Research Topics
| A L FolpeSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
Expression of claudin-1, a recently described tight junction-associated protein, distinguishes soft tissue perineurioma from potential mimicsAndrew L Folpe
H 175 Department of Pathology, Emory University, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Am J Surg Pathol 26:1620-6. 2002..In particular, claudin-1 is often a more robust marker than EMA in a given perineurioma. Claudin-1 is not expressed within the lesional cells of the mesenchymal tumors that enter into the differential diagnosis of perineurioma...
Perivascular epithelioid cell neoplasms: pathology and pathogenesisAndrew L Folpe
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Hum Pathol 41:1-15. 2010....
Alveolar soft-part sarcoma: a review and updateA L Folpe
Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Minnesota, USA
J Clin Pathol 59:1127-32. 2006..The historical, histopathological, ultrastructural, immunohistochemical and genetic aspects of ASPS are reviewed in this article...- Best practices in diagnostic immunohistochemistry: pleomorphic cutaneous spindle cell tumorsAndrew L Folpe
Division of Anatomic Pathology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
Arch Pathol Lab Med 131:1517-24. 2007..Pleomorphic cutaneous spindle cell tumors can be difficult to distinguish solely on histologic grounds. The use of ancillary immunohistochemical studies can greatly assist in this differential diagnosis... - Cutaneous CD30-positive epithelioid angiosarcoma following breast-conserving therapy and irradiation: a potential diagnostic pitfallBrent R Weed
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA
Am J Dermatopathol 30:370-2. 2008..This seems to be the first such case reported. The differential diagnosis of CD30 epithelioid angiosarcoma is discussed... - Spindle epithelial tumor with thymus-like differentiation: a morphologic, immunohistochemical, and molecular genetic study of 11 casesAndrew L Folpe
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Surg Pathol 33:1179-86. 2009..Molecular genetic study may, however, be helpful in selected cases, particularly in limited biopsies... - Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literatureM Manduch
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
J Clin Pathol 62:808-11. 2009..Massive localised lymphoedema (MLL) is a rare, relatively recently described pseudosarcoma most often occurring in morbidly obese patients... - INI1 and GLUT-1 expression in epithelioid sarcoma and its cutaneous neoplastic and nonneoplastic mimicsJared M Orrock
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Dermatopathol 31:152-6. 2009..In contrast, there does not seem to be a role for GLUT-1 immunohistochemistry in this differential diagnosis... - Microphthalmia transcription factor immunohistochemistry: a useful diagnostic marker in the diagnosis and detection of cutaneous melanoma, sentinel lymph node metastases, and extracutaneous melanocytic neoplasmsD J Brat
Department of Dermatology, Emory University School of Medicine, 5309 Woodruff Memorial Bldg, Atlanta, GA 30322, USA
J Am Acad Dermatol 45:414-9. 2001..Use of this stain may facilitate detection of micrometastases in sentinel lymph nodes... - RT-PCR analysis for FGF23 using paraffin sections in the diagnosis of phosphaturic mesenchymal tumors with and without known tumor induced osteomalaciaArmita Bahrami
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester MN 55905, USA
Am J Surg Pathol 33:1348-54. 2009..Our finding of expression of FGF23 in 75% of histologically identical tumors without known TIO confirms the reproducibility of the diagnosis of PMTMCT, even in the absence of known phosphaturia... - The impact of advances in molecular genetic pathology on the classification, diagnosis and treatment of selected soft tissue tumors of the head and neckJoaquin J Garcia
Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 1st St SW, Rochester, MN, USA
Head Neck Pathol 4:70-6. 2010.... - Clusterin is expressed in normal synoviocytes and in tenosynovial giant cell tumors of localized and diffuse types: diagnostic and histogenetic implicationsJennifer M Boland
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Surg Pathol 33:1225-9. 2009..The observed staining patterns provide evidence linking the large mononuclear cells with normal synoviocytes and support that tenosynovial giant cell tumors are neoplasms showing synovial differentiation... - GLUT-1 expression in mesenchymal tumors: an immunohistochemical study of 247 soft tissue and bone neoplasmsWilliam A Ahrens
Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
Hum Pathol 39:1519-26. 2008.... - Adult-type fibrosarcoma: A reevaluation of 163 putative cases diagnosed at a single institution over a 48-year periodArmita Bahrami
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Surg Pathol 34:1504-13. 2010..We conclude that true FS is exceedingly rare, accounting for <1% of approximately 10,000 adult soft tissue sarcomas seen at our institution during this time period, and should be diagnosed with great caution... - Clinical and histopathologic features of chordomas in children and young adultsRobert V Ridenour
Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Pediatr Dev Pathol 13:9-17. 2010.... - Liposarcomas with mixed well-differentiated and pleomorphic features: a clinicopathologic study of 12 casesJennifer M Boland
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Surg Pathol 34:837-43. 2010.... - Osteosarcoma of the skinSangeetha Larsen
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA
Int J Dermatol 49:532-40. 2010..Osteosarcoma is a common malignancy, although skin metastasis is rare. We sought to review the incidence, epidemiology, risk factors, and prognosis of osteosarcoma with skin involvement... - Alveolar soft-part sarcoma of the urinary bladder with urethral recurrence: a unique case with emphasis on differential diagnoses and diagnostic utility of an immunohistochemical panel including TFE3Mahul B Amin
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
Am J Surg Pathol 30:1322-5. 2006.... - Epithelioid sarcoma-like hemangioendotheliomaSteven D Billings
Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
Am J Surg Pathol 27:48-57. 2003..Its distinction from other epithelioid vascular lesions is discussed. We think this tumor fits best into the family of "hemangioendothelioma" or vascular lesions of intermediate malignancy... - Cutaneous angiosarcoma following breast-conserving surgery and radiation: an analysis of 27 casesSteven D Billings
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Surg Pathol 28:781-8. 2004..The median interval to death was 33.5 months. All 4 patients with disease have documented metastasis. CPRASB differs from Stewart-Treves AS by its shorter latency period and lack of association with lymphedema... - Clear cell myomelanocytic tumor of the thigh: report of a unique caseAndrew L Folpe
Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
Am J Surg Pathol 26:809-12. 2002..Histologic examination showed the classic features of CCMMT, and immunohistochemical studies confirmed co-expression of smooth muscle actin, HMB-45, and microphthalmia transcription factor... - Kaposiform hemangioendothelioma: a study of 33 cases emphasizing its pathologic, immunophenotypic, and biologic uniqueness from juvenile hemangiomaLisa L Lyons
Departments of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Am J Surg Pathol 28:559-68. 2004..Given this behavior, its continued classification as a vascular tumor of intermediate malignancy is warranted... - Sclerosing rhabdomyosarcoma in adults: report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma, or angiosarcomaAndrew L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
Am J Surg Pathol 26:1175-83. 2002..Study of additional cases will be necessary to more fully elucidate its place among RMS and its prognostic significance... - The diagnostic value of hepatocyte paraffin antibody 1 in differentiating hepatocellular neoplasms from nonhepatic tumors: a reviewLaura W Lamps
University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Adv Anat Pathol 10:39-43. 2003.... - Proliferating trichilemmal tumors: clinicopathologic evaluation is a guide to biologic behaviorAndrew L Folpe
Emory University, Atlanta, GA, USA
J Cutan Pathol 30:492-8. 2003..The malignant potential of PTT is controversial, as only a small number of histologically malignant PTTs and a smaller number of clinically malignant PTTs have been reported... - Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasmsLucas K Campbell
University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Mod Pathol 16:963-9. 2003..It is possible that our findings reflect cross-reactivity of the 13C4 clone with epitopes present on other ubiquitin hydrolases. Alternatively, PGP 9.5 expression may be aberrantly up-regulated in a variety of mesenchymal neoplasms... - Immunoprofile of ovarian tumors with putative transitional cell (urothelial) differentiation using novel urothelial markers: histogenetic and diagnostic implicationsSanjay Logani
Emory University School of Medicine, Atlanta, Georgia 30322, USA
Am J Surg Pathol 27:1434-41. 2003..They also indicate that the morphologic similarity between TCC-O and TCC-B does not indicate any histogenic similarity and, as others have noted, TCC-O is a variant morphology in the spectrum of surface epithelial carcinomas... - Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literatureAndrew L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
Am J Surg Pathol 28:1-30. 2004..Recognition of PMTMCT is critical, as complete resection cures intractable OO. Immunohistochemistry and RT-PCR for FGF-23 confirm the role of this protein in PMTMCT-associated OO... - Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue: potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumorsBrian F Skinnider
Department of Pathology, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada
Am J Surg Pathol 29:747-54. 2005..In conclusion, CK expression patterns may be helpful in several differential diagnostic situations when dealing with adult RENs... - Potential utility of uroplakin III, thrombomodulin, high molecular weight cytokeratin, and cytokeratin 20 in noninvasive, invasive, and metastatic urothelial (transitional cell) carcinomasDouglas C Parker
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
Am J Surg Pathol 27:1-10. 2003..The results of the study indicate a role for an antibody panel that includes UROIII, THR, HMWCK, and CK20 in the diagnosis of urothelial tumors... - Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed casesAndrew L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Am J Surg Pathol 29:1025-33. 2005.... - C-kit expression distinguishes salivary gland adenoid cystic carcinoma from polymorphous low-grade adenocarcinomaCarla R Penner
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
Mod Pathol 15:687-91. 2002..Our finding of different patterns of c-kit expression in tubular and solid variants of ACC supports the concept of solid variant ACC as a high-grade tumor, with progression toward an entirely "inner cell" phenotype... - Lipoleiomyosarcoma (well-differentiated liposarcoma with leiomyosarcomatous differentiation): a clinicopathologic study of nine cases including one with dedifferentiationAndrew L Folpe
Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
Am J Surg Pathol 26:742-9. 2002..LMS in L-LMS should not be misconstrued as evidence of low-grade dedifferentiation, a phenomenon that identifies a more unstable and potentially metastasizing lesion... - Primary Ewing's sarcoma/primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemical analysis of 11 casesRafael E Jimenez
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
Am J Surg Pathol 26:320-7. 2002..The accurate distinction between these two entities has clear prognostic and therapeutic implications... - Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfallArmita Bahrami
Texas Children s Hospital and Baylor College of Medicine, Houston, TX, USA
Mod Pathol 21:795-806. 2008..These findings emphasize the need to employ a panel of markers, to include desmin, myogenin/MyoD1, and genetic study in the diagnosis of primitive round cell neoplasms in all age groups and in all locations... - Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 casesAndrea T Deyrup
Department of Pathology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
Am J Surg Pathol 32:72-7. 2008..These features seem to diminish in importance with increased tumor size and are probably most useful in tumors less than 5 cm in maximum dimension... - The utility of fluorescence in situ hybridization (FISH) in the diagnosis of myxoid soft tissue neoplasmsErinn Downs-Kelly
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
Am J Surg Pathol 32:8-13. 2008..FISH is capable of providing specific ancillary information useful in this often difficult differential diagnosis... - Dual-color, break-apart fluorescence in situ hybridization for EWS gene rearrangement distinguishes clear cell sarcoma of soft tissue from malignant melanomaRajiv M Patel
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30355, USA
Mod Pathol 18:1585-90. 2005..As the studied probe can be utilized in routinely processed tissue, FISH provides an excellent alternative to reverse-transcriptase polymerase chain reaction in cases where fresh tissue is unavailable... - Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literatureAndrew L Folpe
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Am J Surg Pathol 29:1558-75. 2005..PEComas with two or more worrisome histologic features should be considered malignant. Occasional PEComas express unusual markers, such as S-100 protein, desmin, and rarely CK. The role of TFE3 in PEComas should be further studied... - The diagnostic value of beta-catenin immunohistochemistryElizabeth Montgomery
Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
Adv Anat Pathol 12:350-6. 2005..Immunohistochemistry for beta-catenin may be useful in the differential diagnosis of selected tumors of soft tissue, the gastrointestinal tract, including the pancreas, lung, and female genital tract... - Heterotopic mesenteric ossification: a distinctive pseudosarcoma commonly associated with intestinal obstructionRajiv M Patel
Department of Pathology and Laboratory Medicine, 1364 Clifton Road NE, Emory University, Atlanta, GA 30222, USA
Am J Surg Pathol 30:119-22. 2006.... - Association of the t(12;22)(q13;q12) EWS/ATF1 rearrangement with polyphenotypic round cell sarcoma of bone: a case reportAndrew L Folpe
Am J Surg Pathol 30:1057-8; author reply 1058-9. 2006 - CDX-2, a new marker for adenocarcinoma of gastrointestinal originMelissa K Li
Department of Pathology, University of Florida, Gainesville, Florida, USA
Adv Anat Pathol 11:101-5. 2004..This article reviews the previous studies of this new antibody... - Well-differentiated fetal adenocarcinoma of the lung: cytomorphologic features on fine-needle aspiration with emphasis on use of beta-catenin as a useful diagnostic markerLori Proctor
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
Diagn Cytopathol 35:39-42. 2007.... - Subconjunctival herniated orbital fat: A benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumorIngo Schmack
Emory Eye Center, Emory University School of Medicine, Atlanta, GA, USA
Am J Surg Pathol 31:193-8. 2007..Multinucleated floret cells present in prolapsed orbital fat likely represent a reactive phenomenon, as they are not present in normal orbital fat... - Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasmsHeidi Kenerson
Department of Pathology, University of Washington, Seattle, WA 98195, USA
Hum Pathol 38:1361-71. 2007..This suggests the possibility that mTOR inhibitors such as rapamycin may be therapeutic for this class of disease... - Diagnostically challenging spindle cell lipomas: a report of 34 "low-fat" and "fat-free" variantsSteven D Billings
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
Am J Dermatopathol 29:437-42. 2007..CD34 was diffusely positive (10/11). A high index of suspicion based on clinical context and identification of other typical features of SCL are key features to the diagnosis of low-fat and fat-free SCL... - Composite hemangioendothelioma: report of 5 cases including one with associated Maffucci syndromeMasaharu Fukunaga
Department of Pathology, The Jikei University School of Medicine, Jikei Daisan Hospital, 4 11 1 Izumihoncho, Komaeshi, Tokyo 201 8601, Japan
Am J Surg Pathol 31:1567-72. 2007..We conclude that composite HE should continue to be regarded as a low-grade malignant vascular tumor (HE), with significant potential for local recurrence, but little if any potential for distant metastasis... - National surgical patterns of care: regional lymphadenectomy of breast sarcomasNorleena Poynter Gullett
Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Clin Oncol 30:461-5. 2007..We reviewed national surgical patterns of care for regional lymphadenectomy for breast STS using the Surveillance Epidemiology & End Results (SEER) registry... - Cutaneous and subcutaneous fibrohistiocytic tumors of intermediate malignancy: an updateSteven D Billings
Department of Pathology, Indiana University, Indianapolis, IN, USA
Am J Dermatopathol 26:141-55. 2004..The differential diagnosis of these tumors with a variety of benign and fully malignant cutaneous soft tissue neoplasms is discussed... - Dermatofibrosarcoma protuberans presenting as a subcutaneous mass: a clinicopathological study of 15 cases with exclusive or near-exclusive subcutaneous involvementSylvia Bague
Department of Pathology, Hospital de Sant Pau, Barcelona, Spain
Am J Dermatopathol 30:327-32. 2008..The differential diagnosis with other subcutaneous spindle cell neoplasms is emphasized. Awareness of this rare subset of DFSP should prevent its misdiagnosis as other less aggressive tumor types...