Sherine E Gabriel

..To highlight recent evidence regarding the contribution of traditional and nontraditional [e.g. inflammatory markers, rheumatoid arthritis (RA) features] risk factors toward the excess cardiovascular risk in RA...

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..B-type natriuretic peptide (BNP) may be useful to screen for LVDD in the general population. We compared the effectiveness of BNP as a screening tool for LVDD in RA and non-RA subjects without cardiovascular disease (CVD)...

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..To determine time trends in incidence, prevalence, and clinical characteristics of psoriatic arthritis (PsA) over a 30-year period...

..To compare the clinical presentation, management, and outcome of heart failure in patients with rheumatoid arthritis (RA) compared with non-RA patients...

..The objective of this study is to determine time trends in incidence and survival of psoriasis patients over three decades...

..To examine trends in the incidence and prevalence of rheumatoid arthritis (RA) from 1995 to 2007...

..To study the association between previous cancer and giant cell arteritis (GCA)...

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..Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular diseases (CVD). We compared the histologic features of coronary artery disease in patients with RA and non-RA controls...

..To determine the relationship between glucocorticoid exposure and cardiovascular (CV) events in patients with rheumatoid arthritis (RA)...

..The purpose of this study was to determine the mortality trends among RA patients compared with those in the general population...

..Future studies could utilize this information to devise new biomarkers for the prediction of infection in patients with RA...

..To examine the influence of rheumatoid arthritis (RA) characteristics and antirheumatic medications on the risk of heart failure (HF) in patients with RA...

..To estimate the 10-year absolute risk of cardiovascular (CV) events in newly diagnosed rheumatoid arthritis (RA) patients and the potential contribution of CV risk factors to absolute risk assessment...

..The purpose of this study was to identify a signature of LVDD in patients with RA by analyzing the responsiveness of the innate and adaptive immune systems to stimulation ex vivo...

..To determine the incidence and disease-specific predictors of clinically recognized psoriatic arthritis (PsA) in patients with psoriasis...

..To examine the effect of glucocorticoid use on the risk of various cardiovascular diseases in patients with polymyalgia rheumatica (PMR)...

..Interstitial lung disease (ILD) has been recognized as an important comorbidity in rheumatoid arthritis (RA). We undertook the current study to assess incidence, predictors, and mortality of RA-associated ILD...

..Eliminating the excess risk of CHF in patients with RA could significantly improve their survival...

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..This study was undertaken to identify profiles of immune response that correlate with radiographic joint damage as a first step toward the discovery of new pathogenic mechanisms of joint destruction in RA...

..The relative paucity of rheumatology care following the period of diagnosis may represent an opportunity for improving the care of patients with PMR...

..To examine the impact of systemic inflammation and serum lipids on cardiovascular disease (CVD) in rheumatoid arthritis (RA)...

..To determine the incidence of herpes zoster (HZ) in GCA...

..However, their frequency and clinical significance are uncertain. We examined the frequency of SLE features in RA and their effect on overall mortality...

..Objectives: To determine the association between BMI and polymyalgia rheumatica (PMR) as well as the influence of BMI on glucocorticoid treatment duration and development of giant-cell arteritis (GCA) in patients with PMR...

..To evaluate trends in and risk factors for mortality among patients with rheumatoid arthritis (RA) over a 40-year period...

..These should be considered as confounders when examining the effect of early DMARD treatment on disease progression and mortality...

..CONCLUSION: Higher initial CS doses and faster tapering are significant predictors of future relapses. Our results suggest that efforts should be made to minimize initial CS dose and taper CS slowly in order to avoid disease relapses...

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..In this review, we summarize the current knowledge of the rates and determinants of mortality in RA, identify and discuss potential explanations for excess mortality, and outline promising research avenues for targeting mortality in RA...

..Although well-documented in Eastern populations, epidemiologic data is scarce in North American countries. Here we describe the incidence and prevalence of BD in Olmsted County, Minnesota over 45 years...

..To determine the association between asthma and proinflammatory conditions...

..Efforts should be made, on the part of all physicians who care for RA patients, to ensure that these effective preventive services are provided...

..We also examined whether RA disease characteristics are associated with the presence of MetS in RA patients without CVD...

..To assess incidence and mortality effects of extraarticular rheumatoid arthritis (ExRA) in patients with incident RA in 1995-2007 compared to 1985-1994, in Olmsted County, Minnesota, USA...

..In the face of uncertainty, making a provisional decision with a plan to review it later can be a good strategy. Verifying the patient's comprehension can help ensure that the decisions reached are informed and acceptable...

..28, 95% CI 0.93-1.78). CONCLUSION: Compared with persons without RA, patients with RA have twice the risk of developing CHF. This excess risk is not explained by traditional CV risk factors and/or clinical ischemic heart disease...

..The risk of CHD in RA patients precedes the ACR criteria-based diagnosis of RA, and the risk cannot be explained by an increased incidence of traditional CHD risk factors in RA patients...

..The present review highlights the recent findings on cardiovascular disease in rheumatoid arthritis (RA), and outlines the current concepts and prospects of cardiovascular disease detection and management in RA...

..MTX failure may identify a subgroup of patients who are less likely to respond to other DMARD and therefore could be considered as candidates for biological therapies...

..These incremental costs appear to originate mainly from comorbid cardiovascular conditions that were shown to be more prevalent among subjects with PMR...

..B-type natriuretic peptide (BNP) may be useful to screen for LVDD in the general population. We compared the effectiveness of BNP as a screening tool for LVDD in RA and non-RA subjects without cardiovascular disease (CVD)...

..To determine the frequency of hypothyroidism in patients with rheumatoid arthritis (RA), and to elucidate the association of hypothyroidism and development of cardiovascular disease (CVD) in these patients...

..09, 95% CI 1.50-2.92) when compared with non-RA subjects who maintained normal BMI throughout followup. CONCLUSION: Among patients with RA, low BMI is associated with a significantly increased risk of cardiovascular death...

..To study 90-day complications following total hip arthroplasty (THA) or total knee arthroplasty (TKA)...

..To determine the incidence of cancer in a population-based cohort of patients with giant cell arteritis (GCA) compared with age- and sex-matched referent subjects...

..This may be due to immunomodulatory effects of RA, or to agents with immunosuppressive effects used in its treatment...

..These data underscore the need for more accurate tools to predict CVD risk in patients with RA...

..To describe current trends in arthritis-related joint surgery among a population-based cohort of patients with rheumatoid arthritis (RA) and to examine the influence of joint surgery on mortality...

..The present study was conducted to determine whether patients with polymyalgia rheumatica (PMR) are at an increased risk of peripheral arterial disease (PAD)...

..Thus, our approach lays the foundation for the development of immunologic "signatures" that could be useful in predicting disease course and monitoring the outcomes of therapy among patients with immune-mediated diseases...

..Lack of association of higher BMI with poor pain outcomes post-TKA implies that TKA should not be denied to obese patients for fear of suboptimal outcomes...

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..Electronic claims and medical record databases are increasingly used for observational studies of psoriasis. The purpose of this study was to assess the validity of psoriasis diagnostic codes in an electronic database...

..To compare lipid profiles in patients with rheumatoid arthritis (RA) and in non-RA subjects during the 5 years before and 5 years after the RA incidence/index date...

..To determine whether the incidence of gout is higher in 1995-1996 compared to 1977-1978...

..CONCLUSION: The secular trends demonstrated in this study population, including the progressive decline in the incidence of RA over the last 40 years, suggest that an environmental factor may play a role in the etiology of RA...

..The development of CVD has also been linked to chronic sleep apnea. The purpose of this study was to examine the risk for sleep apnea in patients with RA compared to subjects without RA...

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..Survival among individuals with PMR was not significantly different from that expected in the population (p = 0.06). CONCLUSION: The incidence of PMR has remained relatively stable over the past 30 years...

..This review provides an overview of the clinical studies that demonstrate increased risk of coronary heart disease and heart failure in patients with RA and also discusses the potential role of the various risk factors...

..This review summarizes the current evidence for an increased cardiovascular risk in patients with psoriasis and outlines deficits in our knowledge in this area...

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..We prospectively examined the association of CRP with heart failure and death among patients with myocardial infarction in the community...

..To compare persons with and without hip fracture for subsequent mortality and change in disability and nursing home (NH) use...

..These findings point to the need for additional research to further elucidate the determinants of patient satisfaction...

..To describe the subtypes of lymphocytes in coronary arteries of two patients with rheumatoid arthritis (RA) and coronary artery disease (CAD)...

..CONCLUSION: Corticosteroid use and pregnancy, both of which modulate the immune response, may influence the development of PsA in patients with PS...

..To compare the short-term outcomes of acute knee injuries treated by specialists and generalists...

..Taken together, these findings underscore the complexity of the rheumatic diseases and highlight the key role of epidemiological research in understanding these intriguing conditions...

..This article describes the REP and highlights its research capabilities in the context of the rheumatic diseases...

..However, most patients developed serious adverse side effects related to GCs, indicating that less toxic therapeutic measures are needed...

..To investigate the association between 347 single-nucleotide polymorphisms within candidate genes of the tumor necrosis factor, interleukin 1 and interleukin 6 families with neutrophil count...

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..Fractures are a manifestation of osteoporosis, but therapeutic interventions to reduce the risk of recurrent fractures are not widespread...

..Further initiatives are needed to overcome both system and patient barriers...

..Randomized trials are needed to evaluate the use of oral glucose-lowering agents in transplant recipients, paying particular attention to interactions with immunosuppressive drugs...

..Reconstructive surgeries were common, and women had significantly more surgeries than men. Survivorship among patients with RA undergoing surgeries was similar to that of the RA patient population at large...

..The previously observed cyclic pattern of annual incidence rates was still apparent over a 50-year period. Overall survival in GCA was similar to that in the population...

..These results can be used to prospectively identify high-risk patients, who may benefit from closer followup and implementation of preventive strategies...

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..Although consistency between reviewers was good on both guidelines, inter-guideline discrepancies were noted and reviewers reported some difficulty in using the operationalized format...

..While this protective effect is strong, it only explains a small portion of the observed decrease in RA incidence over the past few decades because the proportion of Rochester women exposed to OC is quite small...

..We provide the rationale for each element and discuss how each element has been addressed in published economic evaluations of DMARD...

..Further work is needed to identify those patients with JRA who may benefit from aggressive therapy targeted at preventing the longterm morbidity associated with osteopenia...

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..Together, these characteristics will ensure its success. ..

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