereotactic radiosurgery provides equivalent tumor control to Simpson Grade 1 resection for patients with small- to medium-size meningiomas
    Bruce E Pollock
    Department of Neurological Surgery, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 55:1000-5. 2003
    ..To compare tumor control rates after surgical resection or stereotactic radiosurgery for patients with small- to medium-size intracranial meningiomas...
  52. ncbi request reprint Isolated, giant cerebellopontine angle craniopharyngioma in a patient with Gardner syndrome: case report
    Michael J Link
    Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Neurosurgery 51:221-5; discussion 225-6. 2002
    ..Our description of this patient is only the second case report of a craniopharyngioma arising primarily in the cerebellopontine angle...
  53. pmc Distinct germ line polymorphisms underlie glioma morphologic heterogeneity
    Robert B Jenkins
    Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA
    Cancer Genet 204:13-8. 2011
    ..77, P = 2.6 × 10(-9)). These observations generate hypotheses concerning the possible mechanisms by which specific SNPs (or alterations in linkage disequilibrium with such SNPs) are associated with glioma development...
  54. doi request reprint Rim and flame signs: postgadolinium MRI findings specific for non-CNS intramedullary spinal cord metastases
    J B Rykken
    Department of Radiology, Division of Neuroradiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    AJNR Am J Neuroradiol 34:908-15. 2013
    ..Our purpose was to retrospectively compare peripheral enhancement features on postgadolinium MR imaging of ISCMs with primary intramedullary cord masses...
  55. pmc p53 isoform profiling in glioblastoma and injured brain
    R Takahashi
    Mayo Clinic, Rochester, MN, USA
    Oncogene 32:3165-74. 2013
    ....
  56. pmc Diffusion-weighted imaging characteristics of biopsy-proven demyelinating brain lesions
    N Abou Zeid
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 78:1655-62. 2012
    ....
  57. ncbi request reprint Transformation of low grade glioma and correlation with outcome: an NCCTG database analysis
    K A Jaeckle
    Mayo Clinic, Cannaday 2 E, Jacksonville, FL 32224, USA
    J Neurooncol 104:253-9. 2011
    ..From time of recurrence, OS was not significantly different for those with primary versus secondary GBM, and it may thus be reasonable include patients with secondary GBM in clinical therapeutic trials for recurrent disease...
  58. ncbi request reprint Primary central nervous system vasculitis: analysis of 101 patients
    Carlo Salvarani
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Ann Neurol 62:442-51. 2007
    ..To analyze the clinical findings, response to therapy, outcome, and incidence of primary central nervous system vasculitis (PCNSV) in a large cohort from a single center...
  59. pmc Characterization and gene expression profiling in glioma cell lines with deletion of chromosome 19 before and after microcell-mediated restoration of normal human chromosome 19
    Kristen L Drucker
    Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Genes Chromosomes Cancer 48:854-64. 2009
    ..This suggests that one or more of these candidates may play a role in glioma formation or progression...
  60. ncbi request reprint Use of a vaccine strain of measles virus genetically engineered to produce carcinoembryonic antigen as a novel therapeutic agent against glioblastoma multiforme
    Loi K Phuong
    Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 63:2462-9. 2003
    ..c. and orthotopic U87 animal models. Monitoring CEA levels in the serum can serve as a low-risk method of detecting viral gene expression during treatment, and could allow dose optimization and individualization of treatment...
  61. ncbi request reprint Iatrogenic cerebellar implantation of a vestibular schwannoma. Case report
    Todd A Patrick
    Department of Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55902, USA
    J Neurosurg 104:452-6. 2006
    ..Given the similarities among these tumors in pathological appearance and mitotic index, the presence of the intraparenchymal cerebellar schwannoma was probably due to intraoperative iatrogenic implantation...
  62. pmc Interleukin-13 displaying retargeted oncolytic measles virus strains have significant activity against gliomas with improved specificity
    Cory Allen
    Molecular Medicine Department, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mol Ther 16:1556-64. 2008
    ..Strains of measles virus retargeted against the glioma-specific IL-13Ralpha2 receptor have comparable therapeutic efficacy, and improved specificity as compared with the unmodified measles virus strain MV-GFP in vitro and in vivo...
  63. ncbi request reprint Oligodendrogliomas: reproducibility and prognostic value of histologic diagnosis and grading
    C Giannini
    Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neuropathol Exp Neurol 60:248-62. 2001
    ..Our study found few factors independently associated with cause specific-survival among morphological parameters. These findings are consistent with the present WHO stratification of oligodendrogliomas into low- and high-grade variants...
  64. ncbi request reprint Concurrent solitary fibrous tumor and low-grade fibrillary astrocytoma of the cerebellum
    J I Lopez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Mayo Clinic College of Medicine, Rochester, MN, USA
    Clin Neuropathol 29:301-6. 2010
    ..We report the clinicopathologic features of a solitary fibrous tumor (SFT) having undergone malignant transformation and being intimately associated with a WHO Grade II astrocytoma...
  65. ncbi request reprint Massive sellar and parasellar schwannoma
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Hilton 11 Bldg, 200 First Street SW, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 64:1198-9. 2007
  66. ncbi request reprint Primary central nervous system vasculitis with prominent leptomeningeal enhancement: a subset with a benign outcome
    Carlo Salvarani
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Arthritis Rheum 58:595-603. 2008
    ..This study was undertaken to evaluate the clinical features and outcomes among patients with PCNSV who presented with prominent gadolinium meningeal enhancement on magnetic resonance imaging (MRI)...
  67. doi request reprint Desmoplastic small round cell tumor of the central nervous system: report of two cases and review of the literature
    Luciano Neder
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
    Virchows Arch 454:431-9. 2009
    ..In conclusion, CNS DSRCT follows a similar aggressive course as do peritoneal examples. Although rare, DSRCT warrants consideration in the differential diagnosis of "malignant small blue cell tumors" of the CNS...
  68. doi request reprint Atypical acute hemorrhagic leukoencephalitis (Hurst's disease) presenting with focal hemorrhagic brainstem lesion
    Nuhad E Abou Zeid
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurocrit Care 12:95-7. 2010
    ..The objective of this study is to report the clinical, radiologic, and pathologic findings in a fatal AHL case with focal brainstem involvement and gross hemorrhage...
  69. ncbi request reprint Choroid plexus papilloma and meningioma: coincidental posterior fossa tumors: case report and review of the literature
    Jon I McIver
    Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Surg Neurol 60:360-5. 2003
    ..The clinical presentation, preoperative imaging, differential diagnosis, surgical treatment and histologic features of the two tumors are discussed...
  70. ncbi request reprint Venous congestive myelopathy: a mimic of neoplasia
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Mod Pathol 18:710-8. 2005
    ..Recognition of this entity by surgical pathologists is important, leading to the correct identification of a non-neoplastic lesion as well as of a surgically treatable disease...
  71. doi request reprint Biopsy findings in primary angiitis of the central nervous system
    Dylan V Miller
    Division of Anatomic Pathology, The Division of Biostatistics, Department of Neurology, Division of Rheumatology, Mayo Clinic, Rochester, MN, USA
    Am J Surg Pathol 33:35-43. 2009
    ..Overall the outcomes were relatively favorable, with only 14% mortality or severe morbidity at 1.14 years (mean) after biopsy...
  72. doi request reprint Frontotemporal dementia mimicking dementia with Lewy bodies
    Daniel O Claassen
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Cogn Behav Neurol 21:157-63. 2008
    ..Clinicopathologic studies are helpful in understanding the underlying neurodegenerative process in such cases...
  73. ncbi request reprint Wegener's granulomatosis and vertebro-basilar thrombosis
    Boby V Maramattom
    Department of Neurology, Mayo Clinic College of Medicine, Division of Critical Care Neurology, Rochester, MN 55905, USA
    Cerebrovasc Dis 20:65-8. 2005
  74. ncbi request reprint Primary central nervous system vasculitis: comparison of patients with and without cerebral amyloid angiopathy
    C Salvarani
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Rheumatology (Oxford) 47:1671-7. 2008
    ..To describe the clinical features and outcomes of patients with primary central nervous system vasculitis (PCNSV) and cerebral amyloid angiopathy (CAA) from a large cohort of consecutive patients with PCNSV treated at a single institution...
  75. pmc Perivenous demyelination: association with clinically defined acute disseminated encephalomyelitis and comparison with pathologically confirmed multiple sclerosis
    Nathan P Young
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Brain 133:333-48. 2010
    ....
  76. pmc Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis
    C F Lucchinetti
    Department of Neurology, College of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Brain 131:1759-75. 2008
    ..Although increased awareness of this broad spectrum may obviate need for biopsy in many circumstances, an important role for diagnostic brain biopsy may be required in some cases...
  77. ncbi request reprint Giant cell arteritis: Involvement of intracranial arteries
    Carlo Salvarani
    Servizio di Reumatologia, Arcispedale S Maria Nuova, Reggio Emilia, Italy
    Arthritis Rheum 55:985-9. 2006
  78. ncbi request reprint Clinicopathologic and genetic profile of intracranial marginal zone lymphoma: a primary low-grade CNS lymphoma that mimics meningioma
    Pang Hsien Tu
    Division of Neuropathology and Section of Hematopathology, Campus Box 8118, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Clin Oncol 23:5718-27. 2005
    ..Although rare overall, marginal zone B-cell lymphoma (MZBCL) is the most common primary low-grade CNS lymphoma reported in the literature. The aim of this study is to elucidate the biology and genetic features of this unusual tumor...
  79. ncbi request reprint Assessment and prognostic significance of mitotic index using the mitosis marker phospho-histone H3 in low and intermediate-grade infiltrating astrocytomas
    Howard Colman
    Department of Neuro Oncology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Surg Pathol 30:657-64. 2006
    ..These results also suggest that pHH3 staining may be a useful method in other neoplasms in which accurate determination of proliferation potential is relevant to tumor grading or clinical treatment decision-making...
  80. ncbi request reprint Primary peripheral PNET/Ewing's sarcoma of the dura: a clinicopathologic entity distinct from central PNET
    Franceska Dedeurwaerdere
    Department of Pathology, Katholieke Universiteit Leuven, Belgium
    Mod Pathol 15:673-8. 2002
    ..The occurrence of PNET-ES at this site is very unusual. Immunophenotypical as well as genetic analysis play a key role in the diagnosis and the distinction from central PNET...
  81. ncbi request reprint Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance
    Kenneth D Aldape
    Department of Pathology and Brain Tumor Center, UT MD Anderson Cancer Center, Houston, Texas, USA
    J Neuropathol Exp Neurol 63:700-7. 2004
    ....
  82. ncbi request reprint Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel
    Jann N Sarkaria
    Department of Neurological Surgery, University of California, San Francisco, Room HSW 792, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Mol Cancer Ther 6:1167-74. 2007
    ....
  83. ncbi request reprint Panel review of anaplastic oligodendroglioma from European Organization For Research and Treatment of Cancer Trial 26951: assessment of consensus in diagnosis, influence of 1p/19q loss, and correlations with outcome
    Johan M Kros
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neuropathol Exp Neurol 66:545-51. 2007
    ..The absence of necrosis and the presence of endothelial abnormalities were correlated with better outcomes. In multivariate analysis, patients' age, 1p/19q loss, and necrosis were identified as independent prognostic factors...
  84. ncbi request reprint Outcome in adult low-grade glioma: the impact of prognostic factors and treatment
    David Schiff
    Neuro Oncology Center, University of Virginia Health Sciences Center, Box 800432, Charlottesville, VA 22908 0432, USA
    Neurology 69:1366-73. 2007
    ..We review contemporary knowledge regarding prognostic factors, our current evidence-based understanding of the roles and timing of radiation and chemotherapy, and ongoing clinical trials that will further elucidate management of LGGs...
  85. ncbi request reprint Neuromuscular choristoma of the sciatic nerve. Case report
    Cormac O Maher
    Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurosurg 96:1123-6. 2002
    ..The authors discuss the clinical presentation, radiological findings, pathological diagnosis, and surgical rationale for this case and review the associated literature...
  86. ncbi request reprint Global democratic consensus on neuropathological disease criteria
    Cristian Achim
    Lancet Neurol 1:340. 2002
  87. ncbi request reprint Retargeted oncolytic measles strains entering via the EGFRvIII receptor maintain significant antitumor activity against gliomas with increased tumor specificity
    Cory Allen
    Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 66:11840-50. 2006
    ....
  88. doi request reprint Angiography-negative primary central nervous system vasculitis: a syndrome involving small cerebral vessels
    Carlo Salvarani
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Medicine (Baltimore) 87:264-71. 2008
    ..Angiography-negative PCNSV appears to be a distinct subtype of cerebral vasculitis with small vessel involvement beyond the resolution of conventional angiography and is associated with a favorable outcome...
  89. ncbi request reprint MGMT immunohistochemical expression and promoter methylation in human glioblastoma
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Appl Immunohistochem Mol Morphol 16:59-65. 2008
    ..This study underscores some of the difficulties in applying immunohistochemistry to assess MGMT expression...
  90. doi request reprint Efficacy of tumor necrosis factor alpha blockade in primary central nervous system vasculitis resistant to immunosuppressive treatment
    Carlo Salvarani
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Arthritis Rheum 59:291-6. 2008
  91. ncbi request reprint Gliomatosis cerebri angiographically mimicking central nervous system angiitis: case report
    Boby V Maramattom
    Division of Critical Care Neurology, Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Neurosurgery 58:E1209; discussion E1209. 2006
    ..The diagnosis of isolated central nervous system angiitis often requires both cerebral angiography and biopsy for diagnosis...
  92. ncbi request reprint Clinical presentation and surgical management of dissecting posterior inferior cerebellar artery aneurysms: 2 case reports
    Nicholas M Wetjen
    Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905, USA
    Surg Neurol 64:462-7; discussion 467. 2005
    ..Direct surgical reconstruction of the dissected segment may be possible. Balloon occlusion testing may be very helpful in determining if the involved PICA segment can be sacrificed...
  93. ncbi request reprint Combined sellar fibrosarcoma and prolactinoma with neuronal metaplasia: report of a case unassociated with radiotherapy
    Mario Moro
    Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Endocr Pathol 15:149-58. 2004
    ..Despite the intimate association of both elements in our lesion, no transition of adenoma to sarcoma was demonstrable by immunohistochemistry or in situ hybridization studies...
  94. ncbi request reprint Adenoviral vectors expressing fusogenic membrane glycoproteins activated via matrix metalloproteinase cleavable linkers have significant antitumor potential in the gene therapy of gliomas
    Cory Allen
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Gene Med 6:1216-27. 2004
    ..Given the high frequency of MMP overexpression in gliomas, AdM40 represents a potentially promising agent in the gene therapy of these tumors...
  95. ncbi request reprint Primary Ewing sarcoma of the orbit in an adult
    Noelene K Pang
    Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Ophthal Plast Reconstr Surg 23:153-4. 2007
    ..Subsequent chemotherapy and radiation resulted in tumor resolution without recurrence for 3.5 years. Although systemic symptoms are associated with a poorer prognosis, longer survival may be possible in the absence of metastasis...