Research Topics
| Zeshan AhmedSummaryAffiliation: Mayo Clinic Country: USA Publications
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Detail Information
Publications
Progranulin in frontotemporal lobar degeneration and neuroinflammationZeshan Ahmed
Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
J Neuroinflammation 4:7. 2007....
Incidental Lewy body disease and preclinical Parkinson diseaseAnthony DelleDonne
Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
Arch Neurol 65:1074-80. 2008..The significance of Lewy bodies detected at autopsy in the brains of clinically normal individuals is uncertain but may represent preclinical Parkinson disease (PD)...- TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's diseaseCatalina Amador-Ortiz
Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
Ann Neurol 61:435-45. 2007.... - Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementiaRosa Rademakers
Department of Neuroscience, Mayo Clinic, Jacksonville, FL FL 32224, USA
Hum Mol Genet 17:3631-42. 2008..Translational regulation by miRNAs may represent a common mechanism underlying complex neurodegenerative disorders... - Neuropathology of variants of progressive supranuclear palsyDennis W Dickson
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
Curr Opin Neurol 23:394-400. 2010..This review highlights the range of clinical and pathologic presentations of PSP and its variants... - Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful agingZeshan Ahmed
Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
Am J Pathol 177:311-24. 2010..Our data suggests that PGRN plays a key role in maintaining neuronal function during aging and supports the notion that PGRN is a trophic factor essential for long-term neuronal survival... - Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's diseaseDennis W Dickson
Neuropathology Laboratory, Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Acta Neuropathol 115:437-44. 2008..The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology... - Beta-amyloid burden is not associated with rates of brain atrophyKeith A Josephs
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Ann Neurol 63:204-12. 2008..To test the hypothesis that beta-amyloid (Abeta) burden is associated with rates of brain atrophy... 
Clinical and neuropathologic features of progressive supranuclear palsy with severe pallido-nigro-luysial degeneration and axonal dystrophyZeshan Ahmed
Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
Brain 131:460-72. 2008..These clinical and pathological findings suggest that PSP-PNLA should be considered a variant of PSP...- Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistryZeshan Ahmed
Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
J Histochem Cytochem 55:687-700. 2007..Because both coronin-1a and IBA-1 are actin-binding proteins that play a role in rearrangement of the membrane cytoskeleton, it suggests that these proteins are critical to dynamic properties of microglia... - Frontotemporal dementia and Parkinsonism linked to chromosome 17 with the N279K tau mutationJerzy Slowinski
Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA
Neuropathology 27:73-80. 2007..FTDP-17 should be suspected in patients with a history of familial parkinsonism combined with behavioral and cognitive changes, onset before age 65 years and an aggressive clinical course... - Single-dose intracerebroventricular administration of galactocerebrosidase improves survival in a mouse model of globoid cell leukodystrophyWing C Lee
Mayo Clinic College of Medicine, 4500 San Pablo Rd, Jacksonville, Florida 32224, USA
FASEB J 21:2520-7. 2007..These results indicate that even a single i.c.v. administration of the recombinant enzyme can have significant clinical impact and suggests that other lysosomal storage disorders with significant CNS involvement may similarly benefit... - Hippocampal sclerosis dementia differs from hippocampal sclerosis in frontal lobe degenerationCatalina Amador Ortiz
Department of Pathology Neuropathology and Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
Acta Neuropathol 113:245-52. 2007..Corpora amylacea tended to be more frequent in HSD than in FTLD-U, but there was no difference in frequency of argyrophilic grains... - Lewy bodies in progressive supranuclear palsy represent an independent disease processHirotake Uchikado
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
J Neuropathol Exp Neurol 65:387-95. 2006.... - Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutationsKeith A Josephs
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
J Neuropathol Exp Neurol 66:142-51. 2007..On the other hand, there is no histopathologic feature or combination of features that is pathognomonic. Neuronal intranuclear inclusions are virtually always present, but they can be detected in PGRN(-) cases... - Frontotemporal lobar degeneration with ubiquitin-positive, but TDP-43-negative inclusionsKeith A Josephs
Department of Neurology, Mayo Clinic, Rochester, MN, USA
Acta Neuropathol 116:159-67. 2008..The findings raise the possibly of an as yet identified protein that may play a pathogenic role in tau-negative FTLD...