Research Topics
| Eduardo ChiniSummaryAffiliation: Mayo Clinic Country: USA Publications
Research Grants
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Detail Information
Publications
CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissuesEduardo N Chini
Department of Anesthesia, Mayo Clinic and Foundation, 200 First Street, Rochester, MN 55905, U S A
Biochem J 362:125-30. 2002....
Role of the second-messenger cyclic-adenosine 5'-diphosphate-ribose on adrenocorticotropin secretion from pituitary cellsSandra M Soares
Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA
Endocrinology 146:2186-92. 2005..These results suggest that cADPR is a second messenger in pituitary cells and regulates ACTH secretion by a mechanism dependent on activation of the ryanodine channel by extracellular Ca2+...- Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndromeCarlos Escande
Department of Anesthesiology and Kogod Aging Center, Mayo Clinic, Rochester, Minnesota, USA
Diabetes 62:1084-93. 2013..Our results show that CD38 is a novel pharmacological target to treat metabolic diseases via NAD(+)-dependent pathways... - CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditionsEduardo Nunes Chini
Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Curr Pharm Des 15:57-63. 2009..The discovery of CD38 as the main cellular NADase in mammalian tissues, and the characterization of its role on the control of cellular NAD levels indicate that CD38 may serve as a pharmacological target for multiple conditions... - FK506 (tacrolimus) increases halothane-induced Ca2+ release from skeletal muscle sarcoplasmic reticulumE N Chini
Departments of Physiology, Biophysics, and Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Anesthesiology 92:1361-5. 2000..The authors investigated the effect of the immunosuppressants FK506 and rapamycin on halothane-induced Ca2+ release in skeletal muscle sarcoplasmic reticulum vesicles... - To be or not to be ... nicotinic acid adenine dinucleotide phosphate (NAADP): a new intracellular second messenger?Eduardo Nunes Chini
Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Biol Res 37:559-63. 2004..In this short review, I will discuss some of these new findings that are helping us to find an answer to the important question: Is NAADP a second messenger or not?.. - Hypertensive crisis in a patient undergoing percutaneous radiofrequency ablation of an adrenal mass under general anesthesiaEduardo N Chini
Department of Anesthesiology, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
Anesth Analg 99:1867-9, table of contents. 2004.... - The cyclic-ADP-ribose signaling pathway in human myometriumEduardo N Chini
Department of Anesthesiology and Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Arch Biochem Biophys 407:152-9. 2002..These data indicate that the cADPR system is present and operational in human myometrial tissue. Further research is warranted to determine the role of this new signaling molecule in uterine contraction... - Effect of halothane on cADP-ribose-induced Ca(2+) release system in tracheal smooth muscleEduardo N Chini
Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Anesthesiology 97:1022-4. 2002 - Interactions between intracellular Ca2+ stores: Ca2+ released from the NAADP pool potentiates cADPR-induced Ca2+ releaseEduardo N Chini
Department of Anesthesia, Mayo Clinic and Foundation, 200 First Street, Rochester, MN 55905, USA
Braz J Med Biol Res 35:543-7. 2002..These data raise the possibility that the NAADP Ca2+ store may have a role as a regulator of the cellular sensitivity to cADPR... - Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger?Eduardo N Chini
Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Am J Physiol Cell Physiol 282:C1191-8. 2002..However, whether NAADP is a new second messenger or a tool for the discovery of a new Ca2+ channel is still an unanswered question... - Selected contribution: effect of volatile anesthetics on cADP-ribose-induced Ca(2+) release systemE N Chini
Department of Anesthesia, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
J Appl Physiol 91:516-21; discussion 504-5. 2001..I propose that the complex effect of volatile anesthetics on intracellular Ca(2+) homeostasis may involve modulation of the cADPR signaling system... - The role of cyclic-ADP-ribose-signaling pathway in oxytocin-induced Ca2+ transients in human myometrium cellsHosana Barata
Signal Transduction Laboratory, Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Endocrinology 145:881-9. 2004.... - NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cellsSandra Soares
Department of Anesthesiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
Am J Physiol Cell Physiol 292:C227-39. 2007..Furthermore, the NAADP mediated mechanism in mammalian cells can be independent of RyRs and CD38. Our data provides novel insights into the understanding of the mechanism of action and metabolism of this new second messenger system... - Role of CD38 in myometrial Ca2+ transients: modulation by progesteroneMichael Thompson
Dept of Anesthesiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
Am J Physiol Endocrinol Metab 287:E1142-8. 2004..We propose that the balance between cytokines and placental steroids regulates the expression of CD38 in vivo and cell responsiveness to oxytocin... - Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCKColleen M Novak
Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota, USA
PLoS ONE 4:e5869. 2009..Therefore, the lean phenotype is characterized by high endurance capacity and high activity and may stem from altered skeletal muscle energetics... - Reduction in soluble guanylyl cyclase-specific activity following prolonged treatment of porcine pulmonary artery with nitric oxideWilliam J Perkins
Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
Am J Physiol Lung Cell Mol Physiol 293:L84-95. 2007..We conclude that prolonged NO treatment induces decreased acute NO responsiveness in part by decreasing both sGC expression and sGC-specific activity... - Metabolism of cyclic ADP-ribose: Zinc is an endogenous modulator of the cyclase/NAD glycohydrolase ratio of a CD38-like enzyme from human seminal fluidWeronika Zielinska
Departments of Anesthesiology and Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Life Sci 74:1781-90. 2004..6 to 4 mM, are responsible for the modulation of the cyclase/NAD glycohydrolase ratio. This new information indicates that the cyclase/NAD glycohydrolase ratio can be modified in vivo... - Agonist-induced cyclic ADP ribose production in airway smooth muscleSertac N Kip
Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Arch Biochem Biophys 452:102-7. 2006..These results indicate that in porcine ASM, certain agonists acting via receptors increase cADPR levels. Furthermore, the extent of cADPR responses to agonist varies, possibly reflecting differences in G-protein coupling... - Differential effects of volatile anesthetics on M3 muscarinic receptor coupling to the Galphaq heterotrimeric G proteinTetsuzo Nakayama
Department of Anesthesiology, Mayo Foundation, Rochester, Minnesota 55905, USA
Anesthesiology 105:313-24. 2006..These differential effects also suggest a mode of anesthetic action that could be due to anesthetic-protein interactions and not simply anesthetic accumulation in the lipid membrane... - Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38Pinar Aksoy
Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN, USA
Biochem Biophys Res Commun 349:353-9. 2006..These findings have strong implications for understanding the basic mechanisms that modulate intracellular NAD levels, energy homeostasis, as well as ageing and cellular protection modulated by the SIRT enzymes... - Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondiiEduardo N Chini
Department of Anesthesiology, Mayo Medical School, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Biochem J 389:269-77. 2005..These results indicate that RyR calcium-release channels that respond to the second-messenger cADPR play an important role in regulating intracellular Ca2+, and hence host cell invasion, in protozoan parasites... - Regulation of intracellular levels of NAD: a novel role for CD38Pinar Aksoy
Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN, USA
Biochem Biophys Res Commun 345:1386-92. 2006..These findings have implications for understanding the mechanisms that regulate intracellular NAD levels and its role in energy homeostasis, signal transduction, and ageing... - Postoperative outcome of patients with narcolepsy. A retrospective analysisBethanie Burrow
Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
J Clin Anesth 17:21-5. 2005..CONCLUSION: Pharmacological therapy for narcolepsy should be continued during the perioperative period. In addition, treated narcolepsy patients are at no increased risk for postoperative complications... - Role of transient receptor potential C3 in TNF-alpha-enhanced calcium influx in human airway myocytesThomas A White
Depertment of Allergy and Immunology, College of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Am J Respir Cell Mol Biol 35:243-51. 2006..These results suggest that TRPC3 may be an important therapeutic target in inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease... - The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesityMaria Thereza P Barbosa
Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
FASEB J 21:3629-39. 2007..Thus, together these results identify a novel pathway regulating body weight and clearly show that CD38 is a nearly obligatory component of the cellular cascade that led to diet-induced obesity...
Research Grants
- Molecular mechanisms of fatty liver disease: role of the protein DBC1Eduardo Chini; Fiscal Year: 2009..These alarming data and predictions clearly show that it is imperative to further understand the molecular mechanisms that modulate the development of liver steatosis. ..
- Molecular mechanisms of fatty liver disease: role of the protein DBC1Eduardo N Chini; Fiscal Year: 2010..These alarming data and predictions clearly show that it is imperative to further understand the molecular mechanisms that modulate the development of liver steatosis. ..