Research Topics
| Charles BurgerSummaryAffiliation: Mayo Clinic Location: Jacksonville, United States Summary: Clinical research and education in pulmonary vascular disease and lymphangioleimyomatosis. Publications: Peer-reviewed Articles 1. Shepard JW Jr, Burger CD. Nasal and oral flow-volume loops in normal subjects and patients with obstructive sleep apnea. Am Rev Respir Dis. 1990 Dec; 142(PART 1 OF 2 PARTS):1288-1293. PMID:2252246. 2. Burger CD, Hyatt RE, Staats BA. Pulmonary mechanics in lymphangioleiomyomatosis. Am Rev Respir Dis 1991 May; 143(5 Pt 1):1030-3. PMID:2024811. 3. Burger CD, Stanson AW, Daniels BK, Sheedy PF, Shepard JW Jr. Fast-CT evaluation of the effect of lung volume on upper airway size and function in normal male subjects. Am Rev Respir Dis 1992; 146:335-339. PMID:1489121. 4. Srivatsa SS, Burger CD, Douglas WW. Upper lobe pulmonary parenchymal calcification in a patient with AIDS and Pneumocystis carinii pneumonia receiving aerosolized pentamidine. Chest 1992 Jan; 101(1):266-7. PMID:1729082. 5. Burger CD, Stanson AW, Sheedy PF 2nd, Daniels BK, Shepard JW Jr. Fast-computed tomography evaluation of age-related changes in upper airway structure and function in normal men. Am Rev Respir Dis 1992 Apr; 145(4 Pt 1):846-52. PMID:1554213. 6. Burger CD, Shepard JW Jr. Sleep-disordered breathing and aging. Lung Biol Health Dis 1993; 63:61-80. 7. Burger CD, Stanson AW, Daniels BK, Sheedy PF 2nd, Shepard JW Jr. Fast-computed tomographic evaluation of the effect of route of breathing on upper airway size and function in normal men. Chest 1993 Apr; 103(4):1032-7. PMID:8131434. 8. Lin SC, Kaplan J, Burger CD, Fredrickson PA. Effect of pramipexole in treatment of resistant restless legs syndrome. Mayo Clin Proc 1998 Jun; 73(6):497-500. PMID:9621854. 9. Becker PM, Jamieson AO, Jewel CE, Bogan RK, James DS, Sutton JT, Corser B, Mayleben DW, Bernard SH, Dinner DS, Emsellem H, Knight E, Erwin CW, Krystal AD, Radtke RA, Farrow S, Odynski T, Pinto J, Steljes D, Feldman NT, OBrien M, Fredrickson PA, Kaplan J, Lin SC, Burger C, Gross PT, et al. Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy. Neurology 2000 Mar 14; 54(5):1166-1175. PMID:. 10. Ott MC, Meschia JF, Mackey DC, Brodersen MP, Burger C, Echols JD, Fenton DS. Cerebral embolization presenting as delayed, severe obtundation in the postanesthesia care unit after total hip arthroplasty. Mayo Clin Proc 2000 Nov; 75(11):1209-13. PMID:. 11. Scolapio JS, Savoy AD, Kaplan J, Burger CD, Lin SC. Sleep patterns of cyclic parenteral nutrition, a pilot study: Are there sleepless nights? JPEN J Parenter Enteral Nutr 2002 May-Jun; 26(3):214-7. PMID:. 12. Yen KT, Krowka MJ, Lee AS, Kramer DJ, Burger CD. Liver and lung: hepatopulmonary syndrome: recognizing the clinical features and selecting the right studies. J Crit Illn 2002 Aug; 17(8):309-15. 13. Yen KT, Krowka MJ, Lee AS, Kramer DJ, Burger CD. Liver and lung: how to manage portopulmonary hypertension: despite high pulmonary artery pressure, ECG findings may be normal. J Crit Illn 2002 Oct; 17(10):401-6. 14. Ott MC, Khoor A, Leventhal JP, Paterick TE, Burger CD. Pulmonary toxicity in patients receiving low-dose amiodarone. Chest 2003 Feb; 123(2):646-51. PMID:. 15. Aduen JF, Stapelfeldt WH, Johnson MM, Jolles HI, Grinton SF, Divertie GD, Burger CD. Clinical relevance of time of onset, duration, and type of pulmonary edema after liver transplantation. Liver Transpl 2003 Jul; 9(7):764-71. PMID:. 16. Yen KT, Lee AS, Krowka MJ, Burger CD. Pulmonary complications in bone marrow transplantation: a practical approach to diagnosis and treatment. Clin Chest Med 2004 Mar; 25(1):189-201. PMID:. 17. Oldenburg WA, Lau LL, Rodenberg TJ, Edmonds HJ, Burger CD. Acute mesenteric ischemia - A clinical review. Arch Intern Med 2004 May 24; 164(10):1054-62. PMID:. 18. Hoh KW, McKinney JM, Burger CD, Bouras EP. Arterioportal fistula. Gastrointest Endosc PMID16047001 2005 Aug; 62(2):305. 19. Aduen JF, Hellinger WC, Kramer DJ, Stapelfeldt WH, Bonatti H, Crook JE, Steers JL, Burger CD. Spectrum of pneumonia in the current era of liver transplantation and its effect on survival. Mayo Clin Proc 2005 Oct; 80(10):1303-6. PMID:. 20. Yen KT, Putzke JD, Staats BA, Burger CD. The prevalence of acute response to bronchodilator in pulmonary lymphangioleiomyomatosis. Respirology 2005 Nov; 10(5):643-8. PMID:. 21. Tun HW, Wallace KH, Grinton SF, Khoor A, Burger CD. Etanercept therapy for late-onset idiopathic pneumonia syndrome after nonmyeloablative allogeneic hematopoietic stem cell transplantation. Transplant Proc 2005 Dec; 37(10):4492-6. PMID:. 22. Bloomfield EL, Divertie GD, Burger CD, Larson JS, Brown DR, Patel BM, Rady MY, Johnson MM, Murray MJ. A comparison of intensive care unit physician staffing costs at the 3 Mayo Clinic sites. Mayo Clin Proc 2006 Nov; 81(11):1457-61. PMID:. 23. Burger CD, Hampton KW, Sorensen CL, Divertie GD. The process and results of implementing the ventilator bundle to reduce ventilator-associated pneumonia rates. Respiratory Therapy 2007; 2:23-25. 24. Burger CD. "Multi-disciplinary rounds: a method to improve quality and safety of critically ill patients. Northeast Florida Medicine 2007; 58:16-19. 25. Burger CD. Utility of positive bronchoalveolar lavage in predicting respiratory failure after hematopoietic stem cell transplantation: a retrospective analysis. Transplant Proc 2007 Jun; 39(5):1623-5. PMID:. DOI:10.1016/j.transproceed.2007.02.065. 26. Li JH, Safford RE, Aduen JF, Heckman MG, Crook JE, Burger CD. Pulmonary hypertension and thyroid disease. Chest 2007 Sep; 132(3):793-7. Epub 2007 Jul 23. PMID:. DOI:10.1378/chest.07-0366. 27. Burger CD, Murali S. The vasoreactive patient: diagnosis, treatment and follow-up. Advances in Pulmonary Hypertension 2008; 6:176-179. 28. 29. Distler O, Behrens F, Pittrow D, Huscher D, Denton CP, Foeldvari I, Humbert M, Matucci-Cerinic M, Nash P, Opitz CF, Rubin LJ, Seibold JR, Furst DE, EPOSS-Omeract Group (On behalf of the Principal Investigators of EPOSS-Omeract Group). Defining appropriate outcome measures in pulmonary arterial hypertension related to systemic sclerosis: a Delphi consensus study with cluster analysis. Arthritis Rheum 2008 Jun 15; 59(6):867-75. PMID:. DOI:10.1002/art.23718. 30. Arunthari V, Burger CD. Utility of d-dimer in the diagnosis of patients with chronic thromboembolic pulmonary hypertension. Open Respir Med J 2009; 3:85-9. Epub 2009 Jun 05. PMID:. PMCID:2703202. DOI:10.2174/. 31. Gisel JJ, Daniels JT, Burger CD. Clinical Utility of thyroperoxidase antibody testing in patients with pulmonary hypertension. Thyroid Science 2009; 4:CLS1-5. 32. Burger CD. Pulmonary hypertension in COPD: a review and consideration of the role of arterial vasodilators. COPD 2009 Apr; 6(2):137-44. PMID:. DOI:10.1080/. 33. Aduen JF, Castello R, Lozano MM, Hepler GN, Keller CA, Alvarez F, Safford RE, Crook JE, Heckman MG, Burger CD. An alternative echocardiographic method to estimate mean pulmonary artery pressure: diagnostic and clinical implications. J Am Soc Echocardiogr 2009 Jul; 22(7):814-9. Epub 2009 Jun 07. PMID:. DOI:10.1016/j.echo.2009.04.007. 34. Arunthari V, Burger CD, Lee AS. Correlation of pulmonary function variables with hemodynamic measurements in patients with pulmonary arterial hypertension. Clin Respir J 2010. DOI:10.1111/j.1752-699X.2010.00188.x. 35. Burger CD. Recent updates in the both the diagnosis and treatment options that impact the clinical treatment of pulmonary arterial hypertension. Clinical Medicine Insights: Therapeutics 2010; 2:291-7. 36. Burger CD, Zeiger T. What can be learned in 6 minutes? 6-minute walk test primer and role in pulmonary arterial hypertension. Advances in Pulmonary Hypertension. 2010; 9:107-111. 37. Patel NM, Burger CD. Two cases of stem cell therapy for pulmonary hypertension: a clinical report. Respiratory Medicine CME 2010. [Epub ahead of print] DOI:10.1016/j.rmedc.2010.09.002. 38. William WH, Safford RE, Heckman MG, Crook JE, Burger CD. Pulmonary arterial hypertension and obesity. Open Obesity J 2010:2:132-36. 39. Arunthari V, Heckman MG, Burger CD. Prevalence of acute vasoresponsiveness in patients with pulmonary hypertension: treatment implications. South Med J 2010 Jul; 103(7):630-4. PMID:. DOI:10.1097/SMJ.0b013e3181e1a8af. 40. Aduen JF, Castello R, Daniels JT, Diaz JA, Safford RE, Heckman MG, Crook JE, Burger CD. Accuracy and Precision of 3 Echocardiographic Methods for Estimating Mean Pulmonary Artery Pressure. Chest 100126published July 22, 2010, doi:10.1378/chest.10-0126 Chest 2011;139:347-352. 41. Burger CD, Foreman AJ, Miller DP, Safford RE, McGoon MD, Badesch DB. Comparison of Body Habitus in Pulmonary Arterial Hypertension Patients Enrolled in the Registry to Evaluate Early and Long-term PAH Disease Management (REVEAL) With Normative Values From the National Health and Nutrition Examination Survey. Mayo Clin Proc 2011;86:105-112. 42. Vazquez AA, Aduen JF, Aduen P, Heckman MG, Burger CD. Should All Patients With Pulmonary Hypertension Undergo HIV Serologic Testing? South Med J 2011; 104:589-592. Book Chapters 1. Shepard JW Jr, Stanson AW, Sheedy PF, Daniels BK, Burger CD. Pharyngeal size in aging adults assessed with fast CT scans. In: Kuna ST, Remmers JE, Suratt PM, editors. Sleep and Respiration in Aging Adults. New York: Elsevier; 1991. p. 205-10. (Book chapter) 2. Lee AS, Utz JP, Burger CD. Sarcoidosis and the Heart. In: Nixon JV. The AHA Clinical Cardiac Consult 3rd edition ed. Lippincott, Williams & Wilkins; 2011. (Book chapter) 3. Patel, NM and Burger CD. Autologous Stem Cell Infusion for Treatment of Pulmonary Disease. In: Stem Cell Transplantation. InTech; 2011. (Book chapter Publications
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Detail Information
Publications
Fast-CT evaluation of the effect of lung volume on upper airway size and function in normal menC D Burger
Sleep Disorder Center, Mayo Clinic, Rochester, MN 55905
Am Rev Respir Dis 146:335-9. 1992..006). There was no change in EMGgg with tidal ventilation or with exhalation to RV. Changes in CSA directly paralleled changes in lung volume in this group of normal awake nonobese men.(ABSTRACT TRUNCATED AT 250 WORDS)..
Spectrum of pneumonia in the current era of liver transplantation and its effect on survivalJavier F Aduen
Division of Pulmonary Medicine, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
Mayo Clin Proc 80:1303-6. 2005..To examine the frequency and microbial pattern of pneumonia and its effect on survival in the current era of orthotopic liver transplantation (OLT)...
The prevalence of acute response to bronchodilator in pulmonary lymphangioleiomyomatosisKenneth T Yen
Division of Pulmonary Medicine, Mayo Clinic, Jacksonville, FL 32224, USA
Respirology 10:643-8. 2005..A positive response to bronchodilator was unusual. Other measures of pulmonary function showed little or no change over a 12-month period...
Etanercept therapy for late-onset idiopathic pneumonia syndrome after nonmyeloablative allogeneic hematopoietic stem cell transplantationH W Tun
Division of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida 32224, USA
Transplant Proc 37:4492-6. 2005..Our two cases showed that IPS could develop late after NMA-AHSCT and inhibition of TNF-alpha activity can be therapeutically effective...
A comparison of intensive care unit physician staffing costs at the 3 Mayo Clinic sitesEric L Bloomfield
Department of Critical Care, Mayo Clinic College of Medicine, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
Mayo Clin Proc 81:1457-61. 2006..To determine the provider cost of administering intensive care unit (ICU) services, comparing 3 different staffing models for ICU coverage, and to compare the costs of using house staff vs nonphysician providers (NPPs)...
Utility of positive bronchoalveolar lavage in predicting respiratory failure after hematopoietic stem cell transplantation: a retrospective analysisC D Burger
Division of Pulmonary Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Transplant Proc 39:1623-5. 2007..All deaths except one occurred as a direct result of respiratory failure. Although this study confirmed the high mortality rate in HSCT patients with respiratory failure, the BAL results were not predictive of outcome...
Pulmonary hypertension and thyroid diseaseJonathan H Li
Division of Pulmonary Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
Chest 132:793-7. 2007..The association between thyroid dysfunction and pulmonary hypertension (PH) has not been well characterized...
Defining appropriate outcome measures in pulmonary arterial hypertension related to systemic sclerosis: a Delphi consensus study with cluster analysisOliver Distler
University Hospital Zurich, Zurich, Switzerland
Arthritis Rheum 59:867-75. 2008..The aim of the present study was to establish an expert consensus regarding which outcome measures are most appropriate for clinical trials in PAH-SSc...
Pulmonary hypertension in COPD: a review and consideration of the role of arterial vasodilatorsCharles D Burger
Mayo Clinic, Jacksonville, FL 32224, USA
COPD 6:137-44. 2009..Vasodilators may worsen gas exchange, however, and to date, have no proven benefit. Rigorous future study will be required to determine whether there is a role for using pulmonary arterial vasodilators in this setting...
An alternative echocardiographic method to estimate mean pulmonary artery pressure: diagnostic and clinical implicationsJavier F Aduen
Division of Pulmonary Medicine, Mayo Clinic, Jacksonville, Florida, USA
J Am Soc Echocardiogr 22:814-9. 2009..The aim of this study was to evaluated an alternative echocardiographic method to calculate mean pulmonary arterial pressure (MPAP)...
Utility of d-dimer in the diagnosis of patients with chronic thromboembolic pulmonary hypertensionVichaya Arunthari
Division of Pulmonary Medicine, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Open Respir Med J 3:85-9. 2009..In patients with idiopathic pulmonary arterial hypertension there is evidence to suggest that D-dimer levels are associated with disease severity; however, data regarding D-dimer in patients with CTEPH are lacking...
Prevalence of acute vasoresponsiveness in patients with pulmonary hypertension: treatment implicationsVichaya Arunthari
Division of Pulmonary Medicine and Biostatistics Unit, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
South Med J 103:630-4. 2010..More recently, using the current criteria, the rate of acute vasodilator response was as low as 6%. This study used the most current guidelines to assess the prevalence of acute vasoresponsiveness in patients with PH...
Correlation of pulmonary function variables with hemodynamic measurements in patients with pulmonary arterial hypertensionVichaya Arunthari
Division of Pulmonary Medicine, Mayo Clinic, Jacksonville, FL, USA
Clin Respir J 5:35-43. 2011..A reduced diffusing capacity of the lung for carbon monoxide (DLCO) measured during a pulmonary function test can suggest pulmonary arterial hypertension (PAH). The DLCO has been reported to weakly correlate with pulmonary hemodynamics...
Arterioportal fistulaKyung W Noh
Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA
Gastrointest Endosc 62:305; discussion 305. 2005
Acute mesenteric ischemia: a clinical reviewW Andrew Oldenburg
Section of Vascular Surgery, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Arch Intern Med 164:1054-62. 2004..Early diagnosis and prompt effective treatment are essential to improve the clinical outcome...
Fast-computed tomography evaluation of age-related changes in upper airway structure and function in normal menC D Burger
Sleep Disorder Center, Mayo Clinic, Rochester, MN 55905
Am Rev Respir Dis 145:846-52. 1992..05). This finding indicated increased compensatory UA dilator muscle activity in response to negative pressures in the older subjects.(ABSTRACT TRUNCATED AT 250 WORDS)..
Upper lobe pulmonary parenchymal calcification in a patient with AIDS and Pneumocystis carinii pneumonia receiving aerosolized pentamidineS S Srivatsa
Division of Thoracic Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905
Chest 101:266-7. 1992..Pulmonary parenchymal calcification due to P carinii is rare. In this case, extensive upper lobe pulmonary parenchymal, splenic, and nodal calcifications occurred after two years of monthly treatments with aerosolized pentamidine...
Pulmonary mechanics in lymphangioleiomyomatosisC D Burger
Division of Thoracic Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905
Am Rev Respir Dis 143:1030-3. 1991..Although there was some decrease in retractive force consistent with emphysema, expiratory flows were reduced predominantly because of airway narrowing or obstruction rather than loss of pulmonary elastic recoil forces...
Nasal and oral flow-volume loops in normal subjects and patients with obstructive sleep apneaJ W Shepard
Mayo Sleep Disorders Center, Mayo Clinic, Rochester, Minnesota 55905
Am Rev Respir Dis 142:1288-93. 1990..89. These results suggest that limitations to ventilation via the nasopharynx may significantly influence both gas exchange and the frequency of sleep-disordered breathing in patients with OSA.(ABSTRACT TRUNCATED AT 250 WORDS)..
Fast-computed tomographic evaluation of the effect of route of breathing on upper airway size and function in normal menC D Burger
Sleep Disorder Center, Mayo Clinic, Rochester, Minn 55905
Chest 103:1032-7. 1993..The doubling of EMGgg activity with oral breathing suggests that active contraction of the genioglossus may function to increase the patency of the OHP segment during oral breathing in supine, awake, normal subjects...
Effect of pramipexole in treatment of resistant restless legs syndromeS C Lin
Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, Florida 32224, USA
Mayo Clin Proc 73:497-500. 1998..To report the results of an open-label trial with a dopaminergic agent, pramipexole, in patients with treatment-resistant restless legs syndrome (RLS)...
Cerebral embolization presenting as delayed, severe obtundation in the postanesthesia care unit after total hip arthroplastyM C Ott
Division of Pulmonary Medicine, Mayo Clinic, Jacksonville, Fla 32224 1865, USA
Mayo Clin Proc 75:1209-13. 2000..Magnetic resonance imaging with T2-weighted sequences is the cranial imaging study of choice for early evaluation of patients with sudden multifocal neurologic deficits and suspected fat embolism syndrome...
Sleep patterns of cyclic parenteral nutrition, a pilot study: are there sleepless nights?James S Scolapio
Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA
JPEN J Parenter Enteral Nutr 26:214-7. 2002..The aim of this pilot study was to evaluate the sleep patterns of 5 patients receiving HPN...
Pulmonary toxicity in patients receiving low-dose amiodaroneMichael C Ott
Mayo Clinic, Jacksonville, FL 32224, USA
Chest 123:646-51. 2003..One patient was unavailable for follow-up. CONCLUSION: Amiodarone-induced pulmonary toxicity can occur at a daily dose of 200 mg. Clinicians must remain alert to this possibility even with this low-dose therapy...
Clinical relevance of time of onset, duration, and type of pulmonary edema after liver transplantationJavier F Aduen
Division of Pulmonary Medicine, Mayo Clinic, Jacksonville, FL, USA
Liver Transpl 9:764-71. 2003..In conclusion, immediate pulmonary edema resolving within 24 hours after liver transplantation had little clinical consequence; persistent permeability-type pulmonary edema portended a worse outcome...
Pulmonary complications in bone marrow transplantation: a practical approach to diagnosis and treatmentKenneth T Yen
Division of Pulmonary Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Clin Chest Med 25:189-201. 2004..In this article, we describe our algorithmic approach to the diagnosis and management of these complications...
Should all patients with pulmonary hypertension undergo HIV serologic testing?Alexis A Vazquez
Division of Pulmonary Medicine, Mayo Clinic, Jacksonville, FL 32224, USA
South Med J 104:589-92. 2011..To evaluate the yield of screening patients with pulmonary hypertension (PH) for human immunodeficiency virus (HIV) infection...
Comparison of body habitus in patients with pulmonary arterial hypertension enrolled in the Registry to Evaluate Early and Long-term PAH Disease Management with normative values from the National Health and Nutrition Examination SurveyCharles D Burger
Division of Pulmonary Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
Mayo Clin Proc 86:105-12. 2011..To investigate the correlation between body mass index (BMI) and pulmonary artery systolic pressure in a large population of patients with pulmonary arterial hypertension (PAH)...
Accuracy and precision of three echocardiographic methods for estimating mean pulmonary artery pressureJavier F Aduen
Division of Pulmonary Medicine, Mayo Clinic, Jacksonville, FL 32224, USA
Chest 139:347-52. 2011..The purpose of this study was to compare the accuracy and precision of three echocardiographic methods for estimating MPAP...
