Mark D P Davis

..These distinctions may be arbitrary, however, and reflect differences in the temporal course of the disease and in the degree of inflammation at the time of biopsy...

..Confluent and reticulate papillomatosis (CRP) (Gougerot-Carteaud syndrome) is a disorder that has been characterized in only small cohorts of patients...

..The standard allergen series used in patch testing contains metals that most commonly cause allergic contact dermatitis, but testing with additional metal allergens is warranted for select patients...

..Body sites susceptible to allergic contact dermatitis to topical medicaments include scalp, face, anogenital area, and lower extremities...

..To assess the frequency and type of vascular changes and neurologic abnormalities in patients with erythromelalgia...

..Red blood cell extravasation and perivascular inflammatory cell infiltrate also may be present. The extent to which each of these elements must be present has been debated...

..Do patch test results vary from one part of the USA to another? Few reports directly compare the results of patch testing across centers within the USA...

..To examine the results of thermoregulatory sweat testing in patients with erythromelalgia and to compare them with the results of other neurophysiologic tests of small-fiber nerve function...

..The differential diagnosis for this entity is presented. This phenotype may be a previously undescribed syndrome...

..Some patients may have delayed allergic patch test reactions that are not identified with a typical 5-day reading protocol...

..To present and interpret results of patch testing with the Mayo Clinic standard series over 5 years...

..Dermatologists may be called to assist in the diagnosis and management of purpura fulminans...

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..Having either mycosis fungoides or B-cell lymphoma may predispose a patient to the other...

..To examine clinical characteristics, laboratory features, and outcomes of patients with lupus-like syndrome attributable to anti-tumor necrosis factor alpha (TNF-alpha) therapy...

..In conclusion, ECP and EDN disrupt skin integrity and cause inflammation. Their presence in ulcerative skin lesions may explain certain findings in human eosinophil-associated diseases...

..To report our experience with low-dose tissue plasminogen activator in the treatment of calciphylaxis, a rare, usually fatal thrombotic condition that results in ischemia, necrosis, and infarction of adipose and cutaneous tissue...

..Erythromelalgia has not been well characterized in the pediatric population...

..Calciphylaxis is characterized by ischemic cutaneous ulceration, high mortality, and ineffective treatment...

..To prospectively determine optimal levels of 6-thioguanine nucleotide for disease remission in patients with immunobullous disease treated with azathioprine...

..05) were observed for 12 of the 43 allergens common to both Mayo Clinic and the NACDG. CONCLUSION: With large standard patch test series, one can identify commonly encountered and potentially relevant contact allergens...

..The effect may be temporary, requiring continued use of tacrolimus, which appears to be safe and effective in controlling disease activity...

..Patch testing to a standard screening series of allergens in combination with supplemental cosmetic allergens is often used to diagnose allergic contact dermatitis due to personal care products...

..Most patients experienced symptomatic improvement in less than 1 month. However, the effect is temporary; when topical tacrolimus is discontinued, oral lichen planus may flare again...

..Patients with a sore or burning mouth associated with clinically normal oral mucosa present a difficult diagnostic challenge...

..Delusional infestation is the conviction that one's skin is infested with foreign organisms or materials despite contradictory objective evidence...

..At our institution, hospitalization for intensive treatment (combining wet dressings and topical corticosteroids) is a primary intervention for severe pediatric atopic dermatitis. Prior reports of this treatment are limited...

..Histologic evidence of intraluminal thrombosis was observed in almost all biopsy specimens reviewed. Laboratory testing revealed numerous heterogeneous coagulation abnormalities, providing further evidence of procoagulant mechanisms...

..The presence of SFN raises the possibility that a subset of patients with primary RP have an underlying, subclinical small-fiber dysfunction. These data open new avenues of research and therapeutics for this common condition...

..Psoriasis is a common, nonulcerative skin disorder...

..Calciphylaxis is a rare, life-threatening syndrome marked by vascular calcification and cutaneous necrosis. The role of radiographic imaging in assisting in diagnosis has not been established...

..Studies have shown the effect of allergic contact dermatitis on quality of life, but few address the impact of patch testing...

..Histopathologic findings were nonspecific. Vascular thrombi were not identified. A relative decrease in small nerve fiber density was noted in specimens from 13 of 16 patients...

..1%, one on day 7 and the other on day 9. CONCLUSIONS: Only 2 reactions (to 1,656 corticosteroids) became apparent at the extended reading. Extended readings were of limited value in our experience...

..It is possible that bexarotene contributed to this progression. Although bexarotene therapy may alleviate symptoms and signs of cutaneous T-cell lymphoma, careful surveillance of lymph nodes and solid organs during treatment is advised...

..Hairdressing chemicals may be associated with allergic contact dermatitis...

..We therefore identified patients who had been formally evaluated in the Department of Psychiatry during their visit to Mayo Clinic...

..Positive allergic patch-test results are generally described as erythematous papules, vesicles, or a spreading reaction with crust and ulceration. This description excludes milder reactions, including macular erythema...

..To assess trends in the cutaneous variants of lupus erythematosus (CLE) and to ascertain the incidence of CLE over the past 4 decades...

..The role of contact allergy in oral cavity disease processes is unknown...

..Patch testing should be performed with suspected woods for diagnostic confirmation and allowance of subsequent avoidance of the allergens...

..Identification of these genes and pathways will direct future research towards controlling AD...

..To review the results of patch testing before or after metal device implantation...

..Although numerous studies have examined the range of disease in cutaneous T-cell lymphoma, a relative paucity of data exists to describe the long-term outcome of patients with SS...

..Because of the lack of published reports on patch testing for this indication, we undertook a retrospective study of patch testing results in patients with suspected peristomal allergic contact dermatitis...

..To describe the response in patients with erythromelalgia to the pain rehabilitation program at Mayo Clinic, Rochester, Minnesota...

..Clinical signs should be documented and analysis of skin biopsy specimens should be performed in patients suspected to have thyroid dermopathy...

..CONCLUSION: Lipodermatosclerosis was associated with female sex, middle age, high body mass index, and venous abnormalities...

..The prevalence of skin eruptions was not diminished by the concurrent use of systemic corticosteroids. Most skin eruptions were mild and did not necessitate withdrawal of lenalidomide therapy...

..Reactivity to Dermatophagoides has been measured by specific IgE and by immediate-type responses to prick test challenge. More recently, patch testing has been advocated as a means of determining reactivity to Dermatophagoides...

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..Mean duration of follow-up was 2.6 years (range, 17 days-18.2 yrs); average duration of remission was 2.6 years (range, 2 mos-12.79 yrs). Goeckerman treatment is an effective treatment for widespread psoriasis in children...

..Patch testing rarely is confounded by localized dermatitis induced in the area being tested (usually the back). Its occurrence renders the interpretation of patch tests impossible...

..To review the results of skin biopsies and patient-provided specimens from patients whose assessment was consistent with delusional infestation, including delusions of parasitosis...

..Allergic contact dermatitis from rubber chemicals is increasingly recognized...

..Wet dressings are a mainstay for initial management of pruritic adult dermatoses at Mayo Clinic, yet few recent reports describe their effectiveness for pruritic conditions other than atopic dermatitis in children...

..Recurrent erythema multiforme (EM) is a condition of substantial morbidity. Our efforts toward the etiologic attribution and treatment of recurrent EM have been less fruitful than those previously described...

..However, few cases have been reported in the United States...

..Although results of photopatch testing have been presented from many European centers, there have been few reports of the results of photopatch testing in the United States...

..Allergy to topical corticosteroids is more common than previously realized. To detect this allergy, a corticosteroid series is used for patch testing in addition to corticosteroid screens on a standard series...

..Institutions should consider including mixed dialkyl thioureas in their standard patch test screening series...

..However, the exact mechanism leading to development of EMN is not understood. In particular, it is not known whether EMN harbour the BRAF mutations which occur frequently in melanoma and most common naevi...

..Treatment of this disease continues to present a therapeutic dilemma with only sporadic remission despite multimodality therapy...

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..The previously reported diagnostic criteria, physical descriptions, differential diagnosis, workup, and treatment options are reviewed. A practical approach to pyoderma gangrenosum and Sweet's syndrome for the provider is described...

..On physical examination, annular plaques were noted. Workup revealed dermatitis herpetiformis (DH) and subclinical celiac disease...

..The ulcers healed after warfarin therapy, which has been reported to be effective in only one previous patient with this condition...

..We present two patients with pyoderma gangrenosum involving the breasts after breast operation. Delays in diagnosis resulted in extensive ulcerations and scarring of the breasts...

..Pyoderma gangrenosum is a rare but significant cause of ulcerations. It is a diagnosis of exclusion. Herein, we suggest diagnostic criteria and some historical perspectives on the diagnosis of pyoderma gangrenosum...

..A thorough evaluation is required in all patients suspected of having pyoderma gangrenosum in order to rule out alternative diagnoses...

..Side effects were rare and minor. CONCLUSIONS: In this retrospective case series of 13 patients, topical tacrolimus was well tolerated and appeared to be an effective therapy to control symptoms and clear lesions of OLP...

..We report three cases of cutaneous hyalohyphomycosis caused by P. lilacinus and review the 17 previously reported cases in which the clinical history and response to therapy were described...

..Blister fluid contained more NE than normal serum. CONCLUSIONS: Both eosinophils and neutrophils likely participate in skin lesion development in CSS...

..With CNKL, dermatologists must recognize associated cutaneous diseases, monitor patients for systemic disorders and cytopenias, and appropriately refer patients to a hematologist...

..He is the only one of 55 patients with Sézary syndrome treated at Mayo Clinic (Rochester, Minnesota, USA) to achieve sustained remission on extracorporeal photopheresis alone...

..RESULTS: Laboratory tests, skin biopsy, and electromyography resulted in a diagnosis of dermatomyositis. CONCLUSIONS: Periorbital edema may appear as the presenting cutaneous manifestation of dermatomyositis...