John N Caviness

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Speech characteristics of patients with pallido-ponto-nigral degeneration and their application to presymptomatic detection in at-risk relatives
    Julie M Liss
    Motor Speech Disorders Laboratory, Department of Speech and Hearing Science, Arizona State University, Tempe, AZ 85287 0102, USA
    Am J Speech Lang Pathol 15:226-35. 2006
  2. ncbi request reprint Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease
    J N Caviness
    Department of Neurology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, USA
    Parkinsonism Relat Disord 13:348-54. 2007
  3. doi request reprint Treatment of myoclonus
    John N Caviness
    Department of Neurology, Mayo Clinic Arizona, 13400 East Shea Blvd, Scottsdale, AZ, 85259, USA
    Neurotherapeutics 11:188-200. 2014
  4. pmc Parkinson's disease, cortical dysfunction, and alpha-synuclein
    John N Caviness
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA
    Mov Disord 26:1436-42. 2011
  5. ncbi request reprint Myoclonus and neurodegenerative disease--what's in a name?
    John N Caviness
    Department of Neurology, Parkinson s Disease and Movement Disorders Center, Mayo Clinic Scottsdale, 13400 East Shea Blvd, Scottsdale, AZ 85259, USA
    Parkinsonism Relat Disord 9:185-92. 2003
  6. ncbi request reprint Cortical myoclonus during lithium exposure
    John N Caviness
    Department of Neurology, Parkinson s Disease and Movement Disorders Center, Mayo Clinic Scottsdale, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    Arch Neurol 60:401-4. 2003
  7. ncbi request reprint Abnormal corticomuscular coherence is associated with the small amplitude cortical myoclonus in Parkinson's disease
    John N Caviness
    Department of Neurology, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    Mov Disord 18:1157-62. 2003
  8. pmc Incidental Lewy body disease: electrophysiological findings suggesting pre-clinical Lewy body disorders
    John N Caviness
    Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Clin Neurophysiol 122:2426-32. 2011
  9. doi request reprint Parkinson's disease dementia and potential therapeutic strategies
    John N Caviness
    Mayo Clinic College of Medicine, Mayo Clinic, USA
    CNS Neurosci Ther 17:32-44. 2011
  10. ncbi request reprint Myoclonus: current concepts and recent advances
    John N Caviness
    Mayo Clinic College of Medicine, Parkinson s Disease and Other Movement Disorders Center, Scottsdale, Arizona 85255, USA
    Lancet Neurol 3:598-607. 2004

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Speech characteristics of patients with pallido-ponto-nigral degeneration and their application to presymptomatic detection in at-risk relatives
    Julie M Liss
    Motor Speech Disorders Laboratory, Department of Speech and Hearing Science, Arizona State University, Tempe, AZ 85287 0102, USA
    Am J Speech Lang Pathol 15:226-35. 2006
    ....
  2. ncbi request reprint Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease
    J N Caviness
    Department of Neurology, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, USA
    Parkinsonism Relat Disord 13:348-54. 2007
    ..PD-MCI has mean quantitative EEG characteristics that represent an intermediate electrophysiological state between PD-CogNL and PD-D...
  3. doi request reprint Treatment of myoclonus
    John N Caviness
    Department of Neurology, Mayo Clinic Arizona, 13400 East Shea Blvd, Scottsdale, AZ, 85259, USA
    Neurotherapeutics 11:188-200. 2014
    ..Segmental myoclonus is difficult to treat, but clonazepam and botulinum toxin are used. Botulinum toxin is used for focal examples of peripheral myoclonus. Myoclonus treatment is commonly not effective and/or limited by side effects. ..
  4. pmc Parkinson's disease, cortical dysfunction, and alpha-synuclein
    John N Caviness
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA
    Mov Disord 26:1436-42. 2011
    ..Alzheimer's disease pathology was not associated with cortical myoclonus in Parkinson's disease. Cortical myoclonus arising from the motor cortex is a model to study cortical dysfunction in Parkinson's disease...
  5. ncbi request reprint Myoclonus and neurodegenerative disease--what's in a name?
    John N Caviness
    Department of Neurology, Parkinson s Disease and Movement Disorders Center, Mayo Clinic Scottsdale, 13400 East Shea Blvd, Scottsdale, AZ 85259, USA
    Parkinsonism Relat Disord 9:185-92. 2003
    ..More study of the myoclonus in neurodegenerative disease will lead to a better understanding of the processes that cause phenotypic variability among these disorders...
  6. ncbi request reprint Cortical myoclonus during lithium exposure
    John N Caviness
    Department of Neurology, Parkinson s Disease and Movement Disorders Center, Mayo Clinic Scottsdale, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    Arch Neurol 60:401-4. 2003
    ..Although clinical case reports exist, no electrophysiologic data are available that provide a source or a neurophysiological mechanism for the myoclonus seen in lithium therapy...
  7. ncbi request reprint Abnormal corticomuscular coherence is associated with the small amplitude cortical myoclonus in Parkinson's disease
    John N Caviness
    Department of Neurology, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    Mov Disord 18:1157-62. 2003
    ..These results have mechanistic implications for cortical dysfunction in Parkinson's disease and for cortical myoclonus in general...
  8. pmc Incidental Lewy body disease: electrophysiological findings suggesting pre-clinical Lewy body disorders
    John N Caviness
    Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Clin Neurophysiol 122:2426-32. 2011
    ..Evaluate electrophysiologic findings in incidental Lewy body disease (ILBD)...
  9. doi request reprint Parkinson's disease dementia and potential therapeutic strategies
    John N Caviness
    Mayo Clinic College of Medicine, Mayo Clinic, USA
    CNS Neurosci Ther 17:32-44. 2011
    ..More research is needed on the specific aspects of cortical dysfunction and degeneration that create PD-D...
  10. ncbi request reprint Myoclonus: current concepts and recent advances
    John N Caviness
    Mayo Clinic College of Medicine, Parkinson s Disease and Other Movement Disorders Center, Scottsdale, Arizona 85255, USA
    Lancet Neurol 3:598-607. 2004
    ..If treatment of the underlying disorder is not possible, treatment of symptoms is worthwhile, although limited by side-effects and a lack of controlled evidence...
  11. ncbi request reprint Corticomuscular coherence is increased in the small postural tremor of Parkinson's disease
    John N Caviness
    Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Mov Disord 21:492-9. 2006
    ..The small amplitude postural tremor in PD arises from heterogeneous oscillator mechanisms. The discovery of increased corticomuscular coupling shows cortical involvement in the small amplitude postural tremor of PD...
  12. ncbi request reprint Electrophysiology of the myoclonus in dementia with Lewy bodies
    J N Caviness
    Department of Neurology, Mayo Clinic Scottsdale, AZ 85259, USA
    Neurology 60:523-4. 2003
  13. ncbi request reprint Clinical-electrophysiological correlation of tremor and myoclonus in a kindred with the N279K tau mutation
    John N Caviness
    Department of Neurology, Parkinson s Disease and Movement Disorders Center, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Parkinsonism Relat Disord 9:151-7. 2003
    ..Electrophysiology yielded remarkable findings in those asymptomatic at-risk individuals that carried the N279K tau mutation...
  14. ncbi request reprint Defining mild cognitive impairment in Parkinson's disease
    John N Caviness
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA
    Mov Disord 22:1272-7. 2007
    ..Defining PD-MCI offers an opportunity for further study of cognitive impairment in PD and targets for earlier therapeutic intervention...
  15. ncbi request reprint Primary care guide to myoclonus and chorea. Characteristics, causes, and clinical options
    J N Caviness
    Department of Neurology, Mayo Clinic Scottsdale, AZ 85259, USA
    Postgrad Med 108:163-6, 169-72. 2000
    ..Symptomatic treatment is available, but reversal of the underlying cause should be considered first if possible. The potential benefits of treatment must be weighed against the risk of drug side effects...
  16. doi request reprint Parkinsonism & related disorders. Myoclonus
    John N Caviness
    College of Medicine, Department of Neurology, Mayo Clinic, Scottsdale, AZ 85255, USA
    Parkinsonism Relat Disord 13:S375-84. 2007
    ..Myoclonus treatment is still limited, and more research on basic mechanisms before truly effective treatment will be available. The best approach for myoclonus is based on the physiological classification of the myoclonus...
  17. ncbi request reprint Analysis of high-frequency electroencephalographic-electromyographic coherence elicited by speech and oral nonspeech tasks in Parkinson's disease
    John N Caviness
    Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA
    J Speech Lang Hear Res 49:424-38. 2006
    ....
  18. doi request reprint Pathophysiology and treatment of myoclonus
    John N Caviness
    Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Neurol Clin 27:757-77, vii. 2009
    ..However, classifying myoclonus according to its source provides insight about its pathophysiology. The best strategy for symptomatic treatment is derived from defining the pathophysiology by way of source physiologic classification...
  19. ncbi request reprint Motor unit number estimates in idiopathic Parkinson's disease
    J N Caviness
    Department of Neurology, Mayo Clinic Scottsdale, 13400 East Shea Blvd, Scottsdale, AZ 85259, USA
    Parkinsonism Relat Disord 8:161-4. 2002
    ..Progress in decreasing the variance of MUNEs will facilitate their use in detecting small motor unit number changes in neurodegenerative disease...
  20. ncbi request reprint Small-amplitude cortical myoclonus in Parkinson's disease: physiology and clinical observations
    John N Caviness
    Parkinson s Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    Mov Disord 17:657-62. 2002
    ..Although the myoclonus occurred without dementia in these cases, its relationship to the subsequent development of cognitive impairment remains to be defined...
  21. pmc Incidental Lewy body disease: clinical comparison to a control cohort
    Charles H Adler
    Parkinson s Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, Arizona 85259, USA
    Mov Disord 25:642-6. 2010
    ..Larger sample size is needed to have the power to better assess group differences...
  22. doi request reprint The Montreal Cognitive Assessment and the mini-mental state examination as screening instruments for cognitive impairment: item analyses and threshold scores
    Anne M Damian
    University of Arizona College of Medicine Phoenix Campus, Phoenix, AZ, USA
    Dement Geriatr Cogn Disord 31:126-31. 2011
    ..To perform an item analysis of the Montreal Cognitive Assessment (MoCA) versus the Mini-Mental State Examination (MMSE) in the prediction of cognitive impairment, and to examine the characteristics of different MoCA threshold scores...
  23. doi request reprint Efficacy of rivastigmine for cognitive symptoms in Parkinson disease with dementia
    Amy C Almaraz
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA
    Neurologist 15:234-7. 2009
    ..Therefore, cholinesterase inhibitors might improve cognitive function in PDD. On the other hand, enhancing cholinergic function could plausibly worsen features of parkinsonism...
  24. pmc Autonomic function, as self-reported on the SCOPA-autonomic questionnaire, is normal in essential tremor but not in Parkinson's disease
    Anne Damian
    University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA
    Parkinsonism Relat Disord 18:1089-93. 2012
    ..To compare autonomic function of subjects with Parkinson's disease (PD) and essential tremor (ET) relative to controls...
  25. pmc Probable RBD is increased in Parkinson's disease but not in essential tremor or restless legs syndrome
    Charles H Adler
    Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Parkinsonism Relat Disord 17:456-8. 2011
    ..Compare the frequency of REM sleep behavior disorder (RBD) and excessive daytime sleepiness (EDS) in Parkinson's disease (PD), restless legs syndrome (RLS), essential tremor (ET), and control subjects...
  26. pmc Neuropathological findings of PSP in the elderly without clinical PSP: possible incidental PSP?
    Virgilio Gerald H Evidente
    Department of Neurology, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    Parkinsonism Relat Disord 17:365-71. 2011
    ..We aimed to describe cases with incidental neuropathological findings of progressive supranuclear palsy (PSP) from the Banner Sun Health Research Institute Brain and Body Donation Program...
  27. pmc Brain biochemistry in autopsied patients with essential tremor
    Holly A Shill
    Banner Sun Health Research Institute, Sun City, Arizona, USA
    Mov Disord 27:113-7. 2012
    ..The hypothesis that essential tremor represents early Parkinson's disease was not supported, as striatal dopaminergic markers were not reduced compared with control subjects...
  28. ncbi request reprint Myoclonus in pallido-ponto-nigral degeneration
    John N Caviness
    Department of Neurology, Mayo Clinic Scottsdale, Scottsdale, Arizona, USA
    Adv Neurol 89:35-9. 2002
  29. ncbi request reprint Myoclonus in Lewy body disorders
    John N Caviness
    Department of Neurology, Mayo Clinic Scottsdale, Scottsdale, Arizona, USA
    Adv Neurol 89:23-30. 2002
  30. doi request reprint Are the yips a task-specific dystonia or "golfer's cramp"?
    Charles H Adler
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA
    Mov Disord 26:1993-6. 2011
    ..2%). Golfers with video evidence of an involuntary movement while putting have excessive rotation of the right wrist in a pronation/supination motion and, as previously reported, a trend for wrist flexor/extensor cocontraction...
  31. pmc Quantifying speech rhythm abnormalities in the dysarthrias
    Julie M Liss
    Department of Speech and Hearing Science, Arizona State University, Tempe, AZ, USA
    J Speech Lang Hear Res 52:1334-52. 2009
    ..dysarthrias; and among the 4 dysarthrias). A cross-validation method was used to test the robustness of each original DFA...
  32. doi request reprint Clinicopathological outcomes of prospectively followed normal elderly brain bank volunteers
    Brittany N Dugger
    From the Banner Sun Health Research Institute BND, MNS, HAS, SJ, CB, KJD, LIS, TGB, Sun City and Mayo Clinic BND, JGH, CHA, JNC, Ed D, Scottsdale, Arizona
    J Neuropathol Exp Neurol 73:244-52. 2014
    ..Although limited by a relatively small sample size, the neuropathological outcome of these initially normal elderly subjects represents a rough estimate of the incidence of these neurodegenerative conditions over a defined time period. ..
  33. doi request reprint Autonomic complaints in patients with restless legs syndrome
    Natalya Shneyder
    Parkinson s Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, AZ, United States
    Sleep Med 14:1413-6. 2013
    ..Data regarding autonomic function in restless legs syndrome (RLS) are limited to heart rate and blood pressure changes in cases with periodic limb movements (PLMS)...
  34. ncbi request reprint Motor impairment in normal aging, clinically possible Parkinson's disease, and clinically probable Parkinson's disease: longitudinal evaluation of a cohort of prospective brain donors
    Charles H Adler
    Parkinson s Disease and Movement Disorders Center, Mayo Clinic Scottsdale, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Parkinsonism Relat Disord 9:103-10. 2002
    ..This study underscores the importance of longitudinal antemortem testing of prospective brain donors as well as the potential value of quantitative motor testing...
  35. ncbi request reprint Gambling and increased sexual desire with dopaminergic medications in restless legs syndrome
    Erika D Driver-Dunckley
    Department of Neurology, Parkinson s Disease and Movement Disorders Center, Mayo Clinic, 13400 E Shea Boulevard, Scottsdale, AZ 85259, USA
    Clin Neuropharmacol 30:249-55. 2007
    ..Do patients with restless legs syndrome (RLS) report gambling or other abnormal behaviors as previously reported in Parkinson disease...
  36. ncbi request reprint Clinical-pathologic study of biomarkers in FTDP-17 (PPND family with N279K tau mutation)
    Zoe Arvanitakis
    Department of Neurology, Mayo Clinic, Jacksonville, FL, USA
    Parkinsonism Relat Disord 13:230-9. 2007
    ..Autopsy of six affected subjects showed frontotemporal degeneration with extensive tauopathy. Further studies of FTDP-17 patients are needed to replicate these findings...
  37. ncbi request reprint Sniffing out Parkinson disease: can olfactory testing differentiate parkinsonian disorders?
    Jonathan H McKinnon
    Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Neurologist 13:382-5. 2007
    ..A recent American Academy of Neurology practice parameter indicated that olfactory testing was "probably useful" for differentiating idiopathic Parkinson disease (IPD) from other diseases with features of parkinsonism...
  38. doi request reprint Case series of painful legs and moving toes: clinical and electrophysiologic observations
    Maria V Alvarez
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA
    Mov Disord 23:2062-6. 2008
    ..Movements were partially suppressible and were diminished but still apparent during light sleep. GABAergic agents were most effective in controlling the pain and the movements...
  39. ncbi request reprint Randomized trial of modafinil for treating subjective daytime sleepiness in patients with Parkinson's disease
    Charles H Adler
    Parkinson s Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic Scottsdale, 13400 E Shea Boulevard, Scottsdale, AZ 85259, USA
    Mov Disord 18:287-93. 2003
    ..Our data demonstrate that, in a small sample size, administration of 200 mg/day of modafinil was associated with few side effects and was modestly effective for the treatment of excessive daytime sleepiness in patients with PD...
  40. ncbi request reprint Abnormal co-contraction in yips-affected but not unaffected golfers: evidence for focal dystonia
    C H Adler
    Parkinson s Disease and Movement Disorders Center, Mayo Clinic Scottsdale, Scottsdale, AZ 85259, USA
    Neurology 64:1813-4. 2005
  41. ncbi request reprint Ropinirole for restless legs syndrome: a placebo-controlled crossover trial
    C H Adler
    Parkinson s Disease and Movement Disorders Center, Mayo Clinic Scottsdale, AZ 85259, USA
    Neurology 62:1405-7. 2004
    ..Eight of the 22 patients had complete resolution of symptoms on ropinirole. Adverse events included nausea and dizziness. Ropinirole was effective and well tolerated for treating the symptoms of RLS...
  42. ncbi request reprint Nonvasculitic autoimmune inflammatory meningoencephalitis imitating Creutzfeldt-Jakob disease
    C Hoffman Snyder
    Department of Neurology, Mayo Clinic Arizona, 13400 E Shea Boulevard, Scottsdale, AZ 85259, USA
    Arch Neurol 63:766-8. 2006
    ....
  43. ncbi request reprint Case studies in movement disorders
    Virgilio Gerald H Evidente
    Movement Disorders Division, Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA
    Semin Neurol 23:277-84. 2003
    ..A detailed discussion of botulinum toxin follows the case on cervical dystonia, focusing on its mechanism of action, clinical indications, side effects, and dosing...
  44. doi request reprint Presymptomatic Parkinson's disease: the Arizona experience
    John N Caviness
    Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic, Scottsdale, Arizona 85259, USA
    Parkinsonism Relat Disord 18:S203-6. 2012
    ..Electroencephalography spectral frequency of ILBD cases was lower than for controls but not as low as for PD cases. The longitudinal assessments of this brain bank offer significant opportunities for the study of presymptomatic PD...
  45. doi request reprint Primary progressive myoclonus of aging
    Maria Alvarez
    Department of Neurology, Wilford Hall Medical Center, San Antonio, Texas, USA
    Mov Disord 23:1658-64. 2008
    ..It is important to distinguish primary PPMA from other syndromes seen in older individuals to avoid diagnostic confusion. Some cases showed a response to levetiracetam...
  46. ncbi request reprint Botulinum toxin type A for treating voice tremor
    Charles H Adler
    Parkinson s Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic Scottsdale, 13400 E Shea Boulevard, Scottsdale, AZ 85259, USA
    Arch Neurol 61:1416-20. 2004
    ..Voice tremor, like spasmodic dysphonia and other tremor disorders, may respond to botulinum toxin type A injections...
  47. doi request reprint Myoclonus
    John N Caviness
    Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA
    Handb Clin Neurol 100:399-420. 2011
    ..Reticular reflex myoclonus can be treated with clonazepam, diazepam and 5-hydrotryptophan. For palatal myoclonus, a variety of drugs have been used...
  48. ncbi request reprint The differential effects of dysarthria type on lexical segmentation
    Julie M Liss
    Dept of Speech and Hearing Sci Arizona State Univ, Tempe, AZ 85287 0102, Clinic Arizona, Scottsdale, AZ 85259
    J Acoust Soc Am 125:2531. 2009
    ..Results will be presented relative to models of lexical segmentation and clinical implications for targets of remediation in the dysarthrias. [Work supported from NIH-NIDCD 5R01 DC6859.]...
  49. ncbi request reprint A randomized, double masked, controlled trial of botulinum toxin type A in essential hand tremor
    M F Brin
    Department of Neurology, Columbia University, New York, NY, USA
    Neurology 56:1523-8. 2001
    ..Hand weakness is a dose-dependent significant side effect of treatment at the doses used in this study...
  50. ncbi request reprint Treatment of essential tremor with methazolamide
    M D Muenter
    Lee Silverman Center for Parkinson s Disease and Movement Disorders, Mayo Clinic Scottsdale, AZ 85259
    Mayo Clin Proc 66:991-7. 1991
    ..Methazolamide may be an effective drug in the treatment of some patients with essential tremor, particularly those with head and voice tremor...
  51. ncbi request reprint Epidemiology of myoclonus
    John N Caviness
    Department of Neurology, Mayo Clinic Scottsdale, Scottsdale, Arizona, USA
    Adv Neurol 89:19-22. 2002
    ..Clearly, posthypoxia etiology, neurodegenerative disease, and epilepsy syndromes are important individual causes of myoclonus. The epidemiology of myoclonus is worthy of further study in other defined populations...
  52. pmc Quantitative EEG as a predictive biomarker for Parkinson disease dementia
    B T Klassen
    Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Neurology 77:118-24. 2011
    ..A reliable predictive QEEG biomarker for PD dementia (PD-D) incidence would be valuable for studying PD-D, including treatment trials aimed at preventing cognitive decline in PD...
  53. ncbi request reprint Serum leptin concentrations and satiety in Parkinson's disease patients with and without weight loss
    V G Evidente
    Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    Mov Disord 16:924-7. 2001
    ..The results indicate that unintended weight loss in PD patients is unlikely to be due to abnormal serum leptin concentrations...
  54. ncbi request reprint Persistent chorea triggered by hyperglycemic crisis in diabetics
    J E Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 16:890-8. 2001
    ..Most previously described cases have involved a reversible clinical syndrome, in contrast to our patients. The pathogenic mechanisms remain uncertain...
  55. pmc Reduced striatal tyrosine hydroxylase in incidental Lewy body disease
    Thomas Gerald Beach
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 115:445-51. 2008
    ..8% (P = 0.01) reduction in ILBD cases, as compared with control cases. The finding suggests that ILBD is not a benign condition but is likely a precursor to PD and/or DLB...
  56. ncbi request reprint Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits
    Thomas G Beach
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 114:419-24. 2007
    ....
  57. ncbi request reprint Lafora disease with primary generalized epileptic myoclonus
    Erika Driver-Dunkley
    Mov Disord 20:907-8. 2005
  58. ncbi request reprint Increased tau burden in the cortices of progressive supranuclear palsy presenting with corticobasal syndrome
    Yoshio Tsuboi
    Department of Neurology, Fukoka University, Fukoka, Japan
    Mov Disord 20:982-8. 2005
    ....