T Brott

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc The Ischemic Stroke Genetics Study (ISGS) Protocol
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA
    BMC Neurol 3:4. 2003
  2. ncbi request reprint Carotid surgery to prevent stroke
    Thomas G Brott
    Mayo Clinic Jacksonville, Neurology Department, Cannaday Building 2 East, 4500 San Pablo Road, Jacksonville, Florida, USA
    Lancet Neurol 3:452-3. 2004
  3. ncbi request reprint Angioplasty and stenting should be performed only in the setting of a clinical trial
    Thomas G Brott
    Mayo Clinic, Jacksonville, Florida 32224, USA
    Stroke 33:2519-20. 2002
  4. ncbi request reprint Carotid endarterectomy versus angioplasty/stenting for carotid stenosis
    Kevin M Barrett
    Department of Neurology Cannaday 2E, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Atheroscler Rep 9:333-40. 2007
  5. pmc The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST): stenting versus carotid endarterectomy for carotid disease
    Vito A Mantese
    Mayo Clinic, Griffin 3rd Floor, 4500 San Pablo Road, Jacksonville, FL 32224
    Stroke 41:S31-4. 2010
  6. ncbi request reprint Novel approaches to stroke prevention in atrial fibrillation: introduction
    Thomas G Brott
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Stroke 38:614. 2007
  7. pmc Stenting versus endarterectomy for treatment of carotid-artery stenosis
    Thomas G Brott
    Mayo Clinic, Griffin 304, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    N Engl J Med 363:11-23. 2010
  8. ncbi request reprint Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage
    William D Freeman
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Fla 32224, USA
    Mayo Clin Proc 79:1495-500. 2004
  9. ncbi request reprint Aging blunts ischemic-preconditioning-induced neuroprotection following transient global ischemia in rats
    Zhen He
    Department of Pharmacology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Neurovasc Res 2:365-74. 2005
  10. ncbi request reprint Carotid revascularization for prevention of stroke: carotid endarterectomy and carotid artery stenting
    Thomas G Brott
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Fla, USA
    Mayo Clin Proc 79:1197-208. 2004

Detail Information

Publications53

  1. pmc The Ischemic Stroke Genetics Study (ISGS) Protocol
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA
    BMC Neurol 3:4. 2003
    ..Our aim is to investigate potential associations between hemostatic gene polymorphisms and ischemic stroke, with particular emphasis on detailed characterization of the phenotype...
  2. ncbi request reprint Carotid surgery to prevent stroke
    Thomas G Brott
    Mayo Clinic Jacksonville, Neurology Department, Cannaday Building 2 East, 4500 San Pablo Road, Jacksonville, Florida, USA
    Lancet Neurol 3:452-3. 2004
  3. ncbi request reprint Angioplasty and stenting should be performed only in the setting of a clinical trial
    Thomas G Brott
    Mayo Clinic, Jacksonville, Florida 32224, USA
    Stroke 33:2519-20. 2002
  4. ncbi request reprint Carotid endarterectomy versus angioplasty/stenting for carotid stenosis
    Kevin M Barrett
    Department of Neurology Cannaday 2E, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Atheroscler Rep 9:333-40. 2007
    ..Particular focus is directed towards results from recently completed and ongoing prospective comparative trials of endarterectomy and carotid angioplasty and stenting...
  5. pmc The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST): stenting versus carotid endarterectomy for carotid disease
    Vito A Mantese
    Mayo Clinic, Griffin 3rd Floor, 4500 San Pablo Road, Jacksonville, FL 32224
    Stroke 41:S31-4. 2010
    ..Carotid endarterectomy (CEA) was introduced as a treatment to prevent stroke in the early 1950s. Carotid stenting (CAS) was introduced as a treatment to prevent stroke in 1994...
  6. ncbi request reprint Novel approaches to stroke prevention in atrial fibrillation: introduction
    Thomas G Brott
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Stroke 38:614. 2007
  7. pmc Stenting versus endarterectomy for treatment of carotid-artery stenosis
    Thomas G Brott
    Mayo Clinic, Griffin 304, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    N Engl J Med 363:11-23. 2010
    ..Carotid-artery stenting and carotid endarterectomy are both options for treating carotid-artery stenosis, an important cause of stroke...
  8. ncbi request reprint Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage
    William D Freeman
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Fla 32224, USA
    Mayo Clin Proc 79:1495-500. 2004
    ..To assess the effects of recombinant factor VIIa (rFVIIa) on hemorrhage volume and functional outcomes in warfarin-related acute intracranial hemorrhage (ICH), which has a 30-day mortality of more than 50%...
  9. ncbi request reprint Aging blunts ischemic-preconditioning-induced neuroprotection following transient global ischemia in rats
    Zhen He
    Department of Pharmacology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Neurovasc Res 2:365-74. 2005
    ..05), suggesting that mechanisms of ischemic cell death may change with aging. In conclusion, aging alters mechanisms of ischemic cell death in CA1 neurons and ischemic tolerance mechanisms are blunted by aging...
  10. ncbi request reprint Carotid revascularization for prevention of stroke: carotid endarterectomy and carotid artery stenting
    Thomas G Brott
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Fla, USA
    Mayo Clin Proc 79:1197-208. 2004
    ..The benefits and durability of CEA compared with carotid artery stenting are still unclear and are being studied in ongoing randomized controlled trials...
  11. pmc IL1RN VNTR polymorphism in ischemic stroke: analysis in 3 populations
    Bradford B Worrall
    Department of Neurology, University of Virginia Health System, Charlottesville, VA, USA
    Stroke 38:1189-96. 2007
    ..The purpose of this study was to confirm our earlier finding of an association between allele 2 of a variable number tandem repeat of the IL-1 receptor antagonist gene (IL1RN) and cerebrovascular disease...
  12. ncbi request reprint Carotid artery stenting versus carotid endarterectomy: current status
    Kevin M Barrett
    Department of Neurology Cannaday 2E, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurol Clin 24:681-95. 2006
    ..CAS will have to be proved equivalent or superior to surgery and as cost-effective to facilitate its widespread acceptance as a treatment alternative for carotid occlusive disease...
  13. ncbi request reprint Emerging therapies for acute ischemic stroke: new therapies on trial
    Marc Fisher
    Department of Neurology, University of Massachusetts Medical School, Memorial Healthcare, Worcester, Mass 01605, USA
    Stroke 34:359-61. 2003
  14. pmc Sex differences in stroke evaluations in the Ischemic Stroke Genetics Study
    Thabele M Leslie-Mazwi
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 16:187-93. 2007
    ..Sex differences in stroke evaluation could lead to sex differences in the validity of diagnosing ischemic stroke subtypes. This study assessed sex differences in the Ischemic Stroke Genetics Study (ISGS)...
  15. ncbi request reprint Aging is neuroprotective during global ischemia but leads to increased caspase-3 and apoptotic activity in hippocampal neurons
    Zhen He
    Department of Pharmacology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Curr Neurovasc Res 3:181-6. 2006
    ..05). Aging appears to delay caspase-3-dependent apoptotic cell death induced by global ischemia in the CA1 region of the hippocampus, consistent with an age-induced neuroprotective process...
  16. ncbi request reprint Diagnosis and invasive management of carotid atherosclerotic stenosis
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Mayo Clin Proc 82:851-8. 2007
    ..Randomized comparisons of endarterectomy vs stenting have been performed in average- and high-risk patients with asymptomatic and symptomatic carotid artery stenosis with mixed results...
  17. pmc The Siblings With Ischemic Stroke Study (SWISS): a progress report
    James F Meschia
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Clin Med Res 4:12-21. 2006
    ..This report updates the progress of enrollment in the SWISS protocol, discusses barriers to pedigree completion and describes innovative approaches used by the SWISS investigators to enhance enrollment...
  18. ncbi request reprint Advances in the care of patients with intracerebral hemorrhage
    Kristine M Thompson
    Department of Emergency Medicine, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Mayo Clin Proc 82:987-90. 2007
    ..Not long ago, ICH was considered virtually untreatable. Diligent efforts in both bench and clinical research are generating hope for patients who experience this catastrophic event...
  19. doi request reprint Computer-assisted volumetric analysis compared with ABC/2 method for assessing warfarin-related intracranial hemorrhage volumes
    William D Freeman
    Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurocrit Care 9:307-12. 2008
    ..We compared 2 methods of measuring ICH volume in patients with warfarin-related ICH...
  20. pmc Joint Commission primary stroke center certification does not affect proband enrollment: the siblings with ischemic stroke study
    Alexa N Richie
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 18:363-6. 2009
    ..Whether certification promotes enrollment of study subjects into stroke research studies is not known. We examined whether enrollment performance of centers was related to JC certification status...
  21. doi request reprint Mayo Acute Stroke Trial for Enhancing Recovery (MASTER) protocol
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 19:299-310. 2010
    ..TRIAL REGISTRATION: Clinicaltrials.gov identifier NCT00805792...
  22. doi request reprint Behavioral symptoms in long-term survivors of ischemic stroke
    Beth K Rush
    Division of Psychology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 19:326-32. 2010
    ..Future research is needed to understand how the identification of behavioral symptoms after stroke can improve care in stroke survivors...
  23. ncbi request reprint Management of stenosis of the extracranial internal carotid artery: endarterectomy versus angioplasty and stenting
    Kevin M Barrett
    Department of Neurology Cannaday 2E, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL, 32224, USA
    Curr Treat Options Neurol 12:475-82. 2010
    ..The efficacy of carotid revascularization compared with modern medical therapy in asymptomatic patients remains an important and unanswered clinical question...
  24. pmc Carotid stenting vs endarterectomy: new results in perspective
    William J Perkins
    Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 85:1101-8. 2010
    ....
  25. ncbi request reprint Thrombolytic treatment of acute ischemic stroke
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Mayo Clin Proc 77:542-51. 2002
    ....
  26. ncbi request reprint Hippocampal progenitor cells express nestin following cerebral ischemia in rats
    Zhen He
    Department of Pharmacology, Mayo Clinic Jacksonville, Jacksonville, Florida 32224, USA
    Neuroreport 16:1541-4. 2005
    ..eight-vessel occlusion, respectively). Confocal microscopy verified that a subset of the bromedeoxyuridine-positive cells expressed nestin. In conclusion, severe ischemia elicits nestin expression in hippocampal progenitor cells in rats...
  27. pmc Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
    Ann Neurol 58:351-61. 2005
    ..There was no evidence of association between variants of ALOX5AP and ischemic stroke. These data suggest that common variants in PDE4D may contribute to the genetic risk for ischemic stroke in multiple populations...
  28. ncbi request reprint Reliability of the questionnaire for verifying stroke-free status
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Fla, USA
    Cerebrovasc Dis 17:218-23. 2004
    ..The Questionnaire for Verifying Stroke-Free Status (QVSS) is a practical instrument for confirming absence of previous symptomatic stroke or transient ischemic attack in control subjects participating in stroke research...
  29. ncbi request reprint Failure to wean from a ventilator caused by ANNA-1 seropositive paraneoplastic syndrome
    James F Meschia
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    Eur Neurol 50:112-4. 2003
  30. ncbi request reprint Familial clustering of stroke according to proband age at onset of presenting ischemic stroke
    James F Meschia
    Dept of Neurology, Mayo Clinic, Jacksonville, Fla, USA
    Stroke 34:e89-91. 2003
    ..We investigated the relationship between age and inherited risk of stroke...
  31. pmc A survey of the SWISS researchers on the impact of sibling privacy protections on pedigree recruitment
    Bradford B Worrall
    Department of Neurology, University of Virginia, Charlottesville, VA, USA
    Neuroepidemiology 25:32-41. 2005
    ..A substantial minority of researchers (37%) said the strategy impeded enrollment, and 44% said it was overly burdensome to probands...
  32. pmc Proband race/ethnicity affects pedigree completion rate in a genetic study of ischemic stroke
    Brett M Kissela
    Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA
    J Stroke Cerebrovasc Dis 17:299-302. 2008
    ..However, little is known about the predictors of enrollment in family-based observational genetic studies. We tested the hypothesis that proband race/ethnicity is a significant predictor of enrolling a pedigree...
  33. doi request reprint Evaluation of subclinical cerebral injury and neuropsychologic function in patients undergoing carotid endarterectomy
    Juergen Falkensammer
    Section of Vascular Surgery, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Ann Vasc Surg 22:497-504. 2008
    ..This was the only individual to obtain a consistently high S100B and NSE increase. Neuropsychological testing combined with measurements of S100B and NSE may improve sensitivity when assessing subtle cerebral damage following CEA...
  34. pmc Sex differences in stroke severity, symptoms, and deficits after first-ever ischemic stroke
    Kevin M Barrett
    Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Stroke Cerebrovasc Dis 16:34-9. 2007
    ..The purpose of the study was to assess whether there were sex differences in stroke severity, infarct characteristics, symptoms, or the symptoms-deficit relationship at the time of acute stroke presentation...
  35. pmc Spouses and unrelated friends of probands as controls for stroke genetics studies
    Bradford Burke Worrall
    Department of Neurology, University of Virginia, Charlottesville, VA, USA
    Neuroepidemiology 22:239-44. 2003
    ..33%; p = 0.0002). Without proper attention to matching, the use of a spouse/friend convenience sample would result in imbalances in basic demographic characteristics...
  36. pmc Stroke genetic research and adults with impaired decision-making capacity: a survey of IRB and investigator practices
    Donna T Chen
    Department of Neurology, Center for Biomedical Ethics and Humanities, University of Virginia, Charlottesville, VA 22908, USA
    Stroke 39:2732-5. 2008
    ..This study was conducted to obtain data on how investigators and IRBs handle surrogate authorization to enroll probands into a genetic study where some may lack capacity because of ischemic stroke...
  37. ncbi request reprint Brain injury after cardiopulmonary arrest and its assessment with diffusion-weighted magnetic resonance imaging
    Kevin M Barrett
    Department of Neurology, College of Medicine, Mayo Clinic, Jacksonville, FL 32224, USA
    Mayo Clin Proc 82:828-35. 2007
    ....
  38. ncbi request reprint Genetics of cerebrovascular disorders
    James F Meschia
    Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Fla, USA
    Mayo Clin Proc 80:122-32. 2005
    ..This article reviews the clinical and genetic features of some mendellan and mitochondrial disorders associated with ischemic stroke, hemorrhagic stroke, and cerebrovascular malformations...
  39. ncbi request reprint Creation of a bilingual Spanish-English version of the Questionnaire for Verifying Stroke-free Status
    Pablo R Castillo
    Division of Cardiovascular Diseases, Mayo Clinic, Jacksonville, FL 32224, USA
    Neuroepidemiology 23:236-9. 2004
    ..Blinded back-translation confirmed conceptual equivalence of the original English-language and final Spanish-language versions...
  40. ncbi request reprint Natural history of perihematomal edema in patients with hyperacute spontaneous intracerebral hemorrhage
    James M Gebel
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Stroke 33:2631-5. 2002
    ..The natural history of perihematomal edema in human hyperacute spontaneous intracerebral hemorrhage (ICH) has not been well described...
  41. ncbi request reprint Relative edema volume is a predictor of outcome in patients with hyperacute spontaneous intracerebral hemorrhage
    James M Gebel
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Stroke 33:2636-41. 2002
    ..We hypothesized that increasing baseline relative edema volume is associated with greater probability of poor functional outcome...
  42. pmc A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release
    Mar Matarin
    Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 6:414-20. 2007
    ..We aimed to identify any common genetic variability exerting a moderate to large effect on risk of ischaemic stroke, and to generate publicly available genome-wide genotype data to facilitate others doing the same...
  43. ncbi request reprint Carotid artery stenting: meeting the recruitment challenge of a clinical trial
    Robert W Hobson
    CREST, UMDNJ New Jersey Medical School, Newark, NJ 07101, USA
    Stroke 36:1314-5. 2005
  44. ncbi request reprint Credentialing of surgeons as interventionalists for carotid artery stenting: experience from the lead-in phase of CREST
    Robert W Hobson
    Department of Surgery, UMDNJ NJ Medical School, Newark, NJ 07101, USA
    J Vasc Surg 40:952-7. 2004
    ....
  45. ncbi request reprint Therapeutic potential of platelet glycoprotein IIb/IIIa receptor antagonists in acute ischaemic stroke: scientific rationale and available evidence
    Arthur M Pancioli
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio 45267 0769, USA
    CNS Drugs 18:981-8. 2004
    ..This article reviews the scientific rationale and available evidence for the potential use of platelet GP IIb/IIIa receptor antagonists in acute ischaemic stroke...
  46. ncbi request reprint Carotid artery stenting is associated with increased complications in octogenarians: 30-day stroke and death rates in the CREST lead-in phase
    Robert W Hobson
    University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark 07101, USA
    J Vasc Surg 40:1106-11. 2004
    ..The occurrence of stroke and death was reviewed by an independent clinical events committee...
  47. ncbi request reprint Beyond subgroup analysis: improving the clinical interpretation of treatment effects in stroke research
    Mei Lu
    Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, MI 48202, USA
    J Neurosci Methods 143:209-16. 2005
    ..Results of NINDS t-PA stroke studies confirmed our previous conclusions on the treatment t-PA benefit within 3-h therapeutic window. No subgroup of patients would lead a physician to withhold the t-PA treatment...
  48. ncbi request reprint Spanish cross-cultural adaptation and validation of the National Institutes of Health Stroke Scale
    Raúl Dominguez
    University of Buenos Aires Hospital Sirio Libanés, Instituto Médico ENERI, Ciudad Autónoma de Buenos Aire, Argentina
    Mayo Clin Proc 81:476-80. 2006
    ..To adapt and validate a Spanish-language version (SV) of the National Institutes of Health Stroke Scale (NIHSS) to facilitate its use in Spanish-speaking contexts...
  49. ncbi request reprint Approval of the MERCI clot retriever: a critical view
    Kyra J Becker
    University of Washington School of Medicine, Harborview Medical Center, Box 359775, 325 9th Ave, Seattle, WA 98104 2499, USA
    Stroke 36:400-3. 2005
  50. pmc Impact of restricting enrollment in stroke genetics research to adults able to provide informed consent
    Donna T Chen
    Department of Public Health Sciences, University of Virginia Center for Biomedical Ethics, University of Virginia, Charlottesville, VA, USA
    Stroke 39:831-7. 2008
    ..The purpose of this study was to assess differences in stroke cohort characteristics between those who provided informed consent and those whose enrollment was authorized by surrogate decision makers...
  51. pmc Association of integrin alpha2 gene variants with ischemic stroke
    Mar Matarin
    Neurogenetics Laboratory, National Institute on Aging, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 28:81-9. 2008
    ..These results provide additional support for a role for platelet receptor genes in the pathogenesis of ischemic stroke of diverse subtypes...
  52. ncbi request reprint Genetics of stroke
    James F Meschia
    N Engl J Med 348:1407. 2003
  53. ncbi request reprint Planning genetic studies and human stroke: sample size estimates based on family history data
    James F Meschia
    Neurology 59:1292. 2002