Daniel D Billadeau
Affiliation: Mayo Clinic
Phillips Krawczak C, Singla A, Starokadomskyy P, Deng Z, Osborne D, Li H, et al
. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Mol Biol Cell. 2015;26:91-103 pubmed publisher
..This work provides a mechanistic explanation for the role of COMMD1 in copper homeostasis and uncovers additional genes involved in the regulation of copper transporter recycling. ..
Ding L, Han L, Dube J, Billadeau D. WASH Regulates Glucose Homeostasis by Facilitating Glut2 Receptor Recycling in Pancreatic Beta Cells. Diabetes. 2018;: pubmed publisher
..Thus patients harboring mutations in components of the WASH complex could be at risk for developing type II diabetes. ..
Wilton K, Billadeau D. VASP Regulates NK Cell Lytic Granule Convergence. J Immunol. 2018;201:2899-2909 pubmed publisher
..Our results demonstrate a novel requirement for VASP and actin polymerization in maintaining lytic granule convergence during NK cell-mediated killing. ..
Ham H, Huynh W, Schoon R, Vale R, Billadeau D. HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing. J Immunol. 2015;194:3984-96 pubmed publisher
..Our results demonstrate an important role for HkRP3 in regulating the clustering of lytic granules and MTOC repositioning during the development of NK cell-mediated killing. ..
Osborne D, Piotrowski J, Dick C, Zhang J, Billadeau D. SNX17 affects T cell activation by regulating TCR and integrin recycling. J Immunol. 2015;194:4555-66 pubmed publisher
..These data suggest that SNX17 plays a role in the maintenance of normal surface levels of activating receptors and integrins to permit optimum T cell activation at the immune synapse. ..
Alekhina O, Burstein E, Billadeau D. Cellular functions of WASP family proteins at a glance. J Cell Sci. 2017;130:2235-2241 pubmed publisher