Panos Z Anastasiadis
Affiliation: Mayo Clinic
Anastasiadis P. p120-ctn: A nexus for contextual signaling via Rho GTPases. Biochim Biophys Acta. 2007;1773:34-46 pubmed
..quiescent phenotype of epithelial cells. Here, we review the new evidence on the relationship of p120 to Rho GTPases, and discuss potential roles for the p120-Rho connection in normal and malignant cells. ..
Lewis Tuffin L, Feathers R, Hari P, Durand N, Li Z, Rodriguez F, et al
. Src family kinases differentially influence glioma growth and motility. Mol Oncol. 2015;9:1783-98 pubmed publisher
..In the context of therapeutic targeting of SFKs, these results suggest that pan-SFK inhibitors may not produce the intended therapeutic benefit when Lyn is present. ..
Kourtidis A, Anastasiadis P. Close encounters of the RNAi kind: the silencing life of the adherens junctions. Curr Opin Cell Biol. 2018;54:30-36 pubmed publisher
..A number of questions emerge regarding the physiological role and the modes of regulation of the junctional RNAi machinery, pointing towards new directions of investigation. ..
Kourtidis A, Lu R, Pence L, Anastasiadis P. A central role for cadherin signaling in cancer. Exp Cell Res. 2017;358:78-85 pubmed publisher
..Collectively, the data indicate that loss of E-cadherin function, especially at the ZA, is a common and crucial step in cancer progression. ..
Kourtidis A, Necela B, Lin W, Lu R, Feathers R, Asmann Y, et al
. Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling. J Cell Biol. 2017;216:3073-3085 pubmed publisher
..The present work reveals a mechanism that directly links junction integrity to the silencing of a set of mRNAs that critically affect epithelial homeostasis. ..