Brooke L Fridley

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Multivariate models to detect genomic signatures for a class of drugs: application to thiopurines pharmacogenomics
    B L Fridley
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pharmacogenomics J 12:105-10. 2012
  2. doi request reprint A Bayesian integrative genomic model for pathway analysis of complex traits
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Genet Epidemiol 36:352-9. 2012
  3. pmc Gene set analysis of survival following ovarian cancer implicates macrolide binding and intracellular signaling genes
    Brooke L Fridley
    Departments of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 21:529-36. 2012
  4. pmc Comparison of variable and model selection methods for genetic association studies using the GAW15 simulated data
    Zhan Ye
    Department of Mathematical Sciences, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA
    BMC Proc 1:S34. 2007
  5. doi request reprint Bayesian variable and model selection methods for genetic association studies
    Brooke L Fridley
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Genet Epidemiol 33:27-37. 2009
  6. pmc A Bayesian hierarchical nonlinear model for assessing the association between genetic variation and drug cytotoxicity
    Brooke L Fridley
    Department of Health Sciences Research, Harwick 766, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Stat Med 28:2709-22. 2009
  7. pmc Gene set analysis of purine and pyrimidine antimetabolites cancer therapies
    Brooke L Fridley
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Pharmacogenet Genomics 21:701-12. 2011
  8. pmc Gene set analysis of SNP data: benefits, challenges, and future directions
    Brooke L Fridley
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Hum Genet 19:837-43. 2011
  9. pmc A latent model for prioritization of SNPs for functional studies
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 6:e20764. 2011
  10. pmc Utilizing genotype imputation for the augmentation of sequence data
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 5:e11018. 2010

Detail Information

Publications82

  1. pmc Multivariate models to detect genomic signatures for a class of drugs: application to thiopurines pharmacogenomics
    B L Fridley
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pharmacogenomics J 12:105-10. 2012
    ..We will illustrate the utility of this multivariate model for cytotoxicity and genomic data collected on the Coriell Human Variation Panel for the class of anti-purine metabolites (6-mercaptopurine and 6-thioguanine)...
  2. doi request reprint A Bayesian integrative genomic model for pathway analysis of complex traits
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Genet Epidemiol 36:352-9. 2012
    ..Further research is required to extend and modify this integrative modeling framework to increase computational efficiency to best capitalize on the wealth of information available across multiple genomic data types...
  3. pmc Gene set analysis of survival following ovarian cancer implicates macrolide binding and intracellular signaling genes
    Brooke L Fridley
    Departments of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 21:529-36. 2012
    ..Gene set analysis (GSA) overcomes this limitation by assessing overall evidence for association of a phenotype with all measured variation in a set of genes...
  4. pmc Comparison of variable and model selection methods for genetic association studies using the GAW15 simulated data
    Zhan Ye
    Department of Mathematical Sciences, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA
    BMC Proc 1:S34. 2007
    ..The answers to Problem 3 were requested and known to the authors...
  5. doi request reprint Bayesian variable and model selection methods for genetic association studies
    Brooke L Fridley
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Genet Epidemiol 33:27-37. 2009
    ....
  6. pmc A Bayesian hierarchical nonlinear model for assessing the association between genetic variation and drug cytotoxicity
    Brooke L Fridley
    Department of Health Sciences Research, Harwick 766, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Stat Med 28:2709-22. 2009
    ....
  7. pmc Gene set analysis of purine and pyrimidine antimetabolites cancer therapies
    Brooke L Fridley
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Pharmacogenet Genomics 21:701-12. 2011
    ..Application of such methods to pharmacogenomic studies may enable the detection of more subtle effects of multiple genes in the same pathway that may be missed by assessing each gene individually...
  8. pmc Gene set analysis of SNP data: benefits, challenges, and future directions
    Brooke L Fridley
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Hum Genet 19:837-43. 2011
    ..This paper provides an overview of GSA, highlighting the key challenges, potential solutions, and directions for ongoing research...
  9. pmc A latent model for prioritization of SNPs for functional studies
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 6:e20764. 2011
    ..13). In summary, the application of the BLVM allows for the systematic integration of multiple SNP "features" for the prioritization of loci for fine-mapping or functional studies, taking into account the uncertainty in ranking...
  10. pmc Utilizing genotype imputation for the augmentation of sequence data
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 5:e11018. 2010
    ..However, the SNPs identified from these GWAS are not necessarily the functional variants. Therefore, the next phase in GWAS will involve the refining of these putative loci...
  11. pmc Bayesian mixture models for the incorporation of prior knowledge to inform genetic association studies
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Genet Epidemiol 34:418-26. 2010
    ..We illustrate the use of this method through a genome-wide linkage study of colorectal cancer, and a genome-wide association study of colorectal polyps...
  12. pmc Single versus multiple imputation for genotypic data
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    BMC Proc 3:S7. 2009
    ..This limited study involving four regions indicates that, contrary to expectations, multiple imputations may not be necessary...
  13. ncbi request reprint Missing phenotype data imputation in pedigree data analysis
    Brooke L Fridley
    Department of Health Sciences Research Mayo Clinic College of Medicine, Division of Biostatistics, Rochester, Minnesota 55905, USA
    Genet Epidemiol 32:52-60. 2008
    ..The method is illustrated using the Genetic Analysis Workshop simulated data...
  14. pmc Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:935-44. 2009
    ..These results exemplify the utility of imputation in candidate gene studies and lend evidence to a role of cell cycle genes in ovarian cancer etiology, suggest a reduced set of SNPs to target in additional cases and controls...
  15. pmc Contribution of FKBP5 genetic variation to gemcitabine treatment and survival in pancreatic adenocarcinoma
    Katarzyna A Ellsworth
    Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 8:e70216. 2013
    ..Genetic variation in FKBP5 could influence its function and, ultimately, treatment response of pancreatic cancer...
  16. pmc Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study
    Nifang Niu
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    BMC Cancer 12:422. 2012
    ....
  17. pmc Gemcitabine and arabinosylcytosin pharmacogenomics: genome-wide association and drug response biomarkers
    Liang Li
    Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 4:e7765. 2009
    ....
  18. pmc FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder
    Katarzyna A Ellsworth
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Pharmacogenet Genomics 23:156-66. 2013
    ....
  19. pmc Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation
    Yuan Ji
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Drug Metab Dispos 40:1984-92. 2012
    ....
  20. pmc Gemcitabine metabolic pathway genetic polymorphisms and response in patients with non-small cell lung cancer
    Liang Li
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Pharmacogenet Genomics 22:105-16. 2012
    ....
  21. pmc Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease study
    Albert O Edwards
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 3:e3813. 2008
    ..Relying on a significant genotype tests using a log-additive model would have excluded 57% of the non-replicated and none of the replicated loci, while use of other SNP features and clustering might have missed true associations...
  22. pmc Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors
    Liewei Wang
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 70:319-28. 2010
    ..Our findings indicate that two common genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to aromatase inhibitors...
  23. pmc Risk of ovarian cancer and inherited variants in relapse-associated genes
    Abraham Peedicayil
    Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 5:e8884. 2010
    ..We previously identified a panel of genes associated with outcome of ovarian cancer. The purpose of the current study was to assess whether variants in these genes correlated with ovarian cancer risk...
  24. pmc Survival is associated with genetic variation in inflammatory pathway genes among patients with resected and unresected pancreatic cancer
    Kaye M Reid-Lombardo
    Division of Gastroenterologic and General Surgery, Mayo Clinic, Rochester, MN 55905, USA
    Ann Surg 257:1096-102. 2013
    ..To test whether or not the association between inflammation and pancreatic ductal adenocarcinoma (PC) is facilitated by host susceptibility, specifically by genetic polymorphisms in inflammation-related genes...
  25. pmc Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mol Carcinog 50:397-402. 2011
    ..11, 95% CI: 1.00-1.23, P = 0.04). These findings are consistent with prior studies implicating these genes in carcinogenesis and suggest that this collection of variants is worthy of follow-up in additional studies...
  26. pmc Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer
    Kristin L White
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Twin Res Hum Genet 13:43-56. 2010
    ..10). These results indicate that the SNPs studied here are not related to risk of this gynecologic malignancy and that the site-specific nature of 8q24.21.a associations may not include ovarian cancer...
  27. pmc Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer
    Abraham Peedicayil
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Gynecol Oncol 114:260-4. 2009
    ..We now examine the hypothesis that inherited alterations in TCEAL7 play a role in the etiology of ovarian cancer...
  28. pmc Primary biliary cirrhosis is associated with a genetic variant in the 3' flanking region of the CTLA4 gene
    Brian D Juran
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 135:1200-6. 2008
    ..We aimed to perform a more comprehensive assessment of CTLA4 genetic variation in PBC using a haplotype-tagging based approach...
  29. pmc TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression
    Mohan Liu
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Endocrinol 27:657-70. 2013
    ..TSPYL5 induced CYP19A1 expression and that of many other genes. These studies have revealed a novel mechanism for regulating aromatase expression and plasma E2 concentrations in postmenopausal women with ER(+) breast cancer...
  30. pmc Inherited variants in regulatory T cell genes and outcome of ovarian cancer
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 8:e53903. 2013
    ..1×10(-4)) among all cases combined. As the products of these genes are known to affect induction, trafficking, or immunosuppressive function of Tregs, these results suggest the need for follow-up phenotypic studies...
  31. pmc Identifying the genetic variation of gene expression using gene sets: application of novel gene Set eQTL approach to PharmGKB and KEGG
    Ryan Abo
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 7:e43301. 2012
    ..Our proposed GS-eQTL method effectively addresses the multiple testing limitations in eQTL studies and provides biological context for SNP-expression associations...
  32. pmc Proteasome beta subunit pharmacogenomics: gene resequencing and functional genomics
    Liewei Wang
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Clin Cancer Res 14:3503-13. 2008
    ..Genetic variation in proteasome subunits could influence both proteasome function and response to drug therapy...
  33. pmc Mycophenolic acid response biomarkers: a cell line model system-based genome-wide screen
    Tse Yu Wu
    Division of Clinical Pharmacology, Department of Pharmacology and Experimental Therapeutics, Rochester, MN 55905, USA
    Int Immunopharmacol 11:1057-64. 2011
    ..These studies have identified novel candidate genes that may contribute to variation in response to MPA therapy and, as a result, may help make it possible to move toward more highly individualized MPA-based immunosuppressive therapy...
  34. pmc A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Nat Genet 42:874-9. 2010
    ..Analysis of HOXD1, MYC, TIPARP and SKAP1 at these loci and of BNC2 at 9p22 supports a functional role for these genes in ovarian cancer development...
  35. pmc Genetic variation predicting cisplatin cytotoxicity associated with overall survival in lung cancer patients receiving platinum-based chemotherapy
    Xiang Lin Tan
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Cancer Res 17:5801-11. 2011
    ....
  36. pmc Assessment of hepatocyte growth factor in ovarian cancer mortality
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 20:1638-48. 2011
    ..Invasive ovarian cancer is a significant cause of gynecologic cancer mortality...
  37. pmc Localizing putative markers in genetic association studies by incorporating linkage disequilibrium into bayesian hierarchical models
    Brooke L Fridley
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA fridley brooke mayo edu
    Hum Hered 70:63-73. 2010
    ..Often these methods do not explicitly model the information regarding the linkage disequilibrium (LD) between SNPs. Furthermore, many methods shrink the SNP effects towards zero, rather than to an unknown latent gene-level effect...
  38. pmc Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel
    Mine S Cicek
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Hum Mol Genet 22:3038-47. 2013
    ..Validation in a bigger cohort of clear-cell tumors of the ovary is warranted. ..
  39. pmc Genome-wide gene-set analysis for identification of pathways associated with alcohol dependence
    Joanna M Biernacka
    Divisions of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    Int J Neuropsychopharmacol 16:271-8. 2013
    ..These findings demonstrate the utility of GSA in the study of complex disease, and suggest specific directions for further research into the genetic architecture of alcohol dependence...
  40. pmc A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation
    Robert B Jenkins
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Nat Genet 44:1122-5. 2012
    ..16-6.66, P=4.7×10(-12) to 2.2×10(-8)) but not for astrocytomas with wild-type IDH1 and IDH2 (smallest P=0.26). The conserved sequence block that includes rs55705857 is consistently modeled as a microRNA...
  41. pmc Ovarian cancer risk associated with inherited inflammation-related variants
    Kristin L White
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Res 72:1064-9. 2012
    ....
  42. pmc Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity
    Fang Li
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Drug Metab Dispos 38:2329-38. 2010
    ..4 × 10(-10), R = -0.376). The thiopurine cellular circulation and genetic polymorphisms for genes encoding the proteins involved should be incorporated into future studies of thiopurine drug therapy and effect...
  43. pmc Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study
    Euijung Ryu
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    Mol Vis 16:2811-21. 2010
    ....
  44. pmc Inherited determinants of ovarian cancer survival
    Ellen L Goode
    Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Cancer Res 16:995-1007. 2010
    ....
  45. doi request reprint Bayseian genomic models for the incorporation of pathway topology knowledge into association studies
    Abra Brisbin
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Stat Appl Genet Mol Biol 12:505-16. 2013
    ..These results demonstrate the value of incorporating pathway information into association analyses...
  46. pmc Identification of novel variants in colorectal cancer families by high-throughput exome sequencing
    Melissa S DeRycke
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 22:1239-51. 2013
    ..Familial linkage analyses have yielded disparate results; the use of exome sequencing in coding regions may identify novel segregating variants...
  47. pmc Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking
    Daniel H LaChance
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Epidemiol 174:574-81. 2011
    ..The authors' observations are consistent with a recent report that the inherited glioma risk variants in chromosome regions 9p21.3 and 20q13.3 may modify the inverse association of allergy and glioma...
  48. pmc Use of the gamma method for self-contained gene-set analysis of SNP data
    Joanna M Biernacka
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Hum Genet 20:565-71. 2012
    ..We also applied all of the considered GSA methods to data from a pharmacogenomic study of cisplatin, and obtained evidence suggesting that the glutathione metabolism GS is associated with cisplatin drug response...
  49. pmc Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22
    Mine S Cicek
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 7:e38175. 2012
    ..02, α = 0.51, 132.52 cM, rs1319036). These previously unreported linkage peaks demonstrate the continued utility of family-based data in complex traits and suggest that new CRC risk alleles remain to be elucidated...
  50. pmc Common variation in Nemo-like kinase is associated with risk of ovarian cancer
    Kristen N Stevens
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 21:523-8. 2012
    ..Overexpression of mitotic kinases has been associated with prognosis, histologic grade, and clinical stage in ovarian cancer, but the relationship between inherited variation in these genes and ovarian cancer risk has not been well defined...
  51. pmc Polymorphisms in NF-kappaB inhibitors and risk of epithelial ovarian cancer
    Kristin L White
    Mayo Clinic College of Medicine, Rochester, MN, USA
    BMC Cancer 9:170. 2009
    ..Inhibitors of kappaB (IkappaB) prevent NF-kappaB activation by sequestering NF-kappaB proteins in the cytoplasm until IkappaB proteins are phosphorylated and degraded...
  52. pmc Assessment of genotype imputation methods
    Joanna M Biernacka
    Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 USA
    BMC Proc 3:S5. 2009
    ..However, in both situations, none of the imputation-based tests provide the same level of evidence of association as the complete data at SNPs strongly associated with disease...
  53. pmc No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
    Ellen L Goode
    Health Sciences Research, Mayo Clinic College of Medicine, Rochester, USA
    BMC Cancer 9:312. 2009
    ..No studies of ovarian cancer have been reported to date...
  54. doi request reprint Human phenylethanolamine N-methyltransferase genetic polymorphisms and exercise-induced epinephrine release
    Yuan Ji
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, Minnesota 55905, USA
    Physiol Genomics 33:323-32. 2008
    ..Our studies suggest that functionally significant variant sequence in the human PNMT gene might contribute to individual variation in levels of circulating epinephrine during exercise...
  55. pmc Linkage analysis using principal components of gene expression data
    Elizabeth J Atkinson
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, Minnesota 55905, USA
    BMC Proc 1:S79. 2007
    ....
  56. doi request reprint Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines
    Liang Li
    Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    BMC Genomics 15:93. 2014
    ..3 million SNPs and 54,000 basal expression probesets to perform genome-wide association studies (GWAS) with gemcitabine and AraC IC50 values...
  57. pmc Kernel canonical correlation analysis for assessing gene-gene interactions and application to ovarian cancer
    Nicholas B Larson
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
    Eur J Hum Genet 22:126-31. 2014
    ..05). Finally, we discuss the advantages of KCCA in gene-gene interaction analysis and its future role in genetic association studies. ..
  58. pmc Genome-wide linkage analysis for uric acid in families enriched for hypertension
    Andrew D Rule
    Division of Nephrology and Hypertension, Division of Biostatistics, Mayo Clinic, Rochester, MN, USA
    Nephrol Dial Transplant 24:2414-20. 2009
    ..Uric acid is heritable and associated with hypertension and insulin resistance. We sought to identify genomic regions influencing serum uric acid in families in which two or more siblings had hypertension...
  59. pmc Germline copy number variation and ovarian cancer survival
    Brooke L Fridley
    Department of Health Sciences Research, Mayo Clinic Rochester, MN, USA
    Front Genet 3:142. 2012
    ..40). Although CNVs that were not well-covered by the Illumina 610 quad array merit investigation, these data suggest no association between inherited CNVs and survival after ovarian cancer...
  60. pmc FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt
    Huadong Pei
    Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Cell 16:259-66. 2009
    ..Overall, our findings identify FKBP51 as a negative regulator of the Akt pathway, with potentially important implications for cancer etiology and response to chemotherapy...
  61. pmc The genetics of gene expression: comparison of linkage scans using two phenotype normalization methods
    Mariza de Andrade
    Division of Biostatistics, Mayo Clinic College of Medicine, 200 First Street Southwest, Harwick 7, Rochester, Minnesota 55905, USA
    BMC Proc 1:S151. 2007
    ..In summary, we conclude, as have other published reports, that normalization methods play an important role in the linkage results, and that some significant linkage signals might be due to a specific normalization method...
  62. pmc Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines
    Nifang Niu
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Genome Res 20:1482-92. 2010
    ..Studies performed with LCLs can help to identify novel biomarkers that might contribute to variation in response to radiation therapy and enhance our understanding of mechanisms underlying that variation...
  63. doi request reprint Complement component 3 (C3) haplotypes and risk of advanced age-related macular degeneration
    Kyu Hyung Park
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 50:3386-93. 2009
    ..Nonsynonymous coding single nucleotide polymorphisms (nsSNPs) in complement component 3 (C3) alter the risk of age-related macular degeneration (AMD). This was a study of the effect of haplotypes across C3 on AMD risk...
  64. pmc Familial aggregation of irritable bowel syndrome: a family case-control study
    Yuri A Saito
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Am J Gastroenterol 105:833-41. 2010
    ..The aims of this study were to (i) compare the prevalence of IBS in case-relatives with control-relatives, and (ii) determine whether gender, relationship, predominant symptom, and environmental risk factors affect familial aggregation...
  65. pmc Identification of a novel percent mammographic density locus at 12q24
    Kristen N Stevens
    Department of Health Sciences Research, Mayo Clinic, Charlton 6 239, 200 First St SW, Rochester, MN 55905, USA
    Hum Mol Genet 21:3299-305. 2012
    ..Understanding the mechanism underlying this association will provide insight into the genetics of breast tissue composition...
  66. pmc Comparison of tagging single-nucleotide polymorphism methods in association analyses
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    BMC Proc 1:S6. 2007
    ..e., whether a SNP or haplotype is responsible); unfortunately, this is often unknown at the time of SNP selection. Additional evaluations using empirical and simulated data are needed...
  67. pmc Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study
    Ann M Moyer
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    Toxicol Sci 120:33-41. 2011
    ..If these observations are validated in future clinical studies, this SNP signal might represent a potential biomarker for risk of acetaminophen hepatotoxicity. The mechanisms responsible for this association remain unclear...
  68. pmc Betaine-homocysteine methyltransferase: human liver genotype-phenotype correlation
    Qiping Feng
    Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Mol Genet Metab 102:126-33. 2011
    ..These observations may help us to understand individual variation in the regulation of BHMT in the human liver and its possible relationship to variation in methylation...
  69. pmc Inflammation-related gene variants as risk factors for pancreatic cancer
    Kaye M Reid-Lombardo
    Division of Gastroenterologic and General Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 20:1251-4. 2011
    ..Recent reports support an association between chronic inflammation and progression to pancreatic cancer (PC)...
  70. pmc Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic
    Stephen T Turner
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Hypertension 52:359-65. 2008
    ..These results support the use of genome-wide association analyses to identify novel genes influencing antihypertensive drug responses...
  71. doi request reprint Toll-like receptor polymorphisms and age-related macular degeneration
    Albert O Edwards
    Department of Ophthalmology, Mayor Clinic, Rochester, MN 55905, USA
    Invest Ophthalmol Vis Sci 49:1652-9. 2008
    ..The purpose of this study was to determine whether common variation in the 10 human toll-like receptors (TLRs) alters the risk of AMD...
  72. pmc Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development
    Abra G Brisbin
    Department of Health Sciences Research, Mayo Clinic, Rochester, USA
    BMC Med Genet 12:156. 2011
    ..However, the abundance of associations around 128 Mb on chromosome 8 could mask the appearance of a weaker, but important, association elsewhere on 8q24...
  73. pmc Association of TNFSF8 polymorphisms with peripheral neutrophil count
    Adelaide M Arruda-Olson
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 86:1075-81. 2011
    ..To investigate the association between 347 single-nucleotide polymorphisms within candidate genes of the tumor necrosis factor, interleukin 1 and interleukin 6 families with neutrophil count...
  74. pmc Density of common complex ocular traits in the aging eye: analysis of secondary traits in genome-wide association studies
    Albert O Edwards
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 3:e2510. 2008
    ....
  75. pmc Distinct germ line polymorphisms underlie glioma morphologic heterogeneity
    Robert B Jenkins
    Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA
    Cancer Genet 204:13-8. 2011
    ..77, P = 2.6 × 10(-9)). These observations generate hypotheses concerning the possible mechanisms by which specific SNPs (or alterations in linkage disequilibrium with such SNPs) are associated with glioma development...
  76. ncbi request reprint Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders
    Animesh Pardanani
    Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Blood 111:2785-9. 2008
    ..Thus, host genetic variation may contribute to phenotypic diversity among myeloproliferative disorders, including in the presence of a shared disease allele...
  77. pmc Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules
    Wen Liu Mares
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    BMC Proc 1:S126. 2007
    ..We conclude that variation in the genes encoding p50 and c-Rel may play a role in NF-kappaB-related transcription of FAS, IRF1, and CD40...
  78. pmc Interacting alleles of the coinhibitory immunoreceptor genes cytotoxic T-lymphocyte antigen 4 and programmed cell-death 1 influence risk and features of primary biliary cirrhosis
    Brian D Juran
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 47:563-70. 2008
    ..As well, we identified the influence of an interaction between the putatively autoimmune-protective CTLA4 49AG:CT60 AA haplotype and autoimmune-risk PDCD1 PD1.3 A allele on development of PBC...
  79. pmc Participation bias and its impact on the assembly of a genetic specimen repository for a myocardial infarction cohort
    Adelaide M Arruda-Olson
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 82:1185-91. 2007
    ..To assess participation bias in the assembly of a specimen repository for genetic studies and to examine the association of participation with outcome within the Olmsted County myocardial infarction (MI) cohort...
  80. ncbi request reprint Model selection and Bayesian methods in statistical genetics: summary of group 11 contributions to Genetic Analysis Workshop 15
    Michael D Swartz
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Genet Epidemiol 31:S96-102. 2007
    ..These group contributions exhibit the value of framing genetic problems in terms of model selection, and highlight the impact of variable selection for gene mapping...
  81. ncbi request reprint Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism
    Holly R Thomas
    Division of Clinical Pharmacology and Toxicology, University of Alabama at Birmingham, Alabama, USA
    Pharmacogenet Genomics 17:973-87. 2007
    ..This study investigates the role of DPYS sequence variations in individuals with unexplained molecular basis of altered uracil catabolism...
  82. doi request reprint Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism
    Holly R Thomas
    Division of Clinical Pharmacology and Toxicology, University of Alabama at Birmingham, Alabama, USA
    Pharmacogenet Genomics 18:25-35. 2008
    ..This study investigates the possible role of UPB1 genetic variations in the regulation of the uracil catabolic pathway in individuals presenting with a deficient uracil breath test (13C-UraBT) despite normal DPD enzyme activity...