Barry A Borlaug

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Treatment of heart failure with preserved ejection fraction
    Barry A Borlaug
    Barry A Borlaug, MD Division of Cardiovascular Diseases, Department of Medicine, The Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Curr Treat Options Cardiovasc Med 11:79-87. 2009
  2. pmc Ventricular-vascular interaction in heart failure
    Barry A Borlaug
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Heart Fail Clin 4:23-36. 2008
  3. pmc Diastolic relaxation and compliance reserve during dynamic exercise in heart failure with preserved ejection fraction
    Barry A Borlaug
    Cardiovascular Division, The Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Heart 97:964-9. 2011
  4. doi request reprint Invasive hemodynamic assessment in heart failure
    Barry A Borlaug
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Cardiol Clin 29:269-80. 2011
  5. pmc Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment
    Barry A Borlaug
    The Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, MN 55906, USA
    Eur Heart J 32:670-9. 2011
  6. pmc Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction
    Barry A Borlaug
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 56:845-54. 2010
  7. pmc Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction
    Barry A Borlaug
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Circ Heart Fail 3:588-95. 2010
  8. pmc Invasive hemodynamic assessment in heart failure
    Barry A Borlaug
    Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Heart Fail Clin 5:217-28. 2009
  9. ncbi request reprint Impact of arterial load and loading sequence on left ventricular tissue velocities in humans
    Barry A Borlaug
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 50:1570-7. 2007
  10. ncbi request reprint Ventricular-vascular interaction in heart failure
    Barry A Borlaug
    Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Cardiol Clin 29:447-59. 2011

Detail Information

Publications46

  1. ncbi request reprint Treatment of heart failure with preserved ejection fraction
    Barry A Borlaug
    Barry A Borlaug, MD Division of Cardiovascular Diseases, Department of Medicine, The Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Curr Treat Options Cardiovasc Med 11:79-87. 2009
    ..Data from published clinical trials are reviewed, and the roles for each class of drug commonly used in practice are examined. Finally, novel therapies and future directions for basic investigation and clinical trials are discussed...
  2. pmc Ventricular-vascular interaction in heart failure
    Barry A Borlaug
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Heart Fail Clin 4:23-36. 2008
    ..We conclude by exploring how novel treatment strategies targeting abnormal ventricular-arterial interaction might prove useful in the treatment of patients who have HFpEF...
  3. pmc Diastolic relaxation and compliance reserve during dynamic exercise in heart failure with preserved ejection fraction
    Barry A Borlaug
    Cardiovascular Division, The Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Heart 97:964-9. 2011
    ....
  4. doi request reprint Invasive hemodynamic assessment in heart failure
    Barry A Borlaug
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Cardiol Clin 29:269-80. 2011
    ....
  5. pmc Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment
    Barry A Borlaug
    The Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, MN 55906, USA
    Eur Heart J 32:670-9. 2011
    ..In this review, the principal mechanisms, diagnostic approaches, and clinical trials are reviewed, along with a discussion of novel treatment strategies that are currently under investigation or hold promise for the future...
  6. pmc Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction
    Barry A Borlaug
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 56:845-54. 2010
    ..The purpose of this study was to comprehensively examine cardiovascular reserve function with exercise in patients with heart failure and preserved ejection fraction (HFpEF)...
  7. pmc Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction
    Barry A Borlaug
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Circ Heart Fail 3:588-95. 2010
    ..However, diagnosis of earlier disease may be challenging because exertional dyspnea is not specific for heart failure, and biomarkers and hemodynamic indicators of volume overload may be absent at rest...
  8. pmc Invasive hemodynamic assessment in heart failure
    Barry A Borlaug
    Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Heart Fail Clin 5:217-28. 2009
    ....
  9. ncbi request reprint Impact of arterial load and loading sequence on left ventricular tissue velocities in humans
    Barry A Borlaug
    Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 50:1570-7. 2007
    ..The aim of this study was to examine the relationship between individual components of left ventricular (LV) afterload and tissue Doppler echocardiography (TDE) velocities in humans...
  10. ncbi request reprint Ventricular-vascular interaction in heart failure
    Barry A Borlaug
    Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Cardiol Clin 29:447-59. 2011
    ..We conclude by exploring how novel treatment strategies targeting abnormal ventricular-arterial interaction might prove useful in the treatment of patients who have HFpEF...
  11. pmc Impact of atrial fibrillation on exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study
    Rosita Zakeri
    Division of Cardiology, Mayo Clinic, Rochester, MN
    Circ Heart Fail 7:123-30. 2014
    ..We sought to compare clinical features and exercise capacity among patients with HFpEF who were in sinus rhythm (SR) or AF...
  12. pmc Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota
    Carolyn S P Lam
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, 200 First St SW, Rochester, MN 55905, USA
    Circulation 115:1982-90. 2007
    ....
  13. doi request reprint Systemic hypertension in low-gradient severe aortic stenosis with preserved ejection fraction
    Mackram F Eleid
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN
    Circulation 128:1349-53. 2013
    ..However, systemic hypertension frequently coexists with low-gradient severe aortic stenosis, which itself may cause elevated left ventricular (LV) filling pressures with resultant symptoms of dyspnea...
  14. pmc Longitudinal changes in left ventricular stiffness: a community-based study
    Barry A Borlaug
    Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN
    Circ Heart Fail 6:944-52. 2013
    ..In addition, it remains unknown whether age-related LV stiffening is merely a reaction to arterial stiffening or caused by other processes...
  15. pmc Sex differences in arterial stiffness and ventricular-arterial interactions
    Thais Coutinho
    Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 61:96-103. 2013
    ..This study sought to assess sex differences in ventricular-arterial interactions...
  16. ncbi request reprint Effects of vasodilation in heart failure with preserved or reduced ejection fraction implications of distinct pathophysiologies on response to therapy
    Shmuel Schwartzenberg
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
    J Am Coll Cardiol 59:442-51. 2012
    ..The purpose of this study was to compare hemodynamic responses to vasodilator therapy in patients with heart failure (HF) and preserved ejection fraction (HFpEF) versus HF and reduced ejection fraction (HFrEF)...
  17. pmc Relationship between diastolic function and heart rate recovery after symptom-limited exercise
    S Michael Gharacholou
    Echocardiography and Hemodynamic Laboratory, Division of Cardiovascular Diseases and Internal Medicine, Rochester, Minnesota, USA
    J Card Fail 18:34-40. 2012
    ....
  18. pmc Size, shape, and stamina: the impact of left ventricular geometry on exercise capacity
    Carolyn S P Lam
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    Hypertension 55:1143-9. 2010
    ..Reverse remodeling strategies may prevent or treat functional decline in patients with structural heart disease...
  19. pmc Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction
    Muaz M Abudiab
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    Eur J Heart Fail 15:776-85. 2013
    ..The current study sought to determine whether increases in cardiac output (CO) during exercise are appropriately matched to metabolic demands in HFpEF...
  20. pmc Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial
    Margaret M Redfield
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    JAMA 309:1268-77. 2013
    ..Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved ejection fraction (HFPEF)...
  21. pmc Comorbidity and ventricular and vascular structure and function in heart failure with preserved ejection fraction: a community-based study
    Selma F Mohammed
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Circ Heart Fail 5:710-9. 2012
    ..We hypothesized that fundamental cardiovascular structural and functional alterations are characteristic of HFpEF, even after accounting for body size and comorbidities...
  22. pmc Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction
    Barry A Borlaug
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Minnesota
    J Am Coll Cardiol 54:410-8. 2009
    ....
  23. ncbi request reprint Resting Ventricular-Vascular Function and Exercise Capacity in Heart Failure With Preserved Ejection Fraction: A RELAX Trial Ancillary Study
    Selma F Mohammed
    From the Division of Cardiovascular Diseases S F M, B A B, G L, R Z, M M R and Mayo Graduate School S F M, R Z, Mayo Clinic, Rochester, MN Duke Clinical Research Institute, Durham, NC S M, A F H Massachusetts General Hospital, Boston, MA G D L, M J S University of Vermont, Burlington, VT M L and Harvard Medical School, Boston, MA E B
    Circ Heart Fail 7:580-9. 2014
    ..We hypothesized that in heart failure with preserved ejection fraction, the severity of resting ventricular and vascular dysfunction are associated with impairment in exercise tolerance as assessed by peak oxygen consumption...
  24. pmc Age-associated increases in pulmonary artery systolic pressure in the general population
    Carolyn S P Lam
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Circulation 119:2663-70. 2009
    ..We sought to define the relationship between PASP and age, to evaluate which factors influence PASP, and to determine whether PASP is independently predictive of mortality in the community...
  25. ncbi request reprint Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction
    Vojtech Melenovsky
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Coll Cardiol 49:198-207. 2007
    ....
  26. ncbi request reprint Age- and gender-related ventricular-vascular stiffening: a community-based study
    Margaret M Redfield
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, USA
    Circulation 112:2254-62. 2005
    ..The prevalence of HFnlEF increases strikingly with age, particularly in women. We hypothesized that ventricular-vascular stiffening may occur with age and be more pronounced in women in the general community...
  27. pmc Biomarkers in acutely decompensated heart failure with preserved or reduced ejection fraction
    Kalkidan Bishu
    Mayo Clinic, Rochester, MN 55905, USA
    Am Heart J 164:763-770.e3. 2012
    ....
  28. doi request reprint Why are women more likely than men to develop heart failure with preserved ejection fraction?
    Dawn C Scantlebury
    The Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, MN 55905, USA
    Curr Opin Cardiol 26:562-8. 2011
    ..e. heart failure with preserved left ventricular ejection fraction (HFpEF)], but the reasons for this disparity are unknown...
  29. doi request reprint Bedside assessment of cardiac hemodynamics: the impact of noninvasive testing and examiner experience
    Aaron M From
    Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Am J Med 124:1051-7. 2011
    ..Echocardiography and B-natriuretic peptide (BNP) testing are commonly used to estimate these pressures, but their incremental value beyond physical examination remains unknown...
  30. ncbi request reprint Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction
    Barry A Borlaug
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Circulation 114:2138-47. 2006
    ..Symptoms of exercise intolerance and dyspnea are most often attributed to diastolic dysfunction; however, impaired systolic and/or arterial vasodilator reserve under stress could also play an important role...
  31. pmc Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial
    Horng H Chen
    Mayo Clinic, Rochester, Minnesota
    JAMA 310:2533-43. 2013
    ..Small studies suggest that low-dose dopamine or low-dose nesiritide may enhance decongestion and preserve renal function in patients with acute heart failure and renal dysfunction; however, neither strategy has been rigorously tested...
  32. doi request reprint Relationships between right ventricular function, body composition, and prognosis in advanced heart failure
    Vojtech Melenovsky
    Department of Cardiology, Institute of Clinical and Experimental Medicine IKEM, Prague, Czech Republic Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota Electronic address
    J Am Coll Cardiol 62:1660-70. 2013
    ..This study sought to examine the relationships between right ventricular (RV) function, body composition, and prognosis in patients with advanced heart failure (HF)...
  33. ncbi request reprint Invasive measures of afterload in low gradient severe aortic stenosis with preserved ejection fraction
    Mackram F Eleid
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Circ Heart Fail 6:703-10. 2013
    ..The pathophysiology of low flow, low gradient severe aortic stenosis (LGSAS) with preserved ejection fraction is poorly understood. It has been proposed that abnormalities of arterial circulation are a major contributor to this syndrome...
  34. pmc Pulmonary hypertension in heart failure with preserved ejection fraction: a community-based study
    Carolyn S P Lam
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA
    J Am Coll Cardiol 53:1119-26. 2009
    ..This study sought to define the prevalence, severity, and significance of pulmonary hypertension (PH) in heart failure with preserved ejection fraction (HFpEF) in the general community...
  35. ncbi request reprint Electrophysiological and hemodynamic characteristics associated with obesity in patients with atrial fibrillation
    Thomas M Munger
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
    J Am Coll Cardiol 60:851-60. 2012
    ..The authors sought to characterize the left atrial (LA) and pulmonary vein (PV) electrophysiological and hemodynamic features in obese patients with atrial fibrillation (AF)...
  36. ncbi request reprint Mechanisms of diastolic dysfunction in heart failure
    Barry A Borlaug
    Division of Cardiology, Department of Medicine, The Mayo Clinic College of Medicine, Rochester, MN 55905 USA
    Trends Cardiovasc Med 16:273-9. 2006
    ..This review focuses on the mechanisms determining normal and pathologic cardiac relaxation and distensibility and highlights how these abnormalities may be therapeutically targeted to improve diastolic function in human HF...
  37. ncbi request reprint Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans
    Barry A Borlaug
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Circulation 112:2642-9. 2005
    ..We therefore tested whether sildenafil blunts dobutamine-stimulated cardiac function in humans...
  38. ncbi request reprint Severe heart failure in the setting of relatively mild mitral stenosis: the role of invasive hemodynamic assessment
    Paul Sorajja
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Catheter Cardiovasc Interv 72:739-48. 2008
    ..This manuscript discusses two cases that illustrate the need for this comprehensive approach, the indications for balloon mitral valvuloplasty, and the recognition of diastolic dysfunction in these patients...
  39. doi request reprint Caveat medicus! Pulmonary hypertension in the elderly: a word of caution
    Barry A Boilson
    The Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Eur J Heart Fail 12:89-93. 2010
    ..This case emphasizes the importance of maintaining a high index of suspicion for HFpEF in elderly patients presenting with PH and illustrates potential hazards associated with selective pulmonary vasodilation in this growing population...
  40. doi request reprint Heart failure with preserved ejection fraction: pathophysiology and emerging therapies
    Aaron M From
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, MN, USA
    Cardiovasc Ther 29:e6-21. 2011
    ....
  41. doi request reprint A randomized pilot study of aortic waveform guided therapy in chronic heart failure
    Barry A Borlaug
    Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN
    J Am Heart Assoc 3:e000745. 2014
    ..We sought to determine whether aggressive titration of vasoactive medicines beyond goal-directed heart failure medical therapy (GDMT) based upon aortic pressure improves exercise capacity and cardiovascular structure-function...
  42. ncbi request reprint Implications of coronary artery disease in heart failure with preserved ejection fraction
    Seok Jae Hwang
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic Rochester, Rochester, Minnesota Division of Cardiology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea
    J Am Coll Cardiol 63:2817-27. 2014
    ..This study investigated the characteristics, evaluation, prognostic impact, and treatment of coronary artery disease (CAD) in patients with heart failure and preserved ejection fraction (HFpEF)...
  43. ncbi request reprint Functional impact of rate irregularity in patients with heart failure and atrial fibrillation receiving cardiac resynchronization therapy
    Vojtech Melenovsky
    Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Eur Heart J 26:705-11. 2005
    ..However, it remains uncertain whether rhythm irregularity per se has unfavourable effects apart from tachycardia, and whether rate regularization alone can improve heart function...
  44. doi request reprint "Carcinoid-like" tricuspid valvulopathy associated with nephrogenic systemic fibrosis
    S Michael Gharacholou
    Division of Cardiology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Echocardiography 28:E46-9. 2011
    ..This report is the first to describe the association between nephrogenic systemic fibrosis and severe valvular heart disease requiring valve replacement...
  45. ncbi request reprint Estimation of central pressure augmentation using automated radial artery tonometry
    Vojtech Melenovsky
    Department of Cardiology, IKEM, Prague, Czech Republic
    J Hypertens 25:1403-9. 2007
    ..However, carotid tonometry is technically challenging and difficult to standardize in practice. We tested whether automated radial pressure analysis provides a viable alternative...
  46. ncbi request reprint Tricuspid annular displacement predicts survival in pulmonary hypertension
    Paul R Forfia
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Hospital, Asthma and Allergy Center, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 174:1034-41. 2006
    ..Right ventricular (RV) function is an important determinant of prognosis in pulmonary hypertension. However, noninvasive assessment of the RV function is often limited by complex geometry and poor endocardial definition...