John Eisenach

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Sex differences in salt sensitivity to nitric oxide dependent vasodilation in healthy young adults
    John H Eisenach
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 112:1049-53. 2012
  2. ncbi Hyperhidrosis: evolving therapies for a well-established phenomenon
    John H Eisenach
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 80:657-66. 2005
  3. ncbi A comparison of peripheral skin blood flow and temperature during endoscopic thoracic sympathotomy
    John H Eisenach
    Mayo Clinic, Department of Anesthesiology, 200 First St S W, Rochester, MN 55905, USA
    Anesth Analg 100:269-76. 2005
  4. ncbi Arg16/Gly beta2-adrenergic receptor polymorphism alters the cardiac output response to isometric exercise
    John H Eisenach
    Dept of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 99:1776-81. 2005
  5. doi {beta}-Adrenoceptor gene variation and intermediate physiological traits: prediction of distant phenotype
    John H Eisenach
    Departments of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Exp Physiol 95:757-64. 2010
  6. pmc Dietary sodium restriction and beta2-adrenergic receptor polymorphism modulate cardiovascular function in humans
    John H Eisenach
    Department of Anaesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Physiol 574:955-65. 2006
  7. ncbi Effects of chronic sympathectomy on vascular function in the human forearm
    John H Eisenach
    Department of Anesthesiology, General Clinical Research Center, Mayo Clinic and Mayo Medical School, Rochester, Minnesota 55905, USA
    J Appl Physiol 92:2019-25. 2002
  8. ncbi The Arg16/Gly beta2-adrenergic receptor polymorphism is associated with altered cardiovascular responses to isometric exercise
    John H Eisenach
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Physiol Genomics 16:323-8. 2004
  9. pmc Sex and ageing differences in resting arterial pressure regulation: the role of the β-adrenergic receptors
    Emma C Hart
    Department of Anaesthesiology, Mayo Clinic, Rochester, MN, USA
    J Physiol 589:5285-97. 2011
  10. ncbi Reduced forearm alpha1-adrenergic vasoconstriction is associated with enhanced heart rate fluctuations in humans
    Shizue Masuki
    Dept of Anesthesiology, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, and Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA
    J Appl Physiol 100:792-9. 2006

Detail Information

Publications41

  1. pmc Sex differences in salt sensitivity to nitric oxide dependent vasodilation in healthy young adults
    John H Eisenach
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 112:1049-53. 2012
    ..We conclude that the NO component of endothelium-dependent vasodilation is altered by dietary sodium intake based on sex, suggesting that endothelial NO production is sensitive to dietary sodium in healthy young men but not women...
  2. ncbi Hyperhidrosis: evolving therapies for a well-established phenomenon
    John H Eisenach
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 80:657-66. 2005
    ..No sole therapy of choice has emerged for craniofacial sweating. The long-term sequelae of hyperhidrosis and its treatment also are discussed...
  3. ncbi A comparison of peripheral skin blood flow and temperature during endoscopic thoracic sympathotomy
    John H Eisenach
    Mayo Clinic, Department of Anesthesiology, 200 First St S W, Rochester, MN 55905, USA
    Anesth Analg 100:269-76. 2005
    ..We conclude that laser Doppler SkBF is superior to temp in temporal resolution for assessment of denervation during sympathotomy and that it provides a superior qualitative and quantitative adjunct to monitoring denervation...
  4. ncbi Arg16/Gly beta2-adrenergic receptor polymorphism alters the cardiac output response to isometric exercise
    John H Eisenach
    Dept of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 99:1776-81. 2005
    ..The influence of polymorphic variants in the beta2-adrenergic receptor gene on the cardiovascular response to sympathoexcitation may have important implications in the development of hypertension and heart failure...
  5. doi {beta}-Adrenoceptor gene variation and intermediate physiological traits: prediction of distant phenotype
    John H Eisenach
    Departments of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Exp Physiol 95:757-64. 2010
    ....
  6. pmc Dietary sodium restriction and beta2-adrenergic receptor polymorphism modulate cardiovascular function in humans
    John H Eisenach
    Department of Anaesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Physiol 574:955-65. 2006
    ..This study provides evidence that dietary Na+ modulates effects of the Arg16Gly polymorphism on cardiovascular function...
  7. ncbi Effects of chronic sympathectomy on vascular function in the human forearm
    John H Eisenach
    Department of Anesthesiology, General Clinical Research Center, Mayo Clinic and Mayo Medical School, Rochester, Minnesota 55905, USA
    J Appl Physiol 92:2019-25. 2002
    ..The normal vasoconstrictor responses to tyramine indicate that there were viable sympathetic nerves in the forearm that were not engaged by LBNP...
  8. ncbi The Arg16/Gly beta2-adrenergic receptor polymorphism is associated with altered cardiovascular responses to isometric exercise
    John H Eisenach
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Physiol Genomics 16:323-8. 2004
    ....
  9. pmc Sex and ageing differences in resting arterial pressure regulation: the role of the β-adrenergic receptors
    Emma C Hart
    Department of Anaesthesiology, Mayo Clinic, Rochester, MN, USA
    J Physiol 589:5285-97. 2011
    ..Our data suggest that the β-adrenergic receptors offset α-adrenergic vasoconstriction in young women but not young men or PM women. These findings may explain in part the tendency for blood pressure to rise after menopause in women...
  10. ncbi Reduced forearm alpha1-adrenergic vasoconstriction is associated with enhanced heart rate fluctuations in humans
    Shizue Masuki
    Dept of Anesthesiology, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, and Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA
    J Appl Physiol 100:792-9. 2006
    ..These results suggest that, in healthy young subjects, the enhanced HR response to changes in systolic pressure helps maintain the stability of arterial blood pressure when alpha1-adrenergic responsiveness is reduced...
  11. ncbi Effects of chronic sympathectomy on locally mediated cutaneous vasodilation in humans
    Nisha Charkoudian
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Appl Physiol 92:685-90. 2002
    ..These data indicate that endothelial function in human skin is largely preserved after sympathectomy. The altered pattern of the response suggests that the nitric oxide-dependent portion may be accelerated in sympathectomized limbs...
  12. pmc Post-junctional alpha-adrenoceptors and basal limb vascular tone in healthy men
    Frank A Dinenno
    Department of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Physiol 540:1103-10. 2002
    ..The potential physiological and pathophysiological implications of these findings are discussed...
  13. pmc beta2-Adrenoceptor gene variation and systemic vasodilatation during ganglionic blockade
    Christiane Hesse
    Department of Anaesthesiology, Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Physiol 588:2669-78. 2010
    ....
  14. pmc Effects of respiratory muscle work on blood flow distribution during exercise in heart failure
    Thomas P Olson
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    J Physiol 588:2487-501. 2010
    ..Further, HF patients are unable to vasoconstrict locomotor vascular beds beyond NB when presented with a respiratory load...
  15. ncbi Arterial baroreflex control of heart rate during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1136-42. 2007
    ..These results suggest that the tachycardia during exercise in POTS was not due to abnormal baroreflex control of HR...
  16. ncbi John H. Eisenach, M.D., recipient of the 2008 Presidential Scholar Award
    Bradly J Narr
    Department of Anesthesiology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Anesthesiology 109:374-6. 2008
  17. ncbi Arterioventricular coupling and ventricular efficiency after antihypertensive therapy: a noninvasive prospective study
    Martin Osranek
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 51:275-81. 2008
    ..This occurs before significant changes in ventricular geometry and may be responsible for early clinical improvements...
  18. pmc Cardiovascular dynamics in healthy subjects with differing heart rate responses to tilt
    Farah A Ramirez-Marrero
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Appl Physiol 105:1448-53. 2008
    ..Although interindividual variability appears to be a fundamental part of cardiovascular regulation, the mechanisms of these differences and the sex discrepancy requires further investigation...
  19. pmc Aging is associated with reduced prostacyclin-mediated dilation in the human forearm
    Wayne T Nicholson
    Department of Anesthesiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Hypertension 53:973-8. 2009
    ..Our data suggest that the reduced dilator effects of PGI(2) in older individuals are attributable to a reduction in the contribution of endothelial-derived NO versus alterations in the direct effects of PGI(2) on vascular smooth muscle...
  20. pmc Sex differences in sympathetic neural-hemodynamic balance: implications for human blood pressure regulation
    Emma C Hart
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 53:571-6. 2009
    ..These findings may have important implications for understanding how hypertension and other disorders of blood pressure regulation occur in men and women...
  21. pmc Age-related differences in the sympathetic-hemodynamic balance in men
    Emma C Hart
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Hypertension 54:127-33. 2009
    ....
  22. pmc Adenosine receptor antagonist and augmented vasodilation during hypoxic exercise
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 107:1128-37. 2009
    ..05 for both). These observations suggest that adenosine receptor activation is not obligatory for the augmented hyperemia during hypoxic exercise in humans...
  23. pmc Nitric oxide contributes to the augmented vasodilatation during hypoxic exercise
    Darren P Casey
    Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    J Physiol 588:373-85. 2010
    ..7 vs. -21.4 +/- 5.2%; P = 0.28) and 20% (-13.4 +/- 3.5 vs. -18.8 +/- 4.5%; P = 0.18) hypoxic exercise. These findings suggest that NO contributes to the augmented vasodilatation observed during hypoxic exercise independent of adenosine...
  24. ncbi Balance between sympathetic response to head-up tilt and cardiac vagal factors in healthy humans
    Farah A Ramirez-Marrero
    Dept of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Clin Auton Res 17:227-30. 2007
    ..BRS was negatively correlated with NE response to HUT (r = -0.36, P < 0.05), suggesting that subjects with high vagal modulation (high BRS) require less sympathetic response (NE) to maintain normotension during orthostatic stress...
  25. pmc Influences of hydration on post-exercise cardiovascular control in humans
    Nisha Charkoudian
    Department of Anaesthesiology, Mayo Clinic and Foundation, Rochester, MN, USA
    J Physiol 552:635-44. 2003
    ..We conclude that exercise-induced dehydration causes post-exercise changes in the baroreflex control of blood pressure that may contribute to, rather than offset, orthostatic intolerance...
  26. ncbi Effects of midodrine on exercise-induced hypotension and blood pressure recovery in autonomic failure
    William G Schrage
    Department of Anesthesia Research, Joseph 4 184W, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol 97:1978-84. 2004
    ..02). We conclude midodrine improves blood pressure and TPR during exercise and dramatically improves the recovery of MAP after exercise...
  27. ncbi Agonist-dependent variablity of contributions of nitric oxide and prostaglandins in human skeletal muscle
    William G Schrage
    Dept of Anesthesiology, Joseph 4 184W, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol 98:1251-7. 2005
    ..The NOS + COX-independent dilation does not appear sensitive to feedback inhibition from NO in the human forearm...
  28. ncbi Selective alpha2-adrenergic properties of dexmedetomidine over clonidine in the human forearm
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Appl Physiol 99:587-92. 2005
    ..The similar vasoconstrictor responses to both drugs after prazosin might be explained by the presynaptic effects on norepinephrine release...
  29. ncbi Intrathecal anesthesia and recovery from radical prostatectomy: a prospective, randomized, controlled trial
    Daniel R Brown
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Anesthesiology 100:926-34. 2004
    ..The authors tested the hypothesis that the addition of intrathecal analgesia to general anesthesia would improve long-term functional status and decrease pain in patients undergoing radical retropubic prostatectomy...
  30. pmc Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with differences in cardiovascular function at rest and during exercise in humans
    Eric M Snyder
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 1st Street, SW, Rochester, MN 55905, USA
    J Physiol 571:121-30. 2006
    ..This may suggest possible genotype-related differences in baseline receptor function or density which causes phenotypic differences at rest that are sustained during short-term exercise...
  31. ncbi Bimodal distribution of vasodilator responsiveness to adenosine due to difference in nitric oxide contribution: implications for exercise hyperemia
    Elizabeth A Martin
    Dept of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 101:492-9. 2006
    ..Finally, our data support the concept that neither Ado nor nitric oxide is obligatory for exercise hyperemia...
  32. pmc The Arg16Gly polymorphism of the beta2-adrenergic receptor and the natriuretic response to rapid saline infusion in humans
    Eric M Snyder
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Physiol 574:947-54. 2006
    ..28 +/- 0.03; P < 0.01). These results suggest that the Arg16Gly polymorphism of the beta2AR is associated with differences in natriuretic response to rapid saline infusion, which may influence long-term regulation of blood pressure...
  33. ncbi Influences of adenosine receptor antagonism on vasodilator responses to adenosine and exercise in adenosine responders and nonresponders
    Elizabeth A Martin
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    J Appl Physiol 101:1678-84. 2006
    ..05 before vs. after Aph). We conclude that there may be reduced Ado receptor responsiveness or sensitivity in nonresponders. Furthermore, Ado may play a limited role exercise hyperemia in both subgroups...
  34. ncbi Beta-2 adrenergic receptor polymorphisms and the forearm blood flow response to mental stress
    Zhong Liu
    Dept of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Auton Res 16:105-12. 2006
    ..Furthermore, the Arg16/Gly beta2-receptor polymorphism has no significant influence on the FBF or cardiovascular responses to mental stress...
  35. pmc Adenosine transporter antagonism in humans augments vasodilator responsiveness to adenosine, but not exercise, in both adenosine responders and non-responders
    Elizabeth A Martin
    Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Physiol 579:237-45. 2007
    ..The failure of DIP to augment exercise hyperemia under these conditions suggests that ADO concentrations may not rise enough during rhythmic handgripping to have a major impact on these responses...
  36. pmc Forearm vascular conductance during mental stress is related to the heart rate response
    Tasha L Pike
    Clinical Research Unit, Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First St S W, Rochester, MN 55905, USA
    Clin Auton Res 19:183-7. 2009
    ..This suggests that the mechanical stimulation is one of the key factors that contribute to the increase in FVC during mental stress...
  37. ncbi Baroreflex sensitivity inversely correlates with ambulatory blood pressure in healthy normotensive humans
    Christiane Hesse
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Hypertension 50:41-6. 2007
    ..Furthermore, the inverse relation between baroreflex sensitivity and mean arterial pressure supports the idea that the baroreflex may exert longer-term effects on blood pressure than thought previously...
  38. ncbi Reduced stroke volume during exercise in postural tachycardia syndrome
    Shizue Masuki
    Department of Anesthesiology, Mayo Clinic Foundation, Rochester, MN 55905, USA
    J Appl Physiol 103:1128-35. 2007
    ..60), and 75 W (R(2) = 0.32) (P < 0.01). These results suggest that greater elevation in HR in POTS patients during exercise, especially while upright, was secondary to reduced SV and associated with exercise intolerance...
  39. ncbi Alternative to ganglionic blockade with anticholinergic and alpha-2 receptor agents
    Brad W Wilkins
    Dept of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Auton Res 17:77-84. 2007
    ..05). Heart rate only decreased 1 +/- 2 bpm during GLY: -DEX: and 1 +/- 1 bpm with TMP. Taken together, our results suggest that GLY: -DEX: is a reasonable alternative to TMP for baroreflex inhibition...
  40. ncbi Excessive heart rate response to orthostatic stress in postural tachycardia syndrome is not caused by anxiety
    Shizue Masuki
    Dept of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Appl Physiol 102:896-903. 2007
    ..1). These results suggest that the HR response to orthostatic stress in POTS patients is not caused by anxiety but that it is a physiological response that maintains arterial pressure during venous pooling...
  41. pmc Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans
    William G Schrage
    Department of Kinesiology, 1149A Natatorium, University of Wisconsin, Madison, WI 53706, USA
    J Physiol 579:227-36. 2007
    ..Lower exercise hyperaemia in older humans may be mediated in part by less NO- and PG-mediated vasodilatation during exercise...

Research Grants9

  1. Beta-2 Receptor Polymorphisms and Vasodilation in Humans
    John Eisenach; Fiscal Year: 2003
    ..My long-term career goals is to become an independent investigator performing physiology and pharmacology studies directed at the genomics of the cardiovascular system in humans. ..
  2. Beta-2 Receptor Polymorphisms and Vasodilation in Humans
    John Eisenach; Fiscal Year: 2006
    ..My long-term career goals is to become an independent investigator performing physiology and pharmacology studies directed at the genomics of the cardiovascular system in humans. ..
  3. Beta-2 Receptor Polymorphisms and Vasodilation in Humans
    John Eisenach; Fiscal Year: 2007
    ..My long-term career goal is to become an independent investigator performing physiology and pharmacology studies directed at the genomics of the cardiovascular system in humans. ..
  4. Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in Humans
    John Eisenach; Fiscal Year: 2009
    ....
  5. Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in Humans
    John H Eisenach; Fiscal Year: 2010
    ....
  6. Beta2-Adrenergic Receptor Gene Variation and Cardiovascular Control in Humans
    John Eisenach; Fiscal Year: 2009
    ....