SANDRA JANE GENDLER

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Structure and function of the cell surface (tethered) mucins
    Christine L Hattrup
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AR 85259, USA
    Annu Rev Physiol 70:431-57. 2008
  2. pmc MUC1 alters oncogenic events and transcription in human breast cancer cells
    Christine L Hattrup
    Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Breast Cancer Res 8:R37. 2006
  3. pmc Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells
    Gargi D Basu
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Scottsdale, Arizona, USA
    Breast Cancer Res 7:R422-35. 2005
  4. ncbi request reprint MUC1, the renaissance molecule
    S J Gendler
    Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Arizona 85259, USA
    J Mammary Gland Biol Neoplasia 6:339-53. 2001
  5. ncbi request reprint Spontaneous adenocarcinoma mouse models for immunotherapy
    S J Gendler
    Department of Biochemistry and Molecular Biology and Tumor Biology Program, Mayo Medical Graduate School, Mayo Clinic Scottsdale, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    Trends Mol Med 7:471-5. 2001
  6. ncbi request reprint Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer
    Gargi D Basu
    Mayo Clinic College of Medicine, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Mol Cancer Res 2:632-42. 2004
  7. ncbi request reprint MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion
    Joyce A Schroeder
    Tumor Biology Program and Department of Biochemistry and Molecular Biology, Mayo Medical Graduate School, Mayo Clinic Scottsdale, AZ 85259, USA
    Oncogene 22:1324-32. 2003
  8. ncbi request reprint MUC1 can interact with adenomatous polyposis coli in breast cancer
    Christine L Hattrup
    Tumor Biology Program, Mayo Clinic College of Medicine, Mayo Clinic, Scottsdale, AZ, USA
    Biochem Biophys Res Commun 316:364-9. 2004
  9. ncbi request reprint Reduced T-cell and dendritic cell function is related to cyclooxygenase-2 overexpression and prostaglandin E2 secretion in patients with breast cancer
    Barbara A Pockaj
    Department of Surgery, Mayo Clinic College of Medicine, Scottsdale, Arizona 85259, USA
    Ann Surg Oncol 11:328-39. 2004
  10. ncbi request reprint ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas
    Joyce A Schroeder
    Tumor Biology Program and Department of Biochemistry and Molecular Biology, Mayo Medical Graduate School, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 277:22692-8. 2002

Research Grants

  1. FUNCTIONAL STUDY OF A CARCINOMA ASSOCIATED MUCIN MUC1
    SANDRA GENDLER; Fiscal Year: 2007
  2. FUNCTIONAL STUDY OF A CARCINOMA ASSOCIATED MUCIN MUC1
    SANDRA GENDLER; Fiscal Year: 2003
  3. Functional Study of Mucin MUC1
    SANDRA JANE GENDLER; Fiscal Year: 2010

Collaborators

  • Pinku Mukherjee
  • Gargi D Basu
  • Christine L Hattrup
  • Lieping Chen
  • Barbara A Pockaj
  • Richard J Gray
  • K C Kim
  • Judith Voynow
  • Erik P Lillehoj
  • Joyce A Schroeder
  • Pankaj K Singh
  • Roisin M Dwyer
  • Helen H Wang
  • Kandavel Shanmugam
  • Gunnar C Hansson
  • Melissa C Thompson
  • Melissa C Adriance
  • Elizabeth J McConnell
  • Ronald L Cerny
  • Michael A Hollingsworth
  • Emily K Malmberg
  • Eric J Thompson
  • Wenju Lu
  • Michael K O'Connor
  • Elizabeth R Bergert
  • John C Morris
  • David Q H Wang
  • Theodore H Lindsay
  • Nezam H Afdhal
  • Kari L Kotlarczyk
  • Malin E V Johansson
  • Tali Shalom-Barak
  • Marina Hinojosa-Kurtzberg
  • Jianchuan Xia
  • A Marina Hinojosa-Kurtzberg
  • María V Croce
  • Cathy S Madsen
  • Kristina A Thomsson
  • Michelle E Behrens
  • John P Eggers
  • Eric P Bennett
  • Jennifer M Bailey
  • Yunfei Wen
  • Benjamin J Swanson
  • Andrius Kazlauskas
  • Karin A Noaksson
  • Wilbur Chen
  • Alan S Cross
  • Takeshi Koga
  • Kosuke Kato
  • Andrew T Gewirtz
  • Judy M Bradley
  • Mia Phillipson
  • Ippei Kuwahara
  • Lena Holm
  • Albert Gutierrez
  • Akinori Hisatsune
  • Michael A Kuskowski
  • Beth M Jonas
  • Patrick W Mantyh
  • Gilbert Y Wong
  • Joseph R Ghilardi
  • Edward B Stelow
  • Kazufumi Kubota
  • Molly A Sevcik
  • Kyle G Halvorson
  • Yaacov Barak
  • Azzah Al Masri
  • Jill M Nicholas
  • Estelita S Ong
  • Ronald M Evans
  • Xiaowen Zhang
  • Yongxu Wang
  • Jennifer C Tessier
  • Timothy H Young
  • Amada Segal-Eiras
  • Carina E Rua
  • Jianlin Gong
  • Yasuhiro Tanaka
  • Todd D Camenisch
  • Martín E Rabassa
  • Shigeo Koido
  • Marina T Isla-Larrain
  • Chunlei Liu
  • Steven E Domino
  • John B Lowe
  • Latha B Pathangey
  • Karin A Axelsson

Detail Information

Publications29

  1. ncbi request reprint Structure and function of the cell surface (tethered) mucins
    Christine L Hattrup
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AR 85259, USA
    Annu Rev Physiol 70:431-57. 2008
    ..This review focuses on the three best-characterized cell surface mucins expressed in the respiratory tract: MUC1, MUC4, and MUC16...
  2. pmc MUC1 alters oncogenic events and transcription in human breast cancer cells
    Christine L Hattrup
    Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Breast Cancer Res 8:R37. 2006
    ..As expected for a protein with oncogenic functions, MUC1 is linked to regulation of proliferation, apoptosis, invasion, and transcription...
  3. pmc Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells
    Gargi D Basu
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Scottsdale, Arizona, USA
    Breast Cancer Res 7:R422-35. 2005
    ..In the present study we evaluated the mechanisms by which a highly selective COX-2 inhibitor, celecoxib, affects tumor growth of two differentially invasive human breast cancer cell lines...
  4. ncbi request reprint MUC1, the renaissance molecule
    S J Gendler
    Department of Biochemistry and Molecular Biology, Mayo Clinic Scottsdale, Arizona 85259, USA
    J Mammary Gland Biol Neoplasia 6:339-53. 2001
    ..The goal of this review is to highlight recent discoveries that suggest that MUC1 may be a multifunctional protein, located on the surfaces of cells as a sensor of the environment, poised to signal to the interior when things go awry...
  5. ncbi request reprint Spontaneous adenocarcinoma mouse models for immunotherapy
    S J Gendler
    Department of Biochemistry and Molecular Biology and Tumor Biology Program, Mayo Medical Graduate School, Mayo Clinic Scottsdale, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    Trends Mol Med 7:471-5. 2001
    ..These models are clinically relevant, as tumors arise in an appropriate tissue background and in a host conditioned by the physiological events of neoplastic progression and tumorigenesis and in the context of a viable immune system...
  6. ncbi request reprint Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer
    Gargi D Basu
    Mayo Clinic College of Medicine, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Mol Cancer Res 2:632-42. 2004
    ..Results from these preclinical studies will form the basis for assessing the feasibility of celecoxib therapy alone or in combination with conventional therapies for treatment and/or prevention of breast cancer...
  7. ncbi request reprint MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion
    Joyce A Schroeder
    Tumor Biology Program and Department of Biochemistry and Molecular Biology, Mayo Medical Graduate School, Mayo Clinic Scottsdale, AZ 85259, USA
    Oncogene 22:1324-32. 2003
    ..These data indicate a potential mechanism for MUC1 promotion of invasive tumorigenesis in the breast through the modulation of beta-catenin localization and subsequent cytoskeletal dynamics...
  8. ncbi request reprint MUC1 can interact with adenomatous polyposis coli in breast cancer
    Christine L Hattrup
    Tumor Biology Program, Mayo Clinic College of Medicine, Mayo Clinic, Scottsdale, AZ, USA
    Biochem Biophys Res Commun 316:364-9. 2004
    ....
  9. ncbi request reprint Reduced T-cell and dendritic cell function is related to cyclooxygenase-2 overexpression and prostaglandin E2 secretion in patients with breast cancer
    Barbara A Pockaj
    Department of Surgery, Mayo Clinic College of Medicine, Scottsdale, Arizona 85259, USA
    Ann Surg Oncol 11:328-39. 2004
    ..Thus, thorough analysis of immune parameters in breast cancer patients may be beneficial in designing effective anticancer immune-based therapies...
  10. ncbi request reprint ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas
    Joyce A Schroeder
    Tumor Biology Program and Department of Biochemistry and Molecular Biology, Mayo Medical Graduate School, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 277:22692-8. 2002
    ....
  11. ncbi request reprint Therapeutic efficacy of MUC1-specific cytotoxic T lymphocytes and CD137 co-stimulation in a spontaneous breast cancer model
    Pinku Mukherjee
    Mayo Clinic College of Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Breast Dis 20:53-63. 2004
    ....
  12. ncbi request reprint MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation
    Joyce A Schroeder
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic Scottsdale, Scottsdale, AZ 85259, USA
    Oncogene 23:5739-47. 2004
    ..These findings are the first to determine that MUC1 overexpression promotes in vivo transformation of the mammary gland...
  13. ncbi request reprint Dendritic cell-tumor cell fusion and staphylococcal enterotoxin B treatment in a pancreatic tumor model
    Elizabeth J McConnell
    Department of Surgery, Mayo Clinic Scottsdale, Arizona 85259, USA
    J Surg Res 107:196-202. 2002
    ..The hypothesis of this investigation is that specific and effective immunotherapeutic vaccine (dendritic/tumor cell fusion) will activate cytotoxic T lymphocytes (CTLs), leading to the eradication of spontaneous pancreatic cancer...
  14. ncbi request reprint Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient mice
    A Marina Hinojosa-Kurtzberg
    Mayo Clinic Scottsdale, Department of Biochemistry and Molecular Biology, Scottsdale, Arizona 85259, USA
    Am J Physiol Gastrointest Liver Physiol 284:G853-62. 2003
    ..Thus MUC1 expression is increased, and it appears that alternate cytoplasmic tails may change its role in signaling. MUC1 could be an important contributor to the CF intestinal phenotype...
  15. ncbi request reprint Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells
    Pankaj K Singh
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Cancer Res 67:5201-10. 2007
    ..We propose that interactions of MUC1 and PDGFRbeta induce signal transduction events that influence the metastatic properties of pancreatic adenocarcinoma...
  16. ncbi request reprint In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter
    Roisin M Dwyer
    Department of Endocrinology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Clin Cancer Res 11:1483-9. 2005
    ..The aim of this study was to create a construct containing NIS under the control of the MUC1 promoter to target expression specifically to MUC1-positive breast cancer cells...
  17. ncbi request reprint Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors
    Roisin M Dwyer
    Department of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    Hum Gene Ther 17:661-8. 2006
    ..0001). The ability to target NIS expression to pancreatic cancer, which has such limited treatment options, may be highly beneficial and warrants further investigation...
  18. ncbi request reprint Tyrosines in the MUC1 cytoplasmic tail modulate transcription via the extracellular signal-regulated kinase 1/2 and nuclear factor-kappaB pathways
    Eric J Thompson
    Cancer Center Scottsdale, Mayo Clinic Arizona, 85259, USA
    Mol Cancer Res 4:489-97. 2006
    ..These data support the growing evidence that MUC1 is involved in transcriptional regulation and link MUC1 for the first time to the NF-kappaB pathway...
  19. ncbi request reprint Evidence that gallbladder epithelial mucin enhances cholesterol cholelithogenesis in MUC1 transgenic mice
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, Massachusetts 02215, USA
    Gastroenterology 131:210-22. 2006
    ..The gel-forming mucins play an important role in the early stage of cholesterol gallstone formation. We investigated whether the gallbladder epithelial mucin encoded by mucin gene 1 (MUC1) influences susceptibility to gallstones...
  20. ncbi request reprint Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice
    Wenju Lu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, 21201, USA
    J Immunol 176:3890-4. 2006
    ..We conclude that MUC1/Muc1 suppresses pulmonary innate immunity and speculate its anti-inflammatory activity may play an important modulatory role during microbial infection...
  21. ncbi request reprint Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression
    Emily K Malmberg
    Department of Medical Biochemistry, Goteborg University, Gothenburg, Sweden
    Am J Physiol Gastrointest Liver Physiol 291:G203-10. 2006
    ..The results suggest that MUC1 is not a major component in the accumulated mucus of CF mice and that MUC1 can influence the amount of other mucins in a still unknown way...
  22. ncbi request reprint Regulation of mucin genes in chronic inflammatory airway diseases
    Judith A Voynow
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 34:661-5. 2006
    ....
  23. ncbi request reprint Pancreatic cancer pain and its correlation with changes in tumor vasculature, macrophage infiltration, neuronal innervation, body weight and disease progression
    Theodore H Lindsay
    Neurosystems Center, 18 208 Moos Tower, School of Dentistry, University of Minnesota, 515 Delaware Street SE, Minneapolis, MN 55455, USA
    Pain 119:233-46. 2005
    ..Defining the mechanisms that mask this pain in early and mid-stage disease and drive the pain in late-stage disease may aid in earlier diagnosis, survival, and increased quality of life of patients with pancreatic cancer...
  24. pmc Peroxisome proliferator-activated receptor gamma controls Muc1 transcription in trophoblasts
    Tali Shalom-Barak
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Mol Cell Biol 24:10661-9. 2004
    ....
  25. ncbi request reprint Targeted disruption of the murine mucin gene 1 decreases susceptibility to cholesterol gallstone formation
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, and Harvard Digestive Diseases Center, Boston, MA 02215, USA
    J Lipid Res 45:438-47. 2004
    ..We conclude that decreased gallstone formation in mice with disrupted Muc1 gene results from reduced mucin secretion and accumulation in the gallbladder...
  26. ncbi request reprint Patterns of MUC1 tissue expression defined by an anti-MUC1 cytoplasmic tail monoclonal antibody in breast cancer
    María V Croce
    Centro de Investigaciones Inmunológicas Básicas y Aplicadas, Facultad de Ciencias Medicas, UNLP, La Plata, Argentina
    J Histochem Cytochem 51:781-8. 2003
    ..The pattern and extension of MUC1 CT positivity do not vary according to the histopathological subtype of the tumor...
  27. ncbi request reprint Prevention of spontaneous breast carcinoma by prophylactic vaccination with dendritic/tumor fusion cells
    Jianchuan Xia
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    J Immunol 170:1980-6. 2003
    ..The findings in the present study are highly relevant to cancers in humans...
  28. pmc Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucalpha1-2 glycosyltransferase
    Kristina A Thomsson
    Department of Medical Biochemistry, Goteborg University, Medicinaregatan 9A, 41390 Gothenburg, Sweden
    Biochem J 367:609-16. 2002
    ..The reason for this up-regulation could be a direct or indirect effect of a non-functional CF transmembrane conductance regulator (CFTR) caused by the absence of CFTR channel...
  29. pmc Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression
    Pankaj K Singh
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    J Biol Chem 283:26985-95. 2008
    ..This correlated with a decrease in hepatocyte growth factor-induced invasiveness when MUC1 was overexpressed. The results demonstrate that MUC1 modulates Met-mediated oncogenic signaling in cancer...

Research Grants16

  1. FUNCTIONAL STUDY OF A CARCINOMA ASSOCIATED MUCIN MUC1
    SANDRA GENDLER; Fiscal Year: 2007
    ..These studies will significantly increase our understanding of the importance of MUC1 function in epithelial tumors during transformation, growth, invasion and metastasis. ..
  2. FUNCTIONAL STUDY OF A CARCINOMA ASSOCIATED MUCIN MUC1
    SANDRA GENDLER; Fiscal Year: 2003
    ..abstract_text> ..
  3. Functional Study of Mucin MUC1
    SANDRA JANE GENDLER; Fiscal Year: 2010
    ....