M Cascalho

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Novel functions of B cells
    Marilia Cascalho
    Transplantation Biology and the Departments of Immunology, Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Crit Rev Immunol 27:141-51. 2007
  2. ncbi request reprint B cell tolerance: lessons from transplantation
    Marilia Cascalho
    Mayo Clinic College of Medicine, 200 First Street SW, Medical Sciences 2 113, Rochester, MN 55905, USA
    Curr Drug Targets Cardiovasc Haematol Disord 5:271-5. 2005
  3. ncbi request reprint Cellular physiology of mismatch repair
    X Wu
    Transplantation Biology, Mayo Clinic, 200 First Street SW, Medical Sciences 2 113, Rochester, MN 55905, USA
    Curr Pharm Des 10:4121-6. 2004
  4. ncbi request reprint B cell-dependent T cell development
    M Cascalho
    Transplantation Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Acta Paediatr Suppl 93:52-3; discussion 54. 2004
  5. ncbi request reprint Advantages and disadvantages of cytidine deamination
    Marilia Cascalho
    Transplantation Biology, and Departments of Immunology, Surgery, and Pediatrics, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 172:6513-8. 2004
  6. pmc New insights into the functions of B cells
    Samuel J Balin
    Transplantation Biology Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pediatr Transplant 12:510-5. 2008
  7. ncbi request reprint Xenotransplantation and other means of organ replacement
    M Cascalho
    Department of Surgery and Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Nat Rev Immunol 1:154-60. 2001
  8. ncbi request reprint New technologies for organ replacement and augmentation
    Marilia Cascalho
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 80:370-8. 2005
  9. ncbi request reprint Fitness of cell-mediated immunity independent of repertoire diversity
    Mouhammed AbuAttieh
    Transplantation Biology Program, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Immunol 178:2950-60. 2007
  10. ncbi request reprint The future of organ transplantation
    Marilia Cascalho
    The Transplantation Biology Program, Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Ann Transplant 11:44-7. 2006

Research Grants

  1. A mutable vaccine for biodefense
    Marilia Cascalho; Fiscal Year: 2005

Collaborators

  • Jeffrey Platt
  • Raymund Rabe Razonable
  • Scott E Strome
  • L J West
  • PETER JOHNSON WETTSTEIN
  • C Joao
  • Koji Tamada
  • Masaki Magari
  • Lieping Chen
  • Mark Litzow
  • Samuel J Balin
  • Brenda M Ogle
  • Xiaosheng Wu
  • Hidefumi Kojima
  • Pedro Geraldes
  • Mouhammed AbuAttieh
  • Denise A Martin
  • Michelle Rebrovich
  • Naoki Kanayama
  • X Wu
  • Irene M Ward
  • Michail V Sitkovsky
  • Loren D Erickson
  • Ted M Ross
  • Matthias Wabl
  • Gillian E Wu
  • Kai Herrmann
  • Zvezdana Vuk-Pavlovic
  • Jamie Wong
  • Andrew H Limper
  • Hans Martin Jack
  • Liwei Lu
  • David J Driscoll
  • Carlos V Paya
  • Hitoshi Ohmori
  • Bernardo Reina-San-Martin
  • Michel C Nussenzweig
  • Kay Minn
  • Timothy B Plummer
  • Z Khalpey
  • Brendan T Jones
  • Jianzhu Chen
  • Kim A Butters
  • Alexandru Olaru
  • Bruce E Knudsen
  • Andre Nussenzweig
  • Junjie Chen
  • Ferenc Livak
  • Kevin R Ring
  • Julie S Lau
  • Teruhito Yasui
  • Brigit G Durell
  • Hitoshi Kikutani
  • Laura A Vogel
  • BRIAN P O'CONNOR
  • Randolph J Noelle

Detail Information

Publications25

  1. ncbi request reprint Novel functions of B cells
    Marilia Cascalho
    Transplantation Biology and the Departments of Immunology, Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Crit Rev Immunol 27:141-51. 2007
    ..These new findings show that the development and function of T cells depend on B cells independently of specific antibody production...
  2. ncbi request reprint B cell tolerance: lessons from transplantation
    Marilia Cascalho
    Mayo Clinic College of Medicine, 200 First Street SW, Medical Sciences 2 113, Rochester, MN 55905, USA
    Curr Drug Targets Cardiovasc Haematol Disord 5:271-5. 2005
    ..Here we review the fundamental mechanisms of B cell tolerance that operate in development and direct the reader to possible mechanisms that may explain how B cell tolerance fails to develop following transplantation...
  3. ncbi request reprint Cellular physiology of mismatch repair
    X Wu
    Transplantation Biology, Mayo Clinic, 200 First Street SW, Medical Sciences 2 113, Rochester, MN 55905, USA
    Curr Pharm Des 10:4121-6. 2004
    ..In this communication, we review how mismatch repair may contribute to the physiology of cells and may be regulated by the intracellular trafficking of mismatch repair proteins...
  4. ncbi request reprint B cell-dependent T cell development
    M Cascalho
    Transplantation Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Acta Paediatr Suppl 93:52-3; discussion 54. 2004
    ..It was found that T cell development and thymocyte selection is modified by the presence of B cells. These results suggest that B cells, or B cell products, contribute to thymocyte selection and T cell development...
  5. ncbi request reprint Advantages and disadvantages of cytidine deamination
    Marilia Cascalho
    Transplantation Biology, and Departments of Immunology, Surgery, and Pediatrics, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 172:6513-8. 2004
    ....
  6. pmc New insights into the functions of B cells
    Samuel J Balin
    Transplantation Biology Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pediatr Transplant 12:510-5. 2008
    ..Here we review "non-humoral" functions of B cells and the implications of these functions to transplantation...
  7. ncbi request reprint Xenotransplantation and other means of organ replacement
    M Cascalho
    Department of Surgery and Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Nat Rev Immunol 1:154-60. 2001
    ..Here, we consider whether, and how, xenotransplantation and various other technologies might be applied in future efforts to replace or supplement the function of human organs and tissues...
  8. ncbi request reprint New technologies for organ replacement and augmentation
    Marilia Cascalho
    Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 80:370-8. 2005
    ..We propose that a melding of these new technologies adapted to the distinct challenges and imperatives of the various organs may address this daunting challenge...
  9. ncbi request reprint Fitness of cell-mediated immunity independent of repertoire diversity
    Mouhammed AbuAttieh
    Transplantation Biology Program, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    J Immunol 178:2950-60. 2007
    ..QM mice also resisted Pneumocystis murina like wild-type mice. Thus, cell-mediated immunity can function normally despite contractions of TCR diversity >90% and possibly >99%...
  10. ncbi request reprint The future of organ transplantation
    Marilia Cascalho
    The Transplantation Biology Program, Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Ann Transplant 11:44-7. 2006
    ..This approach, while speculative and perhaps unlikely, may lead to development of further new technologies and insights, the pursuit of which could provide new approaches to replacing organ function...
  11. ncbi request reprint Spontaneous fusion of cells between species yields transdifferentiation and retroviral transfer in vivo
    Brenda M Ogle
    Transplantation Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    FASEB J 18:548-50. 2004
    ..differentiation * fusion * retrovirus..
  12. ncbi request reprint Basic mechanisms of humoral rejection
    Marilia Cascalho
    Transplantation Biology and the Departments of Immunology, Surgery and Pediatrics, Mayo Clinic, Rochester, MN 55905, USA
    Pediatr Transplant 9:9-16. 2005
    ..Basic considerations may also shed light on mechanisms by which various treatments have recently brought about vastly improved outcomes...
  13. ncbi request reprint Effacing of the T cell compartment by cardiac transplantation in infancy
    Brenda M Ogle
    Transplantation Biology Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Immunol 176:1962-7. 2006
    ..Our findings demonstrate a novel approach to measuring lymphocyte diversity and suggest that understanding how these subjects resist infection could yield important insights into immune fitness...
  14. ncbi request reprint Ig heavy chain promotes mature B cell survival in the absence of light chain
    Pedro Geraldes
    Transplantation Biology Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Immunol 179:1659-68. 2007
    ....
  15. ncbi request reprint HIV genes diversify in B cells
    Samuel J Balin
    Transplantation Biology Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Curr HIV Res 6:10-8. 2008
    ..This result demonstrates that B cells can express and diversify HIV proteins. Thus, B cells may contribute to viral evasion and to the development of multi-drug resistance...
  16. ncbi request reprint The double-edged sword of activation-induced cytidine deaminase
    Xiaosheng Wu
    Transplantation Biology Program and the Department of Biochemistry, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 174:934-41. 2005
    ....
  17. pmc Short-circuiting long-lived humoral immunity by the heightened engagement of CD40
    Loren D Erickson
    Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    J Clin Invest 109:613-20. 2002
    ..These are the first studies to describe the multifaceted function of CD40 in determining the fate of antigen-reactive B cells and provide novel insights into how CD40 agonists can short-circuit humoral immunity...
  18. ncbi request reprint HIF-1 alpha deficiency perturbs T and B cell functions
    Hidefumi Kojima
    Division of Immunology, Institute for Medical Science, Dokkyo University School of Medicine, Tochigi, Japan
    Curr Pharm Des 9:1827-32. 2003
    ..B1 lymphocytes of fetal origin, on the other hand, accumulate and may produce auto-antibodies and autoimmunity...
  19. ncbi request reprint B cell-dependent TCR diversification
    Cristina Joao
    Transplantation Biology Program, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 172:4709-16. 2004
    ..These findings reveal a heretofore unrecognized and vital function of B cells and Ig for generation of T cell diversity and suggest a potential approach to immune reconstitution...
  20. ncbi request reprint Hypoxia-inducible factor 1alpha-deficient chimeric mice as a model to study abnormal B lymphocyte development and autoimmunity
    Hidefumi Kojima
    Division on Immunology, Institute for Medical Science, Dokkyo University School of Medicine, Tochigi, Japan
    Methods Enzymol 381:218-29. 2004
  21. pmc 53BP1 is required for class switch recombination
    Irene M Ward
    1306 Guggenheim, Mayo Clinic, 200 First St, SW, Rochester, MN 55905, USA
    J Cell Biol 165:459-64. 2004
    ..These findings are similar to those observed in mice or cells deficient in the tumor suppressors ATM and H2AX, further suggesting that the functions of ATM, H2AX, and 53BP1 are closely linked...
  22. pmc Dimerization of MLH1 and PMS2 limits nuclear localization of MutLalpha
    Xiaosheng Wu
    Transplantation Biology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Cell Biol 23:3320-8. 2003
    ..Limited nuclear localization of MutLalpha may thus represent a novel mechanism by which cells fine-tune mismatch repair functions. This mechanism may have implications in the pathogenesis of hereditary non-polyposis colon cancer...
  23. ncbi request reprint Maintenance of surrogate light chain expression induces developmental delay in early B cell compartment
    Denise A Martin
    Department of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    J Immunol 179:4996-5005. 2007
    ..The capacity to alter B cell progression by modifying and extending pre-BCR expression argues that the receptor and its associated signals play a unique role in directing developmental outcomes...
  24. ncbi request reprint Contribution of light chain rearrangement in peripheral B cells to the generation of high-affinity antibodies
    Masaki Magari
    Department of Biotechnology, Faculty of Engineering, Okayama University, Okayama, Japan
    Eur J Immunol 32:957-66. 2002
    ..Thus, our findings suggest that L chain rearrangement that occurs in the periphery can contribute to affinity maturation of Ab...
  25. ncbi request reprint Analysis of marginal zone B cell development in the mouse with limited B cell diversity: role of the antigen receptor signals in the recruitment of B cells to the marginal zone
    Naoki Kanayama
    Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Tsushima Naka, Okayama, Japan
    J Immunol 174:1438-45. 2005
    ..Taken together, it is suggested that polyreactivity (including self-reactivity) of BCR is crucial in driving B cells to differentiate into the MZ phenotype...

Research Grants1

  1. A mutable vaccine for biodefense
    Marilia Cascalho; Fiscal Year: 2005
    ..The vaccine will then be tested for ability to promote an immune response against antigenic variants of influenza. ..