Mariza de Andrade

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc SNP interaction detection with Random Forests in high-dimensional genetic data
    Stacey J Winham
    Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    BMC Bioinformatics 13:164. 2012
  2. pmc Genetic analyses of smoking initiation, persistence, quantity, and age-at-onset of regular cigarette use in Brazilian families: the Baependi Heart Study
    Andréa R V R Horimoto
    Laboratory of Genetics and Molecular Cardiology, Heart Institute, Medical School of University of São Paulo, Av, Dr, Enéas de Carvalho Aguiar, 44, Sao Paulo, SP, 05403 000, Brazil
    BMC Med Genet 13:9. 2012
  3. pmc Comparison of variable and model selection methods for genetic association studies using the GAW15 simulated data
    Zhan Ye
    Department of Mathematical Sciences, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA
    BMC Proc 1:S34. 2007
  4. pmc Adjusting for HLA-DRbeta1 in a genome-wide association analysis of rheumatoid arthritis and related biomarkers
    Abigail G Matthews
    Laboratory of Statistical Genetics, Rockefeller University, Box 192, 1230 York Avenue, New York, NY 10065, USA
    BMC Proc 3:S12. 2009
  5. pmc Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules
    Wen Liu Mares
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    BMC Proc 1:S126. 2007
  6. pmc Identification of genes and haplotypes that predict rheumatoid arthritis using random forests
    Rui Tang
    Department of Health Sciences Research, 200 First Street Southwest, Mayo Clinic, Rochester, Minnesota 55905, USA
    BMC Proc 3:S68. 2009
  7. pmc Identification of gene-gene interaction using principal components
    Jia Li
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Harwick 776, Rochester, Minnesota 55905, USA
    BMC Proc 3:S78. 2009
  8. pmc Assessment of genotype imputation methods
    Joanna M Biernacka
    Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 USA
    BMC Proc 3:S5. 2009
  9. pmc Heritability of physical activity traits in Brazilian families: the Baependi Heart Study
    Andréa R V R Horimoto
    Laboratory of Genetics and Molecular Cardiology, Heart Institute, Medical School of University of São Paulo, Av, Dr, Enéas de Carvalho Aguiar, 44, Sao Paulo, SP, 05403 000, Brazil
    BMC Med Genet 12:155. 2011
  10. pmc Heritability of cardiovascular risk factors in a Brazilian population: Baependi Heart Study
    Camila M de Oliveira
    Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil
    BMC Med Genet 9:32. 2008

Research Grants

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. pmc SNP interaction detection with Random Forests in high-dimensional genetic data
    Stacey J Winham
    Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    BMC Bioinformatics 13:164. 2012
    ....
  2. pmc Genetic analyses of smoking initiation, persistence, quantity, and age-at-onset of regular cigarette use in Brazilian families: the Baependi Heart Study
    Andréa R V R Horimoto
    Laboratory of Genetics and Molecular Cardiology, Heart Institute, Medical School of University of São Paulo, Av, Dr, Enéas de Carvalho Aguiar, 44, Sao Paulo, SP, 05403 000, Brazil
    BMC Med Genet 13:9. 2012
    ..The purpose of this study was to estimate the genetic influences on the initiation of cigarette smoking, the persistence, quantity and age-at-onset of regular cigarette use in Brazilian families...
  3. pmc Comparison of variable and model selection methods for genetic association studies using the GAW15 simulated data
    Zhan Ye
    Department of Mathematical Sciences, Michigan Technological University, 1400 Townsend Drive, Houghton, Michigan 49931, USA
    BMC Proc 1:S34. 2007
    ..The answers to Problem 3 were requested and known to the authors...
  4. pmc Adjusting for HLA-DRbeta1 in a genome-wide association analysis of rheumatoid arthritis and related biomarkers
    Abigail G Matthews
    Laboratory of Statistical Genetics, Rockefeller University, Box 192, 1230 York Avenue, New York, NY 10065, USA
    BMC Proc 3:S12. 2009
    ..Other autoantibodies are also associated with RA, specifically rheumatoid factor IgM (RFUW) and anti-cyclic citrullinated peptide (anti-CCP)...
  5. pmc Analysis of variation in NF-kappaB genes and expression levels of NF-kappaB-regulated molecules
    Wen Liu Mares
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    BMC Proc 1:S126. 2007
    ..We conclude that variation in the genes encoding p50 and c-Rel may play a role in NF-kappaB-related transcription of FAS, IRF1, and CD40...
  6. pmc Identification of genes and haplotypes that predict rheumatoid arthritis using random forests
    Rui Tang
    Department of Health Sciences Research, 200 First Street Southwest, Mayo Clinic, Rochester, Minnesota 55905, USA
    BMC Proc 3:S68. 2009
    ..Although RFs are a promising approach for genetic data analysis, extensions beyond simple single-nucleotide polymorphism analyses and modifications to improve computational feasibility are needed...
  7. pmc Identification of gene-gene interaction using principal components
    Jia Li
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Harwick 776, Rochester, Minnesota 55905, USA
    BMC Proc 3:S78. 2009
    ..However, further study is needed to evaluate the power and the feasibility for a whole genome-wide association analysis using the principal components approach...
  8. pmc Assessment of genotype imputation methods
    Joanna M Biernacka
    Department of Health Sciences Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 USA
    BMC Proc 3:S5. 2009
    ..However, in both situations, none of the imputation-based tests provide the same level of evidence of association as the complete data at SNPs strongly associated with disease...
  9. pmc Heritability of physical activity traits in Brazilian families: the Baependi Heart Study
    Andréa R V R Horimoto
    Laboratory of Genetics and Molecular Cardiology, Heart Institute, Medical School of University of São Paulo, Av, Dr, Enéas de Carvalho Aguiar, 44, Sao Paulo, SP, 05403 000, Brazil
    BMC Med Genet 12:155. 2011
    ....
  10. pmc Heritability of cardiovascular risk factors in a Brazilian population: Baependi Heart Study
    Camila M de Oliveira
    Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil
    BMC Med Genet 9:32. 2008
    ..The heritability of cardiovascular risk factors is expected to differ between populations because of the different distribution of environmental risk factors, as well as the genetic make-up of different human populations...
  11. pmc Linkage analysis of obesity phenotypes in pre- and post-menopausal women from a United States mid-western population
    Linda E Kelemen
    Department of Population Health Research, Alberta Health Services Cancer Care, Calgary, AB, Canada
    BMC Med Genet 11:156. 2010
    ..Women are also more likely to distribute weight in the abdomen following menopause. We investigated whether genetic loci link with obesity-related phenotypes differently by menopausal status...
  12. pmc Evaluating gene by sex and age interactions on cardiovascular risk factors in Brazilian families
    Suely R Giolo
    Laboratory of Genetics and Molecular Cardiology, Heart Institute, Medical School of University of São Paulo, Sao Paulo, Brazil
    BMC Med Genet 11:132. 2010
    ..In particular, the relative influences of both genes and the environment may vary in different strata of the population of interest, such as young and old individuals, or males and females...
  13. pmc Imputation methods for missing data for polygenic models
    Brooke Fridley
    Department of Statistics, Iowa State University, Ames, Iowa, USA
    BMC Genet 4:S42. 2003
    ..Thus, we recommend the Gibbs sampler for imputation purposes because of the ease with which it can be extended to more complicated models, the consistency of the results, and the accountability of the variation due to imputation...
  14. pmc Localization of genes involved in the metabolic syndrome using multivariate linkage analysis
    Curtis Olswold
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    BMC Genet 4:S57. 2003
    ..This analysis demonstrates the applicability of using multivariate linkage analysis and how its use increases the power to detect linkage when genes are involved in the same disease mechanism...
  15. pmc Software comparison for evaluating genomic copy number variation for Affymetrix 6.0 SNP array platform
    Jeanette E Eckel-Passow
    Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    BMC Bioinformatics 12:220. 2011
    ..0. We compared bias and variance in the locus-level copy number data, the concordance amongst regions of copy number gains/deletions and the false-positive rate amongst deleted segments...
  16. ncbi request reprint Summary of contributions to GAW15 Group 13: candidate gene association studies
    Mariza de Andrade
    Division of Biostatistics, Department of Health Science Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Genet Epidemiol 31:S110-7. 2007
    ....
  17. pmc Identification of genes involved in alcohol consumption and cigarettes smoking
    Mariza de Andrade
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA
    BMC Genet 6:S112. 2005
    ....
  18. pmc The genetics of gene expression: comparison of linkage scans using two phenotype normalization methods
    Mariza de Andrade
    Division of Biostatistics, Mayo Clinic College of Medicine, 200 First Street Southwest, Harwick 7, Rochester, Minnesota 55905, USA
    BMC Proc 1:S151. 2007
    ..In summary, we conclude, as have other published reports, that normalization methods play an important role in the linkage results, and that some significant linkage signals might be due to a specific normalization method...
  19. ncbi request reprint Statistical models for analysis of cytogenetic biomarkers
    M de Andrade
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, USA
    J Investig Med 48:281-6. 2000
    ....
  20. ncbi request reprint Diagnostic tools in linkage analysis for quantitative traits
    Mariza de Andrade
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Genet Epidemiol 24:302-8. 2003
    ..Data from the Rochester Family Heart Study are used to illustrate the various diagnostic methods and related issues...
  21. ncbi request reprint Extension of variance components approach to incorporate temporal trends and longitudinal pedigree data analysis
    Mariza de Andrade
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Genet Epidemiol 22:221-32. 2002
    ..The results of our analysis show that the apolipoprotein E locus has no effect on interindividual variability in systolic blood pressure. We found that the longitudinal measure of heritability of systolic blood pressure is 0.32...
  22. ncbi request reprint Ascertainment issues in variance components models
    M de Andrade
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Genet Epidemiol 19:333-44. 2000
    ....
  23. ncbi request reprint Summary of contributions to GAW Group 12: multivariate methods
    Mariza de Andrade
    Division of Biostatistics, Department of Health Science Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Genet Epidemiol 29:S91-5. 2005
    ....
  24. pmc Comparison of longitudinal variance components and regression-based approaches for linkage detection on chromosome 17 for systolic blood pressure
    Mariza de Andrade
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, 200 First Street, SW, Rochester, Minnesota, USA
    BMC Genet 4:S17. 2003
    ..No evidence of linkage was found either using the VC longitudinal approach or the regression-based approach, except when all time points were used from Cohorts 1 and 2 and only subjects aged 25 and 75 years were included...
  25. ncbi request reprint Environmental tobacco smoke exposure in women with lung cancer
    M de Andrade
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Lung Cancer 43:127-34. 2004
    ..We report the patterns of ETS exposure history in a clinical cohort of women with newly diagnosed lung cancer...
  26. ncbi request reprint Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation
    Jie Lin
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:2065-71. 2007
    ..As risk assessment for cancer risk is moving toward a multigenic pathway-based approach, future genotype-phenotype correlation studies should also investigate the combined effects of multiple genetic variants...
  27. ncbi request reprint Family-based association study of matrix metalloproteinase-3 and -9 haplotypes with susceptibility to ischemic white matter injury
    Myriam Fornage
    Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler St, Room 530 G, Houston, TX 77030, USA
    Hum Genet 120:671-80. 2007
    ..They provide the basis for further investigation of the role of these genes in susceptibility and/or progression to clinical disease...
  28. pmc Beta-synuclein gene variants and Parkinson's disease: a preliminary case-control study
    Laura Brighina
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurosci Lett 420:229-34. 2007
    ..The results of this preliminary study suggest that the SNCB locus, though not a susceptibility gene for PD, might modify the age at onset of PD...
  29. pmc High-resolution whole-genome association study of Parkinson disease
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Am J Hum Genet 77:685-93. 2005
    ..07 x 10(-6); P=2.96 x 10(-5)) tagged the PARK10 late-onset PD susceptibility locus. Independent replication across populations will clarify the role of the genomic loci tagged by these SNPs in conferring PD susceptibility...
  30. pmc Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma
    Jinliang Xing
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 100:1104-12. 2008
    ..Renal cell carcinoma accounts for 85% of all renal cancers. No studies have investigated the association between mtDNA content and the risk of renal cell carcinoma...
  31. pmc Association of breast cancer susceptibility variants with risk of pancreatic cancer
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:3044-8. 2009
    ..Recently, several breast cancer susceptibility loci have been identified through genome-wide association studies. Here we evaluated possible associations between these single nucleotide polymorphisms (SNP) and pancreatic cancer risk...
  32. ncbi request reprint UCHL1 is associated with Parkinson's disease: a case-unaffected sibling and case-unrelated control study
    Maurizio Facheris
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurosci Lett 381:131-4. 2005
    ..Analyses confirmed a significant inverse association of the UCHL1 S18Y polymorphism with PD overall (OR=0.18, 95% CI=0.05-0.64, p=0.002, recessive model) and in several strata...
  33. pmc Nutrients from fruit and vegetable consumption reduce the risk of pancreatic cancer
    Rick J Jansen
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Gastrointest Cancer 44:152-61. 2013
    ..Our objective was to evaluate the risk of pancreatic cancer associated with nutrients found in fruits and vegetables and nutrient supplementation using a clinic-based case-control design...
  34. ncbi request reprint Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    JAMA 296:661-70. 2006
    ..Alpha-synuclein (SNCA) has been one of the most promising susceptibility genes, but large-scale studies have been lacking...
  35. ncbi request reprint Novel genomic loci influencing plasma homocysteine levels
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn 55905, USA
    Stroke 37:1703-9. 2006
    ..We performed linkage analyses to identify genomic regions that influence homocysteine levels in blacks and non-Hispanic whites...
  36. pmc Genomic susceptibility Loci for brain atrophy, ventricular volume, and leukoaraiosis in hypertensive sibships
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Arch Neurol 66:847-57. 2009
    ....
  37. pmc Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk
    Robert R McWilliams
    Division of Medical Oncology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Cancer Res 68:4928-35. 2008
    ..78; 95% CI, 1.28-6.04) or D711D (OR, 2.19; 95% CI, 1.01-4.73). No other significant differences in risk were identified. Minor alleles in DNA repair genes XPF/ERCC4 and XPD/ERCC2 were associated with altered risk for pancreatic cancer...
  38. ncbi request reprint Case-control study of the alpha-synuclein interacting protein gene and Parkinson's disease
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 18:1233-9. 2003
    ..0001). Recursive partitioning showed no interactions between variants of the SNCAIP gene and variants of the alpha-synuclein gene (SNCA) or the parkin (PARK2) gene...
  39. ncbi request reprint Genomic susceptibility loci for brain atrophy in hypertensive sibships from the GENOA study
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Hypertension 45:793-8. 2005
    ....
  40. ncbi request reprint A novel quantitative trait locus on chromosome 1 with pleiotropic effects on HDL-cholesterol and LDL particle size in hypertensive sibships
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Hypertens 18:1084-90. 2005
    ..We performed univariate and bivariate linkage analyses to identify genomic regions that influence levels of these traits and exert pleiotropic effects on the traits in hypertensive sibships...
  41. doi request reprint Long-term risk of depressive and anxiety symptoms after early bilateral oophorectomy
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Menopause 15:1050-9. 2008
    ..We studied the long-term risk of depressive and anxiety symptoms in women who underwent bilateral oophorectomy before menopause...
  42. pmc Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk
    Robert R McWilliams
    Department of Oncology, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:2549-52. 2009
    ..We hypothesized that common variants in these genes, single nucleotide polymorphisms (SNP), may also influence risk for pancreatic cancer development...
  43. ncbi request reprint Interaction of alpha-synuclein and tau genotypes in Parkinson's disease
    Catherine E Mamah
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Ann Neurol 57:439-43. 2005
    ..These findings are consistent with in vitro experiments that revealed tau-mediated fibrillization of alpha-synuclein protein at low concentrations (dose threshold effect)...
  44. pmc Nucleotide excision repair pathway polymorphisms and pancreatic cancer risk: evidence for role of MMS19L
    Robert R McWilliams
    Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA
    Cancer Epidemiol Biomarkers Prev 18:1295-302. 2009
    ..Single nucleotide polymorphisms (SNP) in the nucleotide excision repair pathway may encode alterations that affect DNA repair function and therefore influence the risk of pancreatic cancer development...
  45. pmc Genetic variants associated with the risk of chronic obstructive pulmonary disease with and without lung cancer
    Mariza de Andrade
    Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Prev Res (Phila) 5:365-73. 2012
    ..Functional studies are needed to elucidate the mechanisms of these genes in the development of COPD, lung cancer, or both...
  46. pmc Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Stabile 2 42, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 19:251-7. 2010
    ..Single nucleotide polymorphisms (SNP) in regulators of mitosis may promote chromosome missegregation and influence pancreatic cancer and/or survival...
  47. ncbi request reprint Chemical exposures and Parkinson's disease: a population-based case-control study
    Roberta Frigerio
    Division of Epidemiology, Department of Health Sciences Research, Mayo College of Medicine, Rochester, Minnesota 55905, USA
    Mov Disord 21:1688-92. 2006
    ..This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women...
  48. pmc Genetic variations and patient-reported quality of life among patients with lung cancer
    Jeff A Sloan
    Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 30:1699-704. 2012
    ..We report an analysis exploring relationships among baseline QOL assessments and candidate genetic variations in a large cohort of patients with lung cancer...
  49. ncbi request reprint Mitochondrial genetic polymorphisms and pancreatic cancer risk
    Liang Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Stabile 241, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:1455-9. 2007
    ..Investigation of other mitochondrial genetic variations (i.e., nuclear-encoded mitochondrial proteins) would be necessary to elucidate any role of mitochondrial DNA variation in PC...
  50. pmc Evaluating the influence of quality control decisions and software algorithms on SNP calling for the affymetrix 6.0 SNP array platform
    Mariza de Andrade
    Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minn, USA mandrade mayo edu
    Hum Hered 71:221-33. 2011
    ..Conclusions: Using our suggested workflow both algorithms performed similarly; however, fewer samples were removed and CRLMM took half the time to run our 854 study samples (4.2 h) compared to Birdseed (8.4 h)...
  51. doi request reprint Interferon gamma allelic variants: sex-biased multiple sclerosis susceptibility and gene expression
    Orhun H Kantarci
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 65:349-57. 2008
    ..Interferon (IFN) gamma (IFNG) allelic variants are associated with susceptibility to multiple sclerosis (MS) in men but not in women...
  52. pmc Genetic variants and risk of lung cancer in never smokers: a genome-wide association study
    Yafei Li
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lancet Oncol 11:321-30. 2010
    ..Lung cancer in individuals who have never smoked tobacco products is an increasing medical and public-health issue. We aimed to unravel the genetic basis of lung cancer in never smokers...
  53. pmc Probability of pancreatic cancer following diabetes: a population-based study
    Suresh T Chari
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 129:504-11. 2005
    ..Although diabetes occurs frequently in pancreatic cancer, the value of new-onset diabetes as a marker of underlying pancreatic cancer is unknown...
  54. pmc Alpha-1-antitrypsin deficiency and smoking as risk factors for mismatch repair deficient colorectal cancer: a study from the colon cancer family registry
    Noralane M Lindor
    Department of Medical Genetics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Mol Genet Metab 99:157-9. 2010
    ..No difference in frequency of A1AT deficiency alleles was found between cases and controls, irrespective of the MSI subtype...
  55. pmc Temporal association of changes in fasting blood glucose and body mass index with diagnosis of pancreatic cancer
    Rahul Pannala
    Department of Gastroenterology and Hepatology, Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 104:2318-25. 2009
    ..Although the association between diabetes mellitus (DM) and pancreatic cancer is well described, temporal patterns of changes in fasting blood glucose (FBG) and body mass index (BMI) before pancreatic cancer diagnosis are not known...
  56. ncbi request reprint Multivariate linkage analysis of blood pressure and body mass index
    Stephen T Turner
    Division of Hypertension and Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Genet Epidemiol 27:64-73. 2004
    ....
  57. pmc Alpha1-antitrypsin deficiency carriers, tobacco smoke, chronic obstructive pulmonary disease, and lung cancer risk
    Ping Yang
    Division of Epidemiology and Cancer Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    Arch Intern Med 168:1097-103. 2008
    ..Genetic susceptibility in lung cancer risk has long been recognized but remains ill defined, as does the role of tobacco smoke exposure and chronic obstructive pulmonary disease (COPD)...
  58. ncbi request reprint CD95 polymorphisms are associated with susceptibility to MS in women. A population-based study of CD95 and CD95L in MS
    Orhun H Kantarci
    Department of Neurology, Mayo Clinic and Foundation, 200 First Street, SW, Rochester, MN 55905, USA
    J Neuroimmunol 146:162-70. 2004
    ..We did not find an association between CD95L and susceptibility to MS nor CD95 or CD95L and age of onset, disease course and disease severity...
  59. doi request reprint Coffee, caffeine-related genes, and Parkinson's disease: a case-control study
    Maurizio F Facheris
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 23:2033-40. 2008
    ..Our study neither supports the hypothesis that coffee protects against PD nor provides evidence for a pharmacogenetic effect...
  60. ncbi request reprint The prevalence of BRCA2 mutations in familial pancreatic cancer
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:342-6. 2007
    ..A total of 10 carriers from 180 families were identified, suggesting that BRCA2 mutations account for 6% of moderate and high-risk pancreatic cancer families...
  61. pmc A genomic pathway approach to a complex disease: axon guidance and Parkinson disease
    Timothy G Lesnick
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS Genet 3:e98. 2007
    ..This genomic pathway approach may also offer insights into other complex diseases such as Alzheimer disease, diabetes mellitus, nicotine and alcohol dependence, and several cancers...
  62. ncbi request reprint CTLA4 is associated with susceptibility to multiple sclerosis
    Orhun H Kantarci
    Department of Neurology, Mayo Clinic and Foundation, 200 First Street, SW, Rochester, MN 55905, USA
    J Neuroimmunol 134:133-41. 2003
    ..005) for the 3'(514)*AT(8) allele. We did not detect linkage with MS susceptibility in multiplex families. We did not find a strong association with age at onset, disease course or severity. CTLA-4 is associated with susceptibility to MS...
  63. pmc Clinical features of bronchioloalveolar carcinoma with new histologic and staging definitions
    Jon O Ebbert
    Division of Primary Care Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    J Thorac Oncol 5:1213-20. 2010
    ....
  64. ncbi request reprint Pleiotropic genetic effects contribute to the correlation between HDL cholesterol, triglycerides, and LDL particle size in hypertensive sibships
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Am J Hypertens 18:99-103. 2005
    ..We investigated heritability of these three lipid traits and the extent to which shared effects of genes (pleiotropy) contribute to the additive genetic variation in each trait in hypertensive sibships...
  65. ncbi request reprint UCHL1 is a Parkinson's disease susceptibility gene
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Ann Neurol 55:512-21. 2004
    ..These findings confirm that UCHL1 is a susceptibility gene for PD and a potential target for disease-modifying therapies...
  66. pmc Association of family history of specific cancers with a younger age of onset of pancreatic adenocarcinoma
    Robert R McWilliams
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 4:1143-7. 2006
    ..Pancreatic adenocarcinoma has been associated with several familial cancer syndromes that also predispose to other malignancies. Younger ages of onset of pancreatic cancer (PC) have been reported in families with these syndromes...
  67. ncbi request reprint A genome-wide linkage scan for ankle-brachial index in African American and non-Hispanic white subjects participating in the GENOA study
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 First Street Southwest, Rochester, MN 55905, USA
    Atherosclerosis 187:433-8. 2006
    ..In conclusion, ABI is a modestly heritable trait in AA and NHW hypertensive sibships. Quantitative trait linkage analyses identified several chromosomal regions that may harbor genes influencing ABI...
  68. ncbi request reprint Missing phenotype data imputation in pedigree data analysis
    Brooke L Fridley
    Department of Health Sciences Research Mayo Clinic College of Medicine, Division of Biostatistics, Rochester, Minnesota 55905, USA
    Genet Epidemiol 32:52-60. 2008
    ..The method is illustrated using the Genetic Analysis Workshop simulated data...
  69. ncbi request reprint CCR5Delta32 polymorphism effects on CCR5 expression, patterns of immunopathology and disease course in multiple sclerosis
    Orhun H Kantarci
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Neuroimmunol 169:137-43. 2005
    ..Furthermore it does not segregate with patterns of immunopathology in MS. We did not find an association between CCR5*Delta32 mutation and disease severity and age of onset in MS...
  70. pmc Fruit and vegetable consumption is inversely associated with having pancreatic cancer
    Rick J Jansen
    Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Causes Control 22:1613-25. 2011
    ..We used a clinic-based case-control study specifically designed to address limitations of both cohort and case-control studies to examine the relationship...
  71. ncbi request reprint Thrombomodulin gene polymorphisms or haplotypes as potential risk factors for venous thromboembolism: a population-based case-control study
    John A Heit
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MI, USA
    J Thromb Haemost 3:710-7. 2005
    ..Null genetic marker allele frequencies did not differ significantly among cases and controls. We conclude that polymorphisms or haplotypes within the TM gene are not common risk factors for incident VTE...
  72. ncbi request reprint Reliability of self-reported ancestry among siblings: implications for genetic association studies
    Melinda S Burnett
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Epidemiol 163:486-92. 2006
    ..Self-reported ancestry may not be a reliable method to reduce the possible impact of population stratification in genetic association studies of outbred populations, such as in the United States...
  73. ncbi request reprint Quantitative trait loci influencing low density lipoprotein particle size in African Americans
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Lipid Res 47:1457-62. 2006
    ..9 cM, LOD = 2.06, P = 0.0069). These genomic regions may contain genes that influence interindividual variation in LDL particle size and potentially coronary heart disease susceptibility in African Americans...
  74. pmc Screening the genome to detect an association with hypertension
    Elizabeth J Atkinson
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    BMC Genet 4:S63. 2003
    ..Although linkage association has previously been reported with hypertension, we found no association using the tree-based methodology...
  75. ncbi request reprint Major histocompatibility complex class I chain-related gene A polymorphisms and extended haplotypes are associated with familial alopecia areata
    Nazila Barahmani
    Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Invest Dermatol 126:74-8. 2006
    ..1 (P=0.004) and HLA-DQB1*0201-DR3-MICA(*)5.1 (P=0.009) with AA. These results suggest that MICA is both a potential candidate gene and part of an extended HLA haplotype that may contribute to susceptibility to and severity of AA...
  76. ncbi request reprint Survival patterns after oophorectomy in premenopausal women: a population-based cohort study
    Walter A Rocca
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Lancet Oncol 7:821-8. 2006
    ..We aimed to investigate survival patterns in a population-based sample of women who had received an oophorectomy and compare these with women who had not received an oophorectomy...
  77. ncbi request reprint Genomic loci with pleiotropic effects on coronary artery calcification
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Atherosclerosis 185:340-6. 2006
    ..Inasmuch as the chromosome 9 and 17 regions were not detected in the univariate linkage analysis for CAC, multivariate linkage analyses of CAC and genetically correlated risk factors may help localize genes for coronary atherosclerosis...
  78. ncbi request reprint Risk of malignancy in first-degree relatives of patients with pancreatic carcinoma
    Robert R McWilliams
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer 104:388-94. 2005
    ..Counseling the families of PC patients regarding their risk of cancer remains problematic because little information is available...
  79. pmc Linkage analysis using principal components of gene expression data
    Elizabeth J Atkinson
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 1st Street SW, Rochester, Minnesota 55905, USA
    BMC Proc 1:S79. 2007
    ....
  80. ncbi request reprint Heritability of longitudinal measures of body mass index and lipid and lipoprotein levels in aging twins
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester Minnesota 55905, USA
    Twin Res Hum Genet 10:703-11. 2007
    ..In summary, longitudinal analyses of twin data indicate that genetic factors do not account for a significant proportion of the variation in age-related changes of BMI or lipid and lipoprotein levels...
  81. ncbi request reprint Two major QTLs and several others relate to factors of metabolic syndrome in the family blood pressure program
    Aldi T Kraja
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63123, USA
    Hypertension 46:751-7. 2005
    ..5, and 30 additional ones with lod score >1.7, offer hope for dissecting the genetic architecture of metabolic syndrome with beneficial implications for molecular diagnosis, prognosis, and in potential medical intervention...
  82. pmc New loci associated with kidney function and chronic kidney disease
    Anna Kottgen
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    Nat Genet 42:376-84. 2010
    ..These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney...
  83. pmc Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy
    Katharine M Brauch
    Cardiovascular Genetics Laboratory, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Am Coll Cardiol 54:930-41. 2009
    ..We sought to identify a novel gene for dilated cardiomyopathy (DCM)...
  84. pmc A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
    Gloria M Petersen
    Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Nat Genet 42:224-8. 2010
    ..19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies...
  85. pmc Association between SLC2A9 transporter gene variants and uric acid phenotypes in African American and white families
    Andrew D Rule
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Rheumatology (Oxford) 50:871-8. 2011
    ....
  86. pmc Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X
    Noralane M Lindor
    Department of Medical Genetics, Mayo Clinic, Rochester, Minn, USA
    JAMA 293:1979-85. 2005
    ..Cancer incidence in AC-I families with MMR gene mutations is reported to be very high, but cancer incidence for individuals in AC-I families with no evidence of an MMR defect is unknown...
  87. pmc Perceptions of lung cancer risk and beliefs in screening accuracy of spiral computed tomography among high-risk lung cancer family members
    Pamela S Sinicrope
    Department of Psychiatry and Psychology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Acad Radiol 17:1012-25. 2010
    ..Our objective was to describe the effect of participation in SCT screening on participants' risk perceptions, worry, and expectations regarding the accuracy of the screening result...
  88. ncbi request reprint The Mayo Clinic cohort study of personality and aging: design and sampling, reliability and validity of instruments, and baseline description
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neuroepidemiology 26:119-29. 2006
    ..68, p < 0.0001). This newly established historical cohort study provides opportunities to test hypotheses regarding the link between personality and aging, aging-related diseases, and overall mortality...
  89. ncbi request reprint Germ line Fanconi anemia complementation group C mutations and pancreatic cancer
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Res 65:383-6. 2005
    ..Taken together these data support the assertion that inherited mutations in FANCC can predispose to pancreatic cancer...
  90. ncbi request reprint Random-effects Cox proportional hazards model: general variance components methods for time-to-event data
    V Shane Pankratz
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    Genet Epidemiol 28:97-109. 2005
    ..The methods outlined here make it possible to perform general variance components analyses on time-to-event endpoints, even on large data sets, in a computationally efficient manner...
  91. pmc Comparison of tagging single-nucleotide polymorphism methods in association analyses
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    BMC Proc 1:S6. 2007
    ..e., whether a SNP or haplotype is responsible); unfortunately, this is often unknown at the time of SNP selection. Additional evaluations using empirical and simulated data are needed...
  92. ncbi request reprint Heritability of leukoaraiosis in hypertensive sibships
    Stephen T Turner
    Division of Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Hypertension 43:483-7. 2004
    ..671+/-0.110 (P<0.0001). This evidence of strong genetic influence on the susceptibility to leukoaraiosis justifies efforts to localize the responsible genes and characterize the predisposing genetic polymorphisms...
  93. ncbi request reprint Complex interactions in Parkinson's disease: a two-phased approach
    Demetrius M Maraganore
    Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Mov Disord 18:631-6. 2003
    ..42; P = 0.003). Our findings are consistent with the hypothesis that PD is a multigenic disorder of the UPS...
  94. ncbi request reprint Pancreatic cancer genetic epidemiology consortium
    Gloria M Petersen
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 15:704-10. 2006
    ..Linkage studies are ongoing. The PACGENE Consortium will be a valuable family-based resource that will greatly enhance genetic epidemiology research in pancreatic cancer...
  95. pmc Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
    Nilufer Ertekin-Taner
    Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Hum Mol Genet 12:3133-43. 2003
    ..These findings indicate that VR22 has variant(s) which influence Abeta42 and contribute to the previously reported linkage for plasma Abeta42 in LOAD families...
  96. ncbi request reprint Influence of genomic loci on measures of chronic kidney disease in hypertensive sibships
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester MN 55905, USA
    J Am Soc Nephrol 17:2048-55. 2006
    ..62, at 85 cM from pter; P = 0.00023). These findings support the utility of genetic linkage analyses for identification of novel risk factors that influence measures of chronic kidney disease, particularly among black individuals...
  97. ncbi request reprint Increased prevalence of antimitochondrial antibodies in first-degree relatives of patients with primary biliary cirrhosis
    Konstantinos N Lazaridis
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hepatology 46:785-92. 2007
    ..1% and 1%, respectively. Greater prevalence of AMA was found in female FDRs of PBC probands [sisters (20.7%), mothers (15.1%), and daughters (9.8%)] than in male FDRs [brothers (7.8%), fathers (3.7%), and sons (0%)]...
  98. pmc Linkage analysis of chromosome 4 in families with familial pancreatic cancer
    Alison P Klein
    The Sol Goldman Pancreatic Research Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 6:320-3. 2007
    ....
  99. pmc Pancreatic cancer-associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer
    Suresh T Chari
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 134:95-101. 2008
    ..The temporal association between diabetes mellitus and pancreatic cancer is poorly understood. We compared temporal patterns in diabetes prevalence in pancreatic cancer and controls...
  100. ncbi request reprint Parkin variants in North American Parkinson's disease: cases and controls
    Sarah J Lincoln
    Department of Neuroscience, Mayo Clinic Jacksonville, Florida 32224, USA
    Mov Disord 18:1306-11. 2003
    ..Furthermore, only stratified subanalyses detected any genetic association between the V380L common coding polymorphism and PD. We discuss the implication of parkin mutations for Parkinson's disease from this population perspective...
  101. pmc EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
    Haris Vikis
    Washington University, St Louis, Missouri, USA
    Cancer Res 67:4665-70. 2007
    ..Our observations show that EGFR-T790M provides a proliferative advantage with respect to WT EGFR and suggest that the enhanced kinase activity of this mutant is the basis for rare cases of inherited susceptibility to lung cancer...

Research Grants2

  1. Novel approaches in linkage analysis for complex traits
    Mariza de Andrade; Fiscal Year: 2003
    ..No new data will be collected for this grant proposal. The application clearly fits the goal of this NHLBI grant program since it will explore new approaches using an existing data set collected through NHLBI support. ..