M Boules

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050
    Amanda M Shaw
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research and Mayo Clinic Jacksonville, Jacksonville, FL, USA
    Eur J Pharmacol 555:30-6. 2007
  2. ncbi request reprint The neurotensin receptor agonist NT69L suppresses sucrose-reinforced operant behavior in the rat
    Mona Boules
    Mayo Foundation for Medical Education and Research and Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 1127:90-8. 2007
  3. doi request reprint Analgesic synergy of neurotensin receptor subtype 2 agonist NT79 and morphine
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Mayo Clinic, Jacksonville, Florida 32224, USA
    Behav Pharmacol 22:573-81. 2011
  4. ncbi request reprint Bioactive analogs of neurotensin: focus on CNS effects
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Peptides 27:2523-33. 2006
  5. ncbi request reprint Neurotensin agonists: potential in the treatment of schizophrenia
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Mayo Clinic Jacksonville, Florida 32224, USA
    CNS Drugs 21:13-23. 2007
  6. doi request reprint NT69L, a novel analgesic, shows synergy with morphine
    M Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Jacksonville, Florida, USA
    Brain Res 1294:22-8. 2009
  7. pmc NT79: A novel neurotensin analog with selective behavioral effects
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Clinic Florida, Jacksonville, FL 32224, USA
    Brain Res 1308:35-46. 2010
  8. ncbi request reprint Current topics: brain penetrating neurotensin analog
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Life Sci 73:2785-92. 2003
  9. ncbi request reprint Selective tolerance to the hypothermic and anticataleptic effects of a neurotensin analog that crosses the blood-brain barrier
    Mona Boules
    Mayo Foundation for Medical Education and Research, and Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 987:39-48. 2003
  10. ncbi request reprint A novel neurotensin analog blocks cocaine- and D-amphetamine-induced hyperactivity
    M Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, and Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Eur J Pharmacol 426:73-6. 2001

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Antidepressant-like effects of novel triple reuptake inhibitors, PRC025 and PRC050
    Amanda M Shaw
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research and Mayo Clinic Jacksonville, Jacksonville, FL, USA
    Eur J Pharmacol 555:30-6. 2007
    ..Therefore it appears that our compounds may possess antidepressant activity and represent a new class of triple reuptake inhibitors...
  2. ncbi request reprint The neurotensin receptor agonist NT69L suppresses sucrose-reinforced operant behavior in the rat
    Mona Boules
    Mayo Foundation for Medical Education and Research and Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 1127:90-8. 2007
    ..The effect of NT69L on dopamine, tyrosine 3-hydroxylase, and dopamine receptor mRNA levels is discussed relative to changes occurring during extinction...
  3. doi request reprint Analgesic synergy of neurotensin receptor subtype 2 agonist NT79 and morphine
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Mayo Clinic, Jacksonville, Florida 32224, USA
    Behav Pharmacol 22:573-81. 2011
    ..Isobolographic analyses show analgesic synergism between NT79 and morphine in persistent pain, thus providing a promise of therapy for pain while minimizing adverse effects associated with morphine use...
  4. ncbi request reprint Bioactive analogs of neurotensin: focus on CNS effects
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Peptides 27:2523-33. 2006
    ....
  5. ncbi request reprint Neurotensin agonists: potential in the treatment of schizophrenia
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Mayo Clinic Jacksonville, Florida 32224, USA
    CNS Drugs 21:13-23. 2007
    ....
  6. doi request reprint NT69L, a novel analgesic, shows synergy with morphine
    M Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Jacksonville, Florida, USA
    Brain Res 1294:22-8. 2009
    ....
  7. pmc NT79: A novel neurotensin analog with selective behavioral effects
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Clinic Florida, Jacksonville, FL 32224, USA
    Brain Res 1308:35-46. 2010
    ..NT79, with its higher selectivity to NTS2, may be potentially useful to treat visceral pain, and psychosis without concomitant side effects of hypothermia or hypotension...
  8. ncbi request reprint Current topics: brain penetrating neurotensin analog
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Life Sci 73:2785-92. 2003
    ....
  9. ncbi request reprint Selective tolerance to the hypothermic and anticataleptic effects of a neurotensin analog that crosses the blood-brain barrier
    Mona Boules
    Mayo Foundation for Medical Education and Research, and Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 987:39-48. 2003
    ..Furthermore, due to the lack of development of tolerance, NT69L or similar analogs might be useful in modulating certain behavioral effects of psychostimulants or have potential use as an antipsychotic drug in humans...
  10. ncbi request reprint A novel neurotensin analog blocks cocaine- and D-amphetamine-induced hyperactivity
    M Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, and Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Eur J Pharmacol 426:73-6. 2001
    ....
  11. ncbi request reprint Antiparkinson-like effects of a novel neurotensin analog in unilaterally 6-hydroxydopamine lesioned rats
    M Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, and Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Eur J Pharmacol 428:227-33. 2001
    ..After three daily injections of NT69L, its effects on this rotational behavior were unchanged, suggesting that no tolerance develops to this effect of NT69L...
  12. doi request reprint A neurotensin analog, NT69L, attenuates intravenous nicotine self-administration in rats
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuropeptides 45:9-16. 2011
    ..These data support further study of the effects of NT analogs on attenuating the reinforcing effects of psychostimulants...
  13. ncbi request reprint Neurotensin analog selective for hypothermia over antinociception and exhibiting atypical neuroleptic-like properties
    M Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, and Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 919:1-11. 2001
    ..Thus, NT77L selectively caused hypothermia, over antinociception, while exhibiting atypical neuroleptic-like effects...
  14. pmc Chronic NT69L potently prevents drug-induced disruption of prepulse inhibition without causing tolerance
    Siobhan Briody
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Behav Brain Res 207:118-24. 2010
    ..The modulatory role of NT69L on the dopaminergic and serotonergic neurotransmission systems both of which are implicated in the pathophysiology of schizophrenia is discussed...
  15. ncbi request reprint Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization
    Paul Fredrickson
    Nicotine Dependence Center, Mayo Foundation for Medical Education and Research, and Mayo Clinic Jacksonville, 32224, Jacksonville, FL, USA
    Brain Res 979:245-8. 2003
    ..The present work demonstrates that NT69L blocks both the initiation and the expression of sensitization. In addition chronic NT69L administration blocked the acute effects of nicotine on norepinephrine and serotonin in prefrontal cortex...
  16. ncbi request reprint Blockade of nicotine-induced locomotor sensitization by a novel neurotensin analog in rats
    Paul Fredrickson
    Nicotine Dependence Center, Mayo Foundation for Medical Education and Research, and Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Eur J Pharmacol 458:111-8. 2003
    ....
  17. ncbi request reprint Neurotensin agonists as an alternative to antipsychotics
    Mona Boules
    Neuropsychopharmacology Laboratory and Nicotine Dependence Center, Mayo Foundation for Medical Education and Research, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Expert Opin Investig Drugs 14:359-69. 2005
    ..In this review, we present the rationale for development of NT receptor agonists for treatment of certain central nervous system diseases, as well as a review of those peptide agonists that are in early stages of development...
  18. ncbi request reprint Neurotensin: peptide for the next millennium
    B M Tyler-McMahon
    Laboratory of Neuropharmacology, Mayo Foundation for Medical and Educational Research, 4500 San Pablo Rd, 32224, Jacksonville, FL, USA
    Regul Pept 93:125-36. 2000
    ..Special emphasis is placed on the behavioral studies, particularly with reference to agonists, antagonists, and antisense studies, as well as, the interaction of neurotensin with other neurotransmitters...
  19. pmc Hyperactivity of the dopaminergic system in NTS1 and NTS2 null mice
    Yanqi Liang
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Neuropharmacology 58:1199-205. 2010
    ..The data strengthen the hypothesis that NT receptors are involved in the pathogenesis of schizophrenia and provide a potential model for the biochemical changes of the disease...
  20. pmc Peptide nucleic acids targeted to the neurotensin receptor and administered i.p. cross the blood-brain barrier and specifically reduce gene expression
    B M Tyler
    Laboratory of Neuropsychopharmacology, Mayo Foundation for Medical and Educational Research, Jacksonville, FL 32224, USA
    Proc Natl Acad Sci U S A 96:7053-8. 1999
    ..p. delivery by crossing the normal blood-brain barrier. Equally important was that an antigene strategy, the sense PNA, was shown in vivo to be a potentially effective therapeutic treatment...
  21. ncbi request reprint Neurotensin analogs indications for use as potential antipsychotic compounds
    Beth M McMahon
    Laboratory of Neuropharmacology, Mayo Foundation for Medical and Educational Research, Jacksonville, FL 32224, USA
    Life Sci 70:1101-19. 2002
    ....
  22. doi request reprint NT69L blocks ethanol-induced increase of dopamine and glutamate levels in striatum of mouse
    Zhimin Li
    Neuroscience Laboratory and Mayo Foundation for Medical Education and Research, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurosci Lett 487:322-4. 2011
    ..These data suggest that NT69L prevents ethanol consumption through the modulation of both dopaminergic and glutamatergic systems implicated in ethanol addiction. NT agonists may provide novel treatment for alcohol addiction...
  23. pmc Similarities in the behavior and molecular deficits in the frontal cortex between the neurotensin receptor subtype 1 knockout mice and chronic phencyclidine-treated mice: relevance to schizophrenia
    Zhimin Li
    Department of Neuropsychopharmacology, Mayo Foundation for Medical Education and Research, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Dis 40:467-77. 2010
    ..In addition, after chronic PCP administration, the DA D(1) receptor was up-regulated in NTS1(-/-) mice, results which suggest a possible interaction of NTS1/DA D(1) in mPFC contributing to chronic PCP-induced schizophrenia-like signs...
  24. ncbi request reprint Neurotensin agonists: possible drugs for treatment of psychostimulant abuse
    Elliott Richelson
    Mayo Clinic Jacksonville, 4500 San Pablo Road, FL 32224, USA
    Life Sci 73:679-90. 2003
    ..This paper reviews the evidence for a role for neurotensin in stimulant abuse and for a neurotensin agonist for its treatment...
  25. pmc Effect of amphetamine on extracellular concentrations of amino acids in striatum in neurotensin subtype 1 and 2 receptor null mice: a possible interaction between neurotensin receptors and amino acid systems for study of schizophrenia
    Zhimin Li
    Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neuropharmacology 58:1174-8. 2010
    ..These results provide further support for the involvement of NT receptors in the pathogenesis of schizophrenia and provide a better understanding of the imbalance of amino acid systems through investigation of a DA-based animal model...
  26. pmc The novel neurotensin analog NT69L blocks phencyclidine (PCP)-induced increases in locomotor activity and PCP-induced increases in monoamine and amino acids levels in the medial prefrontal cortex
    Zhimin Li
    Neuropsychopharmacology Laboratory and Mayo Foundation for Medical Education and Research, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 1311:28-36. 2010
    ..Taken together, these data suggest that NT69L in particular and NT receptor agonists in general, will be useful as broad-spectrum antipsychotic drugs...
  27. doi request reprint Antidepressant-like pharmacological profile of a novel triple reuptake inhibitor, (1S,2S)-3-(methylamino)-2-(naphthalen-2-yl)-1-phenylpropan-1-ol (PRC200-SS)
    Yanqi Liang
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research and Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    J Pharmacol Exp Ther 327:573-83. 2008
    ..Therefore, it seems that PRC200-SS may represent a novel triple reuptake inhibitor and possess antidepressant activity...
  28. doi request reprint Effect of a novel neurotensin analog, NT69L, on nicotine-induced alterations in monoamine levels in rat brain
    Yanqi Liang
    Neuropsychopharmacology Laboratory and Nicotine Dependence Center, Mayo Foundation for Medical Education and Research, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 1231:6-15. 2008
    ..These data further support a role for NT69L or other neurotensin receptor agonists to treat nicotine addiction...
  29. doi request reprint Paliperidone as a mood stabilizer: a pre-frontal cortex synaptoneurosomal proteomics comparison with lithium and valproic acid after chronic treatment reveals similarities in protein expression
    Maria del Pilar Corena-McLeod
    Neuropsychopharmacology Laboratory, Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Brain Res 1233:8-19. 2008
    ....
  30. ncbi request reprint Neurobiologic basis of nicotine addiction and psychostimulant abuse: a role for neurotensin?
    Paul Fredrickson
    Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Psychiatr Clin North Am 28:737-51, 746. 2005
    ....
  31. ncbi request reprint Effects of repeated injections of the neurotensin analog NT69L on dopamine release and uptake in rat striatum in vitro
    Rui Wang
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, and Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Brain Res 1025:21-8. 2004
    ..These results provide further proof for the involvement of different NT receptor subtypes in mediating the effect of NT69L on dopamine release evoked by K(+) or electrical depolarization...
  32. pmc Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice
    H L Melrose
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurobiol Dis 40:503-17. 2010
    ..We hypothesize that Lrrk2 may impact on tau processing which subsequently leads to increased phosphorylation. Our models will be useful for further understanding of the mechanistic actions of LRRK2 and future therapeutic screening...
  33. ncbi request reprint Down-regulation of amyloid precursor protein by peptide nucleic acid in vivo
    Mona Boules
    Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, and Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    J Mol Neurosci 24:123-8. 2004
    ..The injection of antisense PNA showed about 70% decrease in APP as measured by Western blotting. Unmodified PNA can be used in vivo to reduce the levels of APP, which plays a critical role in the development of AD...
  34. ncbi request reprint Effects of 5 daily injections of the neurotensin-mimetic NT69L on the expression of neurotensin receptors in rat brain
    Rui Wang
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, PR China
    Brain Res Mol Brain Res 138:24-34. 2005
    ..The present results suggest that distinct NT receptors involved in the effects exerted by NT69L may contribute to the interactions of NT69L with both neural networks and cellular proteins...