Research Topics
Genomes and Genes
Species | James CerhanSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
A two-stage evaluation of genetic variation in immune and inflammation genes with risk of non-Hodgkin lymphoma identifies new susceptibility locus in 6p21.3 regionJames R Cerhan
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Cancer Epidemiol Biomarkers Prev 21:1799-806. 2012..Non-Hodgkin lymphoma (NHL) is a malignancy of lymphocytes, and there is growing evidence for a role of germline genetic variation in immune genes in NHL etiology...- LIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab eraJames R Cerhan
College of Medicine, Mayo Clinic, Rochester, MN, USA
Leuk Lymphoma 53:1105-12. 2012..In conclusion, germline genetic variation in LMO2 was associated with DLBCL prognosis and provided slightly stronger predictive ability relative to LMO2 IHC status... - Spatial-temporal analysis of non-Hodgkin lymphoma in the NCI-SEER NHL case-control studyDavid C Wheeler
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD, USA
Environ Health 10:63. 2011..Little is known about the etiology of non-Hodgkin lymphoma (NHL), or the latency period that might be relevant for environmental exposures, and there are no published spatial-temporal cluster studies of NHL... - Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studiesLinda E Kelemen
Department of Population Health Research, Alberta Cancer Board, 1331 29th Street NW, Calgary, AB T2N 4N2, Canada
Breast Cancer Res 10:R98. 2008..Altered expression of decorin and lumican is associated with breast tumors. We hypothesized that genetic variation in the decorin (DCN) and lumican (LUM) genes may contribute to breast cancer... 
Hormone replacement therapy and risk of non-hodgkin lymphoma and chronic lymphocytic leukemiaJames R Cerhan
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer Epidemiol Biomarkers Prev 11:1466-71. 2002..For diffuse NHL, 64% of the cases were nodal, and there was no association of HRT with either nodal or extra-nodal sites. These data suggest that HRT is a risk factor for follicular NHL but not for diffuse or small lymphocyte NHL or CLL...- Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older womenJames R Cerhan
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Am J Epidemiol 157:345-54. 2003..Intake of certain antioxidant micronutrients, particularly beta-cryptoxanthin and supplemental zinc, and possibly diets high in fruits and cruciferous vegetables, may be protective against the development of rheumatoid arthritis... - Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphomaJames R Cerhan
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 17:3161-9. 2008.... 
Blood transfusion, anesthesia, surgery and risk of non-Hodgkin lymphoma in a population-based case-control studyJames R Cerhan
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 5905, USA
Int J Cancer 123:888-94. 2008..Multiple surgical procedures and/or repeated administration of anesthesia have not been previously reported to be associated with risk of NHL and these exposures warrant further evaluation...- Association of aspirin and other non-steroidal anti-inflammatory drug use with incidence of non-Hodgkin lymphomaJames R Cerhan
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Int J Cancer 106:784-8. 2003..These data suggest that use of NSAIDs, either aspirin or other non-aspirin NSAIDs, are associated positively with risk of NHL, and that this association is independent of RA history... - Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphomaJames R Cerhan
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Blood 110:4455-63. 2007.... - Prognostic significance of host immune gene polymorphisms in follicular lymphoma survivalJames R Cerhan
Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Blood 109:5439-46. 2007..Common variation in host immune genes warrants further evaluation as a promising class of prognostic factors in follicular lymphoma... - Interaction of adolescent anthropometric characteristics and family history on breast cancer risk in a Historical Cohort Study of 426 families (USA)James R Cerhan
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Cancer Causes Control 15:1-9. 2004..To determine whether the association of adolescent anthropometric characteristics with breast cancer is modified by a family history of the disease... - Anthropometrics, physical activity, related medical conditions, and the risk of non-hodgkin lymphomaJames R Cerhan
Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Cancer Causes Control 16:1203-14. 2005..Physical inactivity increases the risk of obesity and of type 2 diabetes, but there are few data on the association of physical activity with risk of NHL... - Prenatal and perinatal correlates of adult mammographic breast densityJames R Cerhan
Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, Minnesota 55905, USA
Cancer Epidemiol Biomarkers Prev 14:1502-8. 2005..We examined the hypothesis that those factors associated with higher levels of estrogen during pregnancy or shortly after birth are associated with higher mammographic breast density in adulthood... - Family history and prostate cancer risk in a population-based cohort of Iowa menJ R Cerhan
Department of Preventive Medicine, The University of Iowa College of Medicine, Iowa City 52242, USA
Cancer Epidemiol Biomarkers Prev 8:53-60. 1999..These data also support the idea that a family history of breast cancer may also be a prostate cancer risk factor... - Anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma subtypes and B-cell chronic lymphocytic leukemia: a prospective studyJames R Cerhan
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Am J Epidemiol 156:527-35. 2002..The opposite associations of body mass index with small lymphocytic lymphoma versus B-CLL may be a chance finding but, if confirmed, would suggest different etiologies for these malignancies... - Twinship and risk of postmenopausal breast cancerJ R Cerhan
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
J Natl Cancer Inst 92:261-5. 2000..e., belonging to a twin pair) and the risk of breast cancer... - Blood transfusions and risk of non-Hodgkin's lymphoma subtypes and chronic lymphocytic leukemiaJ R Cerhan
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer Epidemiol Biomarkers Prev 10:361-8. 2001..In conclusion, prior blood transfusion was associated with NHL and CLL, and the strongest associations were seen for low-grade NHL, particularly follicular and small lymphocytic NHL... - Blood transfusion, alcohol use, and anthropometric risk factors for rheumatoid arthritis in older womenJames R Cerhan
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
J Rheumatol 29:246-54. 2002..To evaluate whether blood transfusion, alcohol use, or anthropometric characteristics are risk factors for rheumatoid arthritis (RA) in older women... - Host genetics in follicular lymphomaJames R Cerhan
Division of Epidemiology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Best Pract Res Clin Haematol 24:121-34. 2011..While the use of host genetics to identify individuals at high risk of FL or to predict FL treatment response and prognosis appears to be very promising, it is not yet ready for the clinic... - Adherence to the AICR cancer prevention recommendations and subsequent morbidity and mortality in the Iowa Women's Health Study cohortJames R Cerhan
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 13:1114-20. 2004.... - Menstrual and reproductive factors and risk of non-Hodgkin lymphoma: the Iowa women's health study (United States)James R Cerhan
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Cancer Causes Control 13:131-6. 2002..Endogenous sex hormones, particularly estrogens, modulate the immune system, and non-Hodgkin lymphoma (NHL) is a tumor that is related to immunologic status... - Tea consumption and risk of cancer of the colon and rectumJ R Cerhan
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Nutr Cancer 41:33-40. 2001..0, 1.0, 1.1, and 0.4; P for trend = 0.3). These data do not support an overall association, either positive or negative, between tea consumption and risk of colon or rectal cancer in this Mid-western US population... - Risk of non-Hodgkin lymphoma in association with germline variation in complement genesJames R Cerhan
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Br J Haematol 145:614-23. 2009..015; OR = 0.68; 95% 0.56-0.84) remained noteworthy. Associations were similar for the common NHL subtypes. In summary, we provide evidence for a role of genetic variation in complement genes, particularly C5 and C9, and NHL risk... - Evaluation of associations between common variation in mitotic regulatory pathways and risk of overall and high grade breast cancerKristen N Stevens
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Breast Cancer Res Treat 129:617-22. 2011..Further investigation in breast and other cancers are needed to understand the influence of inherited variation in mitotic genes on tumor grade and cancer risk... - Vegetables- and antioxidant-related nutrients, genetic susceptibility, and non-Hodgkin lymphoma riskLinda E Kelemen
Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA
Cancer Causes Control 19:491-503. 2008..Although most associations have not been examined previously with NHL, our results suggest the examined polymorphisms are not modifiers of the association between vegetable and zinc intakes and NHL risk... - Cigarette smoking and colorectal cancer risk by molecularly defined subtypesDavid Limsui
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
J Natl Cancer Inst 102:1012-22. 2010..Because colorectal carcinogenesis is a heterogeneous process, we investigated whether cigarette smoking is differentially associated with molecularly defined subtypes of colorectal cancer... - No interaction of body mass index and smoking on diabetes mellitus risk in elderly womenMichael W Cullen
Nicotine Dependence Center, Primary Care Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
Prev Med 48:74-8. 2009..We sought to assess the interaction of smoking and body mass index (BMI) on diabetes risk... - Antioxidant intake from fruits, vegetables and other sources and risk of non-Hodgkin's lymphoma: the Iowa Women's Health StudyCarrie A Thompson
Department of Medicine, College of Medicine Mayo Clinic, Rochester, MN, USA
Int J Cancer 126:992-1003. 2010..In conclusion, these results support a role for vegetables, and perhaps fruits and associated antioxidants from food sources, as protective factors against the development of NHL and follicular lymphoma in particular... - Does folate intake decrease risk of postmenopausal breast cancer among women with a family history?Thomas A Sellers
Mayo Clinic Cancer Center, Rochester, MN 55905, USA
Cancer Causes Control 15:113-20. 2004..We examined whether the putative benefit extends to women with a family history (FH) of breast cancer using a cohort of 33,552 postmenopausal women aged 55-69 years in 1986... - Postmenopausal cancer risk after self-reported endometriosis diagnosis in the Iowa Women's Health StudyJanet E Olson
Mayo Foundation, Health Sciences Research, Rochester, Minnesota 55905, USA
Cancer 94:1612-8. 2002..2, 0.8, 1.2, 0.7, and 0.7, respectively). CONCLUSIONS: These results corroborate a previously reported association between endometriosis and increased risk of NHL but not cancer at other sites... - Evaluation of familial clustering of breast and prostate cancer in the Minnesota Breast Cancer Family StudyDawn M Grabrick
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Cancer Detect Prev 27:30-6. 2003..8, 95% C.I.: 0.5-1.2). These results provide little evidence that male relatives in high-risk breast cancer families are at increased risk of prostate cancer... - Recreational physical activity and risk of postmenopausal breast cancer based on hormone receptor statusAditya Bardia
Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Arch Intern Med 166:2478-83. 2006..If confirmed in additional studies, these results would suggest that additional mechanisms, besides an effect on body mass, may account for observed protective effects of physical activity in reducing breast cancer... - Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancerJulie M Cunningham
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 16:969-78. 2007..Given that the point estimates for the odds ratio for each of these polymorphisms are <2.0, much larger sample sizes will be required for confirmation... - Cigarette smoking and colorectal cancer: long-term, subsite-specific risks in a cohort study of postmenopausal womenPaul J Limburg
Divisions of Gastroenterology and Hepatology and Epidemiology, Mayo Clinic Cancer Center, Rochester, Minnesota, USA
Clin Gastroenterol Hepatol 1:202-10. 2003..These data support a potential subsite-specific role for cigarette smoking in colorectal carcinogenesis, at least among women. Based on emerging data, an epigenetic pathway for smoking-induced CRC is proposed... - Association of aspirin and nonaspirin nonsteroidal anti-inflammatory drugs with cancer incidence and mortalityAditya Bardia
Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
J Natl Cancer Inst 99:881-9. 2007..We evaluated associations between aspirin and nonaspirin NSAID use with cancer incidence and mortality stratified by smoking history in the Iowa Women's Health Study, a prospective cohort of postmenopausal women... - Texture features from mammographic images and risk of breast cancerArmando Manduca
Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 18:837-45. 2009..However, simultaneous inclusion of these features in a model with PD did not significantly improve the ability to predict breast cancer... - Vegetables, fruit, and antioxidant-related nutrients and risk of non-Hodgkin lymphoma: a National Cancer Institute-Surveillance, Epidemiology, and End Results population-based case-control studyLinda E Kelemen
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Am J Clin Nutr 83:1401-10. 2006..91; P for trend = 0.02). An effect modification by exercise and NHL subtype was observed with some food groups and nutrients. CONCLUSION: Higher intakes of vegetables, lutein and zeaxanthin, and zinc are associated with a lower NHL risk... - Association of correlates of endogenous hormonal exposure with breast cancer risk in 426 families (United States)Dawn M Grabrick
Mayo Clinic, Department of Health Sciences Research, Rochester, Minnesota 55905, USA
Cancer Causes Control 13:333-41. 2002..However, other options for prevention, such as prophylactic surgery or chemoprevention, may be necessary to have a substantial impact on risk reduction in women at high genetic risk... - Polymorphisms in mitochondrial genes and prostate cancer riskLiang Wang
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 17:3558-66. 2008..Overall, these results suggest that polymorphisms in the mitochondrial genome and those in the nuclear-encoded mitochondrial genes evaluated are not substantial risk factors for prostate cancer... - High expression levels of insulin-like growth factor-I receptor predict poor survival among women with clear-cell renal cell carcinomasAlexander S Parker
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Hum Pathol 33:801-5. 2002.... - Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancerXianshu Wang
Department of Laboratory Medicine and Pathology, Mayo Clinic, Stabile 2 42, 200 First Street Southwest, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 17:2101-8. 2008.... - High-folate diets and breast cancer survival in a prospective cohort studyThomas A Sellers
Department of Health Sciences Research, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA
Nutr Cancer 44:139-44. 2002..These findings, although preliminary, afford some reassurance that folate supplementation is unlikely to have a significant adverse effect on survival after chemotherapy for breast cancer... - Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab eraThomas M Habermann
Mayo Clinic College of Medicine, Rochester, MN, USA
Blood 112:2694-702. 2008..These data support a role for germ line variation in immune genes, particularly genes associated with a proinflammatory state, as predictors of late survival in DLBCL... - Role of the Nijmegen breakage syndrome 1 gene in familial and sporadic prostate cancerScott J Hebbring
Mayo Clinic Rochester, 200 First Street Southwest, 920 Hilton Building, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 15:935-8. 2006..However, our data does suggest that mutations within NBS1, and in particular, 657del5, do not significantly contribute to the overall prostate cancer burden within our patient samples... - Prospective evaluation of trans-fatty acid intake and colorectal cancer risk in the Iowa Women's Health StudyPaul J Limburg
Mayo Clinic Cancer Center, Rochester, MN 55905, USA
Int J Cancer 123:2717-9. 2008..Multivariable adjustment yielded slightly attenuated risk estimates, but the observed associations were not meaningfully altered. Given these findings, tFA intake does not appear to be a major CRC risk factor, at least among older women... - Interaction of dietary folate intake, alcohol, and risk of hormone receptor-defined breast cancer in a prospective study of postmenopausal womenThomas A Sellers
Department of Health Sciences Research, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
Cancer Epidemiol Biomarkers Prev 11:1104-7. 2002.... - Factors associated with breast cancer prevention communication between mothers and daughtersPamela S Sinicrope
Behavioral Health Program, Mayo Clinic Rochester College of Medicine, Rochester, Minnesota 55905, USA
J Womens Health (Larchmt) 17:1017-23. 2008..We examined the degree to which mothers reported providing advice on breast cancer prevention to their daughters, the content of such advice, and correlates of providing such advice... - Smoking cessation and renal cell carcinomaAlexander S Parker
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Ann Epidemiol 13:245-51. 2003..Furthermore, conclusions from previous investigations have been hampered by unstable risk estimates, broad exposure categories and/or insufficient adjustment for the inverse correlation of cessation years with lifetime smoking exposure... - Association of parity and ovarian cancer risk by family history of breast or ovarian cancer in a population-based study of postmenopausal womenCeline M Vachon
Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
Epidemiology 13:66-71. 2002..Nulliparity may be more strongly associated with an increased risk of ovarian cancer among women with a family history of breast or ovarian cancer, compared with women who do not have a family history of those cancers... - Association of genetic variation in mitotic kinases with breast cancer riskXianshu Wang
Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Breast Cancer Res Treat 119:453-62. 2010..006) genes. Although requiring replication, these findings suggest that genetic polymorphisms in mitotic kinases that have been implicated in chromosome instability and aneuploidy may contribute to the development of breast cancer... - Interaction of waist/hip ratio and family history on the risk of hormone receptor-defined breast cancer in a prospective study of postmenopausal womenThomas A Sellers
Department of Health Sciences Research, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, MN 55905, USA
Am J Epidemiol 155:225-33. 2002..9, 5.8). Thus, the previously reported interaction between family history and waist/hip ratio is still (weakly) evident and appears to reflect risk for progesterone receptor-negative tumors... - Gender, alcohol consumption, and renal cell carcinomaAlexander S Parker
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Am J Epidemiol 155:455-62. 2002..These findings suggest an inverse association of alcohol consumption and RCC development among women but not among men... - Elevated serum free light chains are associated with event-free and overall survival in two independent cohorts of patients with diffuse large B-cell lymphomaMatthew J Maurer
Mayo Clinic College of Medicine and Mayo Foundation, Rochester, MN 55905, USA
J Clin Oncol 29:1620-6. 2011..This assay has prognostic value in plasma cell proliferative disorders. There are limited data on serum FLC in B-cell malignancies... - Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLLSusan L Slager
Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Blood 117:1911-6. 2011..Our findings support the hypothesis that familial CLL cases have additional genetic variants not seen in sporadic CLL. Additional loci among familial CLL cases may be identified through larger studies... - Polyunsaturated fatty acids and reduced odds of MCI: the Mayo Clinic Study of AgingRosebud O Roberts
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
J Alzheimers Dis 21:853-65. 2010..In this study, higher intake of PUFA and MUFA was associated with a reduced likelihood of MCI among elderly persons in the population-based setting... - Genetic susceptibility variants for chronic lymphocytic leukemiaSusan L Slager
Mayo Clinic College of Medicine, 200 1st Street Southwest, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 19:1098-102. 2010..A recent genome-wide association study of CLL identified seven genetic variants that increased the risk of CLL within a European population... - Statin use and prognosis in patients with diffuse large B-cell lymphoma and follicular lymphoma in the rituximab eraGrzegorz S Nowakowski
Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
J Clin Oncol 28:412-7. 2010..The clinical impact of statin use on the outcome of lymphoma patients treated with a rituximab-containing regimen is unknown... - Gene networks and microRNAs implicated in aggressive prostate cancerLiang Wang
Department of Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Cancer Res 69:9490-7. 2009.... - Genome-wide transcriptional profiling reveals microRNA-correlated genes and biological processes in human lymphoblastoid cell linesLiang Wang
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
PLoS ONE 4:e5878. 2009..However, past studies have focused on the miRNA target genes and used loss- or gain-of-function approach that may not reflect natural association between miRNA and mRNAs... - Relative weight at age 12 and risk of postmenopausal breast cancerAditya Bardia
Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 17:374-8. 2008.... - Smoking, alcohol use, obesity, and overall survival from non-Hodgkin lymphoma: a population-based studySusan M Geyer
Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Cancer 116:2993-3000. 2010..Smoking, alcohol use, and obesity appear to increase the risk of developing non-Hodgkin lymphoma (NHL), but to the authors' knowledge, few studies to date have assessed their impact on NHL prognosis... - Oral contraceptive use and risk of breast cancerPetra M Casey
Department of Obstetrics and Gynecology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Mayo Clin Proc 83:86-90; quiz 90-1. 2008..We also have a better understanding of how estrogen affects breast carcinogenesis; research on this topic is ongoing and has the goal of decreasing breast cancer incidence and mortality... - Prepregnancy exposure to cigarette smoking and subsequent risk of postmenopausal breast cancerJanet E Olson
Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Mayo Clin Proc 80:1423-8. 2005..To examine the association of cigarette smoking before first pregnancy with risk of postmenopausal breast cancer in a large population-based cohort... - Alcohol intake in adolescence and mammographic densityCeline M Vachon
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Int J Cancer 117:837-41. 2005..0-23.4%). However, these associations were not statistically significant (p = 0.27 and p = 0.22, respectively). In summary, there was no evidence that adolescent alcohol use was associated with large and persistent effects on adult PD... - Association of folate and alcohol with risk of ovarian cancer in a prospective study of postmenopausal womenLinda E Kelemen
Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Cancer Causes Control 15:1085-93. 2004..These findings suggest that alcohol consumption is inversely related to postmenopausal ovarian cancer, and that the association of folate with ovarian cancer may vary by the amount of alcohol consumed... - The association of alcohol consumption with coronary heart disease mortality and cancer incidence varies by smoking historyJon O Ebbert
Nicotine Research Center, Division of Community Internal Medicine, Rochester, MN 55905, USA
J Gen Intern Med 20:14-20. 2005..To evaluate the effect of alcohol on coronary heart disease (CHD), cancer incidence, and cancer mortality by smoking history... - Insulin, glucose, insulin resistance, and incident colorectal cancer in male smokersPaul J Limburg
Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Gastroenterol Hepatol 4:1514-21. 2006..To date, few studies have directly examined serum insulin as an indicator of CRC risk, and none have reported associations on the basis of HOMA-IR... - History of urinary tract infection and risk of renal cell carcinomaAlexander S Parker
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
Am J Epidemiol 159:42-8. 2004..Results suggest a positive association of UTI history with RCC development, with elevated risks most notable for males with a history of smoking... - Associations of dietary protein with disease and mortality in a prospective study of postmenopausal womenLinda E Kelemen
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Am J Epidemiol 161:239-49. 2005..07, 1.86) when substituted for servings per 1,000 kcal (4.2 MJ) of carbohydrate foods. Long-term adherence to high-protein diets, without discrimination toward protein source, may have potentially adverse health consequences... - Microarray and microfluidic methodology for genotyping cytokine gene polymorphismsYouvraj R Sohni
Mayo Clinic Cancer Center Microarray Shared Resource, Rochester, MN 55905, USA
Hum Immunol 64:990-7. 2003..Comprehensive genotyping can be achieved for clinical epidemiologic studies on cytokine gene polymorphisms using this approach... - Susceptibility genes and B-chronic lymphocytic leukaemiaSusan L Slager
Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA
Br J Haematol 139:762-71. 2007..The challenge of future studies of this type will be overcoming study design issues, including definition of CLL, sample size limitations and multiple testing issues... - Pathologic T1 clear cell renal cell carcinoma: insulin-like growth factor-I receptor expression and disease-specific survivalAlexander S Parker
Department of Urology, Mayo College of Medicine, Jacksonville, Florida 32224, USA
Cancer 100:2577-82. 2004..The authors conducted a case-cohort investigation to examine the association of insulin-like growth factor I receptor (IGF-IR) expression and disease-specific survival in patients who underwent surgery for pT1 CC-RCC... - Body size and incident colorectal cancer: a prospective study of older womenAmy S Oxentenko
College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Cancer Prev Res (Phila) 3:1608-20. 2010..e., early adulthood versus later adulthood) might also be informative, particularly with respect to defining subsite-specific pathways of colorectal carcinogenesis... - Risk factors for meningioma in postmenopausal women: results from the Iowa Women's Health StudyDerek R Johnson
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Neuro Oncol 13:1011-9. 2011..The positive association with height suggests a role for early life influences on risk, whereas the associations with BMI and physical activity suggest a role for modifiable factors later in life... - GSTM1 and GSTT1 polymorphisms and postmenopausal breast cancer riskWei Zheng
Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA
Breast Cancer Res Treat 74:9-16. 2002..3, 95% CI = 0.4-4.1). This study suggests that certain null GST genotypes may be associated with an elevated risk of breast cancer and the association may be modified by charred meat intake and cigarette smoking... - Dietary flavonoid intake and non-Hodgkin lymphoma riskCara L Frankenfeld
Division of Cancer, Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
Am J Clin Nutr 87:1439-45. 2008..Dietary flavonoids are polyphenolic compounds proposed to be anticarcinogenic. Flavonoids are well-characterized antioxidants and metal chelators, and certain flavonoids exhibit antiproliferative and antiestrogenic effects... - Risk of non-Hodgkin's lymphoma and family history of lymphatic, hematologic, and other cancersNilanjan Chatterjee
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 13:1415-21. 2004..An elevated risk of developing non-Hodgkin's lymphoma (NHL) has been associated with a family history of NHL and several other malignancies, but the magnitude of risks and mechanisms are uncertain... - Sun exposure, vitamin D receptor gene polymorphisms and risk of non-Hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8009, Rockville, MD 20892, USA
Cancer Causes Control 18:989-99. 2007.... - Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)Sophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Blood 109:3479-88. 2007..0; 95% CI = 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology... - Association of gain and loss of weight before and after menopause with risk of postmenopausal breast cancer in the Iowa women's health studyMichelle Harvie
Univeristy Department of Medical Oncology, Christie Hospital, Manchester, United Kingdom
Cancer Epidemiol Biomarkers Prev 14:656-61. 2005..These data suggest prevention of weight gain between age 18 years and menopause or weight loss and maintenance during these years reduces risk of postmenopausal breast cancer... - Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studiesSatu Mannisto
National Public Health Institute, Helsinki, Finland
Am J Epidemiol 165:246-55. 2007..00). The associations observed were generally similar across studies, for both sexes, and for colon cancer and rectal cancer. These pooled data did not suggest that carotenoids play an important role in the etiology of colorectal cancer... - Hormone replacement therapy is not associated with an increased risk of leukemia (United States)Julie A Ross
Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
Cancer Causes Control 16:483-8. 2005..Since estrogen receptors are expressed on certain hematopoietic cells, it is possible that HRT use may also increase the risk of leukemia... - No association between 25-hydroxyvitamin D and mammographic densityJulia A Knight
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 5th Floor, 60 Murray Street, Toronto, Ontario, Canada M5G 1X5
Cancer Epidemiol Biomarkers Prev 15:1988-92. 2006..Unlike some previous reports, vitamin D does not seem to be related to mammographic density in this cohort... - Cigarette smoking and the risk of rheumatoid arthritis among postmenopausal women: results from the Iowa Women's Health StudyLindsey A Criswell
Rosalind Russell Medical Research Center for Arthritis (LAC, University of California, San Francisco, USA
Am J Med 112:465-71. 2002..CONCLUSION: These results suggest that abstinence from smoking may reduce the risk of rheumatoid arthritis among postmenopausal women... - Meat and meat-mutagen intake and risk of non-Hodgkin lymphoma: results from a NCI-SEER case-control studyAmanda J Cross
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA
Carcinogenesis 27:293-7. 2006..39 (0.22-0.70); P trend = 0.004]. Overall, our study suggests that consumption of meat, whether or not it is well-done, does not increase the risk of NHL. Furthermore, neither HCAs nor B[a]P from meat increase the risk of NHL... - Anthropometric characteristics and risk of multiple myelomaCindy K Blair
Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
Epidemiology 16:691-4. 2005..5 (0.92-2.6); for weight, 1.9 (1.1-3.4); for waist circumference, 2.0 (1.1-3.5); and for hip circumference, 1.8 (1.0-3.0). CONCLUSION: Greater adiposity may increase the risk of multiple myeloma... - Common genetic variants in proinflammatory and other immunoregulatory genes and risk for non-Hodgkin lymphomaSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20892 7234, USA
Cancer Res 66:9771-80. 2006..Our results require replication but potentially provide important clues for investigating common genetic variants as susceptibility factors and in disease outcomes, treatment responses, and immunotherapy targets... - Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph ConsortiumNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Lancet Oncol 7:27-38. 2006..We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph)... - Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studiesSatu Mannisto
Harvard School of Public Health, Department of Nutrition, Boston, Massachusetts, USA
Cancer Epidemiol Biomarkers Prev 13:40-8. 2004..Although smoking is the strongest risk factor for lung cancer, greater intake of foods high in beta-cryptoxanthin, such as citrus fruit, may modestly lower the risk... - Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphomaSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
Carcinogenesis 27:1828-34. 2006.... - Risk of non-Hodgkin lymphoma and nitrate and nitrite from drinking water and dietMary H Ward
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, Bethesda, MD 20892, USA
Epidemiology 17:375-82. 2006..Nitrate and nitrite are precursors in the in vivo formation of N-nitroso compounds, potent animal carcinogens... - Asthma history, occupational exposure to pesticides and the risk of non-Hodgkin's lymphomaWon Jin Lee
Department of Preventive Medicine, College of Medicine, Korea University, Seoul
Int J Cancer 118:3174-6. 2006..2-29.0) or daily medication for asthma (OR = infinite) than those among asthmatics who did not have such histories. Our results support the previous finding that the risk of NHL from pesticide exposure may be greater among asthmatics...
Research Grants
- Molecular Epidemiology of NHL and CLLJames R Cerhan; Fiscal Year: 2010....
- Molecular Epidemiology of non-Hodgkin Lymphoma SurvivalJames R Cerhan; Fiscal Year: 2010..Host genetics may also lead to a better understanding of NHL pathophysiology that could lead to new approaches to improve the survival of NHL patients. ..
- Molecular Epidemiology of NHL and CLLJames Cerhan; Fiscal Year: 2009....
- Molecular Epidemiology of non-Hodgkin Lymphoma SurvivalJames Cerhan; Fiscal Year: 2009..Host genetics may also lead to a better understanding of NHL pathophysiology that could lead to new approaches to improve the survival of NHL patients. ..
- Molecular Epidemiology of NHL and CLLJames Cerhan; Fiscal Year: 2007..In summary, we will evaluate critical hypotheses regarding environmental and genetic risk factors for NHL and CLL, and should greatly contribute to our understanding the causes and possible prevention of these cancers. ..
- Immunogenetics of Non-Hodgkin Lymphoma SurvivalJames Cerhan; Fiscal Year: 2006..abstract_text> ..
- Molecular Epidemiology of NHL and CLLJames Cerhan; Fiscal Year: 2009....