Lynn D Cornell

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. doi Renal allograft pathology in the sensitized patient
    Lynn D Cornell
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Organ Transplant 18:327-36. 2013
  2. doi IgG4-related kidney disease
    Lynn D Cornell
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Semin Diagn Pathol 29:245-50. 2012
  3. doi IgG4-related kidney disease
    Lynn D Cornell
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Nephrol Hypertens 21:279-88. 2012
  4. ncbi Kidney transplantation: mechanisms of rejection and acceptance
    Lynn D Cornell
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Annu Rev Pathol 3:189-220. 2008
  5. pmc Laser microdissection and mass spectrometry-based proteomics aids the diagnosis and typing of renal amyloidosis
    Sanjeev Sethi
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Kidney Int 82:226-34. 2012
  6. doi Renal monoclonal immunoglobulin deposition disease: a report of 64 patients from a single institution
    Samih H Nasr
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Hilton 10 20, Rochester, MN 55905, USA
    Clin J Am Soc Nephrol 7:231-9. 2012
  7. pmc Proliferative glomerulonephritis with monoclonal IgG deposits recurs in the allograft
    Samih H Nasr
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin J Am Soc Nephrol 6:122-32. 2011
  8. doi Clinicopathologic correlations in multiple myeloma: a case series of 190 patients with kidney biopsies
    Samih H Nasr
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 59:786-94. 2012
  9. pmc Association of kidney function and metabolic risk factors with density of glomeruli on renal biopsy samples from living donors
    Andrew D Rule
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905
    Mayo Clin Proc 86:282-90. 2011
  10. doi The diagnosis and characteristics of renal heavy-chain and heavy/light-chain amyloidosis and their comparison with renal light-chain amyloidosis
    Samih H Nasr
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Division of Anatomic Pathology, Hilton 10 20 200 First Street, SW, Rochester, Minnesota 55905, USA
    Kidney Int 83:463-70. 2013

Detail Information

Publications40

  1. doi Renal allograft pathology in the sensitized patient
    Lynn D Cornell
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Organ Transplant 18:327-36. 2013
    ..There is likely to be an increasing number of patients with preformed alloantibody undergoing kidney transplantation, and so alloantibody-associated injury will become more prevalent...
  2. doi IgG4-related kidney disease
    Lynn D Cornell
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Semin Diagn Pathol 29:245-50. 2012
    ..This review describes the histopathologic and immunophenotypic patterns of renal involvement by IgG4-RD, with associated clinical, radiographic, and serologic features...
  3. doi IgG4-related kidney disease
    Lynn D Cornell
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Nephrol Hypertens 21:279-88. 2012
    ..Renal involvement can take several forms, which are described in this review...
  4. ncbi Kidney transplantation: mechanisms of rejection and acceptance
    Lynn D Cornell
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Annu Rev Pathol 3:189-220. 2008
    ..Studies in animals have replicated many pathologic features of acute and chronic rejection. We illuminate the pathogenesis of human pathology by reflection from experimental models...
  5. pmc Laser microdissection and mass spectrometry-based proteomics aids the diagnosis and typing of renal amyloidosis
    Sanjeev Sethi
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Kidney Int 82:226-34. 2012
    ....
  6. doi Renal monoclonal immunoglobulin deposition disease: a report of 64 patients from a single institution
    Samih H Nasr
    Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Hilton 10 20, Rochester, MN 55905, USA
    Clin J Am Soc Nephrol 7:231-9. 2012
    ..To better define the clinical-pathologic spectrum and prognosis of monoclonal immunoglobulin deposition disease (MIDD), this study reports the largest series...
  7. pmc Proliferative glomerulonephritis with monoclonal IgG deposits recurs in the allograft
    Samih H Nasr
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin J Am Soc Nephrol 6:122-32. 2011
    ..Proliferative GN with monoclonal IgG deposits (PGNMID) is a newly described entity resembling immune complex GN. Its potential to recur in the allograft is undefined...
  8. doi Clinicopathologic correlations in multiple myeloma: a case series of 190 patients with kidney biopsies
    Samih H Nasr
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 59:786-94. 2012
    ..Renal involvement is common in multiple myeloma. In this study, we examined kidney biopsy findings in patients with multiple myeloma and correlated them with their clinical renal and hematologic characteristics...
  9. pmc Association of kidney function and metabolic risk factors with density of glomeruli on renal biopsy samples from living donors
    Andrew D Rule
    Division of Nephrology and Hypertension, Mayo Clinic, 200 First St SW, Rochester, MN 55905
    Mayo Clin Proc 86:282-90. 2011
    ..To test the hypothesis that kidney function and metabolic risk factors are associated with glomerular density on renal biopsy samples from healthy adults...
  10. doi The diagnosis and characteristics of renal heavy-chain and heavy/light-chain amyloidosis and their comparison with renal light-chain amyloidosis
    Samih H Nasr
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Division of Anatomic Pathology, Hilton 10 20 200 First Street, SW, Rochester, Minnesota 55905, USA
    Kidney Int 83:463-70. 2013
    ..The accurate histological diagnosis of renal AH/AHL and distinction from AL may have important clinical and prognostic implications...
  11. doi Immunotactoid glomerulopathy: clinicopathologic and proteomic study
    Samih H Nasr
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Nephrol Dial Transplant 27:4137-46. 2012
    ..Immunotactoid glomerulopathy (ITG) is a rare glomerular disease. Here, we report the largest clinicopathologic series of ITG and define its proteomic profile...
  12. doi Membranous glomerulonephritis is a manifestation of IgG4-related disease
    Mariam P Alexander
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 83:455-62. 2013
    ..4 mg/dl). Thus, MGN should be included in the spectrum of IgG4-RD and should be suspected in proteinuric IgG4-RD patients. Conversely, patients with MGN and an appropriate clinical history should be evaluated for IgG4-RD...
  13. doi Clinical features of patients with immunoglobulin light chain amyloidosis (AL) with vascular-limited deposition in the kidney
    Alfonso Eirin
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA
    Nephrol Dial Transplant 27:1097-101. 2012
    ..There was a preference for λ light chain in the D-AL that was not noted in the V-AL. Patients with D-AL in this study had a longer median survival but most of them were stem cell transplantation candidates...
  14. doi C1q deposition in the renal allograft: a report of 24 cases
    Samar M Said
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Mod Pathol 23:1080-8. 2010
    ..The rate of preceding infection and the prevalence of proteinuria seem to be similar to the renal transplant recipients in general. Most cases show mesangial hypercellularity or no glomerular changes on light microscopy...
  15. doi C3 glomerulonephritis associated with monoclonal gammopathy: a case series
    Ladan Zand
    Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 62:506-14. 2013
    ..Functional inhibition of the complement-regulating proteins may result from a monoclonal gammopathy...
  16. doi Myeloproliferative neoplasms cause glomerulopathy
    Samar M Said
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 80:753-9. 2011
    ..Greater awareness of this entity and larger studies are needed to define possible therapies...
  17. pmc Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases
    Samar M Said
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Clin J Am Soc Nephrol 8:1515-23. 2013
    ..The kidney is the organ most commonly involved in systemic amyloidosis. This study reports the largest clinicopathologic series of renal amyloidosis...
  18. pmc Fibrosis with inflammation at one year predicts transplant functional decline
    Walter D Park
    Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, Minnesota, USA
    J Am Soc Nephrol 21:1987-97. 2010
    ..Early interventions aimed at altering rejection-like inflammation may improve long-term survival of kidney allografts...
  19. pmc Fibrillary glomerulonephritis: a report of 66 cases from a single institution
    Samih H Nasr
    Mayo Clinic, Division of Anatomic Pathology, Hilton 10 20, 200 First Street SW, Rochester, MN 55905, USA
    Clin J Am Soc Nephrol 6:775-84. 2011
    ..Most previously reported cases were idiopathic. To better define the clinical-pathologic spectrum and prognosis, we report the largest single-center series with the longest follow-up...
  20. pmc Low- and high-molecular-weight urinary proteins as predictors of response to rituximab in patients with membranous nephropathy: a prospective study
    Maria V Irazabal
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN, USA
    Nephrol Dial Transplant 28:137-46. 2013
    ..Selective urinary biomarkers have been considered superior to total proteinuria in predicting response to treatment and outcome in patients with membranous nephropathy (MN)...
  21. doi Postinfectious glomerulonephritis in the elderly
    Samih H Nasr
    Mayo Clinic, Division of Anatomic Pathology, Hilton 10 20, 200 First Street, SW, Rochester, MN 55905, USA
    J Am Soc Nephrol 22:187-95. 2011
    ..Prognosis for these older patients is poor, with fewer than 25% recovering full renal function...
  22. doi Acquired glomerular lesions in patients with Down syndrome
    Samar M Said
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Hum Pathol 43:81-8. 2012
    ..Renal biopsy is necessary to determine the type of glomerular lesion and appropriate treatment...
  23. doi IgG4-related tubulointerstitial nephritis
    Lynn D Cornell
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
    Kidney Int 78:951-3. 2010
    ..Notably, some cases may be mass-forming. Recognition of this specific type of TIN can guide appropriate patient therapy...
  24. pmc Mass spectrometry-based proteomic diagnosis of renal immunoglobulin heavy chain amyloidosis
    Sanjeev Sethi
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Clin J Am Soc Nephrol 5:2180-7. 2010
    ..We also describe the clinicopathologic findings of four problematic cases of renal Ig heavy chain amyloidosis that required LMD/MS proteomic analysis for accurate typing of the amyloid...
  25. doi IgG4-positive plasma cells in granulomatosis with polyangiitis (Wegener's): a clinicopathologic and immunohistochemical study on 43 granulomatosis with polyangiitis and 20 control cases
    Sing Yun Chang
    Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Hum Pathol 44:2432-7. 2013
    ....
  26. doi The role of complement in antibody-mediated rejection in kidney transplantation
    Mark D Stegall
    Department of Surgery, Division of Transplantation Surgery and von Liebig Transplant Center, 200 First Street SW, Mayo Clinic, Rochester, MN 55905, USA
    Nat Rev Nephrol 8:670-8. 2012
    ..In this Review, we discuss the different roles that the complement system might have in antibody-mediated allograft rejection, with specific emphasis on renal transplantation...
  27. pmc Diagnosis of IgG4-related tubulointerstitial nephritis
    Yassaman Raissian
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 1 Street SW, Rochester, MN 55905, USA
    J Am Soc Nephrol 22:1343-52. 2011
    ..When the disease manifests in the kidney, our data support diagnostic criteria that can distinguish IgG4-TIN from other types of TIN...
  28. ncbi Chronic allograft nephropathy
    Lynn D Cornell
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Nephrol Hypertens 14:229-34. 2005
    ..This disease is heterogeneous and the diagnosis is nonspecific, with both immune and nonimmune causes. Increasingly, we are able to recognize specific contributors to the disease...
  29. doi Dense deposit disease associated with monoclonal gammopathy of undetermined significance
    Sanjeev Sethi
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Kidney Dis 56:977-82. 2010
    ..Thus, DDD in some older patients may be a distinct clinicopathologic entity that represents an uncommon complication of MGUS...
  30. ncbi Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease
    Lynn D Cornell
    Departments of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 31:1586-97. 2007
    ....
  31. doi Antibody-mediated rejection following transplantation from an HLA-identical sibling
    Carrie A Grafft
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    Nephrol Dial Transplant 25:307-10. 2010
    ..A biopsy for allograft dysfunction suggested AMR, but DSA could not be detected. Treatment for rejection was transiently successful. Undetectable minor histocompatibility antibodies may have contributed...
  32. doi Crystalline nephropathy due to 2,8-dihydroxyadeninuria: an under-recognized cause of irreversible renal failure
    Samih H Nasr
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Nephrol Dial Transplant 25:1909-15. 2010
    ..Only rare cases of DHA nephrolithiasis have been reported from the USA. Herein, we report three American patients who developed DHA crystalline nephropathy leading to end-stage renal disease (ESRD) with recurrence in the allograft...
  33. pmc The association between age and nephrosclerosis on renal biopsy among healthy adults
    Andrew D Rule
    Mayo Clinic, Rochester, Minnesota, USA
    Ann Intern Med 152:561-7. 2010
    ..Chronic kidney disease is common with older age and is characterized on renal biopsy by global glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis...
  34. doi Distinctive pulmonary histopathology with increased IgG4-positive plasma cells in patients with autoimmune pancreatitis: report of 6 and 12 cases with similar histopathology
    Bijayee Shrestha
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Am J Surg Pathol 33:1450-62. 2009
    ..The significance of increased IgG4+ cells in high proportion of RD cases merits further study as does overlap of RD and IgG4 disease...
  35. doi Using implantation biopsies as a surrogate to evaluate selection criteria for living kidney donors
    Ashutosh Chauhan
    1 William J Von Liebig Transplant Center, Mayo Clinic College of Medicine, Rochester, MN 2 Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 3 Address correspondence to Mark D Stegall, M D, Transplant Center, Rochester Methodist Hospital, 10th Floor, Charlton Building, 201 West Center Street, Rochester, MN 55902
    Transplantation 96:975-80. 2013
    ..The goal of this study was to use implantation biopsies as a surrogate outcome marker to evaluate our living kidney donor selection criteria...
  36. doi Consensus statement on the pathology of IgG4-related disease
    Vikram Deshpande
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mod Pathol 25:1181-92. 2012
    ..As the spectrum of this disease continues to expand, we advocate the use of strict criteria for accepting newly proposed entities or sites as components of the IgG4-related disease spectrum...
  37. pmc Coronary artery disease from isolated non-H2-determined incompatibilities in transplanted mouse hearts
    Paul S Russell
    Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Transplantation 91:847-52. 2011
    ..This report describes examples of coronary vascular disease occurring in transplanted mouse hearts involving isolated, non-H2-determined incompatibilities...
  38. doi Systemic karyomegaly with primary pulmonary presentation
    Damian J Tagliente
    Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA
    Hum Pathol 45:180-4. 2014
    ..The identification and characterization of systemic karyomegaly with symptomatic lung involvement expands the differential diagnosis for relatively young patients presenting with interstitial lung disease. ..
  39. doi Case records of the Massachusetts General Hospital. Case 27-2008. A 64-year-old man with abdominal pain, nausea, and an elevated level of serum creatinine
    Theodore I Steinman
    Renal Division, Beth Israel Deaconess Medical Center, Boston, USA
    N Engl J Med 359:951-60. 2008
  40. ncbi Radiological reasoning: male breast mass with calcifications
    Ann A Shi
    AVON Breast Comprehensive Center, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    AJR Am J Roentgenol 185:S205-10. 2005
    ..It was initially thought to be comedo-type ductal carcinoma in situ because of the dense calcifications, but sonography and MRI suggested a highly vascular lesion. The final pathologic diagnosis was hemangioma...