Research Topics
Species | A O EdwardsSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease studyAlbert O Edwards
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States of America
PLoS ONE 3:e3813. 2008..Relying on a significant genotype tests using a log-additive model would have excluded 57% of the non-replicated and none of the replicated loci, while use of other SNP features and clustering might have missed true associations...- Density of common complex ocular traits in the aging eye: analysis of secondary traits in genome-wide association studiesAlbert O Edwards
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States of America
PLoS ONE 3:e2510. 2008.... 
Toll-like receptor polymorphisms and age-related macular degenerationAlbert O Edwards
Department of Ophthalmology, Mayor Clinic, Rochester, MN 55905, USA
Invest Ophthalmol Vis Sci 49:1652-9. 2008..The purpose of this study was to determine whether common variation in the 10 human toll-like receptors (TLRs) alters the risk of AMD...- Clinical features of the congenital vitreoretinopathiesA O Edwards
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
Eye (Lond) 22:1233-42. 2008..Theses diseases share overlapping clinical features with common complex traits affecting the eye (myopia, corneal endothelial dystrophy, lattice degeneration), and may provide insight into the mechanisms of common eye diseases... - Same-day triple therapy with photodynamic therapy, intravitreal dexamethasone, and bevacizumab in wet age-related macular degenerationSophie J Bakri
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
Retina 29:573-8. 2009..To report the results of same-day triple therapy with reduced fluence photodynamic therapy, intravitreal dexamethasone, and bevacizumab in patients with neovascular age-related macular degeneration... - Persisent ocular hypertension following intravitreal ranibizumabSophie J Bakri
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
Graefes Arch Clin Exp Ophthalmol 246:955-8. 2008..To describe the occurrence of ocular hypertension in four patients following injection of ranibizumab intravitreally... 
A novel gene for autosomal dominant Stargardt-like macular dystrophy with homology to the SUR4 protein familyA O Edwards
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
Invest Ophthalmol Vis Sci 42:2652-63. 2001..To describe a novel gene causing a Stargardt-like phenotype in a family with dominant macular dystrophy and the exclusion of all known genes within the disease locus...- Intraocular inflammation following intravitreal injection of bevacizumabSophie J Bakri
Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Graefes Arch Clin Exp Ophthalmol 246:779-81. 2008..Failure to recognize an eye with anterior chamber and vitreous cell as sterile inflammation can lead to unnecessary treatment for endophthalmitis... - Renal-coloboma syndrome: report of a novel PAX2 gene mutationG W Chung
Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 0957, USA
Am J Ophthalmol 132:910-4. 2001..To report a novel sporadic PAX2 gene mutation in a child with atypical bilateral optic nerve coloboma and congenital renal hypoplasia... - Genetics of age-related macular degenerationAlbert O Edwards
Mayo Clinic, Department of Ophthalmology, 200 First Street SW, Rochester, MN 55905, USA
Adv Exp Med Biol 613:211-9. 2008 - Common variation in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjectsKyu Hyung Park
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
Mol Vis 15:200-7. 2009..This study was performed to replicate the association between SERPING1 and AMD... - Infectious endophthalmitis after intravitreal injection of antiangiogenic agentsTeresa Diago
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
Retina 29:601-5. 2009..To evaluate the rate of infectious endophthalmitis associated with intravitreal injection of bevacizumab, ranibizumab, and pegaptanib sodium... - Bilateral simultaneous intravitreal injections in the office settingSophie J Bakri
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Ophthalmol 148:66-9.e1. 2009..To report the outcomes and complications of bilateral simultaneous intravitreal injections performed in the office... - Genetic control of the alternative pathway of complement in humans and age-related macular degenerationLaura A Hecker
Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
Hum Mol Genet 19:209-15. 2010.... - Genetic control of complement activation in humans and age related macular degenerationLaura A Hecker
Mayo Clinic, Rochester, MN 55905, USA
Adv Exp Med Biol 703:49-62. 2010..Thus, preventing the accumulation of the inflammatory debris underneath the retina could be expected to alleviate much of the vision loss from this devastating disease... - Expression of recombinant protein encoded by LOC387715 in Escherichia coliDequan Chen
Institute for Retina Research, Presbyterian Hospital, 8210 Walnut Hill Lane, Dallas, TX 75231, USA
Protein Expr Purif 54:275-82. 2007..coli was achieved by the synonymous modification of its native ORF cDNA sequence for all the 3 groups of bacterial RCs and the simultaneous elimination of SDLS and RBSCS sequences... - Autosomal dominant Stargardt-like macular dystrophy: I. Clinical characterization, longitudinal follow-up, and evidence for a common ancestry in families linked to chromosome 6q14A O Edwards
Casey Eye Institute, Department of Ophthalmology, Oregon Health Sciences University, Portland, USA
Am J Ophthalmol 127:426-35. 1999..Characterize the phenotype of autosomal dominant Stargardt-like macular dystrophy in two families linked to chromosome 6q14 and determine whether they share a common ancestry... - Complement component 3 (C3) haplotypes and risk of advanced age-related macular degenerationKyu Hyung Park
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
Invest Ophthalmol Vis Sci 50:3386-93. 2009..Nonsynonymous coding single nucleotide polymorphisms (nsSNPs) in complement component 3 (C3) alter the risk of age-related macular degeneration (AMD). This was a study of the effect of haplotypes across C3 on AMD risk... - Molecular genetics of AMD and current animal modelsAlbert O Edwards
Department of Ophthalmology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
Angiogenesis 10:119-32. 2007..No effort has been made to perform a comprehensive citation of all areas of AMD genetics and animal models, but rather a selection of observations and supporting references illustrative of the current state of the field is presented... - Contribution of copy number variation in the regulation of complement activation locus to development of age-related macular degenerationKatharina E Schmid-Kubista
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
Invest Ophthalmol Vis Sci 50:5070-9. 2009.... - E2-2 protein and Fuchs's corneal dystrophyKeith H Baratz
Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA
N Engl J Med 363:1016-24. 2010..Although rare genetic variation that contributes to both early-onset and typical late-onset forms of FCD has been identified, to our knowledge, no common variants have been reported... - Central retinal artery occlusion following forehead injection with a corticosteroid suspensionAlbert O Edwards
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, MN 55905, USA
Pediatr Dermatol 25:460-1. 2008..Injection into or near the ocular adnexa may be performed in small boluses to reduce the chance of retinal embolization following entry into the arterial system... - Posterior chorioretinal atrophy and vitreous phenotype in a family with Stickler syndrome from a mutation in the COL2A1 geneCuong D Vu
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Ophthalmology 110:70-7. 2003..To report posterior chorioretinal atrophy (PCRA) and correlate the vitreous phenotype with inheritance of the disease mutation in a family with vitreoretinal dystrophy... - Intraoperative explosion of prefilled silicone oil syringesTimmy A Kovoor
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Retina 25:942-3. 2005 - Peripherin/RDS and VMD2 mutations in macular dystrophies with adult-onset vitelliform lesionStanislav A Zhuk
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Mol Vis 12:811-5. 2006..The purpose of this investigation was to determine the prevalence of mutations in these two genes in a cohort of cases with macular dystrophies presenting with vitelliform lesions in adulthood... - Snowflake vitreoretinal degeneration: follow-up of the original familyMike M Lee
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Ophthalmology 110:2418-26. 2003..These findings and the exclusion of known genetic loci suggest snowflake is a distinct vitreoretinal degeneration... - Complement factor H polymorphism and age-related macular degenerationAlbert O Edwards
Department of Ophthalmology and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center UTSWMC, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Science 308:421-4. 2005..Possession of at least one histidine at amino acid position 402 increased the risk of AMD 2.7-fold and may account for 50% of the attributable risk of AMD... - Age-related macular degeneration--a genome scan in extended familiesJacek Majewski
Laboratory of Statistical Genetics, Rockefeller University, New York, NY, USA
Am J Hum Genet 73:540-50. 2003..Our study has identified new loci that should be considered in future mapping and mutational analyses of AMD and has strengthened the evidence in support of loci suggested by other studies... - Identification of a stop codon mutation in exon 2 of the collagen 2A1 gene in a large stickler syndrome familyLarry A Donoso
Henry and Corinne Bower Laboratory, Wills Eye Hospital, Philadelphia, Pennsylvania 19107, USA
Am J Ophthalmol 134:720-7. 2002..To describe the clinical features and identify the mutation responsible for an autosomal dominant vitreoretinal degeneration occurring in a previously unreported large family... - Shape discrimination in age-related macular degenerationYi Zhong Wang
Retina Foundation of the Southwest, Dallas, Texas 75231, USA
Invest Ophthalmol Vis Sci 43:2055-62. 2002..In this study, the ability of patients with age-related macular degeneration (AMD) to perform the shape-discrimination task was examined... - Genetic linkage of snowflake vitreoretinal degeneration to chromosome 2q36Xiaodong Jiao
Ophthalmic Genetics and Clinical Services Branch, National Eye Institute, Bethesda, Maryland, USA
Invest Ophthalmol Vis Sci 45:4498-503. 2004.... - Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivoAnne Kasus-Jacobi
Departmens of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 280:20413-20. 2005..We propose that mRDH11 disruption affects retinoid metabolism in photoreceptor inner segments and delays the kinetics of dark adaptation through modulation of calcium homeostasis... - Genetic testing for age-related macular degenerationAlbert O Edwards
Ophthalmology 113:509-10. 2006 - IDOCS: intelligent distributed ontology consensus system--the use of machine learning in retinal drusen phenotypingGeorge Thomas
Department of Computer Science, University of Iowa, Iowa City, Iowa, USA
Invest Ophthalmol Vis Sci 48:2278-84. 2007..To use the power of knowledge acquisition and machine learning in the development of a collaborative computer classification system based on the features of age-related macular degeneration (AMD)...