Karla V Ballman

..Our goal was to develop a normalization technique that yields results similar to cyclic loess normalization and with speed comparable to quantile normalization...

..Finally, there was a strong association between progression-free survival status and overall survival. PFS6 seems to be a reasonable end point for phase II trials in patients with recurrent glioblastoma...

..These data highlight one potential limitation of the evaluation of MGMT methylation by MS-PCR assay and suggest that more detailed evaluation of methylation at individual CpG sites relative to TMZ response may be worth pursuing...

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..Collectively, these findings suggest that CD74 is expressed in a subset of high grade gliomas and may contribute to TMZ resistance...

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..In this study, we sought to determine how dutasteride is functioning at the molecular level, using a prostate cancer xenograft model...

..We hypothesized that an expression biomarker panel can predict which men with a rising PSA would benefit from further therapy...

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..Eliminating the excess risk of CHF in patients with RA could significantly improve their survival...

..This suggests that one or more of these candidates may play a role in glioma formation or progression...

..Stroke results in a >2-fold increase in mortality. Thus, prevention of stroke has the potential to improve survival among patients with HF, particularly among the elderly and those with diabetes or prior stroke...

..In the current study, we evaluated gefitinib, a potent EGFR inhibitor, in the treatment of adults with newly diagnosed GBM...

..To assess baseline quality of life (QOL) and its prognostic importance for adults with newly diagnosed high-grade gliomas, we analyzed QOL and outcome data prospectively collected in three phase II high-grade glioma protocols...

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..Like combined 1p/19q deletion, the 1;19 translocation is associated with superior OS and progression-free survival in low-grade glioma patients...

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..To evaluate the toxicity and maximum tolerated dose (MTD) of erlotinib plus radiation therapy (RT) in patients with glioblastoma multiforme (GBM) in a multicenter phase I trial...

..To determine the relationship between glucocorticoid exposure and cardiovascular (CV) events in patients with rheumatoid arthritis (RA)...

..001), and greater extent of resection (P < 0.001). CONCLUSION: Baseline QOL was predictive of QOL over time. Gross total resection was associated with longer survival and improved QOL over time for patients with high-grade gliomas...

..The data suggest that the single-item LASA scales are valid for assessing QOL of cancer patients and are an appropriate alternative when a shorter instrument is warranted...

..To examine whether a caregiver can provide reliable proxy quality of life (QOL) ratings of their adult significant other with a newly diagnosed high-grade glioma...

..The risk of CHD in RA patients precedes the ACR criteria-based diagnosis of RA, and the risk cannot be explained by an increased incidence of traditional CHD risk factors in RA patients...

..Older patients are more susceptible to hearing loss with CDDP. The low proportion of patients with clinically significant ototoxicity suggests that baseline screening is unnecessary in GBM patients...

..To assess the cognitive performance of high-grade glioma patients, prospectively collected cognitive performance data were analyzed...

..CONCLUSION: When used to cardiovert atrial arrhythmias, the rectilinear biphasic waveform was associated with higher success rates and lower cumulative energies than the monophasic damped sine waveform...

..28, 95% CI 0.93-1.78). CONCLUSION: Compared with persons without RA, patients with RA have twice the risk of developing CHF. This excess risk is not explained by traditional CV risk factors and/or clinical ischemic heart disease...

..Further research is needed to determine the optimal stroke prevention strategies for MI survivors...

..The need for normalization in microarray experiments has been well documented in the literature. Currently, many analysis methods treat normalization and analysis as a series of steps, with summarized data carried forward to the next step...

..Anaplastic oligoastrocytomas (AOA) are relatively uncommon high-grade gliomas. While oligodendroglial elements are thought to be associated with better outcomes, the magnitude of the difference is not clear...

..CONCLUSION: The long-term prognosis of patients with inducible VFL is similar to that of patients with inducible SMVT, even when VFL is induced with a relatively aggressive protocol...

..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat...

..We will summarize the ischemic stroke rate at various time points during follow-up among adults with chronic heart failure...

..To evaluate the long-term outcome of a community-based patient population with incidentally discovered asymptomatic and uncomplicated bundle branch block (BBB)...

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..The intent of the current study was to address this relationship using several EGFR-amplified glioblastoma xenografts in an orthotopic athymic mouse model...

..In estimating the impact of cardiac transplantation on exercise capacity the most important pre-transplant factors to consider are age, gender and height and weight (or, alternatively, body mass index)...

..The authors have previously described a 150-kilobase minimal deletion region in gliomas that maps to 19q13.33 and contains 3 novel candidate genes (GLTSCR1, EHD2, and GLTSCR2)...

..CONCLUSIONS: For long-term survivors after neck dissection and irradiation, especially those who are symptomatic, ultrasonographic carotid artery screening should be considered...

..LA enlargement is independently predictive of postoperative AF and as such, should be integrated into the clinical decision-making process in patients with MR...

..Although the numbers of patients are too small for statistical conclusions, the HDMP regimen deserves further study...

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..At ICD implant, DFT testing is recommended in these patients and in patients with a high (>20 J) ULV before first-shock energy and the need for lead repositioning are determined...

..This regimen was not significantly active and radiosensitization was not observed. Non-EIAC patients with UGT1A1*28 variant alleles appear particularly sensitive to toxicity from irinotecan...

..Additionally, withdrawal of immunosuppression can be associated with fatal GCM recurrence...

..0001), was independent of age differences as assessed by multiple regression analysis. The observed gender differences have important implications for the establishment of cut-off points for cardiovascular risk stratification...

..To determine the frequency of partial normalization of the heart rate response to graded exercise and its relationship to exercise capacity in cardiac transplant recipients...

..These data support B7-H1 blockade as a new approach to enhance the efficacy of T-cell immunotherapy...

..Data collection and review were identified as major contributors to the cost of randomized clinical trials (RCTs)...

..In March 1998, Common Toxicity Criteria (CTC) version 2.0 introduced the collection of attribution of adverse events (AEs) to study drug. We investigate whether attribution adds value to the interpretation of AE data...

..The objective of this investigation was to compare the patterns of gene expression in aortas between TAV and BAV patients with the aim of identifying markers for AscAAs...

..Taken together, our results indicate that targeting of Hsp27 and Hsp70 should be exploited to increase the clinical efficacy of Hsp90-directed therapy...

..09, 95% CI 1.50-2.92) when compared with non-RA subjects who maintained normal BMI throughout followup. CONCLUSION: Among patients with RA, low BMI is associated with a significantly increased risk of cardiovascular death...

..03). In contrast to case reports of extreme tobacco dependence in the TAO population, the degree of tobacco dependence in subjects with TAO is similar to that in subjects with CAD...

..To determine whether neurosurgery (NS) or stereotactic radiosurgery (RS) provided better local tumor control and enhanced patient survival...

..This study provides new insight into the molecular profile of clonal plasma cells and its functional relevance in the pathogenesis of light chain amyloidosis...

..We analyzed the expression of genes to identify reliable molecular markers in the diagnosis and progression of prostate cancer...

..Slight improvements in some cognitive areas are consistent with practice effects attributable to increased familiarity with test procedures and content...

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..The quality of life among the majority of survivors is similar to that of the general population...

..Low HDL-cholesterol and female sex were associated with disease severity. An aggressive approach to diagnosis and treatment may be warranted as atherosclerosis in other arterial beds was prevalent in half of the patients...

..Appropriate treatment with CPAP in OSA patients is associated with lower recurrence of AF...

..On multivariate analysis, the MTRR genotypes were not associated with serum homocysteine or with significant CAD...

..We sought to evaluate the clinical significance of GBM subtypes as defined by EGFRvIII status...

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..No predictors could be found for high and low risk for unstable arrhythmias. These findings support ICD treatment for stable VT survivors...

..Failure to examine younger patients separately may explain why some studies have found no association between the genotype and cardiovascular disease...