Zeshan Ahmed

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. pmc Progranulin in frontotemporal lobar degeneration and neuroinflammation
    Zeshan Ahmed
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    J Neuroinflammation 4:7. 2007
  2. doi Incidental Lewy body disease and preclinical Parkinson disease
    Anthony DelleDonne
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Arch Neurol 65:1074-80. 2008
  3. pmc TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
    Catalina Amador-Ortiz
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Ann Neurol 61:435-45. 2007
  4. pmc Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL FL 32224, USA
    Hum Mol Genet 17:3631-42. 2008
  5. doi Neuropathology of variants of progressive supranuclear palsy
    Dennis W Dickson
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    Curr Opin Neurol 23:394-400. 2010
  6. pmc Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging
    Zeshan Ahmed
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
    Am J Pathol 177:311-24. 2010
  7. doi Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease
    Dennis W Dickson
    Neuropathology Laboratory, Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Acta Neuropathol 115:437-44. 2008
  8. pmc Beta-amyloid burden is not associated with rates of brain atrophy
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Ann Neurol 63:204-12. 2008
  9. pmc Corticobasal degeneration with olivopontocerebellar atrophy and TDP-43 pathology: an unusual clinicopathologic variant of CBD
    Naomi Kouri
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Acta Neuropathol 125:741-52. 2013
  10. ncbi Clinical and neuropathologic features of progressive supranuclear palsy with severe pallido-nigro-luysial degeneration and axonal dystrophy
    Zeshan Ahmed
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Brain 131:460-72. 2008

Detail Information

Publications17

  1. pmc Progranulin in frontotemporal lobar degeneration and neuroinflammation
    Zeshan Ahmed
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    J Neuroinflammation 4:7. 2007
    ....
  2. doi Incidental Lewy body disease and preclinical Parkinson disease
    Anthony DelleDonne
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Arch Neurol 65:1074-80. 2008
    ..The significance of Lewy bodies detected at autopsy in the brains of clinically normal individuals is uncertain but may represent preclinical Parkinson disease (PD)...
  3. pmc TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
    Catalina Amador-Ortiz
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Ann Neurol 61:435-45. 2007
    ....
  4. pmc Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL FL 32224, USA
    Hum Mol Genet 17:3631-42. 2008
    ..Translational regulation by miRNAs may represent a common mechanism underlying complex neurodegenerative disorders...
  5. doi Neuropathology of variants of progressive supranuclear palsy
    Dennis W Dickson
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    Curr Opin Neurol 23:394-400. 2010
    ..This review highlights the range of clinical and pathologic presentations of PSP and its variants...
  6. pmc Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging
    Zeshan Ahmed
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
    Am J Pathol 177:311-24. 2010
    ..Our data suggests that PGRN plays a key role in maintaining neuronal function during aging and supports the notion that PGRN is a trophic factor essential for long-term neuronal survival...
  7. doi Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease
    Dennis W Dickson
    Neuropathology Laboratory, Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Acta Neuropathol 115:437-44. 2008
    ..The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology...
  8. pmc Beta-amyloid burden is not associated with rates of brain atrophy
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Ann Neurol 63:204-12. 2008
    ..To test the hypothesis that beta-amyloid (Abeta) burden is associated with rates of brain atrophy...
  9. pmc Corticobasal degeneration with olivopontocerebellar atrophy and TDP-43 pathology: an unusual clinicopathologic variant of CBD
    Naomi Kouri
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Acta Neuropathol 125:741-52. 2013
    ..These results suggest that CBD-OPCA is a distinct clinicopathologic variant of CBD with olivopontocerebellar TDP-43 pathology...
  10. ncbi Clinical and neuropathologic features of progressive supranuclear palsy with severe pallido-nigro-luysial degeneration and axonal dystrophy
    Zeshan Ahmed
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Brain 131:460-72. 2008
    ..These clinical and pathological findings suggest that PSP-PNLA should be considered a variant of PSP...
  11. ncbi Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry
    Zeshan Ahmed
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
    J Histochem Cytochem 55:687-700. 2007
    ..Because both coronin-1a and IBA-1 are actin-binding proteins that play a role in rearrangement of the membrane cytoskeleton, it suggests that these proteins are critical to dynamic properties of microglia...
  12. ncbi Frontotemporal dementia and Parkinsonism linked to chromosome 17 with the N279K tau mutation
    Jerzy Slowinski
    Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA
    Neuropathology 27:73-80. 2007
    ..FTDP-17 should be suspected in patients with a history of familial parkinsonism combined with behavioral and cognitive changes, onset before age 65 years and an aggressive clinical course...
  13. ncbi Single-dose intracerebroventricular administration of galactocerebrosidase improves survival in a mouse model of globoid cell leukodystrophy
    Wing C Lee
    Mayo Clinic College of Medicine, 4500 San Pablo Rd, Jacksonville, Florida 32224, USA
    FASEB J 21:2520-7. 2007
    ..These results indicate that even a single i.c.v. administration of the recombinant enzyme can have significant clinical impact and suggests that other lysosomal storage disorders with significant CNS involvement may similarly benefit...
  14. pmc Hippocampal sclerosis dementia differs from hippocampal sclerosis in frontal lobe degeneration
    Catalina Amador-Ortiz
    Department of Pathology Neuropathology and Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Acta Neuropathol 113:245-52. 2007
    ..Corpora amylacea tended to be more frequent in HSD than in FTLD-U, but there was no difference in frequency of argyrophilic grains...
  15. ncbi Lewy bodies in progressive supranuclear palsy represent an independent disease process
    Hirotake Uchikado
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Neuropathol Exp Neurol 65:387-95. 2006
    ....
  16. ncbi Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    J Neuropathol Exp Neurol 66:142-51. 2007
    ..On the other hand, there is no histopathologic feature or combination of features that is pathognomonic. Neuronal intranuclear inclusions are virtually always present, but they can be detected in PGRN(-) cases...
  17. doi Frontotemporal lobar degeneration with ubiquitin-positive, but TDP-43-negative inclusions
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Acta Neuropathol 116:159-67. 2008
    ..The findings raise the possibly of an as yet identified protein that may play a pathogenic role in tau-negative FTLD...