ALAN FIELDS

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota
    Eda Erdogan
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    J Biol Chem 281:28450-9. 2006
  2. pmc Protein kinase C iota: human oncogene, prognostic marker and therapeutic target
    Alan P Fields
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Pharmacol Res 55:487-97. 2007
  3. pmc Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells
    Roderick P Regala
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    Cancer Res 68:5888-95. 2008
  4. ncbi request reprint Targeting the oncogenic protein kinase Ciota signalling pathway for the treatment of cancer
    A P Fields
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, U S A
    Biochem Soc Trans 35:996-1000. 2007
  5. pmc Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation
    V Justilien
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Oncogene 28:3597-607. 2009
  6. pmc Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer
    L A Frederick
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Oncogene 27:4841-53. 2008
  7. ncbi request reprint A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells
    Melody Stallings-Mann
    Department of Cancer Biology, Comprehensive Cancer Center, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Cancer Res 66:1767-74. 2006
  8. ncbi request reprint Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer
    Roderick P Regala
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Cancer Res 65:8905-11. 2005
  9. ncbi request reprint Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity
    Roderick P Regala
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 280:31109-15. 2005
  10. ncbi request reprint Protein kinase C in disease: cancer
    Alan P Fields
    The Mayo Clinic Cancer Center, Jacksonville, FL, USA
    Methods Mol Biol 233:519-37. 2003

Research Grants

Collaborators

  • Panos Z Anastasiadis
  • E Aubrey Thompson
  • Nicole R Murray
  • Roderick P Regala
  • Lee Jamieson
  • Capella Weems
  • V Justilien
  • Wangsheng Yu
  • Weidong Su
  • Eda Erdogan
  • Melody Stallings-Mann
  • Jie Zhang
  • Yan Liu
  • L A Frederick
  • Jennifer L Rudolph
  • W Clay Gustafson
  • Michael H A Roehrl
  • Lu Chen
  • L Jamieson
  • D C Radisky
  • Kosaku Fujiwara
  • Shinichi Kurakata
  • E A Thompson
  • J A Matthews
  • Brian M Necela
  • Geng Xian Shi
  • Douglas A Andres
  • Trond Lamark
  • Terje Johansen
  • - Lee Jamieson
  • Maurizio Pellecchia
  • Mauricio Pellechia
  • Christine M Lohse
  • Eric S Edell
  • John A Copland
  • Andras Khoor
  • Zoran Gatalica
  • Yesim Gokmen-Polar
  • Allan R Brasier
  • Michael Leitges
  • Deborah Sier
  • Sutapa Ray
  • Huiping Guo
  • Zhen Yu Jim Sun
  • B Mark Evers
  • Richard Ethridge
  • Sven G Hyberts
  • Gerhard Wagner
  • Jeffrey D Ceci
  • Laurie A Davidson
  • Jessica Leon
  • Robert S Chapkin

Detail Information

Publications20

  1. ncbi request reprint Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota
    Eda Erdogan
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    J Biol Chem 281:28450-9. 2006
    ..We conclude that ATM inhibits cellular transformation by selectively targeting Cys-69 within the PB1 domain of PKCiota...
  2. pmc Protein kinase C iota: human oncogene, prognostic marker and therapeutic target
    Alan P Fields
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Pharmacol Res 55:487-97. 2007
    ..Throughout, we identify key unanswered questions and exciting future avenues of investigation regarding this important oncogenic molecule...
  3. pmc Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells
    Roderick P Regala
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    Cancer Res 68:5888-95. 2008
    ..Our results indicate that PKC iota expression profiling will be useful in identifying lung cancer patients most likely to respond to ATM therapy in an ongoing clinical trial...
  4. ncbi request reprint Targeting the oncogenic protein kinase Ciota signalling pathway for the treatment of cancer
    A P Fields
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, U S A
    Biochem Soc Trans 35:996-1000. 2007
    ..ATM is currently in Phase I clinical trials for the treatment of NSCLC...
  5. pmc Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation
    V Justilien
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Oncogene 28:3597-607. 2009
    ..Our data indicate that Ect2 and PKCiota are genetically and functionally linked in NSCLC, acting to coordinately drive tumor cell proliferation and invasion through formation of an oncogenic PKCiota-Par6alpha-Ect2 complex...
  6. pmc Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer
    L A Frederick
    Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Oncogene 27:4841-53. 2008
    ..Our data define a PKCiota-Par6alpha-Rac1 signaling axis that drives anchorage-independent growth and invasion of NSCLC cells through induction of MMP-10 expression...
  7. ncbi request reprint A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells
    Melody Stallings-Mann
    Department of Cancer Biology, Comprehensive Cancer Center, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Cancer Res 66:1767-74. 2006
    ..ATG and ATM will be useful reagents for studying PKCiota function in transformation and represent promising new agents for the clinical treatment of NSCLC...
  8. ncbi request reprint Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer
    Roderick P Regala
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Cancer Res 65:8905-11. 2005
    ..Our functional data indicate that PKCiota is an attractive target for development of novel, mechanism-based therapeutics to treat NSCLC...
  9. ncbi request reprint Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity
    Roderick P Regala
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 280:31109-15. 2005
    ..Our data indicate that PKCiota may be an attractive molecular target for mechanism-based therapies for treatment of lung cancer...
  10. ncbi request reprint Protein kinase C in disease: cancer
    Alan P Fields
    The Mayo Clinic Cancer Center, Jacksonville, FL, USA
    Methods Mol Biol 233:519-37. 2003
  11. ncbi request reprint Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway
    Jie Zhang
    Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 279:22118-23. 2004
    ..This pathway provides a plausible mechanism by which PKCbetaII promotes colon carcinogenesis...
  12. pmc Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo
    Nicole R Murray
    Mayo Clinic Comprehensive Cancer Center, Griffin Cancer Research Building, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    J Cell Biol 164:797-802. 2004
    ..Our data demonstrate that PKCiota is required for oncogenic Ras- and carcinogen-mediated colon carcinogenesis in vivo and define a procarcinogenic signaling axis consisting of Ras, PKCiota, and Rac1...
  13. ncbi request reprint Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter
    W Clay Gustafson
    Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 279:9400-8. 2004
    ..Our results indicate that Bcr-Abl-mediated transformation involves transcriptional activation of the PKCiota gene, which in turn is required for Bcr-Abl-mediated chemoresistance...
  14. ncbi request reprint Role of cyclooxygenase 2 in protein kinase C beta II-mediated colon carcinogenesis
    Wangsheng Yu
    Sealy Center for Cancer Cell Biology and the Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, Texas 77555 1048, USA
    J Biol Chem 278:11167-74. 2003
    ....
  15. ncbi request reprint Rapid backbone 1H, 13C, and 15N assignment of the V1 domain of human PKC iota using the new program IBIS
    Michael H A Roehrl
    J Biomol NMR 26:373-4. 2003
  16. doi request reprint The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice
    Weidong Su
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Int J Cancer 123:991-7. 2008
    ..We conclude that RS5444 inhibits both initiation and progression of colon tumors in the AOM model of sporadic colon carcinogenesis...
  17. pmc Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction
    Jennifer L Rudolph
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, 741 South Limestone Street, Lexington, KY 40536 0509, USA
    Biochim Biophys Acta 1773:1793-800. 2007
    ..In addition, in vivo binding studies identified a novel mechanism of Par6 interaction, suggesting that the cell polarity machinery may serve to spatially restrict Rit signaling...
  18. ncbi request reprint Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo
    Yan Liu
    Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
    J Biol Chem 279:45556-63. 2004
    ....
  19. ncbi request reprint Characterization of the role of protein kinase C isozymes in colon carcinogenesis using transgenic mouse models
    Alan P Fields
    The Mayo Clinic Cancer Center, Jacksonville, FL, USA
    Methods Mol Biol 233:539-53. 2003
  20. pmc Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis
    Nicole R Murray
    Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1048, USA
    J Cell Biol 157:915-20. 2002
    ..These data indicate that dietary omega-3 fatty acids prevent colon cancer, at least in part, through inhibition of colonic PKCbetaII signaling and restoration of TGF-beta responsiveness...

Research Grants25

  1. PROTEIN KINASE C ISOTYPES IN LEUKEMIA CELL PHYSIOLOGY
    ALAN FIELDS; Fiscal Year: 2002
    ....
  2. PROTEIN KINASE C AND COLON CARCINOGENESIS
    ALAN FIELDS; Fiscal Year: 2003
    ..These studies will allow the first direct analysis of the role of PKC betaII in colon cancer in two relevant animal models of the human disease. ..
  3. Role of Protein Kinase C in Colon Carcinogenesis
    ALAN FIELDS; Fiscal Year: 2007
    ..abstract_text> ..
  4. PROTEIN KINASE C ISOTYPES IN LEUKEMIA CELL PHYSIOLOGY
    ALAN FIELDS; Fiscal Year: 1999
    ..Our results may uncover novel targets for therapeutic intervention in this disease and are likely to be relevant to the biology of many cancers. ..
  5. Protein Kinase C Signaling Mechanisms in Cancer
    Alan P Fields; Fiscal Year: 2010
    ..This project will elucidate the PKC? signaling mechanisms that drive lung cancer growth and assess the importance of PKC? signaling in lung cancer development, progression and spread in pre-clinical animal models in vivo. ..