Mark Frye

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
    Am J Psychiatry 164:1242-9. 2007
  2. doi request reprint Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression
    Mark A Frye
    Department of Psychiatry, Mayo Mood Clinic and Research Program, Mayo Clinic, 200 First St, S W, Rochester, MN 55901, USA
    Am J Psychiatry 166:164-72. 2009
  3. doi request reprint Depressive relapse during lithium treatment associated with increased serum thyroid-stimulating hormone: results from two placebo-controlled bipolar I maintenance studies
    M A Frye
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Acta Psychiatr Scand 120:10-3. 2009
  4. doi request reprint Gender differences in the relationship between depressive symptoms and cravings in alcoholism
    Nelli Boykoff
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Addict 19:352-6. 2010
  5. ncbi request reprint Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: a study using 3-Tesla proton magnetic resonance spectroscopy
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Psychiatry Res 154:259-65. 2007
  6. ncbi request reprint Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trials
    Mark A Frye
    Mood Disorders Research Program, University of California at Los Angeles, USA
    J Clin Psychiatry 67:1721-8. 2006
  7. ncbi request reprint Bipolar disorder and comorbid alcoholism: prevalence rate and treatment considerations
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA, USA
    Bipolar Disord 8:677-85. 2006
  8. ncbi request reprint Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression
    Mark A Frye
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 55905, USA
    Neuropsychopharmacology 32:2490-9. 2007
  9. ncbi request reprint Recurrence in bipolar I disorder: a post hoc analysis excluding relapses in two double-blind maintenance studies
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Biol Psychiatry 59:1061-4. 2006
  10. ncbi request reprint Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007

Collaborators

Detail Information

Publications76

  1. ncbi request reprint A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
    Am J Psychiatry 164:1242-9. 2007
    ..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue...
  2. doi request reprint Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression
    Mark A Frye
    Department of Psychiatry, Mayo Mood Clinic and Research Program, Mayo Clinic, 200 First St, S W, Rochester, MN 55901, USA
    Am J Psychiatry 166:164-72. 2009
    ..This study examined the correlates associated with treatment-emergent mania in patients receiving adjunctive antidepressant treatment for bipolar depression...
  3. doi request reprint Depressive relapse during lithium treatment associated with increased serum thyroid-stimulating hormone: results from two placebo-controlled bipolar I maintenance studies
    M A Frye
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Acta Psychiatr Scand 120:10-3. 2009
    ..To assess the relationship between depressive relapse and change in thyroid function in an exploratory post hoc analysis from a controlled maintenance evaluation of bipolar I disorder...
  4. doi request reprint Gender differences in the relationship between depressive symptoms and cravings in alcoholism
    Nelli Boykoff
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Addict 19:352-6. 2010
    ..78). Further prospective study is encouraged to evaluate whether depressive symptoms and concomitant alcohol cravings in women are a marker for relief cravings and, as such, a target symptom for treatment intervention...
  5. ncbi request reprint Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: a study using 3-Tesla proton magnetic resonance spectroscopy
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Psychiatry Res 154:259-65. 2007
    ..Limitations of this study include small sample size and lack of tissue segmentation. Further study is encouraged to clarify state vs. trait aspects of NAA in bipolar disorder...
  6. ncbi request reprint Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trials
    Mark A Frye
    Mood Disorders Research Program, University of California at Los Angeles, USA
    J Clin Psychiatry 67:1721-8. 2006
    ..Subsyndromal symptoms in bipolar disorder can cause significant functional impairment and are associated with relapse...
  7. ncbi request reprint Bipolar disorder and comorbid alcoholism: prevalence rate and treatment considerations
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA, USA
    Bipolar Disord 8:677-85. 2006
    ..A number of add-on, adjunctive medications, such as naltrexone, acamprosate, topiramate, and the atypical antipsychotics quetiapine and clozapine, may be candidates for further testing...
  8. ncbi request reprint Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression
    Mark A Frye
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 55905, USA
    Neuropsychopharmacology 32:2490-9. 2007
    ..Lamotrigine appears to reduce glutamine levels associated with treatment remission. Further study is encouraged to determine if these MR spectroscopic markers can delineate drug mechanism of action and subsequent treatment response...
  9. ncbi request reprint Recurrence in bipolar I disorder: a post hoc analysis excluding relapses in two double-blind maintenance studies
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Biol Psychiatry 59:1061-4. 2006
    ..To assess the efficacy of lamotrigine or lithium in preventing mood recurrence (i.e., a new mood episode) in bipolar disorder...
  10. ncbi request reprint Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007
    ..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted...
  11. ncbi request reprint A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:426-34. 2007
    ..The objective of this study was to compare sibutramine and topiramate as adjunctive treatments for psychotropic-associated weight gain in overweight or obese outpatients with BD...
  12. ncbi request reprint Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants
    Lori L Altshuler
    Dept of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Box 957057, Los Angeles, CA 90095 7057
    Am J Psychiatry 163:313-5. 2006
    ..The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder...
  13. ncbi request reprint Modal subcomponents of metabolic syndrome in patients with bipolar disorder
    Jeffrey Cardenas
    Department of Psychiatry, UCLA Mood Disorders Research Program, David Geffen School of Medicine at UCLA, Los Angeles, United States
    J Affect Disord 106:91-7. 2008
    ..The metabolic syndrome is a growing global public health problem...
  14. ncbi request reprint Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon
    Trisha Suppes
    Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
    Arch Gen Psychiatry 62:1089-96. 2005
    ..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved...
  15. ncbi request reprint Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study
    Lori L Altshuler
    Department of Psychiatry, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA, USA
    J Clin Psychiatry 70:450-7. 2009
    ..To assess long-term outcome in bipolar disorder, subjects were prospectively followed after receiving acute treatment for bipolar depression...
  16. ncbi request reprint Low cerebrospinal fluid glutamate and glycine in refractory affective disorder
    Mark A Frye
    Department of Psychiatry, University of California Los Angeles Neuropsychiatric Institute, Los Angeles, CA, USA
    Biol Psychiatry 61:162-6. 2007
    ..Glutamatergic dysregulation has been documented in schizophrenia but has received less systematic study in affective illness...
  17. ncbi request reprint Patterns of alcohol consumption in bipolar patients comorbid for alcohol abuse or dependence
    James W McKowen
    UCLA Mood Disorders Research Program, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7057, USA
    Bipolar Disord 7:377-81. 2005
    ..This report evaluates preliminary data of alcohol consumption patterns utilizing the Alcohol Timeline Followback (TLFB) method in actively drinking patients with bipolar disorder...
  18. ncbi request reprint Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:617-24. 2005
    ..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002...
  19. ncbi request reprint Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
    J Clin Psychiatry 67:1551-60. 2006
    ..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder...
  20. ncbi request reprint Subsyndromal depression is associated with functional impairment in patients with bipolar disorder
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
    J Clin Psychiatry 63:807-11. 2002
    ..The purpose of this study was to assess whether a relationship exists between mild depressive symptoms and overall functioning in subjects with bipolar disorder...
  21. ncbi request reprint Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio, USA
    J Clin Psychiatry 63:1012-9. 2002
    ..The objective of this report was to determine rash rates in clinical trials of lamotrigine in DSM-IV unipolar depression or bipolar disorder...
  22. ncbi request reprint Acceleration and augmentation strategies for treating bipolar depression
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, USA
    Biol Psychiatry 53:691-700. 2003
    ..This review will define three types of common combination strategies--adjunctive, acceleration and augmentation--and discuss the limited literature of controlled studies reported on acceleration and augmentation approaches...
  23. ncbi request reprint Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:883-9. 2003
    ..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study...
  24. doi request reprint Utilization of residential alcoholism treatment in bipolar disorder
    Daniel K Hall-Flavin
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Addict 20:40-4. 2011
    ..Future studies are encouraged to better understand utilization rates of addiction treatment among patients with bipolar disorder and to identify clinical correlates that predispose bipolar women to high-dose drinking. ..
  25. ncbi request reprint Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Compr Psychiatry 44:263-9. 2003
    ..The lack of observable prognostic impact may have been, in part, due to the relatively high morbidity and poor functional outcome of a substantial portion of the total cohort...
  26. doi request reprint Are bipolar mood symptoms affected by the phase of the menstrual cycle?
    Geetha Shivakumar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    J Womens Health (Larchmt) 17:473-8. 2008
    ..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue...
  27. ncbi request reprint Treating acute mania
    Mark A Frye
    UCLA Bipolar Disorder Research Program, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, USA
    J Fam Pract . 2003
  28. ncbi request reprint Bipolar depression: best practices for the hospitalized patient
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    CNS Spectr 12:1-13. 2007
    ..The onset and severity of bipolar depression, prevalence of substance abuse, psychosocial treatment options, and clinical issues for the long-term treatment of bipolar depression are also discussed...
  29. ncbi request reprint Chart review of the impact of attention-deficit/hyperactivity disorder comorbidity on response to lithium or divalproex sodium in adolescent mania
    Rosanne C State
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, Calif, USA
    J Clin Psychiatry 65:1057-63. 2004
    ..This study was conducted to evaluate comparative response rates to lithium and divalproex sodium in adolescent mania with and without this comorbidity...
  30. doi request reprint Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively in the Stanley Foundation bipolar treatment outcome network
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute of Neuroscience and Human Behavior, UCLA, USA
    Am J Psychiatry 167:708-15. 2010
    ..The authors assessed gender differences in the proportion of clinical visits spent depressed, manic, or euthymic in patients with bipolar disorder...
  31. ncbi request reprint Unmet needs in bipolar depression
    Mark A Frye
    UCLA Bipolar Disorder Research Program, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Depress Anxiety 19:199-208. 2004
    ....
  32. ncbi request reprint Mania and attention deficit hyperactivity disorder in a prepubertal child: diagnostic and treatment challenges
    Rosanne C State
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Am J Psychiatry 159:918-25. 2002
  33. ncbi request reprint Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism
    Eric Levander
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    J Affect Disord 101:211-7. 2007
    ..This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD)...
  34. ncbi request reprint Tiagabine in treatment refractory bipolar disorder: a clinical case series
    Trisha Suppes
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Bipolar Disord 4:283-9. 2002
    ..We sought to evaluate the effectiveness of tiagabine added to ongoing medication regimens in patients with bipolar disorder inadequately responsive to or intolerant of usual treatments...
  35. ncbi request reprint Comorbid substance use disorder in women with bipolar disorder associated with criminal arrest
    Barbara E McDermott
    Division of Psychiatry and the Law, Department of Psychiatry and Behavioral Sciences, University of California at Davis, Davis, CA, USA
    Bipolar Disord 9:536-40. 2007
    ..This study was conducted to further evaluate possible gender differences in substance use and risk of criminality in BPD...
  36. ncbi request reprint Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 60:1020-2. 2006
    ..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder...
  37. ncbi request reprint Impact of bipolar disorder on a U.S. community sample
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 64:425-32. 2003
    ..Bipolar symptoms have been associated with significant functional impairment. We conducted a study to determine the psychosocial impact of bipolar disorder in a U.S. community sample...
  38. doi request reprint Improving the design of maintenance studies for bipolar disorder
    Michael J Gitlin
    Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Curr Med Res Opin 26:1835-42. 2010
    ..Over the past 15 years, the design of monotherapy maintenance studies in bipolar disorder has evolved significantly, but recent study designs continue to differ in important ways...
  39. ncbi request reprint Healthcare resource utilization in bipolar depression compared with unipolar depression: results of a United States population-based study
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    CNS Spectr 11:704-10; quiz 719. 2006
    ..This study examined healthcare utilization in the past year by subjects who screened positive for bipolar versus unipolar depression...
  40. ncbi request reprint Free T4 index and clinical outcome in patients with depression
    Osama Abulseoud
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Affect Disord 100:271-7. 2007
    ..This study evaluated baseline thyroid function and its relationship to rapidity of treatment response as measured by hospital length of stay (HLOS)...
  41. ncbi request reprint Clinical and legal correlates of inmates with bipolar disorder at time of criminal arrest
    Cameron D Quanbeck
    Department of Psychiatry, Forensic Division, University of California Davis, 2230 Stockton Boulevard, Sacramento, CA 95817, USA
    J Clin Psychiatry 65:198-203. 2004
    ....
  42. pmc Predictors of bipolar disorder risk among patients currently treated for major depression
    Joseph R Calabrese
    Mood Disorders Program, Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
    MedGenMed 8:38. 2006
    ..The primary objective of this study was to assess the rate of bipolar disorder (BPD) risk among patients unsuccessfully treated for major depression and to identify predictors of bipolarity...
  43. ncbi request reprint Reproductive function and risk for PCOS in women treated for bipolar disorder
    Natalie L Rasgon
    Department of Psychiatry, Stanford School of Medicine, Palo Alto, CA, USA
    Bipolar Disord 7:246-59. 2005
    ..This study examined the reproductive function and prevalence of polycystic ovary syndrome (PCOS) in women with bipolar disorder taking antimanic medications...
  44. doi request reprint Incidence of childhood-onset bipolar illness in the USA and Europe
    Robert M Post
    Department of Psychiatry, George Washington University, Washington, DC, USA
    Br J Psychiatry 192:150-1. 2008
    ..In the USA there was also twice the incidence of childhood adversity and genetic/familial risk for affective disorder. The findings deserve replication and further exploration...
  45. pmc Peripheral thyroid hormones and response to selective serotonin reuptake inhibitors
    Michael Gitlin
    Department of Psychiatry, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Psychiatry Neurosci 29:383-6. 2004
    ..To examine the relation between baseline measurements of thyroid function and response to selective serotonin reuptake inhibitors (SSRIs) and to consider the effect of these antidepressants on thyroid hormone levels...
  46. ncbi request reprint Low CSF somatostatin associated with response to nimodipine in patents with affective illness
    Mark A Frye
    UCLA Neuropsychiatric Institute, Los Angeles, California, USA
    Biol Psychiatry 53:180-3. 2003
    ..This study was conducted to assess whether a low baseline level of CSF SRIF was associated with response to nimodipine treatment...
  47. ncbi request reprint Use of health care services among persons who screen positive for bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, California 90095, USA
    Psychiatr Serv 56:1529-33. 2005
    ..This study examined patterns of diagnosis, consultation, and treatment of persons who screened positive for bipolar disorder...
  48. ncbi request reprint Dynamic properties of large-field and small-field optomotor flight responses in Drosophila
    Brian J Duistermars
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1606, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 193:787-99. 2007
    ....
  49. ncbi request reprint Diagnostic dilemmas and clinical correlates of mixed states in bipolar disorder
    Mark A Frye
    Mayo Clinic, Rochester, Minnesota, USA
    J Clin Psychiatry 69:e13. 2008
    ..Inconsistent diagnostic criteria can be problematic for clinicians when treating patients...
  50. ncbi request reprint Correlates of overweight and obesity in 644 patients with bipolar disorder
    Susan L McElroy
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychiatry 63:207-13. 2002
    ..Overweight and obesity are common clinical problems encountered in the treatment of bipolar disorder. We therefore assessed the prevalence and clinical correlates of overweight, obesity, and extreme obesity in 644 bipolar patients...
  51. ncbi request reprint Lack of mania prophylaxis associated with lamotrigine monotherapy in manic-predominant bipolar I disorder
    Emily C Dossett
    J Clin Psychiatry 68:973-4. 2007
  52. ncbi request reprint Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorder
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut 06840, USA
    Biol Psychiatry 63:125-30. 2008
    ..The anticonvulsant lamotrigine has demonstrated efficacy for relapse prevention in bipolar disorder, but its possible mood-stabilizing properties on a day-to-day or week-to-week basis have not previously been investigated...
  53. ncbi request reprint Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
    J Clin Psychiatry 64:680-90; quiz 738-9. 2003
    ..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated...
  54. doi request reprint Aripiprazole efficacy in irritability and disruptive-aggressive symptoms: young mania rating scale line analysis from two, randomized, double-blind, placebo-controlled trials
    Mark A Frye
    J Clin Psychopharmacol 28:243-5. 2008
  55. ncbi request reprint Clinical predictors of response to lamotrigine and gabapentin monotherapy in refractory affective disorders
    Gabriela V Obrocea
    National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, Maryland 20892, USA
    Biol Psychiatry 51:253-60. 2002
    ..The objective of the current study was to examine possible clinical predictors of positive response to lamotrigine or gabapentin monotherapy in treatment-refractory affectively ill patients...
  56. ncbi request reprint A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:396-406. 2003
    ..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations...
  57. ncbi request reprint An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
    ..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed...
  58. ncbi request reprint Impact of antidepressant discontinuation after acute bipolar depression remission on rates of depressive relapse at 1-year follow-up
    Lori Altshuler
    Stanley Bipolar Treatment Network, USA
    Am J Psychiatry 160:1252-62. 2003
    ..This study examined the effect of antidepressant discontinuation or continuation on depressive relapse risk among bipolar subjects successfully treated for an acute depressive episode...
  59. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
    ..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder...
  60. ncbi request reprint Screening for bipolar disorder in the community
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, 77555 188, USA
    J Clin Psychiatry 64:53-9. 2003
    ..Our goal was to estimate the rate of positive screens for bipolar I and bipolar II disorders in the general population of the United States...
  61. ncbi request reprint Acute antimanic efficacy and safety of oxcarbazepine in an open trial with an on-off-on design
    Barbara Hummel
    Stanley Foundation Bipolar Network Centers, Department of Psychiatry, LMU Munich, Germany
    Bipolar Disord 4:412-7. 2002
    ..OXC is not metabolized to the 10, 11-epoxide, which seems to be responsible for several undesirable side-effects of carbamazepine and furthermore OXC has less enzyme-inducing properties...
  62. ncbi request reprint Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 4400, USA
    J Affect Disord 69:1-14. 2002
    ..Understanding the mechanisms of anticonvulsant mood stabilizers, integrated with clinical observations, may ultimately provide important new insights into the pathophysiology and treatment of bipolar disorders...
  63. ncbi request reprint Early physical and sexual abuse associated with an adverse course of bipolar illness
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892 1272, USA
    Biol Psychiatry 51:288-97. 2002
    ..There is growing awareness of the association between physical and sexual abuse and subsequent development of psychopathology, but little is known, however, about their relationship to the longitudinal course of bipolar disorder...
  64. ncbi request reprint Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network
    Willem A Nolen
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Am J Psychiatry 161:1447-54. 2004
    ..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder...
  65. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
    ..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness...
  66. ncbi request reprint Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
    Am J Psychiatry 162:1273-80. 2005
    ..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective...
  67. ncbi request reprint Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
    J Affect Disord 101:275-81. 2007
    ..Increasing evidence indicates that some second-generation antipsychotics are efficacious in bipolar depression, but there are few data on this illness for the novel agent aripiprazole...
  68. ncbi request reprint New findings from the Bipolar Collaborative Network: clinical implications for therapeutics
    Robert M Post
    Penn State College of Medicine, Hershey, PA, USA
    Curr Psychiatry Rep 8:489-97. 2006
    ..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss...
  69. ncbi request reprint Longitudinal evaluation of reproductive function in women treated for bipolar disorder
    Natalie L Rasgon
    Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, 401 Quarry Road, Palo Alto, Ca 94305 5723 Stanford, California, United States
    J Affect Disord 89:217-25. 2005
    ..We assessed reproductive endocrine and metabolic markers in women treated for bipolar disorder over a 2-year time period, controlling for valproate use...
  70. ncbi request reprint Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
    ..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression...
  71. ncbi request reprint Principal components of the Beck Depression Inventory and regional cerebral metabolism in unipolar and bipolar depression
    Robert T Dunn
    Biological Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1272, USA
    Biol Psychiatry 51:387-99. 2002
    ..Then, comparing unipolars and bipolars, these symptom clusters were examined for interrelationships, and for relationships to regional cerebral metabolism for glucose measured by positron emission tomography...
  72. ncbi request reprint Clinical and legal characteristics of inmates with bipolar disorder
    Cameron D Quanbeck
    Department of Psychiatry and Behavioral Sciences, Division of Psychiatry and the Law, University of California, Davis, 2230 Stockton Boulevard, Sacramento, CA 95817, USA
    Curr Psychiatry Rep 7:478-84. 2005
    ..Psychiatric advance directives, new developments in civil commitment law, and mental health courts are legal mechanisms that may be critical in preventing the criminalization of those with bipolar disorder...
  73. ncbi request reprint Validity of the mood disorder questionnaire: a general population study
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 1 302 Rebecca Sealy, 301 University Blvd, Galveston, TX 77555 0188, USA
    Am J Psychiatry 160:178-80. 2003
    ..The Mood Disorder Questionnaire has been validated in a psychiatric outpatient study group...
  74. ncbi request reprint Relationship between criminal arrest and community treatment history among patients with bipolar disorder
    Cameron D Quanbeck
    Forensic Division of the Department of Psychiatry at the University of California Davis, Sacramento, 95817, USA
    Psychiatr Serv 56:847-52. 2005
    ..This study examined the relationship between criminal arrest and gender, substance use disorder, and use of community mental health services among patients with bipolar I disorder...
  75. ncbi request reprint Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 9:531-5. 2007
    ..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder...
  76. ncbi request reprint The poor prognosis of childhood-onset bipolar disorder
    Gabriele S Leverich
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Pediatr 150:485-90. 2007
    ..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness...

Research Grants3

  1. Bipolar Disorder & Alcohol Abuse Comorbidity
    Mark Frye; Fiscal Year: 2006
    ..This naturalistic follow-up period may identify preliminary neurobiological factors associated with relapse and provide direction for further controlled interventional study. ..
  2. 1H-MR Spectroscopy of Bipolar Depression Before and After Lamotrigine Treatment
    Mark A Frye; Fiscal Year: 2010
    ..By doing so, we may be able to increase the likelihood of treatment response and decrease the number of ineffective treatments and/or serious side effects for patients with bipolar depression. ..