Nathan W Cummins

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV
    Nathan W Cummins
    Division of Infectious Diseases, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    Cell Mol Life Sci 70:3355-63. 2013
  2. pmc Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations
    Nathan W Cummins
    Division of Infectious Disease, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e24876. 2011
  3. pmc Isolation of a TRAIL antagonist from the serum of HIV-infected patients
    David J Schnepple
    Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 286:35742-54. 2011
  4. pmc The HIV-1-specific protein Casp8p41 induces death of infected cells through Bax/Bak
    Amy M Sainski
    Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA
    J Virol 85:7965-75. 2011
  5. pmc Intracellular Casp8p41 content is inversely associated with CD4 T cell count
    Nathan W Cummins
    Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Infect Dis 202:386-91. 2010
  6. pmc Patients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells
    Sekar Natesampillai
    Division of Infectious Diseases, Mayo Clinic, Rochester, MN, USA
    PLoS Pathog 6:e1001213. 2010
  7. pmc Casp8p41 expression in primary T cells induces a proinflammatory response
    Julie A Taylor
    Division of Infectious Diseases, Rochester, Minnesota, USA
    AIDS 24:1251-8. 2010
  8. pmc Polymorphism in tumor necrosis factor-related apoptosis-inducing ligand receptor 1 is associated with poor viral response to interferon-based hepatitis C virus therapy in HIV/hepatitis C virus-coinfected individuals
    Stacey A Rizza
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    AIDS 24:2639-44. 2010
  9. pmc Short communication: CD4 T cell declines occurring during suppressive antiretroviral therapy reflect continued production of casp8p41
    Nathan W Cummins
    1 Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota
    AIDS Res Hum Retroviruses 30:476-9. 2014
  10. pmc Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice
    Nathan W Cummins
    Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    FASEB J 26:2911-8. 2012

Collaborators

Detail Information

Publications10

  1. pmc Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV
    Nathan W Cummins
    Division of Infectious Diseases, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    Cell Mol Life Sci 70:3355-63. 2013
    ..Only by understanding how infected cells avoid HIV-induced cell death can an effective strategy to kill infected cells be developed...
  2. pmc Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations
    Nathan W Cummins
    Division of Infectious Disease, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 6:e24876. 2011
    ..This suggests that Gp120 is not an inducer of apoptosis in human osteoblasts and likely does not directly contribute to osteoporosis in infected patients by this mechanism...
  3. pmc Isolation of a TRAIL antagonist from the serum of HIV-infected patients
    David J Schnepple
    Division of Infectious Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 286:35742-54. 2011
    ..Knockdown of TRAIL-s abrogates this resistance. We propose that TRAIL-s is a novel adaptive mechanism of apoptosis resistance acquired by HIV-infected cells to avoid their elimination by TRAIL-dependent effector mechanism...
  4. pmc The HIV-1-specific protein Casp8p41 induces death of infected cells through Bax/Bak
    Amy M Sainski
    Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA
    J Virol 85:7965-75. 2011
    ..This understanding allows the design of strategies to interrupt this form of death of HIV-1-infected cells...
  5. pmc Intracellular Casp8p41 content is inversely associated with CD4 T cell count
    Nathan W Cummins
    Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Infect Dis 202:386-91. 2010
    ..This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection...
  6. pmc Patients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells
    Sekar Natesampillai
    Division of Infectious Diseases, Mayo Clinic, Rochester, MN, USA
    PLoS Pathog 6:e1001213. 2010
    ..Therefore, HIV protease regulates both HIV replication as well as HIV induced T cell depletion, the hallmark of HIV pathogenesis...
  7. pmc Casp8p41 expression in primary T cells induces a proinflammatory response
    Julie A Taylor
    Division of Infectious Diseases, Rochester, Minnesota, USA
    AIDS 24:1251-8. 2010
    ..Herein, we questioned whether Casp8p41-induced NFkappaB activation impacts the cytokine profile of cells expressing Casp8p41...
  8. pmc Polymorphism in tumor necrosis factor-related apoptosis-inducing ligand receptor 1 is associated with poor viral response to interferon-based hepatitis C virus therapy in HIV/hepatitis C virus-coinfected individuals
    Stacey A Rizza
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    AIDS 24:2639-44. 2010
    ..There are currently no biomarkers that predict treatment response in these coinfected patients...
  9. pmc Short communication: CD4 T cell declines occurring during suppressive antiretroviral therapy reflect continued production of casp8p41
    Nathan W Cummins
    1 Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota
    AIDS Res Hum Retroviruses 30:476-9. 2014
    ....
  10. pmc Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice
    Nathan W Cummins
    Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    FASEB J 26:2911-8. 2012
    ..HO-1 affects the immune response to both influenza infection and vaccination, suggesting that therapeutic induction of HO-1 expression may represent a novel adjuvant to enhance influenza vaccine effectiveness...