C A Conover

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Inducible knock out of pregnancy-associated plasma protein-a gene expression in the adult mouse: effect on vascular injury response
    Cheryl A Conover
    The Endocrine Research Unit, Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    Endocrinology 154:2734-8. 2013
  2. pmc Role of PAPP-A in aging and age-related disease
    Cheryl A Conover
    Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Exp Gerontol 48:612-3. 2013
  3. pmc Effects of mutated pregnancy-associated plasma protein-a on atherosclerotic lesion development in mice
    Henning B Boldt
    Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, MN 55905, USA
    Endocrinology 154:246-52. 2013
  4. pmc Key questions and answers about pregnancy-associated plasma protein-A
    Cheryl A Conover
    Division of Endocrinology and Metabolism, Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Trends Endocrinol Metab 23:242-9. 2012
  5. ncbi request reprint Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development
    Cheryl A Conover
    The Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Development 131:1187-94. 2004
  6. ncbi request reprint Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis
    Cheryl A Conover
    Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Growth Horm IGF Res 12:178-83. 2002
  7. ncbi request reprint Cytokine stimulation of pregnancy-associated plasma protein A expression in human coronary artery smooth muscle cells: inhibition by resveratrol
    Cheryl A Conover
    Department of Internal Medicine, Endocrine Research Unit, Rochester, MN 55905, USA
    Am J Physiol Cell Physiol 290:C183-8. 2006
  8. doi request reprint Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice
    Cheryl A Conover
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, College of Medicine Mayo Clinic, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    Endocrinology 152:2837-44. 2011
  9. pmc PAPP-A: a new anti-aging target?
    Cheryl A Conover
    Division of Endocrinology, Metabolism, and Nutrition, Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Aging Cell 9:942-6. 2010
  10. pmc Longevity is not influenced by prenatal programming of body size
    Cheryl A Conover
    Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, MN 55905, USA
    Aging Cell 9:647-9. 2010

Collaborators

Detail Information

Publications68

  1. pmc Inducible knock out of pregnancy-associated plasma protein-a gene expression in the adult mouse: effect on vascular injury response
    Cheryl A Conover
    The Endocrine Research Unit, Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    Endocrinology 154:2734-8. 2013
    ..0001) reduction of neointimal formation in these mice after unilateral carotid artery ligation. ..
  2. pmc Role of PAPP-A in aging and age-related disease
    Cheryl A Conover
    Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Exp Gerontol 48:612-3. 2013
    ..These latter studies will be reviewed in this article...
  3. pmc Effects of mutated pregnancy-associated plasma protein-a on atherosclerotic lesion development in mice
    Henning B Boldt
    Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, MN 55905, USA
    Endocrinology 154:246-52. 2013
    ..Thus, PAPP-A exerts its effect while bound to the cell surface in vivo...
  4. pmc Key questions and answers about pregnancy-associated plasma protein-A
    Cheryl A Conover
    Division of Endocrinology and Metabolism, Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Trends Endocrinol Metab 23:242-9. 2012
    ..In this article we address some of the outstanding questions about PAPP-A, in particular about its newly emerging role in the insulin-like growth factor (IGF) system...
  5. ncbi request reprint Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development
    Cheryl A Conover
    The Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Development 131:1187-94. 2004
    ..These results provide the first direct evidence that PAPPA is an essential growth regulatory factor in vivo, and suggest a novel mechanism for regulated IGF bioavailability during early fetal development...
  6. ncbi request reprint Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis
    Cheryl A Conover
    Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Growth Horm IGF Res 12:178-83. 2002
    ..Furthermore, they provide proof of concept for a novel anabolic approach to increasing bone mass in humans with osteoporosis...
  7. ncbi request reprint Cytokine stimulation of pregnancy-associated plasma protein A expression in human coronary artery smooth muscle cells: inhibition by resveratrol
    Cheryl A Conover
    Department of Internal Medicine, Endocrine Research Unit, Rochester, MN 55905, USA
    Am J Physiol Cell Physiol 290:C183-8. 2006
    ..Our results also suggest that PAPP-A may be a target of the cardiovascular system-protective effects of resveratrol...
  8. doi request reprint Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice
    Cheryl A Conover
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, College of Medicine Mayo Clinic, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    Endocrinology 152:2837-44. 2011
    ..In conclusion, tissue expression patterns and biological consequences of gene KO indicate distinct physiological roles for PAPP-A2 and PAPP-A in mice...
  9. pmc PAPP-A: a new anti-aging target?
    Cheryl A Conover
    Division of Endocrinology, Metabolism, and Nutrition, Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Aging Cell 9:942-6. 2010
    ..The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan...
  10. pmc Longevity is not influenced by prenatal programming of body size
    Cheryl A Conover
    Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, MN 55905, USA
    Aging Cell 9:647-9. 2010
    ..Adult-specific moderation of IGF signaling through PAPP-A inhibition may present a unique opportunity to improve lifespan without affecting important aspects of early life physiology...
  11. ncbi request reprint Surface association of pregnancy-associated plasma protein-A accounts for its colocalization with activated macrophages
    Cheryl A Conover
    Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Am J Physiol Heart Circ Physiol 292:H994-H1000. 2007
    ..Our findings likely account for the observed intense immunostaining for PAPP-A colocalizing with activated macrophages and may have physiological significance in the development of vulnerable plaque...
  12. ncbi request reprint Loss of pregnancy-associated plasma protein A extends lifespan in mice
    Cheryl A Conover
    Endocrine Research Unit, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Aging Cell 6:727-9. 2007
    ..Furthermore, these mice have markedly reduced incidence of spontaneous tumors. The findings implicate PAPP-A as a critical regulator of lifespan and age-related diseases, and suggest PAPP-A as a possible target to promote longevity...
  13. ncbi request reprint Role of extracellular matrix in insulin-like growth factor (IGF) binding protein-2 regulation of IGF-II action in normal human osteoblasts
    Cheryl A Conover
    Endocrine Research Unit, Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Growth Horm IGF Res 13:328-35. 2003
    ..There was no difference between soluble and ECM-associated IGFBP-2 in affinity for IGF-I and IGF-II. These data suggest a unique mechanism for targeting an anabolic IGFBP-2/IGF-II complex in bone...
  14. pmc Differential regulation of pregnancy associated plasma protein-A in human coronary artery endothelial cells and smooth muscle cells
    Cheryl A Conover
    Endocrine Research Unit, Department of Medicine, Mayo Clinic, College of Medicine, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, United States
    Growth Horm IGF Res 18:213-20. 2008
    ..However, little is known about the cellular mechanisms underlying this elevated PAPP-A...
  15. ncbi request reprint Regulation of pregnancy-associated plasma protein-A expression in cultured human osteoblasts
    Cheryl A Conover
    Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Bone 34:297-302. 2004
    ..These findings suggest a mechanism whereby cytokines present in bone and bone marrow could augment IGF bioavailability during skeletal growth and remodeling...
  16. pmc Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A
    Cheryl A Conover
    The Division of Endocrinology and Metabolism, Department of Medicine, Mayo Clinic, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    J Gerontol A Biol Sci Med Sci 65:590-9. 2010
    ..In summary, the major contributors to the extended life span of PAPP-A KO mice are delayed occurrence of fatal neoplasias and decreased incidence of age-related degenerative changes...
  17. ncbi request reprint Insulin-like growth factor-binding proteins and bone metabolism
    Cheryl A Conover
    Endocrine Research Unit, Division of Endocrinology and Metabolosm, Department of Medicine, Mayo Clinic, 200 First St SW, 5 194 Joseph, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 294:E10-4. 2008
    ..This review focuses on recent findings from cell culture, rodent models, and clinical studies concerning local IGFBP-2, IGFBP-4, and IGFBP-5 action in bone...
  18. pmc Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development
    Cheryl A Conover
    Division of Endocrinology, Metabolism and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 299:H284-91. 2010
    ..These data provide further evidence for the importance of PAPP-A in the cardiovascular system and suggest PAPP-A as a potential therapeutic target in the control of atherosclerosis...
  19. ncbi request reprint Insulin-like growth factor (IGF) binding protein-3 potentiation of IGF action is mediated through the phosphatidylinositol-3-kinase pathway and is associated with alteration in protein kinase B/AKT sensitivity
    C A Conover
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Endocrinology 141:3098-103. 2000
    ....
  20. ncbi request reprint In vitro studies of insulin-like growth factor I and bone
    C A Conover
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Growth Horm IGF Res 10:S107-10. 2000
    ..All these components of the IGF-I regulatory system are present and operative in bone cells in vitro...
  21. ncbi request reprint Evidence that the insulin-like growth factor binding protein-4 protease in human ovarian follicular fluid is pregnancy associated plasma protein-A
    C A Conover
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Clin Endocrinol Metab 84:4742-5. 1999
    ..We have the molecular and biochemical tools to begin to delineate the regulation and biological function of PAPP-A in normal and dysregulated follicular development and atresia...
  22. ncbi request reprint Insulin-like growth factor I induction of c-myc expression in bovine fibroblasts can be blocked by antecedent insulin receptor activation
    C A Conover
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Exp Cell Res 238:122-7. 1998
    ....
  23. ncbi request reprint Regulation of insulin-like growth factor binding protein 4 by a specific insulin-like growth factor binding protein 4 proteinase in normal human osteoblast-like cells: implications in bone cell physiology
    S K Durham
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota
    J Bone Miner Res 9:111-7. 1994
    ..However, pretreatment of cultured hOB with IGF-II enhanced IGF-I-stimulated [3H]thymidine incorporation threefold.(ABSTRACT TRUNCATED AT 250 WORDS)..
  24. ncbi request reprint Insulin-like growth factor binding protein-4 protease produced by smooth muscle cells increases in the coronary artery after angioplasty
    A Bayes-Genis
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Arterioscler Thromb Vasc Biol 21:335-41. 2001
    ..PAPP-A, a regulator of IGF-I bioavailability through proteolysis of IGFBP-4, is thus expressed by VSMCs in vitro and in restenotic lesions in vivo. These results suggest a possible role for PAPP-A in neointimal hyperplasia...
  25. pmc The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A
    J B Lawrence
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 96:3149-53. 1999
    ..In conclusion, we have identified an IGF-dependent IGFBP protease and at the same time assigned a function to PAPP-A. This represents an unanticipated union of two areas of research that were not linked in any way before this report...
  26. ncbi request reprint Phorbol ester tumor promoters regulate insulin-like growth factor-binding protein-4 proteolysis
    C A Conover
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905
    Endocrinology 133:1347-51. 1993
    ..Alterations in IGFBP-4 protease activity could affect local IGF action through regulation of IGFBP-4 availability...
  27. ncbi request reprint Pregnancy-associated plasma protein-a is the insulin-like growth factor binding protein-4 protease secreted by human ovarian granulosa cells and is a marker of dominant follicle selection and the corpus luteum
    C A Conover
    Endocrine Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocrinology 142:2155. 2001
    ..In addition the data suggest complex regulation of this system in human ovary...
  28. ncbi request reprint Functional insulin receptors on human epithelial ovarian carcinoma cells: implications for IGF-II mitogenic signaling
    Kimberly R Kalli
    Division of Endocrinology and Metabolism, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Endocrinology 143:3259-67. 2002
    ..This report suggests that the insulin receptor may play a role in the regulation of ovarian cancer cell growth...
  29. pmc Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. Potential insights into increasing bone mass in adults
    S Khosla
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Invest 101:2165-73. 1998
    ..Our findings in HCAO suggest a possible means to increase bone mass in patients with osteoporosis...
  30. ncbi request reprint In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417
    Paul Haluska
    Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Res 66:362-71. 2006
    ..BMS-554417 is a member of a novel class of IGF-IR/insulin receptor inhibitors that have potential clinical applications because of their antiproliferative and proapoptotic activity in vitro and in vivo...
  31. ncbi request reprint Targeted disruption of the pregnancy-associated plasma protein-A gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to neointimal hyperplasia after vascular injury
    Zachary T Resch
    Department of Internal Medicine, Endocrine Research Unit, Mayo Clinic College of Medicine, 200 First Street Southwest, 5 194 Joseph, Rochester, Minnesota 55905, USA
    Endocrinology 147:5634-40. 2006
    ..Thus, PAPP-A-deficient mice are resistant to neointimal formation after injury, which may be explained in part by the ability of PAPP-A to enhance local IGF-I stimulation of vascular SMCs through proteolysis of IGFBP-4...
  32. ncbi request reprint Structural and biological characterization of bovine insulin-like growth factor binding protein-3
    C A Conover
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905
    Endocrinology 127:2795-803. 1990
    ..We propose that IGFBP-3 serves a dual function in modulating IGF action in vivo...
  33. ncbi request reprint Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet
    Sean C Harrington
    Division of Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Circ Res 100:1696-702. 2007
    ..These data indicate that PAPP-A plays a critical role in lesion development in a mouse model of atherosclerosis, at least in part, through amplification of local IGF-I bioavailability...
  34. ncbi request reprint Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: identification of a novel inducible inhibitor
    Bing Kun Chen
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Endocrinology 143:1199-205. 2002
    ..These findings expand our understanding of the IGFBP-4 protease system and suggest an additional level of local cell growth control...
  35. ncbi request reprint Disruption of insulin-like growth factor-II imprinting during embryonic development rescues the dwarf phenotype of mice null for pregnancy-associated plasma protein-A
    Laurie K Bale
    Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic College of Medicine, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    J Endocrinol 186:325-31. 2005
    ..These data provide strong genetic evidence that PAPP-A plays an essential role in determining IGF-II bioavailability for optimal fetal growth and development...
  36. ncbi request reprint Pregnancy-associated plasma protein A as a marker of acute coronary syndromes
    A Bayes-Genis
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    N Engl J Med 345:1022-9. 2001
    ..PAPP-A is a new candidate marker of unstable angina and acute myocardial infarction...
  37. ncbi request reprint Pregnancy-associated plasma protein a gene expression as a target of inflammatory cytokines
    Zachary T Resch
    Division of Endocrinology, Metabolism, and Nutrition, Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Endocrinology 145:1124-9. 2004
    ..These data provide a mechanism for the regulation of PAPP-A in response to injury and further implicate PAPP-A in the wound-healing processes...
  38. ncbi request reprint Localization and regulation of pregnancy-associated plasma protein a expression in healing human skin
    Bing Kun Chen
    Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 88:4465-71. 2003
    ..These data demonstrate localized and regulated expression of PAPP-A in human skin and suggest that PAPP-A may play an important role in an integrated IGF system in wound healing and tissue remodeling in vivo...
  39. ncbi request reprint Insulin-like growth factor-binding protein-1 expression in cultured human bone cells: regulation by insulin and glucocorticoid
    C A Conover
    Division of Endocrinology and Metabolism, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocrinology 137:3295-301. 1996
    ..Insulin acts through insulin receptors on hOB cells. We postulate that IGFBP-1 produced by osteoblasts in vivo can modulate local actions of IGF on bone formation in response to changes in glucocorticoid and insulin concentrations...
  40. ncbi request reprint Mechanisms of lysolipid phosphate effects on cellular survival and proliferation
    E J Goetzl
    Department of Medicine, University of California, San Francisco 94143, USA
    Ann N Y Acad Sci 905:177-87. 2000
    ....
  41. ncbi request reprint Stress-activated signaling pathways mediate the stimulation of pregnancy-associated plasma protein-A expression in cultured human fibroblasts
    Zachary T Resch
    Endocrine Research Unit, Division of Endocrinology, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Endocrinology 147:885-90. 2006
    ..These data indicate that NFkappaB activation is the primary mediator of cytokine-stimulated PAPP-A expression in human fibroblasts...
  42. pmc Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype
    Cheryl A Conover
    Division of Endocrinology, Metabolism and Nutrition, Mayo Clinic, 200 First Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    J Endocrinol 198:599-605. 2008
    ..These findings are discussed in the context of those from other long-lived mouse models...
  43. ncbi request reprint Transforming growth factor-beta regulation of the insulin-like growth factor binding protein-4 protease system in cultured human osteoblasts
    Christopher O Ortiz
    Division of Endocrinology and Metabolism, Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 5590, USA
    J Bone Miner Res 18:1066-72. 2003
    ..These data support a model whereby local TGF-beta and IGF-II in the bone microenvironment coordinately amplify IGF-I bioavailability through controlled IGFBP-4 proteolysis, which may be a means to promote bone formation...
  44. pmc Impact of pregnancy-associated plasma protein-a deletion on the adult murine skeleton
    Sharon J Tanner
    Endocrine Research Unit, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Bone Miner Res 23:655-62. 2008
    ....
  45. ncbi request reprint Heterogeneous role of caspase-8 in fenretinide-induced apoptosis in epithelial ovarian carcinoma cell lines
    Kimberly R Kalli
    Endocrine Research Unit, Joseph 5 194, Mayo Clinic and Foundation, 200 First Street S W, Rochester, MN 55905, USA
    Mol Pharmacol 64:1434-43. 2003
    ..These results indicate that synthetic retinoids can use caspase-8 as an initiating caspase, but they also indicate unexpected heterogeneity in caspase activation pathways among closely related cell lines...
  46. ncbi request reprint Pregnancy-associated plasma protein-A (PAPP-A) expression and insulin-like growth factor binding protein-4 protease activity in normal and malignant ovarian surface epithelial cells
    Kimberly R Kalli
    Division of Endocrinology, Metabolism and Nutrition, Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Int J Cancer 110:633-40. 2004
    ..The concurrent regulation of PAPP-A and its inhibitor, proMBP, suggests that IGFBP-4 proteolysis and local regulation of IGF availability may be altered in malignant ovarian epithelial cells...
  47. ncbi request reprint Insulin and messenger ribonucleic acid expression of insulin receptor isoforms in ovarian follicles from nonhirsute ovulatory women and polycystic ovary syndrome patients
    Jennifer L Phy
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Clin Endocrinol Metab 89:3561-6. 2004
    ..Granulosa cell IR heterogeneity, together with adiposity-dependent intrafollicular insulin availability, introduces a novel mechanism by which insulin may affect granulosa cell function within the follicle...
  48. ncbi request reprint The insulin-like growth factor/insulin system in epithelial ovarian cancer
    Kimberly R Kalli
    Endocrine Research Unit, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Front Biosci 8:d714-22. 2003
    ....
  49. ncbi request reprint Estrogen receptor-positive human epithelial ovarian carcinoma cells respond to the antitumor drug suramin with increased proliferation: possible insight into ER and epidermal growth factor signaling interactions in ovarian cancer
    Kimberly R Kalli
    Department of Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Gynecol Oncol 94:705-12. 2004
    ..The role of estrogen and epidermal growth factor (EGF) in control of cell growth was investigated in a panel of ovarian carcinoma lines...
  50. ncbi request reprint Use of site-specific antibodies to characterize the circulating form of big insulin-like growth factor II in patients with hepatitis C-associated osteosclerosis
    Sundeep Khosla
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 87:3867-70. 2002
    ..As these two forms may have differing biological activities and/or targeting properties, our findings may explain at least in part the different manifestations of IGF-IIE overproduction in the two syndromes...
  51. ncbi request reprint Pregnancy associated plasma protein-A is necessary for expeditious fracture healing in mice
    Bradley S Miller
    Endocrine Research Unit, Mayo Clinic, 200 First, Street SW, 5 194 Joseph, Rochester, Minnesota 55905, USA
    J Endocrinol 192:505-13. 2007
    ..The ability of PAPP-A to enhance local IGF action may be an important mechanism for optimizing the fracture repair response...
  52. doi request reprint IGF system in children with congenital disorders of glycosylation
    Bradley S Miller
    Division of Pediatric Endocrinology, Mayo Clinic, Rochester, MN 55905, USA
    Clin Endocrinol (Oxf) 70:892-7. 2009
    ..In this study we determined the impact of glycosylation on the endocrine IGF system in children with the rare syndrome of congenital disorders of glycosylation (CDG)...
  53. ncbi request reprint Combined effects of insulin-like growth factor-1 and transforming growth factor-beta1 on periosteal mesenchymal cells during chondrogenesis in vitro
    T Fukumoto
    Cartilage and Connective Tissue Research Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Osteoarthritis Cartilage 11:55-64. 2003
    ..In this study, we examined the effects of insulin-like growth factor-1 (IGF-1) and transforming growth factor-beta1 (TGF-beta1), alone and in combination, on periosteal chondrogenesis using an in vitro organ culture model...
  54. pmc Transforming growth factor-beta1 modulates insulin-like growth factor binding protein-4 expression and proteolysis in cultured periosteal explants
    Carlos Gonzalez
    Cartilage and Connective Tissue Research Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Growth Horm IGF Res 20:81-6. 2010
    ..The purpose of this study was to determine the effect of TGF-beta1 on IGF binding protein-4 (IGFBP-4) and the IGFBP-4 protease pregnancy-associated plasma protein-A (PAPP-A) expression in cultured periosteal explants...
  55. ncbi request reprint Effects of insulin-like growth factor-I on cultured human coronary artery smooth muscle cells
    Antoni Bayes-Genis
    Division of Cardiovascular Diseases and Endocrine Research Unit, Mayo Clinic and Foundation, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    Growth Horm IGF Res 13:246-53. 2003
    ..Because CoSMC migration plays a crucial role in atherosclerosis and restenosis, IGF-I blockade has the potential to limit lumen reduction...
  56. ncbi request reprint Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs
    Henning B Boldt
    Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    Growth Horm IGF Res 17:10-8. 2007
    ....
  57. doi request reprint Overexpression of pregnancy-associated plasma protein-A in ovarian cancer cells promotes tumor growth in vivo
    Henning B Boldt
    Division of Endocrinology, Metabolism, and Nutrition, Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocrinology 152:1470-8. 2011
    ..In conclusion, our data show that PAPP-A proteolytic activity enhances the tumorigenic potential of ovarian cancer cells and establish a novel tumor growth-promoting role of PAPP-A...
  58. ncbi request reprint Pregnancy associated plasma protein-A and risk stratification of patients presenting with chest pain in the emergency department
    Ahmad A Elesber
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Int J Cardiol 117:365-9. 2007
    ....
  59. ncbi request reprint Pregnancy-associated plasma protein-A elevation in patients with acute coronary syndrome and subsequent atorvastatin therapy
    Michael D Miedema
    Minneapolis Heart Institute and Foundation, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA
    Am J Cardiol 101:35-9. 2008
    ..High-dose atorvastatin significantly decreased PAPP-A at 1 month and hs-CRP at 6 months in patients with verified CAD. Low-dose atorvastatin did not produce this effect...
  60. ncbi request reprint Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina
    Ahmad A Elesber
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Eur Heart J 27:1678-84. 2006
    ....
  61. pmc Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo
    Yun Ning
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Mol Endocrinol 22:1213-25. 2008
    ....
  62. pmc Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis
    Lisbeth S Laursen
    Department of Molecular and Structural Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    Biochem J 367:31-40. 2002
    ....
  63. ncbi request reprint Pregnancy-associated plasma protein-a is markedly expressed by monocyte-macrophage cells in vulnerable and ruptured carotid atherosclerotic plaques: a link between inflammation and cerebrovascular events
    Giuseppe Sangiorgi
    Department of Cardiovascular Disease, Istituto Policlinico San Donato, San Donato Milanese, Milan, Italy
    J Am Coll Cardiol 47:2201-11. 2006
    ..The study aim was to evaluate serologic expression of pregnancy-associated protein-A (PAPP-A) in patients affected by cerebrovascular accidents and to correlate it with histopathologic carotid plaque complexity...
  64. ncbi request reprint Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity
    Rikke Søe
    Department of Molecular and Structural Biology, Science Park, University of Aarhus, Denmark
    Eur J Biochem 269:2247-56. 2002
    ..Importantly, these data support the development of the mouse as a model organism for the study of PAPP-A, which must take into account the differences between the mouse and the human...
  65. ncbi request reprint The Lin12-notch repeats of pregnancy-associated plasma protein-A bind calcium and determine its proteolytic specificity
    Henning B Boldt
    Department of Molecular Biology, Science Park, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    J Biol Chem 279:38525-31. 2004
    ..We propose a model in which LNR3 is spatially localized in proximity to LNR1 and -2, forming a single functional unit...
  66. ncbi request reprint Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor
    Simon Glerup
    Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    J Biol Chem 282:1769-78. 2007
    ..Because both PAPP-A and proMBP are expressed ubiquitously, this model may be applicable to many tissues in which insulin-like growth factor bioavailability is locally regulated...
  67. ncbi request reprint Detecting vulnerable plaque using peripheral blood: inflammatory and cellular markers
    Robert S Schwartz
    Minnesota Cardiovascular Research Institute, Minneapolis Heart Institute Foundation, Minneapolis, MN 55407, USA
    J Interv Cardiol 16:231-42. 2003
    ..Sensitivity or specificity must be increased by developing a risk marker panel, or by simultaneously finding other markers that themselves are highly sensitive and specific for vulnerable plaque...
  68. ncbi request reprint Insulin-like growth factor (IGF)-II/IGF-binding proteins in constitutionally tall children
    Sundeep Khosla
    J Clin Endocrinol Metab 88:1912-3; author reply 1913. 2003