Eduardo Chini

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues
    Eduardo N Chini
    Department of Anesthesia, Mayo Clinic and Foundation, 200 First Street, Rochester, MN 55905, U S A
    Biochem J 362:125-30. 2002
  2. ncbi request reprint Role of the second-messenger cyclic-adenosine 5'-diphosphate-ribose on adrenocorticotropin secretion from pituitary cells
    Sandra M Soares
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocrinology 146:2186-92. 2005
  3. pmc DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα
    Claudia C S Chini
    Laboratory of Signal Transduction, Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Biochem J 451:453-61. 2013
  4. pmc Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome
    Carlos Escande
    Department of Anesthesiology and Kogod Aging Center, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 62:1084-93. 2013
  5. pmc CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions
    Eduardo Nunes Chini
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Curr Pharm Des 15:57-63. 2009
  6. ncbi request reprint FK506 (tacrolimus) increases halothane-induced Ca2+ release from skeletal muscle sarcoplasmic reticulum
    E N Chini
    Departments of Physiology, Biophysics, and Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Anesthesiology 92:1361-5. 2000
  7. ncbi request reprint To be or not to be ... nicotinic acid adenine dinucleotide phosphate (NAADP): a new intracellular second messenger?
    Eduardo Nunes Chini
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Biol Res 37:559-63. 2004
  8. ncbi request reprint Hypertensive crisis in a patient undergoing percutaneous radiofrequency ablation of an adrenal mass under general anesthesia
    Eduardo N Chini
    Department of Anesthesiology, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Anesth Analg 99:1867-9, table of contents. 2004
  9. ncbi request reprint The cyclic-ADP-ribose signaling pathway in human myometrium
    Eduardo N Chini
    Department of Anesthesiology and Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Arch Biochem Biophys 407:152-9. 2002
  10. ncbi request reprint Selected contribution: effect of volatile anesthetics on cADP-ribose-induced Ca(2+) release system
    E N Chini
    Department of Anesthesia, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Appl Physiol (1985) 91:516-21; discussion 504-5. 2001

Collaborators

Detail Information

Publications27

  1. pmc CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues
    Eduardo N Chini
    Department of Anesthesia, Mayo Clinic and Foundation, 200 First Street, Rochester, MN 55905, U S A
    Biochem J 362:125-30. 2002
    ....
  2. ncbi request reprint Role of the second-messenger cyclic-adenosine 5'-diphosphate-ribose on adrenocorticotropin secretion from pituitary cells
    Sandra M Soares
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocrinology 146:2186-92. 2005
    ..These results suggest that cADPR is a second messenger in pituitary cells and regulates ACTH secretion by a mechanism dependent on activation of the ryanodine channel by extracellular Ca2+...
  3. pmc DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα
    Claudia C S Chini
    Laboratory of Signal Transduction, Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Biochem J 451:453-61. 2013
    ..In summary, our data identify DBC1 as an important regulator of the circadian receptor Rev-erbα and proposes that Rev-erbα could be involved in mediating some of the physiological effects of DBC1...
  4. pmc Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome
    Carlos Escande
    Department of Anesthesiology and Kogod Aging Center, Mayo Clinic, Rochester, Minnesota, USA
    Diabetes 62:1084-93. 2013
    ..Our results show that CD38 is a novel pharmacological target to treat metabolic diseases via NAD(+)-dependent pathways...
  5. pmc CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions
    Eduardo Nunes Chini
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Curr Pharm Des 15:57-63. 2009
    ..The discovery of CD38 as the main cellular NADase in mammalian tissues, and the characterization of its role on the control of cellular NAD levels indicate that CD38 may serve as a pharmacological target for multiple conditions...
  6. ncbi request reprint FK506 (tacrolimus) increases halothane-induced Ca2+ release from skeletal muscle sarcoplasmic reticulum
    E N Chini
    Departments of Physiology, Biophysics, and Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Anesthesiology 92:1361-5. 2000
    ..The authors investigated the effect of the immunosuppressants FK506 and rapamycin on halothane-induced Ca2+ release in skeletal muscle sarcoplasmic reticulum vesicles...
  7. ncbi request reprint To be or not to be ... nicotinic acid adenine dinucleotide phosphate (NAADP): a new intracellular second messenger?
    Eduardo Nunes Chini
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Biol Res 37:559-63. 2004
    ..In this short review, I will discuss some of these new findings that are helping us to find an answer to the important question: Is NAADP a second messenger or not?..
  8. ncbi request reprint Hypertensive crisis in a patient undergoing percutaneous radiofrequency ablation of an adrenal mass under general anesthesia
    Eduardo N Chini
    Department of Anesthesiology, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Anesth Analg 99:1867-9, table of contents. 2004
    ....
  9. ncbi request reprint The cyclic-ADP-ribose signaling pathway in human myometrium
    Eduardo N Chini
    Department of Anesthesiology and Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Arch Biochem Biophys 407:152-9. 2002
    ..These data indicate that the cADPR system is present and operational in human myometrial tissue. Further research is warranted to determine the role of this new signaling molecule in uterine contraction...
  10. ncbi request reprint Selected contribution: effect of volatile anesthetics on cADP-ribose-induced Ca(2+) release system
    E N Chini
    Department of Anesthesia, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Appl Physiol (1985) 91:516-21; discussion 504-5. 2001
    ..I propose that the complex effect of volatile anesthetics on intracellular Ca(2+) homeostasis may involve modulation of the cADPR signaling system...
  11. ncbi request reprint Effect of halothane on cADP-ribose-induced Ca(2+) release system in tracheal smooth muscle
    Eduardo N Chini
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Anesthesiology 97:1022-4. 2002
  12. ncbi request reprint Interactions between intracellular Ca2+ stores: Ca2+ released from the NAADP pool potentiates cADPR-induced Ca2+ release
    Eduardo N Chini
    Department of Anesthesia, Mayo Clinic and Foundation, 200 First Street, Rochester, MN 55905, USA
    Braz J Med Biol Res 35:543-7. 2002
    ..These data raise the possibility that the NAADP Ca2+ store may have a role as a regulator of the cellular sensitivity to cADPR...
  13. ncbi request reprint Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger?
    Eduardo N Chini
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Cell Physiol 282:C1191-8. 2002
    ..However, whether NAADP is a new second messenger or a tool for the discovery of a new Ca2+ channel is still an unanswered question...
  14. ncbi request reprint The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cells
    Hosana Barata
    Signal Transduction Laboratory, Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Endocrinology 145:881-9. 2004
    ....
  15. ncbi request reprint NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells
    Sandra Soares
    Department of Anesthesiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Cell Physiol 292:C227-39. 2007
    ..Furthermore, the NAADP mediated mechanism in mammalian cells can be independent of RyRs and CD38. Our data provides novel insights into the understanding of the mechanism of action and metabolism of this new second messenger system...
  16. ncbi request reprint Role of CD38 in myometrial Ca2+ transients: modulation by progesterone
    Michael Thompson
    Dept of Anesthesiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 287:E1142-8. 2004
    ..We propose that the balance between cytokines and placental steroids regulates the expression of CD38 in vivo and cell responsiveness to oxytocin...
  17. ncbi request reprint Reduction in soluble guanylyl cyclase-specific activity following prolonged treatment of porcine pulmonary artery with nitric oxide
    William J Perkins
    Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Lung Cell Mol Physiol 293:L84-95. 2007
    ..We conclude that prolonged NO treatment induces decreased acute NO responsiveness in part by decreasing both sGC expression and sGC-specific activity...
  18. ncbi request reprint Metabolism of cyclic ADP-ribose: Zinc is an endogenous modulator of the cyclase/NAD glycohydrolase ratio of a CD38-like enzyme from human seminal fluid
    Weronika Zielinska
    Departments of Anesthesiology and Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Life Sci 74:1781-90. 2004
    ..6 to 4 mM, are responsible for the modulation of the cyclase/NAD glycohydrolase ratio. This new information indicates that the cyclase/NAD glycohydrolase ratio can be modified in vivo...
  19. pmc Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK
    Colleen M Novak
    Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA
    PLoS ONE 4:e5869. 2009
    ..Therefore, the lean phenotype is characterized by high endurance capacity and high activity and may stem from altered skeletal muscle energetics...
  20. pmc Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii
    Eduardo N Chini
    Department of Anesthesiology, Mayo Medical School, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Biochem J 389:269-77. 2005
    ..These results indicate that RyR calcium-release channels that respond to the second-messenger cADPR play an important role in regulating intracellular Ca2+, and hence host cell invasion, in protozoan parasites...
  21. ncbi request reprint Agonist-induced cyclic ADP ribose production in airway smooth muscle
    Sertac N Kip
    Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Arch Biochem Biophys 452:102-7. 2006
    ..These results indicate that in porcine ASM, certain agonists acting via receptors increase cADPR levels. Furthermore, the extent of cADPR responses to agonist varies, possibly reflecting differences in G-protein coupling...
  22. ncbi request reprint Differential effects of volatile anesthetics on M3 muscarinic receptor coupling to the Galphaq heterotrimeric G protein
    Tetsuzo Nakayama
    Department of Anesthesiology, Mayo Foundation, Rochester, Minnesota 55905, USA
    Anesthesiology 105:313-24. 2006
    ....
  23. ncbi request reprint Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38
    Pinar Aksoy
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN, USA
    Biochem Biophys Res Commun 349:353-9. 2006
    ..These findings have strong implications for understanding the basic mechanisms that modulate intracellular NAD levels, energy homeostasis, as well as ageing and cellular protection modulated by the SIRT enzymes...
  24. ncbi request reprint Regulation of intracellular levels of NAD: a novel role for CD38
    Pinar Aksoy
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN, USA
    Biochem Biophys Res Commun 345:1386-92. 2006
    ..These findings have implications for understanding the mechanisms that regulate intracellular NAD levels and its role in energy homeostasis, signal transduction, and ageing...
  25. ncbi request reprint Postoperative outcome of patients with narcolepsy. A retrospective analysis
    Bethanie Burrow
    Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Clin Anesth 17:21-5. 2005
    ..To determine the postoperative outcome of narcolepsy patients, a population that may be at increased risk of perioperative complications, including postoperative hypersomnia, prolonged emergence after general anesthesia, and apnea...
  26. pmc Role of transient receptor potential C3 in TNF-alpha-enhanced calcium influx in human airway myocytes
    Thomas A White
    Depertment of Allergy and Immunology, College of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Am J Respir Cell Mol Biol 35:243-51. 2006
    ..These results suggest that TRPC3 may be an important therapeutic target in inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease...
  27. ncbi request reprint The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity
    Maria Thereza P Barbosa
    Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    FASEB J 21:3629-39. 2007
    ..Thus, together these results identify a novel pathway regulating body weight and clearly show that CD38 is a nearly obligatory component of the cellular cascade that led to diet-induced obesity...

Research Grants2

  1. Molecular mechanisms of fatty liver disease: role of the protein DBC1
    Eduardo Chini; Fiscal Year: 2009
    ..These alarming data and predictions clearly show that it is imperative to further understand the molecular mechanisms that modulate the development of liver steatosis. ..
  2. Molecular mechanisms of fatty liver disease: role of the protein DBC1
    Eduardo N Chini; Fiscal Year: 2010
    ..These alarming data and predictions clearly show that it is imperative to further understand the molecular mechanisms that modulate the development of liver steatosis. ..