A O Edwards

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease study
    Albert O Edwards
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 3:e3813. 2008
  2. pmc Density of common complex ocular traits in the aging eye: analysis of secondary traits in genome-wide association studies
    Albert O Edwards
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 3:e2510. 2008
  3. doi Toll-like receptor polymorphisms and age-related macular degeneration
    Albert O Edwards
    Department of Ophthalmology, Mayor Clinic, Rochester, MN 55905, USA
    Invest Ophthalmol Vis Sci 49:1652-9. 2008
  4. doi Clinical features of the congenital vitreoretinopathies
    A O Edwards
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Eye (Lond) 22:1233-42. 2008
  5. doi Same-day triple therapy with photodynamic therapy, intravitreal dexamethasone, and bevacizumab in wet age-related macular degeneration
    Sophie J Bakri
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Retina 29:573-8. 2009
  6. doi Persisent ocular hypertension following intravitreal ranibizumab
    Sophie J Bakri
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Graefes Arch Clin Exp Ophthalmol 246:955-8. 2008
  7. ncbi A novel gene for autosomal dominant Stargardt-like macular dystrophy with homology to the SUR4 protein family
    A O Edwards
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Invest Ophthalmol Vis Sci 42:2652-63. 2001
  8. doi Intraocular inflammation following intravitreal injection of bevacizumab
    Sophie J Bakri
    Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Graefes Arch Clin Exp Ophthalmol 246:779-81. 2008
  9. ncbi Renal-coloboma syndrome: report of a novel PAX2 gene mutation
    G W Chung
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 0957, USA
    Am J Ophthalmol 132:910-4. 2001
  10. doi Genetics of age-related macular degeneration
    Albert O Edwards
    Mayo Clinic, Department of Ophthalmology, 200 First Street SW, Rochester, MN 55905, USA
    Adv Exp Med Biol 613:211-9. 2008

Collaborators

Detail Information

Publications34

  1. pmc Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease study
    Albert O Edwards
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 3:e3813. 2008
    ..Relying on a significant genotype tests using a log-additive model would have excluded 57% of the non-replicated and none of the replicated loci, while use of other SNP features and clustering might have missed true associations...
  2. pmc Density of common complex ocular traits in the aging eye: analysis of secondary traits in genome-wide association studies
    Albert O Edwards
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 3:e2510. 2008
    ....
  3. doi Toll-like receptor polymorphisms and age-related macular degeneration
    Albert O Edwards
    Department of Ophthalmology, Mayor Clinic, Rochester, MN 55905, USA
    Invest Ophthalmol Vis Sci 49:1652-9. 2008
    ..The purpose of this study was to determine whether common variation in the 10 human toll-like receptors (TLRs) alters the risk of AMD...
  4. doi Clinical features of the congenital vitreoretinopathies
    A O Edwards
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Eye (Lond) 22:1233-42. 2008
    ..Theses diseases share overlapping clinical features with common complex traits affecting the eye (myopia, corneal endothelial dystrophy, lattice degeneration), and may provide insight into the mechanisms of common eye diseases...
  5. doi Same-day triple therapy with photodynamic therapy, intravitreal dexamethasone, and bevacizumab in wet age-related macular degeneration
    Sophie J Bakri
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Retina 29:573-8. 2009
    ..To report the results of same-day triple therapy with reduced fluence photodynamic therapy, intravitreal dexamethasone, and bevacizumab in patients with neovascular age-related macular degeneration...
  6. doi Persisent ocular hypertension following intravitreal ranibizumab
    Sophie J Bakri
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Graefes Arch Clin Exp Ophthalmol 246:955-8. 2008
    ..To describe the occurrence of ocular hypertension in four patients following injection of ranibizumab intravitreally...
  7. ncbi A novel gene for autosomal dominant Stargardt-like macular dystrophy with homology to the SUR4 protein family
    A O Edwards
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9057, USA
    Invest Ophthalmol Vis Sci 42:2652-63. 2001
    ..To describe a novel gene causing a Stargardt-like phenotype in a family with dominant macular dystrophy and the exclusion of all known genes within the disease locus...
  8. doi Intraocular inflammation following intravitreal injection of bevacizumab
    Sophie J Bakri
    Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Graefes Arch Clin Exp Ophthalmol 246:779-81. 2008
    ..Failure to recognize an eye with anterior chamber and vitreous cell as sterile inflammation can lead to unnecessary treatment for endophthalmitis...
  9. ncbi Renal-coloboma syndrome: report of a novel PAX2 gene mutation
    G W Chung
    Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 0957, USA
    Am J Ophthalmol 132:910-4. 2001
    ..To report a novel sporadic PAX2 gene mutation in a child with atypical bilateral optic nerve coloboma and congenital renal hypoplasia...
  10. doi Genetics of age-related macular degeneration
    Albert O Edwards
    Mayo Clinic, Department of Ophthalmology, 200 First Street SW, Rochester, MN 55905, USA
    Adv Exp Med Biol 613:211-9. 2008
  11. pmc Common variation in the SERPING1 gene is not associated with age-related macular degeneration in two independent groups of subjects
    Kyu Hyung Park
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Mol Vis 15:200-7. 2009
    ..This study was performed to replicate the association between SERPING1 and AMD...
  12. doi Infectious endophthalmitis after intravitreal injection of antiangiogenic agents
    Teresa Diago
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Retina 29:601-5. 2009
    ..To evaluate the rate of infectious endophthalmitis associated with intravitreal injection of bevacizumab, ranibizumab, and pegaptanib sodium...
  13. doi Bilateral simultaneous intravitreal injections in the office setting
    Sophie J Bakri
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Ophthalmol 148:66-9.e1. 2009
    ..To report the outcomes and complications of bilateral simultaneous intravitreal injections performed in the office...
  14. pmc Genetic control of the alternative pathway of complement in humans and age-related macular degeneration
    Laura A Hecker
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Hum Mol Genet 19:209-15. 2010
    ....
  15. doi Genetic control of complement activation in humans and age related macular degeneration
    Laura A Hecker
    Mayo Clinic, Rochester, MN 55905, USA
    Adv Exp Med Biol 703:49-62. 2010
    ..Thus, preventing the accumulation of the inflammatory debris underneath the retina could be expected to alleviate much of the vision loss from this devastating disease...
  16. pmc Expression of recombinant protein encoded by LOC387715 in Escherichia coli
    Dequan Chen
    Institute for Retina Research, Presbyterian Hospital, 8210 Walnut Hill Lane, Dallas, TX 75231, USA
    Protein Expr Purif 54:275-82. 2007
    ..coli was achieved by the synonymous modification of its native ORF cDNA sequence for all the 3 groups of bacterial RCs and the simultaneous elimination of SDLS and RBSCS sequences...
  17. ncbi Autosomal dominant Stargardt-like macular dystrophy: I. Clinical characterization, longitudinal follow-up, and evidence for a common ancestry in families linked to chromosome 6q14
    A O Edwards
    Casey Eye Institute, Department of Ophthalmology, Oregon Health Sciences University, Portland, USA
    Am J Ophthalmol 127:426-35. 1999
    ..Characterize the phenotype of autosomal dominant Stargardt-like macular dystrophy in two families linked to chromosome 6q14 and determine whether they share a common ancestry...
  18. doi Complement component 3 (C3) haplotypes and risk of advanced age-related macular degeneration
    Kyu Hyung Park
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 50:3386-93. 2009
    ..Nonsynonymous coding single nucleotide polymorphisms (nsSNPs) in complement component 3 (C3) alter the risk of age-related macular degeneration (AMD). This was a study of the effect of haplotypes across C3 on AMD risk...
  19. ncbi Molecular genetics of AMD and current animal models
    Albert O Edwards
    Department of Ophthalmology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
    Angiogenesis 10:119-32. 2007
    ..No effort has been made to perform a comprehensive citation of all areas of AMD genetics and animal models, but rather a selection of observations and supporting references illustrative of the current state of the field is presented...
  20. doi Contribution of copy number variation in the regulation of complement activation locus to development of age-related macular degeneration
    Katharina E Schmid-Kubista
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 50:5070-9. 2009
    ....
  21. doi E2-2 protein and Fuchs's corneal dystrophy
    Keith H Baratz
    Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA
    N Engl J Med 363:1016-24. 2010
    ..Although rare genetic variation that contributes to both early-onset and typical late-onset forms of FCD has been identified, to our knowledge, no common variants have been reported...
  22. doi Central retinal artery occlusion following forehead injection with a corticosteroid suspension
    Albert O Edwards
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, MN 55905, USA
    Pediatr Dermatol 25:460-1. 2008
    ..Injection into or near the ocular adnexa may be performed in small boluses to reduce the chance of retinal embolization following entry into the arterial system...
  23. ncbi Posterior chorioretinal atrophy and vitreous phenotype in a family with Stickler syndrome from a mutation in the COL2A1 gene
    Cuong D Vu
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Ophthalmology 110:70-7. 2003
    ..To report posterior chorioretinal atrophy (PCRA) and correlate the vitreous phenotype with inheritance of the disease mutation in a family with vitreoretinal dystrophy...
  24. ncbi Intraoperative explosion of prefilled silicone oil syringes
    Timmy A Kovoor
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Retina 25:942-3. 2005
  25. ncbi Peripherin/RDS and VMD2 mutations in macular dystrophies with adult-onset vitelliform lesion
    Stanislav A Zhuk
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Mol Vis 12:811-5. 2006
    ..The purpose of this investigation was to determine the prevalence of mutations in these two genes in a cohort of cases with macular dystrophies presenting with vitelliform lesions in adulthood...
  26. ncbi Snowflake vitreoretinal degeneration: follow-up of the original family
    Mike M Lee
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Ophthalmology 110:2418-26. 2003
    ..The ocular findings, systemic features, and genetic loci distinguishing known genetic causes of vitreoretinal degenerations were studied in the original Snowflake family...
  27. ncbi Complement factor H polymorphism and age-related macular degeneration
    Albert O Edwards
    Department of Ophthalmology and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center UTSWMC, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Science 308:421-4. 2005
    ..Possession of at least one histidine at amino acid position 402 increased the risk of AMD 2.7-fold and may account for 50% of the attributable risk of AMD...
  28. pmc Age-related macular degeneration--a genome scan in extended families
    Jacek Majewski
    Laboratory of Statistical Genetics, Rockefeller University, New York, NY, USA
    Am J Hum Genet 73:540-50. 2003
    ..Our study has identified new loci that should be considered in future mapping and mutational analyses of AMD and has strengthened the evidence in support of loci suggested by other studies...
  29. ncbi Identification of a stop codon mutation in exon 2 of the collagen 2A1 gene in a large stickler syndrome family
    Larry A Donoso
    Henry and Corinne Bower Laboratory, Wills Eye Hospital, Philadelphia, Pennsylvania 19107, USA
    Am J Ophthalmol 134:720-7. 2002
    ..To describe the clinical features and identify the mutation responsible for an autosomal dominant vitreoretinal degeneration occurring in a previously unreported large family...
  30. ncbi Shape discrimination in age-related macular degeneration
    Yi Zhong Wang
    Retina Foundation of the Southwest, Dallas, Texas 75231, USA
    Invest Ophthalmol Vis Sci 43:2055-62. 2002
    ..In this study, the ability of patients with age-related macular degeneration (AMD) to perform the shape-discrimination task was examined...
  31. ncbi Genetic linkage of snowflake vitreoretinal degeneration to chromosome 2q36
    Xiaodong Jiao
    Ophthalmic Genetics and Clinical Services Branch, National Eye Institute, Bethesda, Maryland, USA
    Invest Ophthalmol Vis Sci 45:4498-503. 2004
    ....
  32. ncbi Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo
    Anne Kasus-Jacobi
    Departmens of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 280:20413-20. 2005
    ..We propose that mRDH11 disruption affects retinoid metabolism in photoreceptor inner segments and delays the kinetics of dark adaptation through modulation of calcium homeostasis...
  33. ncbi Genetic testing for age-related macular degeneration
    Albert O Edwards
    Ophthalmology 113:509-10. 2006
  34. ncbi IDOCS: intelligent distributed ontology consensus system--the use of machine learning in retinal drusen phenotyping
    George Thomas
    Department of Computer Science, University of Iowa, Iowa City, Iowa, USA
    Invest Ophthalmol Vis Sci 48:2278-84. 2007
    ..To use the power of knowledge acquisition and machine learning in the development of a collaborative computer classification system based on the features of age-related macular degeneration (AMD)...