Leslie T Cooper

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. doi request reprint Genomic and proteomic analysis of myocarditis and dilated cardiomyopathy
    Leslie T Cooper
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Heart Fail Clin 6:75-85. 2010
  2. ncbi request reprint Biventricular assist device placement and immunosuppression as therapy for necrotizing eosinophilic myocarditis
    Leslie T Cooper
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Nat Clin Pract Cardiovasc Med 2:544-8. 2005
  3. ncbi request reprint Giant cell myocarditis. Diagnosis and treatment
    L T Cooper
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA
    Herz 37:632-6. 2012
  4. doi request reprint Republished: pathogenesis and diagnosis of myocarditis
    Chantal Elamm
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Postgrad Med J 88:539-44. 2012
  5. pmc Application of adaptive design and decision making to a phase II trial of a phosphodiesterase inhibitor for the treatment of intermittent claudication
    Roger J Lewis
    Department of Emergency Medicine, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, California 90509, USA
    Trials 12:134. 2011
  6. ncbi request reprint A prospective, case-control study of tobacco dependence in thromboangiitis obliterans (Buerger's Disease)
    Leslie T Cooper
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Angiology 57:73-8. 2006
  7. ncbi request reprint National Institutes of Health-sponsored workshop on inflammation and immunity in dilated cardiomyopathy
    Leslie T Cooper
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 81:199-204. 2006
  8. ncbi request reprint Acute heart failure due to fulminant and giant cell myocarditis
    Leslie T Cooper
    College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Herz 31:767-70. 2006
  9. ncbi request reprint A pilot study to assess the use of protein a immunoadsorption for chronic dilated cardiomyopathy
    Leslie T Cooper
    Cardiovascular Division, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Apher 22:210-4. 2007
  10. ncbi request reprint Giant cell and granulomatous myocarditis
    Leslie T Cooper
    Mayo Clinic College of Medicine, Rochester, MN 55906, USA
    Heart Fail Clin 1:431-7. 2005

Research Grants

Detail Information

Publications52

  1. doi request reprint Genomic and proteomic analysis of myocarditis and dilated cardiomyopathy
    Leslie T Cooper
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Heart Fail Clin 6:75-85. 2010
    ..This article reviews several examples of noncandidate genomic and proteomic screening, as well as the potential strengths and pitfalls of these strategies for the evaluation of myocarditis and nonischemic DCM...
  2. ncbi request reprint Biventricular assist device placement and immunosuppression as therapy for necrotizing eosinophilic myocarditis
    Leslie T Cooper
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Nat Clin Pract Cardiovasc Med 2:544-8. 2005
    ..The only reported medical history was urinary tract infection and an ankle fracture sustained 5 months before presentation. She was receiving no medication other than estrogen patches for menopause and did not smoke or use illicit drugs...
  3. ncbi request reprint Giant cell myocarditis. Diagnosis and treatment
    L T Cooper
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA
    Herz 37:632-6. 2012
    ..The long-term management of GCM patients, who initially recover, is not known and highlights the need for continuing multicenter collaborative clinical investigations...
  4. doi request reprint Republished: pathogenesis and diagnosis of myocarditis
    Chantal Elamm
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Postgrad Med J 88:539-44. 2012
    ..Recent advances in the understanding of disease pathogenesis described in this review should lead to more accurate diagnostic algorithms and non-invasive tests...
  5. pmc Application of adaptive design and decision making to a phase II trial of a phosphodiesterase inhibitor for the treatment of intermittent claudication
    Roger J Lewis
    Department of Emergency Medicine, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, California 90509, USA
    Trials 12:134. 2011
    ..We describe the design, oversight, and implementation of an adaptive, phase II, dose-finding trial evaluating K-134 for the treatment of stable, intermittent claudication...
  6. ncbi request reprint A prospective, case-control study of tobacco dependence in thromboangiitis obliterans (Buerger's Disease)
    Leslie T Cooper
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Angiology 57:73-8. 2006
    ..03). In contrast to case reports of extreme tobacco dependence in the TAO population, the degree of tobacco dependence in subjects with TAO is similar to that in subjects with CAD...
  7. ncbi request reprint National Institutes of Health-sponsored workshop on inflammation and immunity in dilated cardiomyopathy
    Leslie T Cooper
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 81:199-204. 2006
    ..The major recommendations from the members of the workshop are organized according to the following themes: cardiotropic viruses, innate and acquired immune responses, environmental factors, novel diagnostics, and novel therapeutics...
  8. ncbi request reprint Acute heart failure due to fulminant and giant cell myocarditis
    Leslie T Cooper
    College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Herz 31:767-70. 2006
    ....
  9. ncbi request reprint A pilot study to assess the use of protein a immunoadsorption for chronic dilated cardiomyopathy
    Leslie T Cooper
    Cardiovascular Division, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Apher 22:210-4. 2007
    ..Even without IVIG substitution, IA for the treatment of chronic DCM is associated with improved QOL up to 6 months after treatment. A randomized, sham-controlled trial is required to confirm the benefits of IA for DCM...
  10. ncbi request reprint Giant cell and granulomatous myocarditis
    Leslie T Cooper
    Mayo Clinic College of Medicine, Rochester, MN 55906, USA
    Heart Fail Clin 1:431-7. 2005
  11. ncbi request reprint The roles of selenium and mercury in the pathogenesis of viral cardiomyopathy
    Leslie T Cooper
    Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Congest Heart Fail 13:193-9. 2007
    ..Based on recent studies, the authors propose a novel paradigm for the pathogenesis of viral DCM that incorporates trace element imbalance and its interactions with the cellular physiology of viral-induced cardiomyocyte dysfunction...
  12. pmc Usefulness of immunosuppression for giant cell myocarditis
    Leslie T Cooper
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    Am J Cardiol 102:1535-9. 2008
    ..Additionally, withdrawal of immunosuppression can be associated with fatal GCM recurrence...
  13. doi request reprint Peripheral arterial disease: diagnosis and management
    Faisel A Arain
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 83:944-49; quiz 949-50. 2008
    ..As a general rule, patients with lifestyle-limiting claudication who do not respond to medical management or those with critical limb ischemia should be referred to a vascular specialist for consideration of revascularization...
  14. ncbi request reprint Idiopathic giant-cell myocarditis--natural history and treatment. Multicenter Giant Cell Myocarditis Study Group Investigators
    L T Cooper
    Department of Medicine, University of California at San Diego Medical Center, USA
    N Engl J Med 336:1860-6. 1997
    ..Idiopathic giant-cell myocarditis is a rare and frequently fatal disorder. We used a multicenter data base to define the natural history of giant-cell myocarditis and the effect of treatment...
  15. ncbi request reprint Giant cell myocarditis: diagnosis and treatment
    L T Cooper
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    Herz 25:291-8. 2000
    ..To confirm and extend these findings, a randomized trial of immunosuppression including muromonab-CD3, cyclosporine, and steroids is underway...
  16. ncbi request reprint The natural history and role of immunoadsorption in dilated cardiomyopathy
    Leslie T Cooper
    Cardiovascular Division, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Apher 20:256-60. 2005
  17. ncbi request reprint Proteinuria in a placebo-controlled study of basic fibroblast growth factor for intermittent claudication
    L T Cooper
    Mayo Clinic and Foundation, Cardiovascular Division, Rochester, MN 55905, USA
    Vasc Med 6:235-9. 2001
    ..Future clinical trials of bFGF protein should carefully monitor renal function and consider alternative dosing schedules and drug administration routes...
  18. ncbi request reprint A clinical and histopathologic comparison of cardiac sarcoidosis and idiopathic giant cell myocarditis
    Yuji Okura
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 41:322-9. 2003
    ..The goal of this study was to determine the prognostic value of clinical data available at presentation and histology in cardiac sarcoidosis (CS) and idiopathic giant cell myocarditis (IGCM)...
  19. doi request reprint Diagnostic features, treatment, and outcomes of Takayasu arteritis in a US cohort of 126 patients
    Jean Schmidt
    Division of Rheumatology, Mayo Clinic, Rochester, MN Department of Internal Medicine and RECIF, Amiens University Hospital, and INSERM U 1088, Jules Verne University of Picardy, Amiens, France
    Mayo Clin Proc 88:822-30. 2013
    ..To describe the clinical features, treatment, and outcomes in a longitudinal cohort of patients with Takayasu arteritis (TAK)...
  20. doi request reprint Speckle tracking echocardiography in acute myocarditis
    Ju Feng Hsiao
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Int J Cardiovasc Imaging 29:275-84. 2013
    ..Most importantly, this imaging technique had a role in predicting deterioration and overall event-free survival...
  21. doi request reprint Atrial giant cell myocarditis: a distinctive clinicopathologic entity
    Brandon T Larsen
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Circulation 127:39-47. 2013
    ..We describe a novel variant of GCM, primarily involving the atria, that displays distinctive clinical features and follows a more benign course than ventricular GCM...
  22. doi request reprint Pathogenesis and diagnosis of myocarditis
    Chantal Elamm
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Heart 98:835-40. 2012
    ..Recent advances in the understanding of disease pathogenesis described in this review should lead to more accurate diagnostic algorithms and non-invasive tests...
  23. ncbi request reprint Treatment of chronic dilated cardiomyopathy with immunoadsorption using the staphylococcal A-agarose column: a comparison of immunoglobulin reduction using two different techniques
    Edwin A Burgstaler
    Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Apher 22:224-32. 2007
    ..This small study, demonstrated that a modified technique (T-2) with superior fluid balance should be used when treating DCM with the Immunosorba system...
  24. doi request reprint Coronary sarcoidosis presenting as acute coronary syndrome
    Carolyn S P Lam
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Clin Cardiol 32:E68-71. 2009
    ..A review of the literature also suggests the need for improvement in diagnostic approaches and prospective clinical trials to establish the best management strategy for this disease...
  25. pmc Diagnosis and treatment of viral myocarditis
    Jason C Schultz
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:1001-9. 2009
    ..Main keywords searched were myocarditis, dilated cardiomyopathy, endomyocardial biopsy, cardiac magnetic resonance imaging, and immunotherapy...
  26. doi request reprint Myocarditis
    Lori A Blauwet
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Prog Cardiovasc Dis 52:274-88. 2010
    ..Prognosis in acute myocarditis is generally good except in patients with giant cell myocarditis. Persistent, chronic myocarditis usually has a progressive course but may respond to immunosuppression...
  27. ncbi request reprint The role of right ventricular endomyocardial biopsy for idiopathic giant cell myocarditis
    Raymond C Shields
    Department of Cardiology, Mayo Clinic, Rochester, MN 55905, USA
    J Card Fail 8:74-8. 2002
    ..The purpose of this study was to estimate the sensitivity of right ventricular EMB for GCM in a referral population...
  28. doi request reprint Myocarditis
    Sandeep Sagar
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Lancet 379:738-47. 2012
    ..Findings from recent clinical trials suggest that some patients with chronic inflammatory cardiomyopathy have a progressive clinical course despite standard medical care and might improve with a short course of immunosuppression...
  29. pmc Statistical analysis of relative labeled mass spectrometry data from complex samples using ANOVA
    Ann L Oberg
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Proteome Res 7:225-33. 2008
    ..The modeling approach, implementation, and useful visualization tools are demonstrated via a case study of complex biological samples assessed using the iTRAQ relative labeling protocol...
  30. pmc Spontaneous myocarditis mimicking human disease occurs in the presence of an appropriate MHC and non-MHC background in transgenic mice
    Veena Taneja
    Department of Immunology, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    J Mol Cell Cardiol 42:1054-64. 2007
    ..This model of myocarditis occurs predominantly in female mice and may provide insight into the pathogenesis of heart disease in women...
  31. ncbi request reprint Echocardiographic features of atrial myocarditis with giant cells: a case report
    Kwan K Law
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Am Soc Echocardiogr 17:1073-6. 2004
    ..After immunosuppressive therapy, the endomyocardial thickening completely resolved, but the restrictive cardiomyopathy did not reverse...
  32. ncbi request reprint Noninvasive imaging in myocarditis
    Hadi N Skouri
    Cardiovascular Department, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 48:2085-93. 2006
    ..Novel imaging modalities that are currently in preclinical development are discussed with recommendations for future clinical research...
  33. ncbi request reprint Greater symptom duration predicts response to immunomodulatory therapy in dilated cardiomyopathy
    Christopher Stanton
    Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    Int J Cardiol 128:38-41. 2008
    ..We hypothesized that clinical response to immunomodulation would be dependent on symptom duration. Pooled immunomodulatory trial data was used to test this hypothesis...
  34. pmc Myocardial recovery in peripartum cardiomyopathy: prospective comparison with recent onset cardiomyopathy in men and nonperipartum women
    Leslie T Cooper
    Mayo Clinic, Rochester, MN, USA
    J Card Fail 18:28-33. 2012
    ..This was examined through an analysis of outcomes in the Intervention in Myocarditis and Acute Cardiomyopathy 2 (IMAC2) registry...
  35. pmc Early identification of cardiovascular risk using genomics and proteomics
    Iftikhar J Kullo
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Nat Rev Cardiol 7:309-17. 2010
    ..In this article, we use the specific example of atherosclerosis to discuss the role of genomics and proteomics in cardiovascular risk assessment...
  36. ncbi request reprint Eosinophilic-lymphocytic myocarditis after smallpox vaccination
    Joseph G Murphy
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Lancet 362:1378-80. 2003
    ..A better understanding of the aberrant immune mechanism of myocyte injury after smallpox vaccination might improve the risk/benefit assessment for people considering smallpox vaccination and better smallpox vaccines in the future...
  37. doi request reprint The role of autoimmunity in thromboangiitis obliterans (Buerger's disease)
    Siva S Ketha
    Gonda Vascular Center, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Ann N Y Acad Sci 1285:15-25. 2013
    ..The possible links between tobacco exposure and loss of tolerance for vascular tissues, current management strategy for patients with TAO, and opportunities for translational science are discussed...
  38. pmc Increased risk of peripheral arterial disease in polymyalgia rheumatica: a population-based cohort study
    Kenneth J Warrington
    Department of Medicine, Division of Rheumatology, Mayo Clinic, Rochester, MN 55905, USA
    Arthritis Res Ther 11:R50. 2009
    ..The present study was conducted to determine whether patients with polymyalgia rheumatica (PMR) are at an increased risk of peripheral arterial disease (PAD)...
  39. doi request reprint Cardiac calcified amorphous tumor in a patient presenting for ventricular tachycardia ablation: intracardiac echocardiogram diagnosis and management
    Ammar Habib
    Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    J Interv Card Electrophysiol 29:175-8. 2010
    ..The imaging characteristics and management are described...
  40. doi request reprint Idiopathic giant cell myocarditis and cardiac sarcoidosis
    Lori A Blauwet
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA
    Heart Fail Rev 18:733-46. 2013
    ..The prognosis of patients with GCM is poor, while the prognosis for patients with CS varies according to degree of left ventricular dysfunction. ..
  41. ncbi request reprint Takayasu's arteritis: operative results and influence of disease activity
    Charles E Fields
    Division of Vascular Surgery, Mayo Clinic and Foundation, Rochester, Minn, USA
    J Vasc Surg 43:64-71. 2006
    ..To determine the short- and long-term outcomes of patients treated operatively for Takayasu's arteritis and the effect of disease activity on results...
  42. ncbi request reprint Use of intermittent pneumatic compression for treatment of upper extremity vascular ulcers
    David H Pfizenmaier
    Division of Vascular Medicine and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Angiology 56:417-22. 2005
    ..A prospective, randomized, sham-controlled study of IPC is needed to determine whether IPC treatment improves wound healing compared to standard medical care...
  43. doi request reprint Median arcuate ligament syndrome: a nonvascular, vascular diagnosis
    Nedaa Skeik
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Vasc Endovascular Surg 45:433-7. 2011
    ..We illustrate the current gaps in our knowledge of MALS with the case of a 51-year-old woman with a 4-year history of chronic abdominal pain who responded to a combination of ganglion resection and celiac artery reconstruction...
  44. ncbi request reprint Iron and peripheral arterial disease: revisiting the iron hypothesis in a different light
    Gautam Ramakrishna
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Vasc Med 8:203-10. 2003
    ..This background will be expanded upon to provide insights into ongoing studies and paths for future investigations into the role of iron and peripheral arterial disease...
  45. ncbi request reprint Transplantation for myocarditis: a controversy revisited
    Edward D Moloney
    Department of Respiratory Medicine, Mater Misericordiae University Hospital, Dublin, Ireland
    J Heart Lung Transplant 24:1103-10. 2005
    ..We present the case of a 42-year-old man with recurrence of GCM 8 years after transplantation and review the literature on the role of cardiac transplantation for patients with myocarditis...
  46. ncbi request reprint Cautious interpretation of data regarding myopericarditis associated with smallpox vaccination
    Appor S Gami
    J Am Coll Cardiol 45:160; author reply 160-1. 2005
  47. ncbi request reprint The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Endorsed by the Heart Failure Society of
    Leslie T Cooper
    J Am Coll Cardiol 50:1914-31. 2007
  48. ncbi request reprint Viral infection, inflammation, and the risk of idiopathic dilated cardiomyopathy: can the fire be extinguished?
    Leslie T Cooper
    Am J Cardiol 90:751-4. 2002
  49. ncbi request reprint The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology
    Leslie T Cooper
    Mayo Clinic
    Circulation 116:2216-33. 2007
  50. ncbi request reprint Long-term survival and amputation risk in thromboangiitis obliterans (Buerger's disease)
    Leslie T Cooper
    J Am Coll Cardiol 44:2410-1. 2004
  51. ncbi request reprint The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology Endorsed by the Heart Failure Society of
    Leslie T Cooper
    American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231, USA
    Eur Heart J 28:3076-93. 2007
  52. ncbi request reprint Total lymphoid irradiation: new therapeutic option for refractory giant cell myocarditis
    Tajinder P Singh
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Heart Lung Transplant 23:492-5. 2004
    ..This novel treatment should be considered in all patients with GCM who do not have histologic remission with the currently employed anti-T-cell immunosuppression...

Research Grants2

  1. Inflammation and Immunity in Dilated Cardiomyopathy
    Leslie Cooper; Fiscal Year: 2004
    ..The long-term overall goal of this workshop is to translate advances in molecular and cellular mechanisms of disease into improvements in the diagnosis and treatment of patients with DCM. ..
  2. Giant Cell Myocarditis Treatment Trial Pilot Study
    COOPER LESLIE; Fiscal Year: 2005
    ..Abstract Not Provided ..