Research Topics
Species | A L FeldmanSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
PAX5-positive T-cell anaplastic large cell lymphomas associated with extra copies of the PAX5 gene locusAndrew L Feldman
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Mod Pathol 23:593-602. 2010..As PAX5 overexpression causes T-cell neoplasms in experimental models, PAX5 may have contributed to lymphomagenesis in our cases...
Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomasA L Feldman
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Leukemia 23:574-80. 2009..Further, due to its involvement in translocations, MUM1/IRF4 protein may play an important biologic role in some PTCLs, and might represent a possible therapeutic target...
Diagnostic uses of Pax5 immunohistochemistryAndrew L Feldman
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Adv Anat Pathol 14:323-34. 2007..With these exceptions, Pax5 immunohistochemistry is fairly specific for B-cell lineage and is a valuable addition to the armamentarium of markers available for lymphoma subtyping...
Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomasA L Feldman
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Leukemia 22:1139-43. 2008....
Composite hodgkin and non-hodgkin lymphoma of the mitral and aortic valvesAmber D Khanna
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
J Am Soc Echocardiogr 23:1113.e5-7. 2010..Both tumors were Epstein-Barr virus positive and were clonally related; however, they were not related to his DLBCL from 14 years prior. This is the first case report of a patient with a composite lymphoma affecting two cardiac valves...
Germinal center B (GCB) and non-GCB cell-like diffuse large B cell lymphomas have similar outcomes following autologous haematopoietic stem cell transplantationLuciano J Costa
Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
Br J Haematol 142:404-12. 2008..We conclude that patients with relapsed or primary refractory chemosensitive GCB and non-GCB-like DLBCL derive similar benefit from autologous HSC transplant...
A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activationMamta Gupta
Mayo Clinic, Rochester, MN 55905, USA
Blood 113:5206-16. 2009..These studies are the first to characterize APRIL-TACI-specific signaling and suggest a role for this ligand-receptor pair in FL B-cell growth...
Incidence of TCR and TCL1 gene translocations and isochromosome 7q in peripheral T-cell lymphomas using fluorescence in situ hybridizationAndrew L Feldman
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Clin Pathol 130:178-85. 2008..One of the latter cases also had a translocation of TCRA, and further studies confirmed a novel t(5;14) translocation...
Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma cloneAndrew L Feldman
Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 1500, USA
Blood 111:5433-9. 2008..1 was seen in all cases tested. These results provide evidence for a common clonal origin of FL and H/DC neoplasms when occurring in the same patient, and suggest that lineage plasticity may occur in mature lymphoid neoplasms...
Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorderAnja C Roden
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Mod Pathol 21:455-63. 2008..Although the follow-up time was relatively short, our series and other reported cases suggest that primary anaplastic large-cell lymphoma adjacent to breast implants is an indolent T-cell lymphoproliferative disorder...
Interferon gamma-inducible protein 10 selectively inhibits proliferation and induces apoptosis in endothelial cellsElizabeth D Feldman
Surgical Metabolism Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B07, Bethesda, Maryland 20892-1502, USA
Ann Surg Oncol 13:125-33. 2006....
Proteomic analysis of apoptotic pathways reveals prognostic factors in follicular lymphomaChristian Gulmann
National Cancer Institute--Food and Drug Administration Clinical Proteomics Program, Laboratory of Pathology, Bethesda, MD 20892, USA
Clin Cancer Res 11:5847-55. 2005..Proteomic end points should be incorporated in larger, multicenter trials to validate the clinical utility of these protein microarray findings...
Modulation of tumor-host interactions, angiogenesis, and tumor growth by tissue inhibitor of metalloproteinase 2 via a novel mechanismAndrew L Feldman
Metabolism Section, Surgery Branch, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 64:4481-6. 2004..Phosphatase activity appears important in regulating tumor angiogenesis, offering a promising direction for the identification of novel molecular targets and antiangiogenic compounds for the treatment of cancer...
Use of proteomic patterns to screen for gastrointestinal malignanciesAndrew L Feldman
Laboratory of Pathology, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
Surgery 135:243-7. 2004
Inhibition of the mammary carcinoma angiogenic switch in C3(1)/SV40 transgenic mice by a mutated form of human endostatinAlfonso Calvo
Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Int J Cancer 101:224-34. 2002..These results demonstrate that P125A endostatin inhibits the angiogenic switch during mammary gland adenocarcinoma tumor progression in the C3(1)/Tag transgenic model...
Retroviral gene transfer of interferon-inducible protein 10 inhibits growth of human melanoma xenograftsAndrew L Feldman
Surgery Branch, National Cancer Institute, Bethesda, MD 20892, USA
Int J Cancer 99:149-53. 2002..These findings suggest that IP-10 gene therapy might be an effective therapy in patients with cancer...
