Nilufer Ertekin-Taner

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
    Sruti Rayaprolu
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Mol Neurodegener 8:19. 2013
  2. pmc Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme
    Anthony DelleDonne
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, FL 32224, USA
    Mol Neurodegener 4:39. 2009
  3. pmc Gene expression endophenotypes: a novel approach for gene discovery in Alzheimer's disease
    Nilufer Ertekin-Taner
    Mayo Clinic Florida, Departments of Neurology and Neuroscience, 4500 San Pablo Road, Birdsall 210, Jacksonville, Florida 32224 USA
    Mol Neurodegener 6:31. 2011
  4. pmc Genetics of Alzheimer's disease: a centennial review
    Nilufer Ertekin-Taner
    Department of Neurology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Neurol Clin 25:611-67, v. 2007
  5. pmc Genetics of Alzheimer disease in the pre- and post-GWAS era
    Nilufer Ertekin-Taner
    Mayo Clinic Florida, Departments of Neurology and Neuroscience, 4500 San Pablo Road, Birdsall 210, Jacksonville, FL 32224 USA
    Alzheimers Res Ther 2:3. 2010
  6. pmc Novel late-onset Alzheimer disease loci variants associate with brain gene expression
    Mariet Allen
    Department of Neuroscience, Biostatistics Unit, Mayo Clinic Florida, Jacksonville, FL, USA
    Neurology 79:221-8. 2012
  7. pmc Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
    PLoS ONE 5:e8764. 2010
  8. pmc Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
    Mariet Allen
    Mayo Clinic Florida, Department of Neuroscience, Jacksonville, FL, USA
    Mol Neurodegener 7:13. 2012
  9. ncbi request reprint Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease
    Nilufer Ertekin-Taner
    Mayo Clinic Jacksonville, Department of Neuroscience, Jacksonville, FL, USA
    Hum Mutat 23:334-42. 2004
  10. pmc Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    Nat Genet 41:192-8. 2009

Collaborators

Detail Information

Publications18

  1. pmc TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
    Sruti Rayaprolu
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Mol Neurodegener 8:19. 2013
    ..With this in mind we set out to assess the genetic association of the Alzheimer's disease-related risk variant in TREM2 (rs75932628, p.R47H) with other related neurodegenerative disorders...
  2. pmc Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme
    Anthony DelleDonne
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, FL 32224, USA
    Mol Neurodegener 4:39. 2009
    ..abstract:..
  3. pmc Gene expression endophenotypes: a novel approach for gene discovery in Alzheimer's disease
    Nilufer Ertekin-Taner
    Mayo Clinic Florida, Departments of Neurology and Neuroscience, 4500 San Pablo Road, Birdsall 210, Jacksonville, Florida 32224 USA
    Mol Neurodegener 6:31. 2011
    ....
  4. pmc Genetics of Alzheimer's disease: a centennial review
    Nilufer Ertekin-Taner
    Department of Neurology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Neurol Clin 25:611-67, v. 2007
    ..The future directions for genetic research in AD as a common and complex condition are also discussed...
  5. pmc Genetics of Alzheimer disease in the pre- and post-GWAS era
    Nilufer Ertekin-Taner
    Mayo Clinic Florida, Departments of Neurology and Neuroscience, 4500 San Pablo Road, Birdsall 210, Jacksonville, FL 32224 USA
    Alzheimers Res Ther 2:3. 2010
    ..Potential approaches that could provide further insight into the genetics of AD in the post-GWAS era are also discussed...
  6. pmc Novel late-onset Alzheimer disease loci variants associate with brain gene expression
    Mariet Allen
    Department of Neuroscience, Biostatistics Unit, Mayo Clinic Florida, Jacksonville, FL, USA
    Neurology 79:221-8. 2012
    ..Single nucleotide polymorphisms that influence gene expression (eSNPs) constitute an important class of functional variants. We therefore investigated the influence of the novel LOAD risk loci on human brain gene expression...
  7. pmc Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, United States of America
    PLoS ONE 5:e8764. 2010
    ..The insulin-degrading enzyme gene (IDE) is a strong functional and positional candidate for late onset Alzheimer's disease (LOAD)...
  8. pmc Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
    Mariet Allen
    Mayo Clinic Florida, Department of Neuroscience, Jacksonville, FL, USA
    Mol Neurodegener 7:13. 2012
    ..4,617 controls) and PD (678 PDs vs. 712 controls) for association with disease risk (case-controls), age-at-diagnosis (cases) and brain gene expression levels (autopsied subjects)...
  9. ncbi request reprint Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease
    Nilufer Ertekin-Taner
    Mayo Clinic Jacksonville, Department of Neuroscience, Jacksonville, FL, USA
    Hum Mutat 23:334-42. 2004
    ..007) in our family series. These results provide strong evidence for pathogenic variant(s) in the 276-kb region harboring IDE that influence intermediate AD phenotypes and risk for AD...
  10. pmc Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    Nat Genet 41:192-8. 2009
    ..0 x 10(-7)) and 1.26 (95% CI = 1.05-1.51) for female heterozygotes (P = 0.01) compared to female noncarriers. For male hemizygotes (P = 0.07) compared to male noncarriers, the odds ratio was 1.18 (95% CI = 0.99-1.41)...
  11. pmc LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD)
    Sarah Lincoln
    Mayo Clinic Florida, Department of Neuroscience, Jacksonville, Florida, USA
    PLoS ONE 8:e64164. 2013
    ....
  12. pmc DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss
    Christopher J Klein
    Department of Neurology, Division of Peripheral Nerve Diseases, Mayo Clinic, Rochester, MN, USA
    Neurology 80:824-8. 2013
    ..The chromosomal location of the DNMT1 gene at 19p13.2 has been linked to familial late-onset Alzheimer disease...
  13. pmc Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants
    Fanggeng Zou
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA
    PLoS Genet 8:e1002707. 2012
    ..Our findings have implications for the design and interpretation of eGWAS in general and the use of brain expression quantitative trait loci in the study of human disease genetics...
  14. pmc Association and heterogeneity at the GAPDH locus in Alzheimer's disease
    Mariet Allen
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neurobiol Aging 33:203.e25-33. 2012
    ..The most promising rs3741916 variant is unlikely to be functional given opposing effects in different series. Identification of functional variant(s) in this region likely awaits deep sequencing...
  15. pmc Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
    Nilufer Ertekin-Taner
    Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Hum Mol Genet 12:3133-43. 2003
    ..These findings indicate that VR22 has variant(s) which influence Abeta42 and contribute to the previously reported linkage for plasma Abeta42 in LOAD families...
  16. pmc Association of common KIBRA variants with episodic memory and AD risk
    Jeremy D Burgess
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Aging 32:557.e1-9. 2011
    ..06) but not cerebellum. These results suggest a modest role for KIBRA as a cognition and AD risk gene, and also highlight the multifactorial complexity of its genetic associations...
  17. ncbi request reprint Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene
    Nilufer Ertekin-Taner
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Hum Mol Genet 14:447-60. 2005
    ..PLAU_1 is a plausible pathogenic mutation that could act by increasing Abeta42, but additional biological experiments are required to show this definitively...
  18. pmc Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease
    F Zou
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neurology 74:480-6. 2010
    ..Late-onset Alzheimer disease (LOAD) is a common disorder with a substantial genetic component. We postulate that many disease susceptibility variants act by altering gene expression levels...

Research Grants4

  1. Mapping Novel Genes for Late-Onset Alzheimer's Disease
    Nilufer Ertekin Taner; Fiscal Year: 2007
    ..These studies could potentially provide new insights to the pathogenesis of AD, lead to the discovery of novel therapeutic targets and allow for the identificationof "at risk" people by using plasma A6 as a biomarker. ..
  2. Genome wide association study of gene expression levels in Alzheimer's disease
    Nilufer Ertekin Taner; Fiscal Year: 2009
    ..Our proposal is aimed at the discovery of AD risk variants that work through regulation of gene expression using a genome-wide association study design. ..
  3. Genome wide association study of gene expression levels in Alzheimer's disease
    Nilufer Ertekin Taner; Fiscal Year: 2010
    ..Our proposal is aimed at the discovery of AD risk variants that work through regulation of gene expression using a genome-wide association study design. ..