Affiliation: Mayo Clinic
- Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasionTim Eiseler
Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Breast Cancer Res 11:R13. 2009..The biological and molecular events that regulate the invasiveness of breast tumour cells need to be further revealed to develop effective therapies that stop breast cancer from expanding and metastasising...
- Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshotTim Eiseler
Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
Nat Cell Biol 11:545-56. 2009..Consequently, expression of constitutively active PKD1 in invasive tumour cells enhanced the phosphorylation of cofilin and effectively blocked the formation of free actin-filament barbed ends and directed cell migration...
- Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1Catherine F Cowell
Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
J Cell Biochem 106:714-28. 2009..We propose that this pathway is of relevance for epithelial tumor cell biology, where loss of cell-cell contacts has been implicated in regulating cell survival and motility...
- Neuregulin mediates F-actin-driven cell migration through inhibition of protein kinase D1 via Rac1 proteinHeike Döppler
Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Jacksonville, Florida 32224, USA
J Biol Chem 288:455-65. 2013..Our data provide a mechanism through which the Rho GTPase Rac1 cross-talks with PKD1 signaling pathways to facilitate directed cell migration...