Adil Bharucha

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. doi request reprint Effects of clonidine in women with fecal incontinence
    Adil E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota Electronic address
    Clin Gastroenterol Hepatol 12:843-851.e2. 2014
  2. pmc High amplitude propagated contractions
    A E Bharucha
    Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 24:977-82. 2012
  3. doi request reprint A randomised controlled study of the effect of cholinesterase inhibition on colon function in patients with diabetes mellitus and constipation
    Adil E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research CENTER Program, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Gut 62:708-15. 2013
  4. doi request reprint Differential effects of selective and non-selective muscarinic antagonists on gastrointestinal transit and bowel function in healthy women
    A E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program C E N T E R, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 25:e35-43. 2013
  5. pmc Obstetric trauma, pelvic floor injury and fecal incontinence: a population-based case-control study
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 107:902-11. 2012
  6. pmc Effects of vaginal hysterectomy on anorectal sensorimotor functions--a prospective study
    A E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Department of Medicine, Rochester, MN, USA
    Neurogastroenterol Motil 24:235-41. 2012
  7. pmc Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects
    A E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program C E N T E R, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 20:891-9. 2008
  8. pmc Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans
    Adil E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 295:R874-80. 2008
  9. pmc First-in-human study demonstrating pharmacological activation of heme oxygenase-1 in humans
    A E Bharucha
    Enteric Neurosciences Program, Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Clin Pharmacol Ther 87:187-90. 2010
  10. doi request reprint Lower gastrointestinal functions
    A E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program C E N T E R, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 20:103-13. 2008

Research Grants

  1. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2005
  2. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
  3. Pathophysiology of Anorectal Disorders
    Adil Bharucha; Fiscal Year: 2009
  4. Pathophysiology of Anorectal Disorders
    Adil E Bharucha; Fiscal Year: 2010

Collaborators

Detail Information

Publications68

  1. doi request reprint Effects of clonidine in women with fecal incontinence
    Adil E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota Electronic address
    Clin Gastroenterol Hepatol 12:843-851.e2. 2014
    ..We evaluated the effects of the α2-adrenergic agonist clonidine on symptoms and anorectal functions in women with FI in a prospective, placebo-controlled trial...
  2. pmc High amplitude propagated contractions
    A E Bharucha
    Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 24:977-82. 2012
    ..This editorial comprehensively reviews the characteristics, physiology and pharmacology of HAPC, their assessment by manometry, and relevance to constipation and diarrhea...
  3. doi request reprint A randomised controlled study of the effect of cholinesterase inhibition on colon function in patients with diabetes mellitus and constipation
    Adil E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research CENTER Program, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Gut 62:708-15. 2013
    ..Cholinesterase inhibitors increase colonic motility. This study evaluated the effects of a cholinesterase inhibitor on gastrointestinal and colonic transit and bowel function in diabetic patients with constipation...
  4. doi request reprint Differential effects of selective and non-selective muscarinic antagonists on gastrointestinal transit and bowel function in healthy women
    A E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program C E N T E R, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 25:e35-43. 2013
    ..We compared the effects of non-selective (fesoterodine) and M(3)-selective (solifenacin) antimuscarinics on gastrointestinal transit in healthy women...
  5. pmc Obstetric trauma, pelvic floor injury and fecal incontinence: a population-based case-control study
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 107:902-11. 2012
    ..Hence, the objectives of this study were to evaluate the relationship between prior obstetric events, pelvic floor injury, and FI among community women...
  6. pmc Effects of vaginal hysterectomy on anorectal sensorimotor functions--a prospective study
    A E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Department of Medicine, Rochester, MN, USA
    Neurogastroenterol Motil 24:235-41. 2012
    ..Our aims were to prospectively evaluate anorectal sensorimotor functions before and after a hysterectomy...
  7. pmc Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects
    A E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program C E N T E R, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 20:891-9. 2008
    ..e. GC(24) was 3.0 +/- 0.4 vs 2.1 +/- 0.5, P = 0.1). These data suggest that CYP2D6 and CYP3A4 genotypes which determine the metabolism of yohimbine may influence its sympathetic and gastrointestinal effects...
  8. pmc Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans
    Adil E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 295:R874-80. 2008
    ..GLP-1 increases skeletal muscle sympathetic nerve activity but does not appear to affect cardiac sympathetic or parasympathetic activity in humans...
  9. pmc First-in-human study demonstrating pharmacological activation of heme oxygenase-1 in humans
    A E Bharucha
    Enteric Neurosciences Program, Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    Clin Pharmacol Ther 87:187-90. 2010
    ..70 +/- 9.20 (baseline), 1,126.20 +/- 293.30 (24 h), 1,192.20 +/- 333.30 (48 h)) in four of five subjects as compared with albumin alone (P </= 0.03). This represents the overcoming of a fundamental hurdle to HO-1 research in humans...
  10. doi request reprint Lower gastrointestinal functions
    A E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program C E N T E R, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 20:103-13. 2008
    ..This article is a broad perspective of the current status and a personal perspective of future challenges in understanding lower gastrointestinal functions in health and disease in humans...
  11. doi request reprint Effect of tolterodine on gastrointestinal transit and bowel habits in healthy subjects
    A E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program CENTER, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Neurogastroenterol Motil 20:643-8. 2008
    ..Further studies are necessary to elucidate whether these observations are explained by tolterodine effects at muscarinic receptors which stimulate and inhibit gastrointestinal motility...
  12. pmc Effect of nifedipine on anorectal sensorimotor functions in health and fecal incontinence
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 301:G175-80. 2011
    ....
  13. ncbi request reprint Constipation
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, Clinical and Enteric Neuroscience Translational and Epidemiological Research Program CENTER, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Best Pract Res Clin Gastroenterol 21:709-31. 2007
    ..Functional defaecatory disorders are primarily treated with pelvic floor retraining using biofeedback therapy...
  14. ncbi request reprint Recent advances in assessing anorectal structure and functions
    Adil E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 133:1069-74. 2007
  15. pmc Pilot study of pyridostigmine in constipated patients with autonomic neuropathy
    Adil E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Clin Auton Res 18:194-202. 2008
    ..Our aims were to evaluate the efficacy of cholinesterase inhibitors for dysautonomia and chronic constipation and to assess whether acute effects could predict the long term response...
  16. doi request reprint Relationship between clinical features and gastric emptying disturbances in diabetes mellitus
    Adil E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Clin Endocrinol (Oxf) 70:415-20. 2009
    ..Gastric emptying (GE) may be delayed or rapid in diabetes mellitus. We sought to ascertain differences in risk factors or associated features (i.e. diabetic 'phenotype') among patients with diabetes who have rapid, slow or normal GE...
  17. pmc Functional and chronic anorectal and pelvic pain disorders
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
    Gastroenterol Clin North Am 37:685-96, ix. 2008
    ..Although nomenclature suggests that these conditions are distinct, there is considerable overlap of their symptoms and these disorders have much in common...
  18. pmc Linaclotide - a secretagogue and antihyperalgesic agent - what next?
    A E Bharucha
    From the Enteric Neurosciences Program, Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
    Neurogastroenterol Motil 22:227-31. 2010
    ..Further studies are also necessary to elucidate the mechanisms as these effects cannot be explained by linaclotide's known effects on epithelial GC-C receptors...
  19. pmc Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humans
    Adil E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program C E N T E R Mayo Clinic and Mayo Foundation, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 299:G215-9. 2010
    ..At doses that affect small and large intestinal transit, M(3) antagonists do not affect gastric emptying in humans. The efficacy of darifenacin in diarrhea-predominant irritable bowel syndrome should be evaluated...
  20. pmc The effects of clonidine on symptoms and anorectal sensorimotor function in women with faecal incontinence
    A E Bharucha
    Department of Medicine, Rochester, MN, USA
    Aliment Pharmacol Ther 32:681-8. 2010
    ..Women with faecal incontinence and rectal urgency have increased rectal stiffness and sensation...
  21. pmc Bowel disturbances are the most important risk factors for late onset fecal incontinence: a population-based case-control study in women
    Adil E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 139:1559-66. 2010
    ..However, the contribution of obstetric injury to the development of FI later in life is unclear. We sought to better understand the risk factors for FI...
  22. pmc Gastric motor disturbances in patients with idiopathic rapid gastric emptying
    A E Bharucha
    Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Neurogastroenterol Motil 23:617-e252. 2011
    ..Our hypotheses were that increased gastric motility and reduced postprandial gastric accommodation contribute to rapid gastric emptying...
  23. doi request reprint Recent advances in functional anorectal disorders
    Adil E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
    Curr Gastroenterol Rep 13:316-22. 2011
    ..Pelvic floor retraining with biofeedback therapy is beneficial for patients who do not respond to bowel management. Sacral nerve stimulation should be considered in patients who do not respond to conservative therapy...
  24. doi request reprint Difficult defecation: difficult problem assessment and management; what really helps?
    Adil E Bharucha
    Clinical Enteric Neurosciences Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Gastroenterol Clin North Am 40:837-44. 2011
    ..Colonic transit is normal or slow in patients with defecatory disorders. Pelvic floor retraining by biofeedback therapy is superior to laxatives for managing defecatory disorders...
  25. ncbi request reprint Treatment of severe and intractable constipation
    Adil E Bharucha
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, Rochester, MN 55905, USA
    Rev Gastroenterol Mex 69:89-94. 2004
  26. pmc Effects of a serotonin 5-HT(4) receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans
    A E Bharucha
    Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Gut 47:667-74. 2000
    ..5-HT(4) receptors on primary afferent neurones have been postulated to modulate visceral sensation. While 5-HT(4) agonists are used as prokinetic agents, the physiological role of 5-HT(4) receptors in the human gut is unknown...
  27. ncbi request reprint Dissecting oesophageal sensori-motor functions: the fourth domain
    Adil E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Program, Mayo Clinic College of Medicine, Rochester, MN, USA
    Neurogastroenterol Motil 18:169-71. 2006
  28. ncbi request reprint Contractile response to colonic distention is influenced by oscillation frequency
    A E Bharucha
    Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Neurogastroenterol Motil 17:64-75. 2005
    ..The frequency-dependence of colonic mechanical properties is worthy of future study because it may provide insights into reflex responses in health and disease...
  29. ncbi request reprint Prevalence and burden of fecal incontinence: a population-based study in women
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 129:42-9. 2005
    ..The epidemiology of fecal incontinence (FI) is incompletely understood. We report the prevalence, clinical spectrum, health care-seeking behavior, and quality of life (QOL) in community women with FI...
  30. ncbi request reprint Phenotypic variation in functional disorders of defecation
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Gastroenterology 128:1199-210. 2005
    ..Our aim was to characterize phenotypic variability in constipated patients by anorectal assessments...
  31. ncbi request reprint A new questionnaire for constipation and faecal incontinence
    A E Bharucha
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Aliment Pharmacol Ther 20:355-64. 2004
    ..The prevalence, severity and risk factors of faecal incontinence in women in the community are incompletely characterized...
  32. ncbi request reprint Symptoms and quality of life in community women with fecal incontinence
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Clin Gastroenterol Hepatol 4:1004-9. 2006
    ..However, there is no consensus on how self-reported symptom severity in FI should be measured for this purpose, and the relationship between symptoms of FI and its impact on quality of life (QOL) is not known...
  33. ncbi request reprint Comparison of rectoanal axial forces in health and functional defecatory disorders
    Adil E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1164-9. 2006
    ..e., contracted) their pelvic floor muscles, suggestive of generalized pelvic floor weakness...
  34. ncbi request reprint Day-to-day reproducibility of anorectal sensorimotor assessments in healthy subjects
    A E Bharucha
    Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Neurogastroenterol Motil 16:241-50. 2004
    ....
  35. ncbi request reprint Fecal incontinence
    Adil E Bharucha
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 124:1672-85. 2003
  36. ncbi request reprint Update of tests of colon and rectal structure and function
    Adil E Bharucha
    Department of Medicine, Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Clin Gastroenterol 40:96-103. 2006
    ..Because the measurement of pudendal nerve latencies suffers from several limitations, anal sphincter electromyography is recommended when neurogenic sphincter weakness is suspected...
  37. ncbi request reprint Viscoelastic properties of the human colon
    A E Bharucha
    Gastroenterology Research Unit and Enteric Neurosciences Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Gastrointest Liver Physiol 281:G459-66. 2001
    ..We conclude that colonic viscoelastic properties can be assessed by quasi-static P-V curves. Rapid colonic distension activated neural reflexes, thereby reducing colonic compliance compared with quasi-static distensions...
  38. ncbi request reprint Pelvic floor: anatomy and function
    A E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R, Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurogastroenterol Motil 18:507-19. 2006
    ..Faecal incontinence and functional defecatory disorders may result from structural changes and/or functional disturbances in the mechanisms of faecal continence and defecation...
  39. pmc Relationship between symptoms and disordered continence mechanisms in women with idiopathic faecal incontinence
    A E Bharucha
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program CENTER, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Gut 54:546-55. 2005
    ..Anal sphincter weakness and rectal sensory disturbances contribute to faecal incontinence (FI). Our aims were to investigate the relationship between symptoms, risk factors, and disordered anorectal and pelvic floor functions in FI...
  40. pmc Phenotypic variation of colonic motor functions in chronic constipation
    Karthik Ravi
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Gastroenterology 138:89-97. 2010
    ..We sought to characterize the phenotypic variability in chronic constipation...
  41. ncbi request reprint Nitrergic contribution to gastric relaxation induced by glucagon-like peptide-1 (GLP-1) in healthy adults
    Christopher N Andrews
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1359-65. 2007
    ..01 vs. GLP-1 alone). These data are consistent with the hypothesis that nitric oxide partly mediates the effects of GLP-1 on postprandial but not fasting gastric volumes in humans...
  42. pmc Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjects
    Seth Sweetser
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER Group, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 296:G295-301. 2009
    ..Effects of lubiprostone on sensitivity deserve further study...
  43. ncbi request reprint Rectal sensorimotor dysfunction in women with fecal incontinence
    Christopher Andrews
    Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 292:G282-9. 2007
    ..In addition to reduced rectal capacity and compliance, women with FI had an exaggerated rate-dependent reduction in rectal distensibility, lower sensory thresholds, and more prolonged perception, indicative of rectoanal dysfunctions...
  44. ncbi request reprint Anal sphincter motor unit potential (MUP) differences between sides, between rest and voluntary contraction, and between MUP analysis programs in normal subjects
    Jasper R Daube
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Suppl Clin Neurophysiol 60:287-92. 2009
    ..MUPs were readily isolated and metric values compared favorably with those recorded with different software...
  45. ncbi request reprint Rectal and colonic distension elicit viscerovisceral reflexes in humans
    Ngai Moh Law
    Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    Am J Physiol Gastrointest Liver Physiol 283:G384-9. 2002
    ..In contrast, rectal balloon volume declined, reflecting increased tone during phasic and staircase colonic distensions. Thus rectal distension inhibited colonic motor activity, indicative of a viscerovisceral inhibitory reflex...
  46. ncbi request reprint Role of extrinsic innervation in modulating nitrergic transmission in the canine ileocolonic region
    Somchai Leelakusolvong
    Division of Gastroenterology and Hepatology, Gastroenterology Research Unit and Enteric Neurosciences Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Gastrointest Liver Physiol 283:G230-9. 2002
    ..Nonnitrergic extrinsic nerve pathways mediate reflex colonic relaxation during ileal distension. Enteric isolation augments the number of NOS fibers, an effect not modified by extrinsic denervation...
  47. pmc Behavioural and new pharmacological treatments for constipation: getting the balance right
    Michael Camilleri
    Mayo Clinic, Charlton 8 110, 200 First St S W, Rochester, MN 55905, USA
    Gut 59:1288-96. 2010
    ....
  48. ncbi request reprint Outcome measures for fecal incontinence: anorectal structure and function
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 126:S90-8. 2004
    ..These standardized, reproducible assessments of the multifaceted mechanisms maintaining fecal incontinence should be incorporated as outcome variables in therapeutic trials of fecal incontinence...
  49. pmc Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Group and Gastroenterology Research Unit, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Gastroenterology 132:17-25. 2007
    ..We explored the hypothesis that expression of these 2 proteins in colonic and rectal mucosa is abnormal in patients with IBS as compared with healthy controls...
  50. pmc Influence of hysterectomy on long-term fracture risk
    L Joseph Melton
    Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Fertil Steril 88:156-62. 2007
    ..To assess long-term fracture risk after hysterectomy, with or without oophorectomy...
  51. ncbi request reprint Risk factors for fecal incontinence: a population-based study in women
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 101:1305-12. 2006
    ..However, the relative contributions of obstetric trauma and bowel symptoms to FI in the community are unknown...
  52. ncbi request reprint Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic, Charlton 8 110, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 290:G942-7. 2006
    ..Thus the ClC-2 activator lubiprostone accelerates small intestinal and colonic transit, which confers potential in the treatment of constipation...
  53. ncbi request reprint Functional anorectal disorders
    Adil E Bharucha
    Mayo Clinic, Rochester, Minnesota, USA
    Gastroenterology 130:1510-8. 2006
    ..Functional disorders of defecation may be amenable to pelvic floor retraining by biofeedback therapy (such as dyssynergic defecation)...
  54. ncbi request reprint Pro: Anorectal testing is useful in fecal incontinence
    Adil E Bharucha
    Clinical Enteric Neuroscience, Translational and Epidemiological Research Program, Mayo Clinic College of Medicine, Rochester, MN, USA
    Am J Gastroenterol 101:2679-81. 2006
  55. pmc Insights into normal and disordered bowel habits from bowel diaries
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Am J Gastroenterol 103:692-8. 2008
    ..While symptom questionnaires provide a snapshot of bowel habits, they may not reflect day-to-day variations or the relationship between bowel symptoms and stool form...
  56. pmc Incidence of pelvic floor repair after hysterectomy: A population-based cohort study
    Roberta E Blandon
    Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Obstet Gynecol 197:664.e1-7. 2007
    ..The objective of the study was to assess the incidence of and risk factors for pelvic floor repair (PFR) procedures after hysterectomy...
  57. ncbi request reprint Pelvic organ prolapse in defecatory disorders
    Christopher J Klingele
    Department of Obstetrics and Gynecology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Obstet Gynecol 106:315-20. 2005
    ..To compare the prevalence of pelvic organ prolapse in subjects with defecatory disorders with that in control subjects...
  58. pmc Risk factors for pelvic floor repair after hysterectomy
    Roberta E Blandon
    Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA
    Obstet Gynecol 113:601-8. 2009
    ..Having demonstrated that prior history of prolapse was a risk factor for pelvic floor repair procedures after hysterectomy, the objective of this study was to assess medical risk factors for pelvic floor repair after hysterectomy...
  59. pmc Reproducibility and performance characteristics of colonic compliance, tone, and sensory tests in healthy humans
    Suwebatu T Odunsi
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R, College of Medicine, Mayo Clinic, Charlton 8 110, Rochester, MN 55905, USA
    Dig Dis Sci 55:709-15. 2010
    ..The performance characteristics of colonic sensation and motility measurements are unclear...
  60. ncbi request reprint Differences between painless and painful constipation among community women
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Am J Gastroenterol 101:604-12. 2006
    ..e., "painless constipation" (PLC)). What differences, if any, exist between FC without (i.e., PLC) and with AP (i.e., PC) are unclear...
  61. ncbi request reprint Limitations of implantable, miniature ultrasonic transducers to measure wall movement in the canine jejunum
    Toshimi Chiba
    Division of Gastroenterology, Rochester, MN 55905, USA
    J Surg Res 116:219-26. 2004
    ..We hoped to differentiate circular from longitudinal smooth muscle contractions and to correlate physical measurements of change in distance within the jejunal wall with intraluminal manometry...
  62. ncbi request reprint Effect of aging on anorectal and pelvic floor functions in females
    Jean C Fox
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Dis Colon Rectum 49:1726-35. 2006
    ..In females, fecal incontinence often is attributed to birth trauma; however, symptoms sometimes begin decades after delivery, suggesting that anorectal sensorimotor functions decline with aging...
  63. pmc Decreasing utilization of hysterectomy: a population-based study in Olmsted County, Minnesota, 1965-2002
    Ebenezer O Babalola
    Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Obstet Gynecol 196:214.e1-7. 2007
    ..The purpose of this study was to assess temporal trends for hysterectomy among Olmsted County, Minnesota women...
  64. ncbi request reprint The etiology, assessment, and treatment of fecal incontinence
    Christopher N Andrews
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Nat Clin Pract Gastroenterol Hepatol 2:516-25. 2005
    ..Assessment should be tailored to age and symptom severity. Modulation of disordered bowel habits is the key to management; biofeedback and surgery might also be beneficial...
  65. pmc Utilization of surgical procedures for pelvic organ prolapse: a population-based study in Olmsted County, Minnesota, 1965-2002
    Ebenezer O Babalola
    Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA
    Int Urogynecol J Pelvic Floor Dysfunct 19:1243-50. 2008
    ..The most common indication for PFR was uterovaginal prolapse. Among women in the community, the rate of utilization and age distribution of pelvic organ prolapse surgery changed substantially between 1965 and 2002...
  66. pmc Relation of bowel habits to fecal incontinence in women
    Adil E Bharucha
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Am J Gastroenterol 103:1470-5. 2008
    ..Though most women with fecal incontinence (FI) have anorectal dysfunctions, a majority have intermittent symptoms. Variations in bowel habits and daily routine may partly explain this...
  67. ncbi request reprint Dietary fructose and gastrointestinal symptoms: a review
    Suzanne M Skoog
    Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Am J Gastroenterol 99:2046-50. 2004
    ....
  68. pmc Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome
    Jeroen Aerssens
    Johnson and Johnson Pharmaceutical Research and Development, Division of Janssen Pharmaceutica N V, Beerse, Belgium
    Clin Gastroenterol Hepatol 6:194-205. 2008
    ..We used microarray expression profiling of sigmoid colon mucosa to assess whether there are stably expressed sets of genes that suggest there are objective molecular biomarkers associated with IBS...

Research Grants11

  1. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2005
    ..abstract_text> ..
  2. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
    ..abstract_text> ..
  3. Pathophysiology of Anorectal Disorders
    Adil Bharucha; Fiscal Year: 2009
    ..This proposal will enhance our understanding of the mechanisms and assess novel approaches to manage FI. ..
  4. Pathophysiology of Anorectal Disorders
    Adil E Bharucha; Fiscal Year: 2010
    ..This proposal will enhance our understanding of the mechanisms and assess novel approaches to manage FI. ..