O Gajic

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Towards prevention of acute lung injury: frequency and outcomes of emergency department patients at-risk - a multicenter cohort study
    Peter C Hou
    Department of Emergency Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Int J Emerg Med 5:22. 2012
  2. pmc Lung injury prediction score for the emergency department: first step towards prevention in patients at risk
    Marie Carmelle Elie-Turenne
    Department of Emergency Medicine, University of Florida College of Medicine, PO Box 100186, 1329 SW 16th Street, Gainesville, FL 32610, USA
    Int J Emerg Med 5:33. 2012
  3. pmc Clinical review: the hospital of the future - building intelligent environments to facilitate safe and effective acute care delivery
    Brian W Pickering
    Department of Anesthesiology, Division of Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Crit Care 16:220. 2012
  4. pmc Risk factors for the development of acute lung injury in patients with infectious pneumonia
    Marija Kojicic
    The Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Crit Care 16:R46. 2012
  5. pmc Systems modeling and simulation applications for critical care medicine
    Yue Dong
    Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo Clinic, Rochester, MN, USA
    Ann Intensive Care 2:18. 2012
  6. pmc Year in review 2006: Critical Care--Resource management
    Marcus J Schultz
    Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Crit Care 11:223. 2007
  7. pmc Failure of non-invasive ventilation in patients with acute lung injury: observational cohort study
    Sameer Rana
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota USA
    Crit Care 10:R79. 2006
  8. pmc Bedside quantification of dead-space fraction using routine clinical data in patients with acute lung injury: secondary analysis of two prospective trials
    Hassan Siddiki
    Department of Radiology, Mayo Clinic College of Medicine, 200 1stStreet, Rochester 55905, USA
    Crit Care 14:R141. 2010
  9. pmc Towards the prevention of acute lung injury: a population based cohort study protocol
    Sweta J Thakur
    Multidisciplinary Epidemiology and Translational Research in Intensive Care, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    BMC Emerg Med 10:8. 2010
  10. pmc Prediction of death and prolonged mechanical ventilation in acute lung injury
    Ognjen Gajic
    Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Crit Care 11:R53. 2007

Research Grants

Detail Information

Publications95

  1. pmc Towards prevention of acute lung injury: frequency and outcomes of emergency department patients at-risk - a multicenter cohort study
    Peter C Hou
    Department of Emergency Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Int J Emerg Med 5:22. 2012
    ..Few emergency department (ED) evaluations on acute lung injury (ALI) have been carried out; hence, we sought to describe a cohort of hospitalized ED patients at risk for ALI development...
  2. pmc Lung injury prediction score for the emergency department: first step towards prevention in patients at risk
    Marie Carmelle Elie-Turenne
    Department of Emergency Medicine, University of Florida College of Medicine, PO Box 100186, 1329 SW 16th Street, Gainesville, FL 32610, USA
    Int J Emerg Med 5:33. 2012
    ..We aimed to derive and validate an acute lung injury prediction score (EDLIPS) in a multicenter sample of emergency department (ED) patients...
  3. pmc Clinical review: the hospital of the future - building intelligent environments to facilitate safe and effective acute care delivery
    Brian W Pickering
    Department of Anesthesiology, Division of Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Crit Care 16:220. 2012
    ....
  4. pmc Risk factors for the development of acute lung injury in patients with infectious pneumonia
    Marija Kojicic
    The Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Crit Care 16:R46. 2012
    ..The objective of this study was to determine frequency, risk factors, and outcome of ALI in patients with infectious pneumonia...
  5. pmc Systems modeling and simulation applications for critical care medicine
    Yue Dong
    Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo Clinic, Rochester, MN, USA
    Ann Intensive Care 2:18. 2012
    ..Finally, we identify certain challenges to, and opportunities for, future research in the area...
  6. pmc Year in review 2006: Critical Care--Resource management
    Marcus J Schultz
    Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Crit Care 11:223. 2007
    ..Finally, several aspects of scientific research in critically ill patients were investigated, focusing on the possibility of obtaining informed consent and recall of having given informed consent...
  7. pmc Failure of non-invasive ventilation in patients with acute lung injury: observational cohort study
    Sameer Rana
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota USA
    Crit Care 10:R79. 2006
    ..We sought to assess the outcome of ALI that was initially treated with NIPPV and to identify specific risk factors for NIPPV failure...
  8. pmc Bedside quantification of dead-space fraction using routine clinical data in patients with acute lung injury: secondary analysis of two prospective trials
    Hassan Siddiki
    Department of Radiology, Mayo Clinic College of Medicine, 200 1stStreet, Rochester 55905, USA
    Crit Care 14:R141. 2010
    ..The objective of this study was to determine prognostic value of Vd/Vt estimated from routinely collected pulmonary variables...
  9. pmc Towards the prevention of acute lung injury: a population based cohort study protocol
    Sweta J Thakur
    Multidisciplinary Epidemiology and Translational Research in Intensive Care, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    BMC Emerg Med 10:8. 2010
    ..Olmsted County, MN, geographically isolated from other urban areas offers the opportunity to study clinical pathogenesis of ALI in a search for potential prevention targets...
  10. pmc Prediction of death and prolonged mechanical ventilation in acute lung injury
    Ognjen Gajic
    Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Crit Care 11:R53. 2007
    ..We aimed to identify risk factors for a combined end-point of death and/or prolonged ventilator dependence and developed an ALI-specific prediction model...
  11. ncbi request reprint Transfusion from male-only versus female donors in critically ill recipients of high plasma volume components
    Ognjen Gajic
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Crit Care Med 35:1645-8. 2007
    ..The objective of this study was to evaluate the effect of transfusing components from male-only vs. female donors on development of ALI, gas exchange, and outcome in critically ill patients...
  12. pmc Transfusion-related acute lung injury in the critically ill: prospective nested case-control study
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Respir Crit Care Med 176:886-91. 2007
    ..Several transfusion characteristics have been postulated as risk factors for TRALI, but the evidence is limited to retrospective studies...
  13. pmc Eight-year trend of acute respiratory distress syndrome: a population-based study in Olmsted County, Minnesota
    Guangxi Li
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Respir Crit Care Med 183:59-66. 2011
    ..significant progress has been made in understanding the pathogenesis of acute respiratory distress syndrome (ARDS). Recent advances in hospital practice may have reduced the incidence of this lethal syndrome...
  14. ncbi request reprint Effect of 24-hour mandatory versus on-demand critical care specialist presence on quality of care and family and provider satisfaction in the intensive care unit of a teaching hospital
    Ognjen Gajic
    Mayo Clinic College of Medicine, Rochester, MN, USA
    Crit Care Med 36:36-44. 2008
    ..We compared the quality of care and patient/family and provider satisfaction before and after changing the staffing model from on-demand to continuous 24-hr critical care specialist presence in the intensive care unit...
  15. doi request reprint The Stability and Workload Index for Transfer score predicts unplanned intensive care unit patient readmission: initial development and validation
    Ognjen Gajic
    Department of Internal Medicine and the Mayo Epidemiology and Translational Research in Intensive Care Program, Mayo Clinic College of Medicine, Rochester, MN, USA
    Crit Care Med 36:676-82. 2008
    ..The objective of this study is to develop and validate a numerical index, named the Stability and Workload Index for Transfer, to predict ICU readmission...
  16. pmc Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study
    Ognjen Gajic
    Mayo Clinic, Rochester, MN 55905, USA
    Am J Respir Crit Care Med 183:462-70. 2011
    ..Objectives: To determine the frequency and outcome of ALI development in patients at risk and validate a lung injury prediction score (LIPS)...
  17. ncbi request reprint Fresh frozen plasma and platelet transfusion for nonbleeding patients in the intensive care unit: benefit or harm?
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Crit Care Med 34:S170-3. 2006
    ..We searched the National Library of Medicine PubMed database as well as references of retrieved articles and summarized the current evidence for the use of FFP and platelet transfusions in critically ill patients...
  18. ncbi request reprint Pulmonary edema after transfusion: how to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Crit Care Med 34:S109-13. 2006
    ..In this review article we searched the National Library of Medicine PubMed database as well as references of retrieved articles and summarized the methods for differentiating between hydrostatic and permeability pulmonary edema...
  19. ncbi request reprint Acute lung injury after blood transfusion in mechanically ventilated patients
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic Rochester, Minnesota 55905, USA
    Transfusion 44:1468-74. 2004
    ..We tested the hypotheses that storage age and specific type of blood products are associated with increased risk of ALI in mechanically ventilated patients...
  20. ncbi request reprint Ventilator settings as a risk factor for acute respiratory distress syndrome in mechanically ventilated patients
    Ognjen Gajic
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Intensive Care Med 31:922-6. 2005
    ..We tested this hypothesis in a larger sample of patients prospectively enrolled in a multicenter study on mechanical ventilation...
  21. ncbi request reprint Infectious complications in survivors of cardiac arrest admitted to the medical intensive care unit
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Resuscitation 60:65-9. 2004
    ..To describe the incidence, associated factors and outcome of infectious complications in patients admitted to the medical intensive care unit (MICU) after cardiopulmonary resuscitation (CPR)...
  22. ncbi request reprint Ventilator-induced cell wounding and repair in the intact lung
    Ognjen Gajic
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Thoracic Diseases Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Respir Crit Care Med 167:1057-63. 2003
    ..25 +/- 0.09 to 0.08 +/- 0.08, p < 0.01). We conclude that cells of ventilator-injured lungs are subject to reversible plasma membrane stress failure...
  23. ncbi request reprint Transfusion-related acute lung injury and pulmonary edema in critically ill patients: a retrospective study
    Rimki Rana
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Transfusion 46:1478-83. 2006
    ..Using the recent Consensus Panel recommendations, we sought to describe the incidence of transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO) in critically ill patients...
  24. doi request reprint Acute lung injury prediction score: derivation and validation in a population-based sample
    C Trillo-Alvarez
    Dept of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Eur Respir J 37:604-9. 2011
    ..If externally validated, this model will serve to define the population of patients at high risk for ALI in whom future mechanistic studies and ALI prevention trials will be conducted...
  25. doi request reprint The association between nighttime transfer from the intensive care unit and patient outcome
    Tarik Hanane
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA
    Crit Care Med 36:2232-7. 2008
    ..To determine the impact of nighttime transfer of patients from the intensive care unit (ICU) on clinical outcome...
  26. doi request reprint Comparison of two ventilatory strategies in elderly patients undergoing major abdominal surgery
    T N Weingarten
    Department of Anesthesiology and Anesthesia Clinical Research Unit, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Br J Anaesth 104:16-22. 2010
    ..The feasibility of an 'open lung' ventilatory strategy in elderly patients under general anaesthesia has not previously been assessed...
  27. ncbi request reprint Fresh-frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients
    Hasrat Khan
    Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Chest 131:1308-14. 2007
    ..Transfusion has long been identified as a risk factor for acute lung injury (ALI)/ARDS. No study has formally evaluated the transfusion of specific blood products as a risk factor for ALI/ARDS in critically ill medical patients...
  28. ncbi request reprint Toward the prevention of acute lung injury: protocol-guided limitation of large tidal volume ventilation and inappropriate transfusion
    Murat Yilmaz
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Crit Care Med 35:1660-6; quiz 1667. 2007
    ..We evaluated the effect of two quality improvement interventions (low tidal volume ventilation and restrictive transfusion) on the development of acute lung injury in mechanically ventilated patients...
  29. ncbi request reprint Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic Rochester, MN, USA
    Crit Care Med 32:1817-24. 2004
    ..We tested the hypothesis that acute lung injury, which develops after the initiation of mechanical ventilation, is associated with known risk factors for ventilator-induced lung injury such as ventilation with large tidal volume...
  30. ncbi request reprint Early identification of patients with or at risk of acute lung injury
    A Ahmed
    Multidisciplinary Epidemiology and Translational Research in Intensive Care METRIC, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, USA
    Neth J Med 67:268-71. 2009
    ..Automated electronic screening tools and novel scoring systems applied at the time of hospital admission may facilitate enrollment of patients into mechanistic and outcome studies, as well as future ALI /ARDS prevention trials...
  31. doi request reprint Blood product transfusion in the critical care setting
    Daryl J Kor
    Department of Anesthesiology Division of Critical Care Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Crit Care 16:309-16. 2010
    ..The purpose of this review is to present the current state of knowledge regarding blood transfusion in the critically ill and to identify gaps in our current understanding for future research...
  32. doi request reprint Statin administration did not influence the progression of lung injury or associated organ failures in a cohort of patients with acute lung injury
    Daryl J Kor
    Division of Critical Care Medicine, Department of Anesthesiology, Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Intensive Care Med 35:1039-46. 2009
    ..We evaluated whether statins are associated with attenuation of lung injury and prevention of associated organ failure in patients with ALI/ARDS...
  33. pmc Incidence and transfusion risk factors for transfusion-associated circulatory overload among medical intensive care unit patients
    Guangxi Li
    Division of Pulmonary and Critical Care Medicine, Mayo Epidemiology and Translational Research in Intensive Care, Mayo Clinic, Rochester, Minnesota, USA
    Transfusion 51:338-43. 2011
    ..Transfusion-associated circulatory overload (TACO) is a frequent complication of blood transfusion. Investigations identifying risk factors for TACO in critically ill patients are lacking...
  34. pmc Arterial pulmonary hypertension in noncardiac intensive care unit
    Mykola V Tsapenko
    Division of Pulmonary and Critical Care Medicine, Mayo Epidemiology and Translational Research in Intensive Care, Mayo Clinic, Rochester, MN 55905, USA
    Vasc Health Risk Manag 4:1043-60. 2008
    ....
  35. pmc The accuracy of natriuretic peptides (brain natriuretic peptide and N-terminal pro-brain natriuretic) in the differentiation between transfusion-related acute lung injury and transfusion-related circulatory overload in the critically ill
    Guangxi Li
    Department of Guanganmen Hospital, Division of Pulmonary, China Academy of Chinese Medical Science, Beijing, China
    Transfusion 49:13-20. 2009
    ..Brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic (NT-pro-BNP) accurately diagnosed TACO in preliminary studies that did not include patients with TRALI...
  36. ncbi request reprint Comparison of community and referral intensive care unit patients in a tertiary medical center: evidence for referral bias in the critically ill
    Edward G Seferian
    Division of Pediatric Critical Care Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA
    Crit Care Med 36:2779-86. 2008
    ....
  37. ncbi request reprint Fetal outcomes of critically ill pregnant women admitted to the intensive care unit for nonobstetric causes
    Rodrigo Cartin-Ceba
    Mayo Clinic of Medicine, Rochester, MN, USA
    Crit Care Med 36:2746-51. 2008
    ..We evaluated the risk factors for adverse fetal outcomes in critically ill pregnant women admitted to the intensive care unit for nonobstetrical reasons...
  38. pmc Derivation and validation of automated electronic search strategies to identify pertinent risk factors for postoperative acute lung injury
    Anas Alsara
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 86:382-8. 2011
    ..To develop and validate time-efficient automated electronic search strategies for identifying preoperative risk factors for postoperative acute lung injury...
  39. doi request reprint Physician staffing models and patient safety in the ICU
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Chest 135:1038-44. 2009
    ..In this commentary, we will discuss the available evidence behind the current models and express our opinions about current and future ICU intensivist staffing...
  40. pmc Association between ICU admission during morning rounds and mortality
    Bekele Afessa
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Chest 136:1489-95. 2009
    ..No previous study has evaluated the association between admission to ICUs during round time and patient outcome. The objective of this study was to determine the association between round-time ICU admission and patient outcome...
  41. doi request reprint Diagnostic accuracy of a simple ultrasound measurement to estimate central venous pressure in spontaneously breathing, critically ill patients
    A Scott Keller
    Division of Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Hosp Med 4:350-5. 2009
    ..In addition, nonintensivists may not start early aggressive fluid resuscitation because of difficulty estimating CVP and concerns for inadvertent volume overload...
  42. ncbi request reprint Outcome of critically ill patients with influenza virus infection
    Guangxi Li
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, United States
    J Clin Virol 46:275-8. 2009
    ..An accurate prognosis is essential for decision-making during pandemic as well as interpandemic periods...
  43. pmc Ventilator settings and outcome of respiratory failure in chronic interstitial lung disease
    Evans R Fernandez-Perez
    Department of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, East 18, Mayo Clinic, Rochester, MN 55905, USA
    Chest 133:1113-9. 2008
    ..While patients with interstitial lung disease (ILD) may be particularly susceptible to ventilator-induced lung injury, ventilator strategies have not been studied in this group of patients...
  44. doi request reprint Evaluation of "Loss" and "End stage renal disease" after acute kidney injury defined by the Risk, Injury, Failure, Loss and ESRD classification in critically ill patients
    Rodrigo Cartin-Ceba
    Multidisciplinary Epidemiology and Translational Research in Intensive Care, Mayo Clinic College of Medicine, Rochester, MN, USA
    Intensive Care Med 35:2087-95. 2009
    ..We aim to describe and evaluate the development of "Loss" and "ESRD" in a group of critically ill patients...
  45. pmc Long-term survival and quality of life after transfusion-associated pulmonary edema in critically ill medical patients
    Guangxi Li
    Division of Pulmonary and Critical Care Medicine, Old Marion Hall, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Chest 137:783-9. 2010
    ..Prior outcome studies of TACO and TRALI have focused on short-term morbidity and mortality, but the long-term survival and quality of life (QOL) of these patients remain unknown...
  46. pmc Prehospitalization antiplatelet therapy is associated with a reduced incidence of acute lung injury: a population-based cohort study
    Jason M Erlich
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Chest 139:289-95. 2011
    ..We examined the association of prehospitalization antiplatelet therapy with development of ALI in critically ill patients...
  47. ncbi request reprint Practice variability in management of acute respiratory distress syndrome: bringing evidence and clinician education to the bedside using a web-based teaching tool
    Thomas E Belda
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, 2 114 Old Marian Hall, Rochester MN 55905, USA
    Respir Care 49:1015-21. 2004
    ..Clinical practice often lags behind publication of evidence-based research and national consensus guidelines...
  48. ncbi request reprint Perioperative coagulation management--fresh frozen plasma
    Daryl J Kor
    Department of Anesthesiology Division of Critical Care Medicine Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Best Pract Res Clin Anaesthesiol 24:51-64. 2010
    ..Both provide an opportunity for increasing the safe plasma donor pool. Although prothrombin complex concentrates and factor VIIa may be used as alternatives to FFP in a variety of specific clinical contexts, additional study is needed...
  49. pmc Hypercapnic acidosis impairs plasma membrane wound resealing in ventilator-injured lungs
    Clinton H Doerr
    Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Respir Crit Care Med 171:1371-7. 2005
    ..02). This finding was subsequently confirmed in alveolar epithelial cell scratch models. The potential relevance of these observations for lung inflammation and remodeling after mechanical injury is discussed...
  50. ncbi request reprint The addition of decision support into computerized physician order entry reduces red blood cell transfusion resource utilization in the intensive care unit
    Evans R Fernandez Perez
    Mayo Clinic College of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Hematol 82:631-3. 2007
    ..In conclusion, the implementation of an evidenced-based decision support system through a CPOE can decrease RBC transfusion resource utilization in critically ill patients...
  51. ncbi request reprint Review article: age related alterations in respiratory function - anesthetic considerations
    Juraj Sprung
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Can J Anaesth 53:1244-57. 2006
    ....
  52. ncbi request reprint Intraoperative tidal volume as a risk factor for respiratory failure after pneumonectomy
    Evans R Fernandez-Perez
    Division of Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Anesthesiology 105:14-8. 2006
    ..The authors hypothesized that intraoperative mechanical ventilation with large tidal volumes (VTs) would be associated with increased risk of postpneumonectomy respiratory failure...
  53. ncbi request reprint The influence of missing components of the Acute Physiology Score of APACHE III on the measurement of ICU performance
    Bekele Afessa
    Division of Pulmonary and Critical Care, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Intensive Care Med 31:1537-43. 2005
    ..To determine the impact of missing Acute Physiology Score (APS) values on risk-adjusted mortality...
  54. ncbi request reprint B-type natriuretic peptide in the assessment of acute lung injury and cardiogenic pulmonary edema
    Rimki Rana
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Crit Care Med 34:1941-6. 2006
    ..We postulated that a low BNP level would exclude cardiac dysfunction as the principal cause of pulmonary edema and therefore help in the diagnosis of acute lung injury...
  55. ncbi request reprint Severity of illness and organ failure assessment in adult intensive care units
    Bekele Afessa
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905, USA
    Crit Care Clin 23:639-58. 2007
    ..Their roles as clinical decision support tools at the bedside await future studies because of their unknown or poor performance at the individual patient level...
  56. ncbi request reprint Acute abdomen in the medical intensive care unit
    Ognjen Gajic
    Critical Care Service, Mayo Clinic, Rochester MN 55905, USA
    Crit Care Med 30:1187-90. 2002
    ..We hypothesize that delays in surgery because of atypical presentation, such as the absence of peritoneal signs, may contribute to mortality...
  57. ncbi request reprint Low baseline serum creatinine concentration predicts mortality in critically ill patients independent of body mass index
    Rodrigo Cartin-Ceba
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Epidemiology and Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Crit Care Med 35:2420-3. 2007
    ..We hypothesized that low baseline serum creatinine would predict poor outcome in the critically ill...
  58. ncbi request reprint Acute respiratory failure due to pneumocystis pneumonia in patients without human immunodeficiency virus infection: outcome and associated features
    Emir Festic
    Division of Primary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Chest 128:573-9. 2005
    ..To examine outcome and associated factors of acute respiratory failure (ARF) in non-HIV-related Pneumocystis pneumonia (PCP) in patients admitted to a medical ICU between 1995 and 2002...
  59. ncbi request reprint Tracheostomy in critically ill patients
    Sameer Rana
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 80:1632-8. 2005
    ..Depending on local medical expertise and costs, either the percutaneous or the surgical technique may be used...
  60. ncbi request reprint Evaluating the performance of an institution using an intensive care unit benchmark
    Bekele Afessa
    Department of Internal Medicine and Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 80:174-80. 2005
    ..To describe the performances of selected intensive care units (ICUs) in a single institution using the Acute Physiology and Chronic Health Evaluation (APACHE) III benchmark and to propose interventions that may improve performance...
  61. doi request reprint Limiting ventilator-induced lung injury through individual electronic medical record surveillance
    Vitaly Herasevich
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, and Multidisciplinary Epidemiology and Translational Research in Intensive Care METRIC, Mayo Clinic College of Medicine, Rochester, MN, USA
    Crit Care Med 39:34-9. 2011
    ....
  62. doi request reprint Intraoperative ventilator settings and acute lung injury after elective surgery: a nested case control study
    E R Fernandez-Perez
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Jewish Health, 1400 Jackson Street, G10a, Denver, CO 80206, USA
    Thorax 64:121-7. 2009
    ..While acute lung injury (ALI) is among the most serious postoperative pulmonary complications, its incidence, risk factors and outcome have not been prospectively studied...
  63. ncbi request reprint Optimal ventilator settings in acute lung injury and acute respiratory distress syndrome
    M Yilmaz
    Mayo Clinic College of Medicine, Division of Pulmonary and Critical Care Medicine, Rochester, MN 55905, USA
    Eur J Anaesthesiol 25:89-96. 2008
    ..Alternative modes of ventilation such as high-frequency ventilation and prone position should be reserved for selected patients in whom conventional lung-protective ventilation strategies have failed...
  64. ncbi request reprint Fresh frozen plasma transfusion in critically ill medical patients with coagulopathy
    Saqib I Dara
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA
    Crit Care Med 33:2667-71. 2005
    ..We hypothesized that the practice of FFP transfusion in the medical intensive care unit is variable and that liberal use may not be associated with improved outcome...
  65. doi request reprint Intermittent hemodialysis versus continuous renal replacement therapy for acute renal failure in the intensive care unit: an observational outcomes analysis
    Anis Abdul Rauf
    Departments of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Intensive Care Med 23:195-203. 2008
    ....
  66. ncbi request reprint When less is more in the intensive care unit; lessons learned
    Emir Festic
    Mayo Clinic, Jacksonville, FL, USA
    Bosn J Basic Med Sci 9:54-8. 2009
    ..However, they have to be sensitive to individual circumstances, patient and family preferences, and avoidance of harm...
  67. ncbi request reprint Transfusion-related acute lung injury
    Ognjen Gajic
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 80:766-70. 2005
    ..As many as one third of all patients who develop acute lung injury have been exposed to blood products. TRALI may be an important and potentially preventable cause of acute lung injury...
  68. doi request reprint Outcome of emergency ERCP in the intensive care unit
    A Saleem
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endoscopy 43:549-51. 2011
    ....
  69. ncbi request reprint A review of red cell transfusion in the neurological intensive care unit
    Shanthan Pendem
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurocrit Care 4:63-7. 2006
    ..Although there is little reason to suspect that restrictive transfusion protocols would be detrimental, further studies are needed to determine optimal transfusion threshold in this population...
  70. pmc Informatics infrastructure for syndrome surveillance, decision support, reporting, and modeling of critical illness
    Vitaly Herasevich
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 85:247-54. 2010
    ..To develop and validate an informatics infrastructure for syndrome surveillance, decision support, reporting, and modeling of critical illness...
  71. ncbi request reprint Red blood cell storage lesion
    Daryl J Kor
    Mayo Clinic, Rochester, MN 55905, USA
    Bosn J Basic Med Sci 9:21-7. 2009
    ..This review will address the alterations occurring within the RBC and storage media during RBC preservation and will address the potential clinical consequence thereof...
  72. pmc Validation of an electronic surveillance system for acute lung injury
    Vitaly Herasevich
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Intensive Care Med 35:1018-23. 2009
    ..We aimed to determine the accuracy of computerized syndrome surveillance for detection of ALI in hospitalized patients and compare it with routine clinical assessment...
  73. pmc Prophylactic endotracheal intubation in critically ill patients undergoing endoscopy for upper GI hemorrhage
    Ahmer Rehman
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastrointest Endosc 69:e55-9. 2009
    ..Cardiopulmonary complications are common after endoscopy for upper GI (UGI) hemorrhage in the intensive care unit (ICU)...
  74. doi request reprint Paroxysmal atrial fibrillation in critically ill patients with sepsis
    Salam Salman
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Intensive Care Med 23:178-83. 2008
    ..It occurs more frequently in patients with advanced age, history of paroxysmal atrial fibrillation, high severity of illness, and lower left ventricular ejection fraction and is associated with increased mortality...
  75. ncbi request reprint A novel multimedia workshop on portable cardiac critical care ultrasonography: a practical option for the busy intensivist
    H Sekiguchi
    Mayo Clinic, Rochester, MN 55905, USA
    Anaesth Intensive Care 40:838-43. 2012
    ..Further studies are needed to assess the sustainability of observed improvements. This module may be a practical option for the acquisition and maintenance of cardiac critical care ultrasonography knowledge and skills...
  76. doi request reprint Alveolar recruitment and arterial desflurane concentration during bariatric surgery
    Juraj Sprung
    Department of Anesthesiology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Anesth Analg 108:120-7. 2009
    ..We investigated whether reversal of intraoperative atelectasis with the lung recruitment maneuver (RM) affects desflurane arterial concentrations during bariatric surgery...
  77. ncbi request reprint Medical informatics: an essential tool for health sciences research in acute care
    Man Li
    Multidisciplinary Epidemiology and Translational Research in Intensive Care METRIC Mayo Clinic, Rochester, MN 55905, USA
    Bosn J Basic Med Sci 9:34-9. 2009
    ..Examples of intelligent alarms -- "sniffers", administrative reports, decision support and clinical research applications are presented...
  78. doi request reprint Risk factors for the development of acute lung injury in patients with septic shock: an observational cohort study
    Remzi Iscimen
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clini, Rochester, Minnesota, USA
    Crit Care Med 36:1518-22. 2008
    ..The understanding why some patients do and others do not develop ALI is limited. The objective of this study was to test the hypothesis that delayed treatment of septic shock is associated with the development of ALI...
  79. ncbi request reprint Accuracy of the preoperative assessment in predicting pulmonary risk after nonthoracic surgery
    Finlay A McAlister
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    Am J Respir Crit Care Med 167:741-4. 2003
    ..0; p = 0.007). Thus, preoperative factors can identify those patients referred to pulmonologists or internists who are at increased risk for pulmonary complications after nonthoracic surgery...
  80. ncbi request reprint The practice of platelet transfusion in the intensive care unit
    Salam S Salman
    Pulmonary and Critical Care Medicine, Graduate Hospital, Philadelphia, PA, USA
    J Intensive Care Med 22:105-10. 2007
    ..The practice of platelet transfusion in critically ill patients with thrombocytopenia varies. Prospective studies evaluating restrictive versus liberal platelet transfusion strategies are warranted...
  81. ncbi request reprint Promoting recognition and prevention of transfusion-related acute lung injury
    Steven Kleinman
    AABB American Association of Blood Banks, Bethesda, MD 20814 2749, USA
    Crit Care Nurse 27:49-53. 2007
  82. ncbi request reprint Repeat percutaneous tracheostomy in the neurocritically ill patient
    Murat Yilmaz
    Department of Anesthesiology and Intensive Care, Faculty of Medicine, Antalya, Turkey
    Neurocrit Care 5:120-3. 2006
    ..The aim of this study was to determine the safety of repeat percutaneous tracheostomy in neurocritically ill patients with a history of previous tracheostomy...
  83. ncbi request reprint Evidence-based red cell transfusion in the critically ill: quality improvement using computerized physician order entry
    Rimki Rana
    Family Medicine Residency, Mercy Medical Center North Iowa, Mason City, IA, USA
    Crit Care Med 34:1892-7. 2006
    ..In this quality improvement intervention we assessed the effect of an institutional protocol and computerized decision support for red cell transfusion in the critically ill...
  84. ncbi request reprint What tidal volumes should be used in patients without acute lung injury?
    Marcus J Schultz
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, University of Amsterdam, and Interdepartmental Division of Critical Care, St Michael s Hospital, Toronto, Ontario, Canada
    Anesthesiology 106:1226-31. 2007
    ..Prospective studies should be performed to evaluate optimal ventilator management strategies for patients without ALI...
  85. ncbi request reprint Transfusion and mechanical ventilation: two interrelated causes of acute lung injury?
    Marcus J Schultz
    Crit Care Med 33:2857-8; author reply 2858. 2005
  86. ncbi request reprint Neurogenic pulmonary edema: another multiple-hit model of acute lung injury
    Ognjen Gajic
    Crit Care Med 35:1979-80. 2007
  87. ncbi request reprint Liberal vs. conservative vasopressor use to maintain mean arterial blood pressure during resuscitation of septic shock: an observational study
    Sanjay Subramanian
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester 55905, MN, USA
    Intensive Care Med 34:157-62. 2008
    ..The optimal role of vasopressor therapy in septic shock is not known. We hypothesized that the variability in the use of vasopressors to treat hypotension is associated with subsequent organ failures...
  88. ncbi request reprint 67-year-old man with fever, back pain, and lower extremity weakness
    Ron Reilkoff
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 80:1510-3. 2005
  89. ncbi request reprint Transfusion-related acute lung injury
    Pearl Toy
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143 0100, USA
    Anesth Analg 99:1623-4, table of contents. 2004
    ..The treatment is supportive. The blood bank needs to be notified promptly so that an appropriate workup and prevention are initiated in a timely manner...
  90. ncbi request reprint Long-haul air travel before major surgery: a prescription for thromboembolism?
    Ognjen Gajic
    Department of Internal Medicine and Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 80:728-31. 2005
    ..To investigate the Incidence of postoperative venous thromboembolism (VTE) in patients who had flown long distances before major surgery...
  91. ncbi request reprint Mechanical ventilation in patients with Guillain-Barré syndrome
    Mohamed I Ali
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester MN 55905, USA
    Respir Care 51:1403-7. 2006
    ..Patients with Guillain-Barré syndrome are commonly exposed to prolonged mechanical ventilation. Specific data on ventilatory management of these patients have been limited...
  92. doi request reprint Images in clinical medicine. Severe kyphosis
    Boris Blechacz
    Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 358:e28. 2008
  93. ncbi request reprint Fatal acute pulmonary embolism in a patient with pelvic lipomatosis after surgery performed after transatlantic airplane travel
    Ognjen Gajic
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Anesth Analg 99:1032-4, table of contents. 2004
    ..This is particularly true in tertiary referral centers, where patients with rare diseases may have a major surgical intervention within days of prolonged air travel...
  94. ncbi request reprint Six-month survival of patients with acute lung injury: prospective cohort study
    Murat Yilmaz
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Crit Care Med 35:2303-7. 2007
    ..We sought to determine the outcome of consecutive acute lung injury patients after the implementation of these interventions...
  95. ncbi request reprint The effects of the alveolar recruitment maneuver and positive end-expiratory pressure on arterial oxygenation during laparoscopic bariatric surgery
    Francis X Whalen
    Department of Anesthesiology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Anesth Analg 102:298-305. 2006
    ..Our results showed the effect to be short lived and associated with more frequent intraoperative use of vasopressors...

Research Grants2

  1. Transfusion Related Lung Injury in the Critically Ill
    Ognjen Gajic; Fiscal Year: 2007
    ..These results will form the basis for future trials with major public health implications. (End of Abstract) ..