Leslie J Donato
Affiliation: Mayo Clinic
Donato L, Myhre N, Murray M, McDonah M, Myers J, Maxson J, et al
. Assessment of Test Performance and Potential for Environmental Contamination Associated with a Point-of-Care Molecular Assay for Group A Streptococcus in an End User Setting. J Clin Microbiol. 2019;57: pubmed publisher
..The cobas Liat platform and GAS assay demonstrated reliable performance in the end user setting and may serve as a rapid, POC option for routine diagnostic testing for certain infectious diseases, including GAS. ..
Donato L, Deobald G, Wockenfus A, Hornseth J, Saenger A, Karon B. Comparison of two point of care devices for capillary lipid screening in fasting and postprandial adults. Clin Biochem. 2015;48:174-6 pubmed publisher
Donato L, Meeusen J, Lieske J, Bergmann D, Sparwaßer A, Jaffe A. Analytical performance of an immunoassay to measure proenkephalin. Clin Biochem. 2018;58:72-77 pubmed publisher
..The association of PENK concentration with mGFR is influenced by gender, age, and history of kidney transplantation. Future studies will determine if blood PENK can be used clinically to estimate GFR and/or detect AKI. ..
Donato L, Karras R, Katzmann J, Murray D, Snyder M. Quantitation of circulating wild-type alpha-1-antitrypsin in heterozygous carriers of the S and Z deficiency alleles. Respir Res. 2015;16:96 pubmed publisher
..Given the wide range of circulating wild-type protein observed in heterozygous patients, this method has the potential to reveal correlations between allele concentration and development and/or severity of clinical symptoms. ..
Donato L, Meeusen J, Callanan H, Saenger A, Jaffe A. Advantages of the lipoprotein-associated phospholipase A2 activity assay. Clin Biochem. 2016;49:172-5 pubmed publisher
..The assay performance is significantly improved over the predecessor immunoassay allowing for adoption of Lp-PLA2 activity in clinical practice. ..
Donato L, Meeusen J, Jenkins S, Hartman S, Saenger A, Baumann N, et al
. Biological variability of lipoprotein-associated phospholipase A2 activity in healthy individuals. Clin Biochem. 2017;50:347-349 pubmed publisher
..The between individual variability and corresponding RCV for the activity assay are lower than previously reported results for the Lp-PLA2 mass assay. ..
Donato L, Snyder M, Greene D. Measuring and Interpreting Serum AAT Concentration. Methods Mol Biol. 2017;1639:21-32 pubmed publisher
..Emerging techniques for AAT quantitation by mass spectrometry are also described given that both AAT quantitation and allele identification can be performed on the same assay. ..
Donato L, Lueke A, Kenyon S, Meeusen J, Camilleri M. Description of analytical method and clinical utility of measuring serum 7-alpha-hydroxy-4-cholesten-3-one (7aC4) by mass spectrometry. Clin Biochem. 2018;52:106-111 pubmed publisher
..We have developed a sensitive and precise assay for measuring the concentration of 7aC4 in serum. The assay can be used to screen for diarrhea caused by bile acid malabsorption. ..