MICHAEL L CAMILLERI

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi Cannabinoid receptor 1 gene and irritable bowel syndrome: phenotype and quantitative traits
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 304:G553-60. 2013
  2. ncbi Clinical guideline: management of gastroparesis
    Michael Camilleri
    Department of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Gastroenterol 108:18-37; quiz 38. 2013
  3. ncbi Performance characteristics of scintigraphic measurement of gastric emptying of solids in healthy participants
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 24:1076-e562. 2012
  4. ncbi Randomized controlled phase Ib study of ghrelin agonist, RM-131, in type 2 diabetic women with delayed gastric emptying: pharmacokinetics and pharmacodynamics
    Andrea Shin
    1Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Diabetes Care 36:41-8. 2013
  5. ncbi Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, Charlton 8 110, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 303:G775-85. 2012
  6. ncbi What are the important subsets of gastroparesis?
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 24:597-603. 2012
  7. ncbi Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1075-84. 2012
  8. ncbi Governance of clinical research
    Michael Camilleri
    Division of Gastroenterology and Hepatology and Office of Human Research Protection, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 107:336-8. 2012
  9. ncbi The role of pharmacogenetics in nonmalignant gastrointestinal diseases
    Michael Camilleri
    College of Medicine, Mayo Clinic, Charlton 8 110, 200 First Street South West, Rochester, MN 55905, USA
    Nat Rev Gastroenterol Hepatol 9:173-84. 2012
  10. ncbi New treatment options for chronic constipation: mechanisms, efficacy and safety
    Michael Camilleri
    College of Medicine, Mayo Clinic, Rochester, MN, USA
    Can J Gastroenterol 25:29B-35B. 2011

Research Grants

  1. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
  2. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    Michael Camilleri; Fiscal Year: 2009
  3. Pharmacogenomics of Gastric Function & Weight in Obesity
    Michael Camilleri; Fiscal Year: 2007
  4. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
  5. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2007
  6. ALPHA 2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2001
  7. Pharmacogenomics of Gastric Function & Weight in Obesity
    MICHAEL L CAMILLERI; Fiscal Year: 2010

Collaborators

Detail Information

Publications121 found, 100 shown here

  1. ncbi Cannabinoid receptor 1 gene and irritable bowel syndrome: phenotype and quantitative traits
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 304:G553-60. 2013
    ....
  2. ncbi Clinical guideline: management of gastroparesis
    Michael Camilleri
    Department of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Gastroenterol 108:18-37; quiz 38. 2013
    ..Partial gastrectomy and pyloroplasty should be used rarely, only in carefully selected patients. Attention should be given to the development of new effective therapies for symptomatic control...
  3. ncbi Performance characteristics of scintigraphic measurement of gastric emptying of solids in healthy participants
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 24:1076-e562. 2012
    ..Our aim was to assess inter- and intra-subject coefficients of variation (COV) of scintigraphic GE measurements in healthy subjects, and associations of GE with gender and body mass index (BMI)...
  4. ncbi Randomized controlled phase Ib study of ghrelin agonist, RM-131, in type 2 diabetic women with delayed gastric emptying: pharmacokinetics and pharmacodynamics
    Andrea Shin
    1Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Diabetes Care 36:41-8. 2013
    ..To investigate the pharmacokinetics (PK), pharmacodynamics, and safety of single-dose RM-131 in type 2 diabetic patients with gastrointestinal cardinal symptoms (GCSI) and previously documented delayed gastric emptying (DGE)...
  5. ncbi Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, Charlton 8 110, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 303:G775-85. 2012
    ....
  6. ncbi What are the important subsets of gastroparesis?
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 24:597-603. 2012
    ....
  7. ncbi Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1075-84. 2012
    ..No published genome-wide association studies in functional gastrointestinal or motility disorders have been published...
  8. ncbi Governance of clinical research
    Michael Camilleri
    Division of Gastroenterology and Hepatology and Office of Human Research Protection, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 107:336-8. 2012
    ....
  9. ncbi The role of pharmacogenetics in nonmalignant gastrointestinal diseases
    Michael Camilleri
    College of Medicine, Mayo Clinic, Charlton 8 110, 200 First Street South West, Rochester, MN 55905, USA
    Nat Rev Gastroenterol Hepatol 9:173-84. 2012
    ..However, pharmacogenetics could have a beneficial role in enabling pharmacotherapy for nonmalignant gastrointestinal diseases to be targeted to the individual patient...
  10. ncbi New treatment options for chronic constipation: mechanisms, efficacy and safety
    Michael Camilleri
    College of Medicine, Mayo Clinic, Rochester, MN, USA
    Can J Gastroenterol 25:29B-35B. 2011
    ..Nevertheless, the spectrum of mechanisms and demonstrated efficacy and safety augur well for satisfactory treatment outcomes...
  11. ncbi Challenges to the therapeutic pipeline for irritable bowel syndrome: end points and regulatory hurdles
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 135:1877-91. 2008
    ..The hope of providing relief to patients should galvanize all parties to achieve these goals...
  12. ncbi Drug development and IBS drugs: experience from the past, current challenges, and proposal for the future
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER Program, Mayo Clinic, Rochester, MN 55905, USA
    Curr Opin Pharmacol 8:671-6. 2008
    ..These extra validation steps will undoubtedly result in delays in drug development. Providing relief to patients should galvanize all parties to achieve effective and fair strategies for regulatory approval...
  13. ncbi Intra-abdominal vagal blocking (VBLOC therapy): clinical results with a new implantable medical device
    M Camilleri
    The Mayo Clinic, Rochester, Minnesota, USA
    Surgery 143:723-31. 2008
    ..The aim is to assess the effects of vagal blocking on excess weight loss (EWL), safety, dietary intake, and vagal function...
  14. ncbi Candidate genes and sensory functions in health and irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R, Mayo Clinic, Charlton 8 110, 200 1st St SW, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 295:G219-25. 2008
    ....
  15. ncbi The stomach in diabetes: from villain to ally
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiologic Research CENTER, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 7:285-7. 2009
    ..The stomach is not always a villain, but is an ally in patients with type 2 diabetes...
  16. ncbi A placebo-controlled trial of prucalopride for severe chronic constipation
    Michael Camilleri
    College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    N Engl J Med 358:2344-54. 2008
    ..In this 12-week trial, we aimed to determine the efficacy of prucalopride, a selective, high-affinity 5-hydroxytryptamine4 receptor agonist, in patients with severe chronic constipation...
  17. ncbi Enteric neurodegeneration in ageing
    M Camilleri
    Department of Medicine and Physiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 20:418-29. 2008
    ..There is evidence that 5-HT(2) and 5-HT(4) mechanisms are involved in development, maintenance and survival of enteric neurons. Further research is needed to understand and potentially reverse enteric neurodegeneration...
  18. ncbi Enteric neurodegeneration in ageing
    M Camilleri
    Departments of Medicine and Physiology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 20:185-96. 2008
    ..There is evidence that 5-HT(2) and 5-HT(4) mechanisms are involved in development, maintenance and survival of enteric neurons. Further research is needed to understand and potentially reverse enteric neurodegeneration...
  19. ncbi Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation
    Michael Camilleri
    Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 294:G13-9. 2008
    ....
  20. ncbi Clinical practice. Diabetic gastroparesis
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiologic Research, Mayo Clinic College of Medicine, Rochester, MN, USA
    N Engl J Med 356:820-9. 2007
  21. ncbi Conflicts of interest and disclosures in publications
    Michael Camilleri
    Mayo Clinic, Charlton 8-110, 200 First Street SW, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 5:268-73. 2007
  22. ncbi Managing conflict of interest in clinical practice
    Michael Camilleri
    Conflict of Interest Review Board and Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 82:607-14. 2007
    ..Conflict of interest is of concern because it compromises the trust of the patient and of society in the individual physician or the medical center...
  23. ncbi Appetite and obesity: a gastroenterologist's perspective
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 19:333-41. 2007
    ....
  24. ncbi Intestinal permeability and irritable bowel syndrome
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 19:545-52. 2007
    ....
  25. ncbi Pharmacogenomics and serotonergic agents: research observations and potential clinical practice implications
    M Camilleri
    CENTER Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 19:40-5. 2007
    ....
  26. ncbi alpha2delta ligand: a new, smart pill for visceral pain in patients with hypersensitive irritable bowel syndrome?
    Michael Camilleri
    Mayo Clinic, Charlton 8 110, 200 First St SW, Rochester, MN 55905, USA
    Gut 56:1337-8. 2007
  27. ncbi Functional dyspepsia: mechanisms of symptom generation and appropriate management of patients
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic College of Medicine, Charlton 8 110, 200 First Street, SW, Rochester, MN 55905, USA
    Gastroenterol Clin North Am 36:649-64, xi-x. 2007
    ..To achieve greater therapeutic efficacy, it may be necessary to target the therapeutic approach to a specific pathophysiology, such as impaired gastric emptying...
  28. ncbi Serotonin in the gastrointestinal tract
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, Mayo Clinic, Rochester, Minnesota 55905, USA
    Curr Opin Endocrinol Diabetes Obes 16:53-9. 2009
    ..To assess the role of serotonin and its control in the manifestations and treatment of lower functional gastrointestinal disorders...
  29. ncbi Pharmacogenetics of low dose clonidine in irritable bowel syndrome
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 21:399-410. 2009
    ..alpha2A, GNbeta3 and SLC6A4 genotypes significantly modify responses to CLO on sensory and motor GI functions in health and IBS...
  30. ncbi Measurement of serum 7alpha-hydroxy-4-cholesten-3-one (or 7alphaC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tandem mass spectrometry
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 21:734-e43. 2009
    ..This assay has potential as a non-invasive test for BAM in IBS...
  31. ncbi Enteroendocrine and neuronal mechanisms in pathophysiology of acute infectious diarrhea
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, Charlton 8 110, 200 First St SW, Rochester, MN 55905, USA
    Dig Dis Sci 57:19-27. 2012
    ....
  32. ncbi Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Neurogastroenterol Motil 23:995-9, e458. 2011
    ..Our aim was to assess the association of genetic variation in TGR5 and small bowel transit (SBT) and colonic transit...
  33. ncbi Proximal and overall gastric emptying of solids in patients with reduced gastric volume accommodation compared to matched controls
    Michael Camilleri
    Mayo Clinic College of Medicine, Charlton 8 110, 200 First Street SW, Rochester, MN 55905, USA
    Dig Dis Sci 56:1729-34. 2011
    ..The effect of non-surgical impairment of gastric accommodation on gastric emptying is unclear. Non-surgical impairment of gastric accommodation is associated with accelerated gastric emptying...
  34. ncbi LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 23:193-200. 2011
    ....
  35. ncbi Validation of a bowel function diary for assessing opioid-induced constipation
    Michael Camilleri
    Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 106:497-506. 2011
    ..Validated tools to assess opioid-induced constipation (OIC) are needed. The aim of this study was to validate a Bowel Function Diary (BF-Diary) that includes patient-reported outcomes (PROs) associated with OIC...
  36. ncbi Behavioural and new pharmacological treatments for constipation: getting the balance right
    Michael Camilleri
    Mayo Clinic, Charlton 8 110, 200 First St S W, Rochester, MN 55905, USA
    Gut 59:1288-96. 2010
    ....
  37. ncbi Wireless pH-motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation
    M Camilleri
    College of Medicine, Mayo Clinic, Rochester, MN, USA
    Neurogastroenterol Motil 22:874-82, e233. 2010
    ..Colon transit (CT) measurements are used in the management of significant constipation. The radiopaque marker (ROM) method provides limited information...
  38. ncbi Prucalopride for constipation
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R, College of Medicine, Mayo Clinic, Charlton 8 110, 200 First St S W, Rochester, MN 55905, USA
    Expert Opin Pharmacother 11:451-61. 2010
    ..Chronic constipation has a high prevalence, and current medical and pharmacological therapies do not restore normal bowel function in all patients...
  39. ncbi Perspective: Conflict of interest and professional organizations: considerations and recommendations
    Michael Camilleri
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Acad Med 85:85-91. 2010
    ..The perspectives offered are intended to encourage individuals and learned bodies to further study and provide commentary and recommendations on managing COIs of a professional organization...
  40. ncbi Review article: new receptor targets for medical therapy in irritable bowel syndrome
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Aliment Pharmacol Ther 31:35-46. 2010
    ....
  41. ncbi Safety assessment of prucalopride in elderly patients with constipation: a double-blind, placebo-controlled study
    M Camilleri
    Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 21:1256-e117. 2009
    ..Prucalopride up to 2 mg once daily for 4 weeks was safe and well-tolerated by constipated elderly patients, with no differences vs placebo in ECG or a range of Holter-monitoring parameters...
  42. ncbi Current and novel therapeutic options for irritable bowel syndrome management
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, Charlton 8 110, 200 First St SW, Rochester, MN 55905, United States
    Dig Liver Dis 41:854-62. 2009
    ..The mechanisms and current evidence regarding efficacy of these agents are reviewed...
  43. ncbi Genetics and irritable bowel syndrome: from genomics to intermediate phenotype and pharmacogenetics
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Dig Dis Sci 54:2318-24. 2009
    ..The aim of this study was to review the evidence of genetics in IBS based on genetic epidemiology, studies of association with intermediate phenotypes and pharmacogenetics...
  44. ncbi Understanding measurements of intestinal permeability in healthy humans with urine lactulose and mannitol excretion
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 22:e15-26. 2010
    ..The 0-5 or 6 h 2-SE urine likely reflects both SI and colon permeability; the higher LMR in the 8-24 h urine relative to 0-2 h urine should be interpreted with caution and does not mean that colon is more permeable than SI...
  45. ncbi Actions and therapeutic pathways of ghrelin for gastrointestinal disorders
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Nat Rev Gastroenterol Hepatol 6:343-52. 2009
    ..The potential of this new class of therapeutic agents to influence appetite and glycemic control strongly indicates that they should be tested in clinical trials...
  46. ncbi Peripheral mechanisms in the control of appetite and related experimental therapies in obesity
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, College of Medicine, Mayo Clinic, Rochester, Minnesota, United States
    Regul Pept 156:24-7. 2009
    ..Novel therapies are being developed to mimic or enhance these feedback mechanisms and to control appetite as a means to treat obesity...
  47. ncbi Neuropeptide S receptor induces neuropeptide expression and associates with intermediate phenotypes of functional gastrointestinal disorders
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Division of Biostatistics, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 138:98-107.e4. 2010
    ..We aimed to determine whether NPS induces expression of GI neuropeptides; and to associate NPSR1 single nucleotide polymorphisms (SNPs) with symptom phenotype and GI functions in health and functional GI disorders (FGID)...
  48. ncbi Is there a role for probiotics in irritable bowel syndrome?
    Michael Camilleri
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Dig Liver Dis 38:S266-9. 2006
    ..These experimental and clinical observations suggest that probiotics may play a role in the management of IBS...
  49. ncbi Clinical subgroups of chronic constipation: exploring the potential of polyethylene glycol
    M Camilleri
    Mayo Clinic, Rochester, MN, USA
    Ital J Gastroenterol Hepatol 31:S253-4. 1999
    ..However, first-line therapies such as dietary fibre and bulking agents should be tried initially prior to resorting to osmotic agents such as polyethylene glycol electrolyte solutions...
  50. ncbi Testing the sensitivity hypothesis in practice: tools and methods, assumptions and pitfalls
    M Camilleri
    Enteric Neuroscience Program, Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Gut 51:i34-40. 2002
    ..The principles and techniques involved in testing the hypothesis that visceral sensitivity is important are discussed, together with the controversies in the assumptions, methods, and interpretations of the data acquired to date...
  51. ncbi Serotonergic modulation of visceral sensation: lower gut
    M Camilleri
    Enteric Neuroscience Program, Gastroenterology Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Gut 51:i81-6. 2002
    ..They offer promise for the development of novel therapies for the treatment and control of irritable bowel syndrome...
  52. ncbi Clinical perspectives, mechanisms, diagnosis and management of irritable bowel syndrome
    M Camilleri
    Mayo Clinic, Rochesster, MN 55905, USA
    Aliment Pharmacol Ther 16:1407-30. 2002
    ..Patient and physician education, early identification of psychosocial issues and better therapies are important strategies to reduce the suffering and societal cost of irritable bowel syndrome...
  53. ncbi Drugs targeting functional bowel disorders: lessons from drug trials
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Curr Opin Pharmacol 2:684-90. 2002
    ....
  54. ncbi Review article: clinical evidence to support current therapies of irritable bowel syndrome
    M Camilleri
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Aliment Pharmacol Ther 13:48-53. 1999
    ..In summary, current therapies targeted on the predominant symptoms in IBS are moderately successful. New therapies are needed to more effectively relieve this syndrome, not just symptoms...
  55. ncbi Diagnosis and treatment of enteric neuromuscular diseases
    Michael Camilleri
    Mayo Clinic, Charlton 8 110, 200 First St S W, Rochester, MN 55905, USA
    Clin Auton Res 13:10-5. 2003
    ....
  56. ncbi Opioid-induced constipation: challenges and therapeutic opportunities
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 106:835-42; quiz 843. 2011
    ..Novel patient response outcomes have been developed to facilitate demonstration of efficacy and safety of drugs in development for OIC...
  57. ncbi A randomized, controlled exploratory study of clonidine in diarrhea-predominant irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 1:111-21. 2003
    ....
  58. ncbi GI clinical research 2002-2003: the year in review
    Michael Camilleri
    Mayo Clinic, Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Rochester, MN 55905, USA
    Clin Gastroenterol Hepatol 1:415-20. 2003
  59. ncbi Alvimopan, a selective peripherally acting mu-opioid antagonist
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER Program, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurogastroenterol Motil 17:157-65. 2005
    ..This review addresses the basic and applied pharmacology and current evidence for the use of the medication, alvimopan, in clinical gastroenterology...
  60. ncbi Objectives of the meeting: think opiates
    M Camilleri
    Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 16:1-2. 2004
  61. ncbi Effect of renzapride on transit in constipation-predominant irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Program, Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 2:895-904. 2004
    ....
  62. ncbi Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic, Charlton 8 110, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 290:G942-7. 2006
    ..Thus the ClC-2 activator lubiprostone accelerates small intestinal and colonic transit, which confers potential in the treatment of constipation...
  63. ncbi Management of patients with chronic abdominal pain in clinical practice
    M Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 18:499-506. 2006
    ....
  64. ncbi Pharmacology and clinical experience with alosetron
    M Camilleri
    Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Expert Opin Investig Drugs 9:147-59. 2000
    ..It also improves quality of life, has a high degree of tolerability and has an excellent safety profile to date...
  65. ncbi Review article: tegaserod
    M Camilleri
    Enteric Neuroscience Program, Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Aliment Pharmacol Ther 15:277-89. 2001
    ..Tegaserod was well-tolerated; the most frequent adverse event was transient diarrhoea...
  66. ncbi Pharmacodynamic effects of a novel prokinetic 5-HT receptor agonist, ATI-7505, in humans
    M Camilleri
    Department of Health Sciences Research, Division of Biostatistics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 19:30-8. 2007
    ..056) with the 10 and 20 mg t.i.d. doses. No safety issues were identified. ATI-7505 accelerates overall colonic transit and tends to accelerate GE and AC emptying and loosen stool consistency...
  67. ncbi Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Foundation, Rochester, Minnesota 55905, USA
    Gastroenterology 123:425-32. 2002
    ..Our hypothesis is that polymorphisms of the promoter region for the SERT influence colonic transit in response to treatment with alosetron in D-IBS...
  68. ncbi Does delayed gastric emptying really cause symptoms in functional dyspepsia?
    M Camilleri
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gut 55:909-10. 2006
  69. ncbi Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Group and Gastroenterology Research Unit, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Gastroenterology 132:17-25. 2007
    ..We explored the hypothesis that expression of these 2 proteins in colonic and rectal mucosa is abnormal in patients with IBS as compared with healthy controls...
  70. ncbi Pharmacological and pharmacokinetic aspects of functional gastrointestinal disorders
    Michael Camilleri
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 130:1421-34. 2006
    ..It is anticipated that the interaction between investigators of basic science, basic and applied pharmacology, and clinical trials will lead to better treatment of these disorders...
  71. ncbi Enteric nervous system disorders: genetic and molecular insights for the neurogastroenterologist
    M Camilleri
    Enteric Neuroscience Program, Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Neurogastroenterol Motil 13:277-95. 2001
    ....
  72. ncbi Functional bowel disease: roles of sensation and motility
    M Camilleri
    Gastroenterology Research Unit, Mayo Clinic, Charlton 7 154 200 First St S W, Rochester, MN 55905, USA
    Schweiz Med Wochenschr 130:1772-81. 2000
    ..Serotonergic and adrenergic agents are among the novel approaches that may have a significant impact on these disorders...
  73. ncbi American Neurogastroenterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice
    M Camilleri
    CENTER Program, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 20:1269-82. 2008
    ..Thus, intraluminal pressure measurements may contribute to the management of patients with disorders of gastrointestinal and colonic motility...
  74. ncbi Urine sugars for in vivo gut permeability: validation and comparisons in irritable bowel syndrome-diarrhea and controls
    Archana S Rao
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Division of Biomedical Statistics and Informatics, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Am J Physiol Gastrointest Liver Physiol 301:G919-28. 2011
    ..Urine sugars at 0-2 h and 8-24 h reflect SB and colonic permeability, respectively. IBS-D is associated with increased SB and colonic mucosal permeability...
  75. ncbi Alteration of gastric functions and candidate genes associated with weight reduction in response to sibutramine
    Maria I Vazquez Roque
    Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 5:829-37. 2007
    ....
  76. ncbi Pharmacogenomics in gastrointestinal disorders
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Methods Mol Biol 448:395-412. 2008
    ..Although only a few genotyping tests are used regularly in clinical practice, we anticipate that in the future there will be more routine use of many of the tests described in this review...
  77. ncbi Phenotypic variation of colonic motor functions in chronic constipation
    Karthik Ravi
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Gastroenterology 138:89-97. 2010
    ..We sought to characterize the phenotypic variability in chronic constipation...
  78. ncbi Nitrergic contribution to gastric relaxation induced by glucagon-like peptide-1 (GLP-1) in healthy adults
    Christopher N Andrews
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1359-65. 2007
    ..01 vs. GLP-1 alone). These data are consistent with the hypothesis that nitric oxide partly mediates the effects of GLP-1 on postprandial but not fasting gastric volumes in humans...
  79. ncbi Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjects
    Seth Sweetser
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER Group, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 296:G295-301. 2009
    ..Effects of lubiprostone on sensitivity deserve further study...
  80. ncbi A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity
    Athanasios Papathanasopoulos
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Obesity (Silver Spring) 18:1201-11. 2010
    ..With independent validation, these markers may guide patient selection of weight-loss therapies directed at gastric motor functions...
  81. ncbi Effect of GLP-1 on gastric volume, emptying, maximum volume ingested, and postprandial symptoms in humans
    Silvia Delgado-Aros
    Enteric Neuroscience Program, Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Gastrointest Liver Physiol 282:G424-31. 2002
    ..GLP-1 does not induce postprandial symptoms despite significant inhibition of gastric emptying and vagal function; this may be partly explained by the increase in postprandial gastric volume...
  82. ncbi Is there an association between GNbeta3-C825T genotype and lower functional gastrointestinal disorders?
    Viola Andresen
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Program, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 130:1985-94. 2006
    ....
  83. ncbi A community-based, controlled study of the epidemiology and pathophysiology of dyspepsia
    Emma Janet Castillo
    Clnical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 2:985-96. 2004
    ..Community dyspeptic patients have higher symptom scores after a fully satiating meal, consistent with gastric hypersensitivity. This is associated with higher somatization scores rather than disorders of gastric emptying or volumes...
  84. ncbi A study of candidate genotypes associated with dyspepsia in a U.S. community
    Christopher E Camilleri
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Gastroenterol 101:581-92. 2006
    ..The role of genetic predisposition to the development of dyspepsia is unclear. Recently, a significant association was reported with CC genotype of GNbeta3...
  85. ncbi Effect of different macronutrients in excess on gastric sensory and motor functions and appetite in normal-weight, overweight, and obese humans
    Moo In Park
    Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Clin Nutr 85:411-8. 2007
    ..The effects of supplementation with different macronutrients on gastric sensory and motor functions are unclear...
  86. ncbi Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials
    Viola Andresen
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER Program, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 6:545-55. 2008
    ....
  87. ncbi Pharmacogenomics and functional gastrointestinal disorders
    Michael Camilleri
    Mayo Clinic College of Medicine, Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Gastroenterology Research Unit, Charlton 8-110200 First Street S.W, Rochester, MN 55905, USA
    Pharmacogenomics 6:491-501. 2005
    ..These observations suggest that pharmacogenomics will introduce a new era in pharmacotherapeutics in gastroenterology...
  88. ncbi A controlled pharmacogenetic trial of sibutramine on weight loss and body composition in obese or overweight adults
    April B M Grudell
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 135:1142-54. 2008
    ..Weight loss in response to sibutramine is highly variable. We assessed the association of specific markers of polymorphisms of candidate alpha2A adrenoreceptor, 5-HT transporter, and GNbeta3 genes and weight loss with sibutramine...
  89. ncbi Obesity is associated with increased risk of gastrointestinal symptoms: a population-based study
    Silvia Delgado-Aros
    Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) Program, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Am J Gastroenterol 99:1801-6. 2004
    ..Clarification of the cause-and-effect relationships and the mechanisms of these associations require further investigation...
  90. ncbi Effects of a kappa-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans
    Silvia Delgado-Aros
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Gastrointest Liver Physiol 284:G558-66. 2003
    ..03) and pain scores at distensions of 8 and 16 mmHg (P = 0.003 and 0.03, respectively) but not at higher levels of distension. Further studies of this compound in diseases with altered satiation or visceral sensation are warranted...
  91. ncbi Gastric accommodation and emptying in evaluation of patients with upper gastrointestinal symptoms
    Albert J Bredenoord
    Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) Program, Mayo Clinic, 200 First Street S.W, Rochester, MN 55905, USA
    Clin Gastroenterol Hepatol 1:264-72. 2003
    ..These noninvasive tests identify single or combined pathophysiologic disturbances and may help to identify subgroups of patients as candidates for more selective pharmacotherapy in the future...
  92. ncbi Effects of amitriptyline on gastric sensorimotor function and postprandial symptoms in healthy individuals: a randomized, double-blind, placebo-controlled trial
    Ernest P Bouras
    Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida 32211, USA
    Am J Gastroenterol 103:2043-50. 2008
    ..However, there are only limited data on the effects of these drugs on upper gastrointestinal function...
  93. ncbi Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health
    Heather J Chial
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Gastrointest Liver Physiol 284:G130-7. 2003
    ..Buspirone, paroxetine, and venlafaxine-XR affect upper gastrointestinal functions in healthy humans. These data support the need for clinical and physiological studies of these agents in functional gastrointestinal disorders...
  94. ncbi Gastric motor and sensory functions in obesity
    Moo-In Park
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Obes Res 13:491-500. 2005
    ..Further well-controlled, validated studies are needed to clarify the potential role of altering the stomach's function as a means of controlling food intake in obesity...
  95. ncbi Effect of somatostatin analog on postprandial satiation in obesity
    Filippo Cremonini
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Obes Res 13:1572-9. 2005
    ..The role of somatostatin as a permissive factor in the development of obesity by reducing postprandial sensations deserves further study...
  96. ncbi Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome
    Viola Andresen
    Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 133:761-8. 2007
    ....
  97. ncbi Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans
    Heather J Chial
    Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 1:211-8. 2003
    ..These data support the need for further clinical and physiologic studies of venlafaxine in colonic disorders affecting motor and possibly sensory functions...
  98. ncbi Gastric sensorimotor functions and hormone profile in normal weight, overweight, and obese people
    Maria I Vazquez Roque
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 131:1717-24. 2006
    ..The aim of this study was to compare gastric volumes, emptying, maximum tolerated volumes, postchallenge symptoms, and selected gut hormones in normal, overweight, or obese healthy volunteers...
  99. ncbi Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Charlton 8 110, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 296:G510-6. 2009
    ..Thus variation in mtDNA may be associated with satiation, gastric emptying, and possibly pain; further studies of mtDNA in appetite regulation and larger numbers of patients with FGIDs are warranted...
  100. ncbi Lubiprostone for the treatment of opioid-induced bowel dysfunction
    Banny S Wong
    College of Medicine, Mayo Clinic, Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R, Rochester, MN 55905, USA
    Expert Opin Pharmacother 12:983-90. 2011
    ..Lubiprostone seems safe for long-term use in CIC patients, and a similar safety profile is anticipated in OBD...
  101. ncbi Independent influences of body mass and gastric volumes on satiation in humans
    Silvia Delgado-Aros
    Clinical Enteric Neuroscience, Translational and Epidemiological Research Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Gastroenterology 126:432-40. 2004
    ..CONCLUSIONS: Greater body mass index and fasting gastric volume are associated with reduced satiation. Increased body mass index or height was not associated with greater gastric volumes...

Research Grants17

  1. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  2. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    Michael Camilleri; Fiscal Year: 2009
    ..The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
  3. Pharmacogenomics of Gastric Function & Weight in Obesity
    Michael Camilleri; Fiscal Year: 2007
    ..It will also identify physiological and genetic factors that predict therapeutic success in the treatment of obesity with sibutramine. ..
  4. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..abstract_text> ..
  5. ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROME
    Michael Camilleri; Fiscal Year: 2007
    ..Significance: This project will characterize pharmacogenetic mechanisms determining the response to clonidine through studies of candidate genes that control alpha2-adrenoreceptor function and norepinephrine transport in IBS. ..
  6. ALPHA 2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2001
    ....
  7. Pharmacogenomics of Gastric Function & Weight in Obesity
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ....