Genomes and Genes


Mariza de Andrade


Affiliation: Mayo Clinic
Country: USA


  1. de Andrade M, Warwick Daw E, Kraja A, Fisher V, Wang L, Hu K, et al. The challenge of detecting genotype-by-methylation interaction: GAW20. BMC Genet. 2018;19:81 pubmed publisher
    ..In the simulation (200 replications), power appeared generally good for large interaction effects, but smaller effects will require larger studies or consortium collaboration for realizing a sufficient power. ..
  2. Bielinski S, Berardi C, Decker P, Kirsch P, Larson N, Pankow J, et al. P-selectin and subclinical and clinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2015;240:3-9 pubmed publisher
    ..However, association was only significant in non-Hispanic white Americans (HR: 1.81, 95% CI 1.07 to 3.07, P=0.027). We observed ethnic heterogeneity in the association of P-selectin and risk of CHD. ..
  3. Atkinson E, Eckel Passow J, Wang A, Greenberg A, Scott C, Pankratz V, et al. The association of copy number variation and percent mammographic density. BMC Res Notes. 2015;8:297 pubmed publisher
    ..Even so, the proximity of the identified CNV regions to loci known to be associated with breast cancer risk suggests further investigation and potentially shared genetic mechanisms underlying the PD and breast cancer association. ..
  4. de Andrade M, Olswold C, Slusser J, Tordsen L, Atkinson E, Rabe K, et al. Identification of genes involved in alcohol consumption and cigarettes smoking. BMC Genet. 2005;6 Suppl 1:S112 pubmed
  5. de Andrade M, Olswold C. Comparison of longitudinal variance components and regression-based approaches for linkage detection on chromosome 17 for systolic blood pressure. BMC Genet. 2003;4 Suppl 1:S17 pubmed
    ..No evidence of linkage was found either using the VC longitudinal approach or the regression-based approach, except when all time points were used from Cohorts 1 and 2 and only subjects aged 25 and 75 years were included. ..
  6. Musolf A, Simpson C, de Andrade M, Mandal D, Gaba C, Yang P, et al. Familial Lung Cancer: A Brief History from the Earliest Work to the Most Recent Studies. Genes (Basel). 2017;8: pubmed publisher
    ..Though not common, some germline mutations have also been identified via sequencing studies. Ongoing genomics studies aim to identify additional high penetrance germline susceptibility alleles for this deadly disease. ..
  7. Mazo Lopera M, Coombes B, de Andrade M. An Efficient Test for Gene-Environment Interaction in Generalized Linear Mixed Models with Family Data. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..Using our approach, we identified an interaction between BMI and the Peroxisome Proliferator Activated Receptor Gamma (PPARG) gene associated with diabetes. ..
  8. de Andrade M, Armasu S, McCauley B, Petterson T, Heit J. Identification of Genetic Interaction with Risk Factors Using a Time-To-Event Model. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..We showed that the time-to-event model is a useful approach for identifying potential hazard-modification of the genetic variants when the event of interest (VTE) occurs due to a risk factor (pre- or post-partum). ..
  9. Fridley B, Rabe K, de Andrade M. Imputation methods for missing data for polygenic models. BMC Genet. 2003;4 Suppl 1:S42 pubmed
    ..Thus, we recommend the Gibbs sampler for imputation purposes because of the ease with which it can be extended to more complicated models, the consistency of the results, and the accountability of the variation due to imputation. ..

More Information


  1. Bailey Wilson J, Almasy L, de Andrade M, Bailey J, Bickeböller H, Cordell H, et al. Genetic Analysis Workshop 14: microsatellite and single-nucleotide polymorphism marker loci for genome-wide scans. BMC Genet. 2005;6 Suppl 1:S1 pubmed