DANIEL BILLADEAU

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Cell growth and metastasis in pancreatic cancer: is Vav the Rho'd to activation?
    Daniel D Billadeau
    Division of Developmental Oncology Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Int J Gastrointest Cancer 31:5-13. 2002
  2. pmc Differential regulation of TCR-mediated gene transcription by Vav family members
    Shaheen Zakaria
    Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Exp Med 199:429-34. 2004
  3. doi request reprint Characterization of the CXCR4 signaling in pancreatic cancer cells
    Daniel D Billadeau
    Oncology Research Department, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Int J Gastrointest Cancer 37:110-9. 2006
  4. pmc The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1
    Jeffrey C Nolz
    Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Cell Biol 182:1231-44. 2008
  5. pmc Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse
    Joanna Kim
    Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 9:e85090. 2014
  6. pmc Primers on molecular pathways. The glycogen synthase kinase-3beta
    Daniel D Billadeau
    Department of Immunology and Oncology Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 7:398-402. 2007
  7. ncbi request reprint T cell activation at the immunological synapse: vesicles emerge for LATer signaling
    Daniel D Billadeau
    Department of Immunology, Division of Oncology Research, and Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Sci Signal 3:pe16. 2010
  8. pmc CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies
    Barbara Schroeder
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Mol Biol Cell 23:3602-11. 2012
  9. pmc Focal adhesion assembly in myofibroblasts fosters a microenvironment that promotes tumor growth
    Ningling Kang
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Pathol 177:1888-900. 2010
  10. pmc A FAM21-containing WASH complex regulates retromer-dependent sorting
    Timothy S Gomez
    Department of Immunology, Division of Oncology Research and Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Dev Cell 17:699-711. 2009

Research Grants

  1. Regulation of Actin Dynamics During T Cell Activation
    DANIEL BILLADEAU; Fiscal Year: 2009
  2. Regulation of Actin Dynamics During T Cell Activation
    Daniel D Billadeau; Fiscal Year: 2010
  3. Regulation of Actin Dynamics During T Cell Activation
    DANIEL BILLADEAU; Fiscal Year: 2005
  4. MECHANISMS OF NATURAL KILLER CELL ACTIVATION
    Daniel D Billadeau; Fiscal Year: 2010
  5. MECHANISMS OF NATURAL KILLER CELL ACTIVATION
    DANIEL BILLADEAU; Fiscal Year: 2009
  6. Regulation of Actin Dynamics During T Cell Activation
    DANIEL BILLADEAU; Fiscal Year: 2007
  7. MECHANISMS OF NATURAL KILLER CELL ACTIVATION
    DANIEL BILLADEAU; Fiscal Year: 2007
  8. Regulation of Actin Dynamics During T Cell Activation
    DANIEL BILLADEAU; Fiscal Year: 2006

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Cell growth and metastasis in pancreatic cancer: is Vav the Rho'd to activation?
    Daniel D Billadeau
    Division of Developmental Oncology Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Int J Gastrointest Cancer 31:5-13. 2002
    ..In this review, we will discuss our current understanding of how Vav proteins are regulated, and how Vav and their target GTP-binding proteins participate in tumorigenesis...
  2. pmc Differential regulation of TCR-mediated gene transcription by Vav family members
    Shaheen Zakaria
    Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Exp Med 199:429-34. 2004
    ..These data indicate that, although both Vav proteins are biochemically coupled to the TCR, they regulate distinct molecular pathways leading to defined gene transcriptional events...
  3. doi request reprint Characterization of the CXCR4 signaling in pancreatic cancer cells
    Daniel D Billadeau
    Oncology Research Department, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Int J Gastrointest Cancer 37:110-9. 2006
    ....
  4. pmc The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1
    Jeffrey C Nolz
    Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Cell Biol 182:1231-44. 2008
    ..These findings identify a previously unknown mechanism by which the WAVE2 complex regulates TCR signaling to Rap1 and integrin activation...
  5. pmc Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse
    Joanna Kim
    Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 9:e85090. 2014
    ..Taken together, our results suggest that COTL1 regulates lamellipodia dynamics in part by protecting F-actin from cofilin-mediated disassembly. ..
  6. pmc Primers on molecular pathways. The glycogen synthase kinase-3beta
    Daniel D Billadeau
    Department of Immunology and Oncology Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Pancreatology 7:398-402. 2007
    ..Thus, GSK-3beta has emerged as a viable therapeutic target in the treatment of several human neoplasms...
  7. ncbi request reprint T cell activation at the immunological synapse: vesicles emerge for LATer signaling
    Daniel D Billadeau
    Department of Immunology, Division of Oncology Research, and Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Sci Signal 3:pe16. 2010
    ..Together, these data provide new insight into signaling at the IS and suggest that the endosomal network likely participates in T cell signaling...
  8. pmc CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies
    Barbara Schroeder
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Mol Biol Cell 23:3602-11. 2012
    ..These findings provide novel insights into how src- kinase-based regulation of a cbl adaptor regulates the fate of the EGFR...
  9. pmc Focal adhesion assembly in myofibroblasts fosters a microenvironment that promotes tumor growth
    Ningling Kang
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Pathol 177:1888-900. 2010
    ..Taken together, our results identify Ena/VASP as a significant modifier of tumor growth through regulation of FA dynamics and ensuing pericyte/myofibroblast function within the tumor microenvironment...
  10. pmc A FAM21-containing WASH complex regulates retromer-dependent sorting
    Timothy S Gomez
    Department of Immunology, Division of Oncology Research and Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Dev Cell 17:699-711. 2009
    ....
  11. pmc Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation
    Andrei V Ougolkov
    Division of Oncology Research, Gastrointestinal Unit, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Cancer Res 12:5074-81. 2006
    ....
  12. pmc HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse
    Timothy S Gomez
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Immunity 24:741-52. 2006
    ..Taken together, our studies show that HS1 is indispensable for signaling events leading to actin assembly and IL-2 production during T cell activation...
  13. ncbi request reprint Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells
    Andrei V Ougolkov
    Division of Oncology Research and GI Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Cancer Res 65:2076-81. 2005
    ..Taken together, our results simultaneously identify a previously unrecognized role for GSK-3beta in cancer cell survival and proliferation and suggest GSK-3beta as a potential therapeutic target in the treatment of pancreatic cancer...
  14. ncbi request reprint Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse
    Timothy S Gomez
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Nat Immunol 6:261-70. 2005
    ..These data identify a functionally important interaction between Dyn2 and Vav1 that regulates actin reorganization and multiple signaling pathways in T lymphocytes...
  15. pmc Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse
    Timothy S Gomez
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Immunity 26:177-90. 2007
    ..Altogether, our results have identified Arp2/3 complex-independent cytoskeletal reorganization events in T lymphocytes and indicate that formins are essential cytoskeletal regulators of centrosome polarity in T cells...
  16. pmc A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding
    Barbara Schroeder
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA
    EMBO J 29:3039-53. 2010
    ..These findings provide novel insights into a previously unknown protein complex that can regulate EGFR traffic at very late stages of the endocytic pathway...
  17. ncbi request reprint Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis
    Martin E Fernandez-Zapico
    Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Cancer Cell 7:39-49. 2005
    ..Thus, the discovery of prooncogenic pathways regulated by Vav1 makes it an attractive target for therapeutic intervention...
  18. doi request reprint T cell activation and the cytoskeleton: you can't have one without the other
    Timothy S Gomez
    Department of Immunology and Oncology Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Adv Immunol 97:1-64. 2008
    ....
  19. ncbi request reprint TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation
    Jeffrey C Nolz
    Department of Immunology, Mayo Clinic College of Medicine, MN 55905, USA
    J Immunol 179:1104-12. 2007
    ..Overall, these findings establish that disrupting actin cytoskeletal dynamics impairs TCR/CD28-mediated calcium flux required for NFAT1-mediated c-rel transcription and, thus, activation of the CD28RE/AP...
  20. pmc Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element
    Michael J Hamann
    Division of Oncology Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Mol Cell Biol 27:1380-93. 2007
    ....
  21. ncbi request reprint The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors
    Jadee L Upshaw
    Department of Immunology, and Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Immunol 175:213-8. 2005
    ..More broadly, these observations reveal a basis for selectively targeting the functions initiated by distinct immune recognition receptors...
  22. pmc Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes
    Sergey A Trushin
    Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mol Cell Biol 23:7068-81. 2003
    ..Taken together, our results suggest that PKCalpha acts upstream of PKCtheta to activate the IKK complex and NF-kappaB in T lymphocytes following TCR activation...
  23. ncbi request reprint NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells
    Jadee L Upshaw
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Nat Immunol 7:524-32. 2006
    ..These findings identify a previously unknown mechanism by which NKG2D-DAP10 mediates cytotoxicity and provides a framework for evaluating activation by other receptor complexes that lack immunoreceptor tyrosine-based activation motifs...
  24. pmc Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells
    Alexey A Leontovich
    Department of Biochemistry and Molecular Biology, Mayo Clinic, College of Medicine, Rochester, MN, USA
    Oncol Rep 29:1785-8. 2013
    ....
  25. pmc Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy
    Xue Wei Meng
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 285:888-902. 2010
    ....
  26. pmc Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells
    Andrei V Ougolkov
    Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, MN, USA
    Blood 110:735-42. 2007
    ....
  27. pmc Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2
    Andrei V Ougolkov
    Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Cancer Res 14:6790-6. 2008
    ..Our objectives were to determine the expression pattern of EZH2 and to assess the anticancer effect of EZH2 depletion in pancreatic cancer cells...
  28. ncbi request reprint Regulation of T-cell activation by the cytoskeleton
    Daniel D Billadeau
    Department of Immunology, Mayo Clinic College of Medicine, 200 First Street South West, Rochester, Minnesota 55905, USA
    Nat Rev Immunol 7:131-43. 2007
    ..Here, we discuss recent advances that have furthered our understanding of the crucial importance of the T-cell cytoskeleton in controlling these aspects of T-cell immune recognition...
  29. pmc The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation
    Jeffrey C Nolz
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Curr Biol 16:24-34. 2006
    ..However, whether these proteins participate in actin reorganization at the IS or signaling pathways in T cells has not been investigated...
  30. ncbi request reprint Targeting GSK-3: a promising approach for cancer therapy?
    Andrei V Ougolkov
    Division of Oncology Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Future Oncol 2:91-100. 2006
    ..Herein, the authors will discuss the current understanding of the role of GSK-3 in human cancer and its potential as a therapeutic target...
  31. ncbi request reprint NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway
    Daniel D Billadeau
    Division of Oncology Research, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, Minnesota 55905, USA
    Nat Immunol 4:557-64. 2003
    ..Yet the signals initiated by NKG2D-DAP10 are fully capable of inducing killing. Our findings identify a previously unknown mechanism by which receptor complexes that lack ITAM motifs can trigger lymphocyte activation...
  32. pmc Regulation of cytoskeletal dynamics at the immune synapse: new stars join the actin troupe
    Daniel D Billadeau
    Department of Immunology and Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Traffic 7:1451-60. 2006
    ..In this review, we turn the spotlight on the expanding cast of actin regulatory proteins, which co-ordinate actin dynamics at the IS...
  33. pmc Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum
    Xian Ming Chen
    The Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic and Foundation, Rochester, Minnesota 55905, USA
    Infect Immun 72:3011-21. 2004
    ..parvum invasion. These data suggest that C. parvum invasion of target epithelia results from the organism's ability to activate a host cell Cdc42 GTPase signaling pathway to induce host cell actin remodeling at the attachment site...
  34. pmc PI3K links NKG2D signaling to a CrkL pathway involved in natural killer cell adhesion, polarity, and granule secretion
    Colin M Segovis
    Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 182:6933-42. 2009
    ..Taken together, our data identify an NKG2D-activated signaling pathway that collectively orchestrates NK cell adhesion, cell polarization, and granule release...
  35. doi request reprint Inhibition of glycogen synthase kinase-3
    Andrei V Ougolkov
    Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, MN, USA
    Methods Mol Biol 468:67-75. 2008
    ..Here, we discuss two methods of GSK-3 inhibition, which can be used to determine the involvement of GSK-3 in a cellular process of interest...
  36. ncbi request reprint Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42
    Xian Ming Chen
    The Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Medical School, Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Biol Chem 279:31671-8. 2004
    ..parvum invasion of target epithelia results from the ability of the organism to trigger host cell PI3K/frabin signaling to activate the Cdc42 pathway, resulting in host cell actin remodeling at the host cell-parasite interface...
  37. ncbi request reprint The Ezh2 methyltransferase complex: actin up in the cytosol
    Jeffrey C Nolz
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Trends Cell Biol 15:514-7. 2005
    ..Overall, these findings implicate lysine methylation as a posttranslational modification crucial for receptor-mediated signal transduction events...
  38. ncbi request reprint The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis
    Ja Eun Kim
    Department of Oncology Research, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    J Biol Chem 280:5733-9. 2005
    ..Whereas these domains negatively regulate Ect2 GEF activity in interphase cells, they are also required for the proper function of Ect2 during cytokinesis...
  39. pmc Dynamin 2 regulates granule exocytosis during NK cell-mediated cytotoxicity
    Laura N Arneson
    Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 181:6995-7001. 2008
    ..These findings identify a novel role for Dyn2 in the exocytic events required for effective NK cell-mediated cytotoxicity...
  40. pmc WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse
    Jeffrey C Nolz
    Department of Immunology and Division of Oncology Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Mol Cell Biol 27:5986-6000. 2007
    ....
  41. pmc ITAMs versus ITIMs: striking a balance during cell regulation
    Daniel D Billadeau
    Division of Developmental Oncology Research, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 109:161-8. 2002
  42. pmc Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line
    Youjia Cao
    Department of Pharmacology and Cancer Biology and Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    EMBO J 21:4809-19. 2002
    ..Vav1 cells. Finally, evidence is presented to suggest that the alternative Vav family members, Vav-2 and Vav-3, are activated during TCR ligation, and partially compensate for the loss of Vav-1 in Jurkat T cells...
  43. ncbi request reprint Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation
    Abbas Shakoori
    Division of Diagnostic Molecular Oncology, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
    Biochem Biophys Res Commun 334:1365-73. 2005
    ....
  44. ncbi request reprint Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76
    Celine Charvet
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 280:15289-99. 2005
    ..Altogether, our data show that TCR-induced association of Vav3 with SLP-76 is required for its membrane/IS localization and function...
  45. ncbi request reprint SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site
    Rong Zeng
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 171:1360-8. 2003
    ..Taken together, these findings reconstruct the signaling pathway leading from TCR ligation to localized WASP activation...
  46. pmc Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation
    Ana V Miletic
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 281:38257-65. 2006
    ....
  47. pmc The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity
    Wenyu Ming
    Cancer Research Institute, 1044 W Walnut Street, R4 402C, Indianapolis, IN 46202, USA
    Mol Cell Biol 27:312-23. 2007
    ....
  48. doi request reprint Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis
    John R Goodell
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Med Chem 51:179-82. 2008
    ..We conclude that the drug-DNA complex formed blocks topoisomerase II binding and activity leading to catalytic inhibition of the enzyme and the induction of apoptosis and programmed cell death...
  49. doi request reprint A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum
    Yufeng Chen
    Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA
    J Med Chem 51:3437-48. 2008
    ..Lastly, these new HDACIs were studied for both their anticancer and antimalarial activity, which serve to validate the superior activity of the HDACI 10c...
  50. ncbi request reprint Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen
    Andrew C Pearce
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK
    J Biol Chem 279:53955-62. 2004
    ..This is the first time that absolute redundancy between two protein isoforms has been observed with respect to the regulation of PLC gamma 2 in platelets...
  51. pmc Chemistry, biology, and QSAR studies of substituted biaryl hydroxamates and mercaptoacetamides as HDAC inhibitors-nanomolar-potency inhibitors of pancreatic cancer cell growth
    Alan P Kozikowski
    Drug Discovery Program, College of Pharmacy, University of Illinois at Chicago, 833 S Wood St, Chicago, Illinois 60612, USA
    ChemMedChem 3:487-501. 2008
    ..Of particular interest is the selectivity of the mercaptoacetamides for HDAC6...

Research Grants10

  1. Regulation of Actin Dynamics During T Cell Activation
    DANIEL BILLADEAU; Fiscal Year: 2009
    ..abstract_text> ..
  2. Regulation of Actin Dynamics During T Cell Activation
    Daniel D Billadeau; Fiscal Year: 2010
    ..The experiments in this proposal are aimed at understanding the role of the novel actin regulatory protein WASH in T cell activation and thymocyte selection. ..
  3. Regulation of Actin Dynamics During T Cell Activation
    DANIEL BILLADEAU; Fiscal Year: 2005
    ..abstract_text> ..
  4. MECHANISMS OF NATURAL KILLER CELL ACTIVATION
    Daniel D Billadeau; Fiscal Year: 2010
    ..More broadly, these studies will provide a basis for therapeutically targeting specific cellular processes in order to enhance antitumor and antiviral immunity. ..
  5. MECHANISMS OF NATURAL KILLER CELL ACTIVATION
    DANIEL BILLADEAU; Fiscal Year: 2009
    ..More broadly, these studies will provide a basis for therapeutically targeting specific cellular processes in order to enhance antitumor and antiviral immunity. ..
  6. Regulation of Actin Dynamics During T Cell Activation
    DANIEL BILLADEAU; Fiscal Year: 2007
    ..abstract_text> ..
  7. MECHANISMS OF NATURAL KILLER CELL ACTIVATION
    DANIEL BILLADEAU; Fiscal Year: 2007
    ..abstract_text> ..
  8. Regulation of Actin Dynamics During T Cell Activation
    DANIEL BILLADEAU; Fiscal Year: 2006
    ..abstract_text> ..