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Genomes and GenesSpecies | Adil BharuchaSummaryAffiliation: Mayo Clinic Country: USA Publications
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Publications
High amplitude propagated contractionsA E Bharucha
Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Neurogastroenterol Motil 24:977-82. 2012..This editorial comprehensively reviews the characteristics, physiology and pharmacology of HAPC, their assessment by manometry, and relevance to constipation and diarrhea...
A randomised controlled study of the effect of cholinesterase inhibition on colon function in patients with diabetes mellitus and constipationAdil E Bharucha
Clinical and Enteric Neuroscience Translational and Epidemiological Research CENTER Program, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Gut 62:708-15. 2013..Cholinesterase inhibitors increase colonic motility. This study evaluated the effects of a cholinesterase inhibitor on gastrointestinal and colonic transit and bowel function in diabetic patients with constipation...- Differential effects of selective and non-selective muscarinic antagonists on gastrointestinal transit and bowel function in healthy womenA E Bharucha
Clinical and Enteric Neuroscience Translational and Epidemiological Research Program C E N T E R, Mayo Clinic, Rochester, MN 55905, USA
Neurogastroenterol Motil 25:e35-43. 2013..We compared the effects of non-selective (fesoterodine) and M(3)-selective (solifenacin) antimuscarinics on gastrointestinal transit in healthy women... - Obstetric trauma, pelvic floor injury and fecal incontinence: a population-based case-control studyAdil E Bharucha
Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Gastroenterol 107:902-11. 2012..Hence, the objectives of this study were to evaluate the relationship between prior obstetric events, pelvic floor injury, and FI among community women... - Effects of vaginal hysterectomy on anorectal sensorimotor functions--a prospective studyA E Bharucha
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Department of Medicine, Rochester, MN, USA
Neurogastroenterol Motil 24:235-41. 2012..Our aims were to prospectively evaluate anorectal sensorimotor functions before and after a hysterectomy... - Functional and chronic anorectal and pelvic pain disordersAdil E Bharucha
Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
Gastroenterol Clin North Am 37:685-96, ix. 2008..Although nomenclature suggests that these conditions are distinct, there is considerable overlap of their symptoms and these disorders have much in common... - Relationship between clinical features and gastric emptying disturbances in diabetes mellitusAdil E Bharucha
Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Clin Endocrinol (Oxf) 70:415-20. 2009..Gastric emptying (GE) may be delayed or rapid in diabetes mellitus. We sought to ascertain differences in risk factors or associated features (i.e. diabetic 'phenotype') among patients with diabetes who have rapid, slow or normal GE... - Pilot study of pyridostigmine in constipated patients with autonomic neuropathyAdil E Bharucha
Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
Clin Auton Res 18:194-202. 2008..Our aims were to evaluate the efficacy of cholinesterase inhibitors for dysautonomia and chronic constipation and to assess whether acute effects could predict the long term response... - Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humansAdil E Bharucha
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
Am J Physiol Regul Integr Comp Physiol 295:R874-80. 2008..GLP-1 increases skeletal muscle sympathetic nerve activity but does not appear to affect cardiac sympathetic or parasympathetic activity in humans... - Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjectsA E Bharucha
Clinical and Enteric Neuroscience Translational and Epidemiological Research Program C E N T E R, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Neurogastroenterol Motil 20:891-9. 2008..e. GC(24) was 3.0 +/- 0.4 vs 2.1 +/- 0.5, P = 0.1). These data suggest that CYP2D6 and CYP3A4 genotypes which determine the metabolism of yohimbine may influence its sympathetic and gastrointestinal effects... - Effect of tolterodine on gastrointestinal transit and bowel habits in healthy subjectsA E Bharucha
Clinical and Enteric Neuroscience Translational and Epidemiological Research Program CENTER, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
Neurogastroenterol Motil 20:643-8. 2008..Further studies are necessary to elucidate whether these observations are explained by tolterodine effects at muscarinic receptors which stimulate and inhibit gastrointestinal motility... 
Recent advances in assessing anorectal structure and functionsAdil E Bharucha
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Gastroenterology 133:1069-74. 2007- ConstipationAdil E Bharucha
Division of Gastroenterology and Hepatology, Clinical and Enteric Neuroscience Translational and Epidemiological Research Program CENTER, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
Best Pract Res Clin Gastroenterol 21:709-31. 2007..Functional defaecatory disorders are primarily treated with pelvic floor retraining using biofeedback therapy... - Lower gastrointestinal functionsA E Bharucha
Clinical and Enteric Neuroscience Translational and Epidemiological Research Program C E N T E R, Mayo Clinic, Rochester, MN 55905, USA
Neurogastroenterol Motil 20:103-13. 2008..This article is a broad perspective of the current status and a personal perspective of future challenges in understanding lower gastrointestinal functions in health and disease in humans... - First-in-human study demonstrating pharmacological activation of heme oxygenase-1 in humansA E Bharucha
Enteric Neurosciences Program, Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
Clin Pharmacol Ther 87:187-90. 2010..70 +/- 9.20 (baseline), 1,126.20 +/- 293.30 (24 h), 1,192.20 +/- 333.30 (48 h)) in four of five subjects as compared with albumin alone (P </= 0.03). This represents the overcoming of a fundamental hurdle to HO-1 research in humans... - Difficult defecation: difficult problem assessment and management; what really helps?Adil E Bharucha
Clinical Enteric Neurosciences Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
Gastroenterol Clin North Am 40:837-44. 2011..Colonic transit is normal or slow in patients with defecatory disorders. Pelvic floor retraining by biofeedback therapy is superior to laxatives for managing defecatory disorders... - Recent advances in functional anorectal disordersAdil E Bharucha
Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
Curr Gastroenterol Rep 13:316-22. 2011..Pelvic floor retraining with biofeedback therapy is beneficial for patients who do not respond to bowel management. Sacral nerve stimulation should be considered in patients who do not respond to conservative therapy... - Effect of nifedipine on anorectal sensorimotor functions in health and fecal incontinenceAdil E Bharucha
Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Am J Physiol Gastrointest Liver Physiol 301:G175-80. 2011.... - Gastric motor disturbances in patients with idiopathic rapid gastric emptyingA E Bharucha
Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
Neurogastroenterol Motil 23:617-e252. 2011..Our hypotheses were that increased gastric motility and reduced postprandial gastric accommodation contribute to rapid gastric emptying... - Bowel disturbances are the most important risk factors for late onset fecal incontinence: a population-based case-control study in womenAdil E Bharucha
Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, Rochester, Minnesota 55905, USA
Gastroenterology 139:1559-66. 2010..However, the contribution of obstetric injury to the development of FI later in life is unclear. We sought to better understand the risk factors for FI... - The effects of clonidine on symptoms and anorectal sensorimotor function in women with faecal incontinenceA E Bharucha
Department of Medicine, Rochester, MN, USA
Aliment Pharmacol Ther 32:681-8. 2010..Women with faecal incontinence and rectal urgency have increased rectal stiffness and sensation... - Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humansAdil E Bharucha
Clinical and Enteric Neuroscience Translational and Epidemiological Research Program C E N T E R Mayo Clinic and Mayo Foundation, 200 First St S W, Rochester, MN 55905, USA
Am J Physiol Gastrointest Liver Physiol 299:G215-9. 2010..At doses that affect small and large intestinal transit, M(3) antagonists do not affect gastric emptying in humans. The efficacy of darifenacin in diarrhea-predominant irritable bowel syndrome should be evaluated... - Linaclotide - a secretagogue and antihyperalgesic agent - what next?A E Bharucha
From the Enteric Neurosciences Program, Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
Neurogastroenterol Motil 22:227-31. 2010..Further studies are also necessary to elucidate the mechanisms as these effects cannot be explained by linaclotide's known effects on epithelial GC-C receptors... - Treatment of severe and intractable constipationAdil E Bharucha
Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, Rochester, MN 55905, USA
Rev Gastroenterol Mex 69:89-94. 2004 - Symptoms and quality of life in community women with fecal incontinenceAdil E Bharucha
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Clin Gastroenterol Hepatol 4:1004-9. 2006..However, there is no consensus on how self-reported symptom severity in FI should be measured for this purpose, and the relationship between symptoms of FI and its impact on quality of life (QOL) is not known... - Fecal incontinenceAdil E Bharucha
Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
Gastroenterology 124:1672-85. 2003 - A new questionnaire for constipation and faecal incontinenceA E Bharucha
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA
Aliment Pharmacol Ther 20:355-64. 2004..The prevalence, severity and risk factors of faecal incontinence in women in the community are incompletely characterized... - Dissecting oesophageal sensori-motor functions: the fourth domainAdil E Bharucha
Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) Program, Mayo Clinic College of Medicine, Rochester, MN, USA
Neurogastroenterol Motil 18:169-71. 2006 - Prevalence and burden of fecal incontinence: a population-based study in womenAdil E Bharucha
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Gastroenterology 129:42-9. 2005..The epidemiology of fecal incontinence (FI) is incompletely understood. We report the prevalence, clinical spectrum, health care-seeking behavior, and quality of life (QOL) in community women with FI... - Contractile response to colonic distention is influenced by oscillation frequencyA E Bharucha
Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
Neurogastroenterol Motil 17:64-75. 2005..The frequency-dependence of colonic mechanical properties is worthy of future study because it may provide insights into reflex responses in health and disease... - Relationship between symptoms and disordered continence mechanisms in women with idiopathic faecal incontinenceA E Bharucha
Clinical Enteric Neuroscience Translational and Epidemiological Research Program CENTER, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Gut 54:546-55. 2005..Anal sphincter weakness and rectal sensory disturbances contribute to faecal incontinence (FI). Our aims were to investigate the relationship between symptoms, risk factors, and disordered anorectal and pelvic floor functions in FI... - Comparison of rectoanal axial forces in health and functional defecatory disordersAdil E Bharucha
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Am J Physiol Gastrointest Liver Physiol 290:G1164-9. 2006..e., contracted) their pelvic floor muscles, suggestive of generalized pelvic floor weakness... - Update of tests of colon and rectal structure and functionAdil E Bharucha
Department of Medicine, Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Clin Gastroenterol 40:96-103. 2006..Because the measurement of pudendal nerve latencies suffers from several limitations, anal sphincter electromyography is recommended when neurogenic sphincter weakness is suspected... - Phenotypic variation in functional disorders of defecationAdil E Bharucha
Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Gastroenterology 128:1199-210. 2005..Our aim was to characterize phenotypic variability in constipated patients by anorectal assessments... - Day-to-day reproducibility of anorectal sensorimotor assessments in healthy subjectsA E Bharucha
Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Neurogastroenterol Motil 16:241-50. 2004.... - Pelvic floor: anatomy and functionA E Bharucha
Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R, Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Neurogastroenterol Motil 18:507-19. 2006..Faecal incontinence and functional defecatory disorders may result from structural changes and/or functional disturbances in the mechanisms of faecal continence and defecation... - Effects of a serotonin 5-HT(4) receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humansA E Bharucha
Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Gut 47:667-74. 2000..5-HT(4) receptors on primary afferent neurones have been postulated to modulate visceral sensation. While 5-HT(4) agonists are used as prokinetic agents, the physiological role of 5-HT(4) receptors in the human gut is unknown... - Viscoelastic properties of the human colonA E Bharucha
Gastroenterology Research Unit and Enteric Neurosciences Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Am J Physiol Gastrointest Liver Physiol 281:G459-66. 2001..We conclude that colonic viscoelastic properties can be assessed by quasi-static P-V curves. Rapid colonic distension activated neural reflexes, thereby reducing colonic compliance compared with quasi-static distensions... - Phenotypic variation of colonic motor functions in chronic constipationKarthik Ravi
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Gastroenterology 138:89-97. 2010..We sought to characterize the phenotypic variability in chronic constipation... - Nitrergic contribution to gastric relaxation induced by glucagon-like peptide-1 (GLP-1) in healthy adultsChristopher N Andrews
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St S W, Rochester, MN 55905, USA
Am J Physiol Gastrointest Liver Physiol 292:G1359-65. 2007..01 vs. GLP-1 alone). These data are consistent with the hypothesis that nitric oxide partly mediates the effects of GLP-1 on postprandial but not fasting gastric volumes in humans... - Rectal sensorimotor dysfunction in women with fecal incontinenceChristopher Andrews
Clinical and Enteric Neuroscience Translational and Epidemiological Research Program, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Am J Physiol Gastrointest Liver Physiol 292:G282-9. 2007..In addition to reduced rectal capacity and compliance, women with FI had an exaggerated rate-dependent reduction in rectal distensibility, lower sensory thresholds, and more prolonged perception, indicative of rectoanal dysfunctions... - Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjectsSeth Sweetser
Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER Group, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
Am J Physiol Gastrointest Liver Physiol 296:G295-301. 2009..Effects of lubiprostone on sensitivity deserve further study... - Role of extrinsic innervation in modulating nitrergic transmission in the canine ileocolonic regionSomchai Leelakusolvong
Division of Gastroenterology and Hepatology, Gastroenterology Research Unit and Enteric Neurosciences Program, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Physiol Gastrointest Liver Physiol 283:G230-9. 2002..Nonnitrergic extrinsic nerve pathways mediate reflex colonic relaxation during ileal distension. Enteric isolation augments the number of NOS fibers, an effect not modified by extrinsic denervation... - Anal sphincter motor unit potential (MUP) differences between sides, between rest and voluntary contraction, and between MUP analysis programs in normal subjectsJasper R Daube
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Suppl Clin Neurophysiol 60:287-92. 2009..MUPs were readily isolated and metric values compared favorably with those recorded with different software... - Rectal and colonic distension elicit viscerovisceral reflexes in humansNgai-Moh Law
Gastroenterology Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Am J Physiol Gastrointest Liver Physiol 283:G384-9. 2002..In contrast, rectal balloon volume declined, reflecting increased tone during phasic and staircase colonic distensions. Thus rectal distension inhibited colonic motor activity, indicative of a viscerovisceral inhibitory reflex... - Behavioural and new pharmacological treatments for constipation: getting the balance rightMichael Camilleri
Mayo Clinic, Charlton 8 110, 200 First St S W, Rochester, MN 55905, USA
Gut 59:1288-96. 2010.... - Outcome measures for fecal incontinence: anorectal structure and functionAdil E Bharucha
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
Gastroenterology 126:S90-8. 2004..These standardized, reproducible assessments of the multifaceted mechanisms maintaining fecal incontinence should be incorporated as outcome variables in therapeutic trials of fecal incontinence... - Influence of hysterectomy on long-term fracture riskL Joseph Melton
Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Fertil Steril 88:156-62. 2007..To assess long-term fracture risk after hysterectomy, with or without oophorectomy... - Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndromeMichael Camilleri
Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Group and Gastroenterology Research Unit, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Gastroenterology 132:17-25. 2007..We explored the hypothesis that expression of these 2 proteins in colonic and rectal mucosa is abnormal in patients with IBS as compared with healthy controls... - Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteersMichael Camilleri
Clinical Enteric Neuroscience Translational and Epidemiological Research Group, Mayo Clinic, Charlton 8 110, 200 First Street SW, Rochester, MN 55905, USA
Am J Physiol Gastrointest Liver Physiol 290:G942-7. 2006..Thus the ClC-2 activator lubiprostone accelerates small intestinal and colonic transit, which confers potential in the treatment of constipation... - Risk factors for fecal incontinence: a population-based study in womenAdil E Bharucha
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Am J Gastroenterol 101:1305-12. 2006..These observations reinforce the importance of behavioral, dietary, and pharmacological measures to ameliorate bowel disturbances before anal imaging in women with "idiopathic" FI... - Insights into normal and disordered bowel habits from bowel diariesAdil E Bharucha
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Am J Gastroenterol 103:692-8. 2008..While symptom questionnaires provide a snapshot of bowel habits, they may not reflect day-to-day variations or the relationship between bowel symptoms and stool form... - Pro: Anorectal testing is useful in fecal incontinenceAdil E Bharucha
Clinical Enteric Neuroscience, Translational and Epidemiological Research Program, Mayo Clinic College of Medicine, Rochester, MN, USA
Am J Gastroenterol 101:2679-81. 2006 - Functional anorectal disordersAdil E Bharucha
Mayo Clinic, Rochester, Minnesota, USA
Gastroenterology 130:1510-8. 2006..Functional disorders of defecation may be amenable to pelvic floor retraining by biofeedback therapy (such as dyssynergic defecation)... - Limitations of implantable, miniature ultrasonic transducers to measure wall movement in the canine jejunumToshimi Chiba
Division of Gastroenterology, Rochester, MN 55905, USA
J Surg Res 116:219-26. 2004..Contraction of circular and longitudinal muscles, although phase-locked, do not appear to occur exactly synchronously in canine jejunum... - Differences between painless and painful constipation among community womenAdil E Bharucha
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Am J Gastroenterol 101:604-12. 2006..CONCLUSIONS: Patients with PC more closely resemble those with C-IBS than PLC. Consideration should be given to separating PC from PLC in the Rome criteria and in therapeutic trials... - Pelvic organ prolapse in defecatory disordersChristopher J Klingele
Department of Obstetrics and Gynecology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
Obstet Gynecol 106:315-20. 2005..However, a subset of subjects with defecatory disorders, predominantly obstructed defecation, have excessive perineal descent, which is associated with pelvic organ prolapse... - Incidence of pelvic floor repair after hysterectomy: A population-based cohort studyRoberta E Blandon
Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Am J Obstet Gynecol 197:664.e1-7. 2007..The objective of the study was to assess the incidence of and risk factors for pelvic floor repair (PFR) procedures after hysterectomy... - Risk factors for pelvic floor repair after hysterectomyRoberta E Blandon
Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA
Obstet Gynecol 113:601-8. 2009..Having demonstrated that prior history of prolapse was a risk factor for pelvic floor repair procedures after hysterectomy, the objective of this study was to assess medical risk factors for pelvic floor repair after hysterectomy... - Reproducibility and performance characteristics of colonic compliance, tone, and sensory tests in healthy humansSuwebatu T Odunsi
Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R, College of Medicine, Mayo Clinic, Charlton 8 110, Rochester, MN 55905, USA
Dig Dis Sci 55:709-15. 2010..The performance characteristics of colonic sensation and motility measurements are unclear... - Utilization of surgical procedures for pelvic organ prolapse: a population-based study in Olmsted County, Minnesota, 1965-2002Ebenezer O Babalola
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA
Int Urogynecol J Pelvic Floor Dysfunct 19:1243-50. 2008..The most common indication for PFR was uterovaginal prolapse. Among women in the community, the rate of utilization and age distribution of pelvic organ prolapse surgery changed substantially between 1965 and 2002... - Relation of bowel habits to fecal incontinence in womenAdil E Bharucha
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Am J Gastroenterol 103:1470-5. 2008..Though most women with fecal incontinence (FI) have anorectal dysfunctions, a majority have intermittent symptoms. Variations in bowel habits and daily routine may partly explain this... - The etiology, assessment, and treatment of fecal incontinenceChristopher N Andrews
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Nat Clin Pract Gastroenterol Hepatol 2:516-25. 2005..Assessment should be tailored to age and symptom severity. Modulation of disordered bowel habits is the key to management; biofeedback and surgery might also be beneficial... - Decreasing utilization of hysterectomy: a population-based study in Olmsted County, Minnesota, 1965-2002Ebenezer O Babalola
Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Am J Obstet Gynecol 196:214.e1-7. 2007..The purpose of this study was to assess temporal trends for hysterectomy among Olmsted County, Minnesota women... - Effect of aging on anorectal and pelvic floor functions in femalesJean C Fox
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Dis Colon Rectum 49:1726-35. 2006..Together, these changes may predispose to fecal incontinence in elderly females... - Dietary fructose and gastrointestinal symptoms: a reviewSuzanne M Skoog
Division of Gastroenterology and Hepatology, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
Am J Gastroenterol 99:2046-50. 2004.... - Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndromeJeroen Aerssens
Johnson and Johnson Pharmaceutical Research and Development, Division of Janssen Pharmaceutica N V, Beerse, Belgium
Clin Gastroenterol Hepatol 6:194-205. 2008..We used microarray expression profiling of sigmoid colon mucosa to assess whether there are stably expressed sets of genes that suggest there are objective molecular biomarkers associated with IBS...
Research Grants
- Epidemiology and Mechanisms of Fecal IncontinenceAdil Bharucha; Fiscal Year: 2005..abstract_text> ..
- Pathophysiology of Anorectal DisordersAdil Bharucha; Fiscal Year: 2009..This proposal will enhance our understanding of the mechanisms and assess novel approaches to manage FI. ..
- ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDERAdil Bharucha; Fiscal Year: 2002..abstract_text> ..
- Pathophysiology of Anorectal DisordersAdil E Bharucha; Fiscal Year: 2010..This proposal will enhance our understanding of the mechanisms and assess novel approaches to manage FI. ..