J Eric Ahlskog

Summary

Affiliation: Mayo Clinic
Country: USA

Publications

  1. ncbi request reprint Benign tremulous parkinsonism
    Keith A Josephs
    Division of Movement Disorders, Department of Neurology, Mayo Clinic, Rochester, Minn, USA
    Arch Neurol 63:354-7. 2006
  2. ncbi request reprint Early-onset familial parkinsonism due to POLG mutations
    Guido Davidzon
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Ann Neurol 59:859-62. 2006
  3. doi request reprint Pathological behaviors provoked by dopamine agonist therapy of Parkinson's disease
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, United States
    Physiol Behav 104:168-72. 2011
  4. pmc Cheaper, simpler, and better: tips for treating seniors with Parkinson disease
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 86:1211-6. 2011
  5. pmc Rasagiline, Parkinson neuroprotection, and delayed-start trials: still no satisfaction?
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 74:1143-8. 2010
  6. doi request reprint Pearls: parkinsonism
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Semin Neurol 30:10-4. 2010
  7. pmc Does vigorous exercise have a neuroprotective effect in Parkinson disease?
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 77:288-94. 2011
  8. ncbi request reprint Beating a dead horse: dopamine and Parkinson disease
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 69:1701-11. 2007
  9. pmc Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 86:876-84. 2011
  10. pmc Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson's disease
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 15:721-7. 2009

Detail Information

Publications89

  1. ncbi request reprint Benign tremulous parkinsonism
    Keith A Josephs
    Division of Movement Disorders, Department of Neurology, Mayo Clinic, Rochester, Minn, USA
    Arch Neurol 63:354-7. 2006
    ..Benign tremulous parkinsonism has never been precisely defined nor has the long-term course been studied...
  2. ncbi request reprint Early-onset familial parkinsonism due to POLG mutations
    Guido Davidzon
    Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA
    Ann Neurol 59:859-62. 2006
    ..To define the molecular etiology of early-onset parkinsonism and peripheral neuropathy...
  3. doi request reprint Pathological behaviors provoked by dopamine agonist therapy of Parkinson's disease
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, United States
    Physiol Behav 104:168-72. 2011
    ..This experience points to the dopamine D3 receptor as a potential therapeutic target for gambling, sex or other addictions occurring spontaneously in the general population...
  4. pmc Cheaper, simpler, and better: tips for treating seniors with Parkinson disease
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 86:1211-6. 2011
    ..A dozen tips for optimizing treatment of Parkinson disease are discussed herein...
  5. pmc Rasagiline, Parkinson neuroprotection, and delayed-start trials: still no satisfaction?
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 74:1143-8. 2010
    ..These studies further illustrate the difficulty in documenting a disease-modifying effect when considering a PD drug with symptomatic benefit...
  6. doi request reprint Pearls: parkinsonism
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
    Semin Neurol 30:10-4. 2010
    ..g., fatigue, depression, insomnia, pain, stiffness). Many subtle clues provided by history and examination are crucial, with laboratory and imaging being primarily supportive...
  7. pmc Does vigorous exercise have a neuroprotective effect in Parkinson disease?
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 77:288-94. 2011
    ..3) Levodopa and other forms of dopamine replenishment therapy should be utilized to achieve the maximum capability and motivation for patients to maintain fitness...
  8. ncbi request reprint Beating a dead horse: dopamine and Parkinson disease
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 69:1701-11. 2007
    ..Finally, the benefits from transplantation surgeries aimed at restoring dopaminergic neurotransmission will be limited because later-stage PD disability comes from nondopaminergic substrates. Scale...
  9. pmc Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 86:876-84. 2011
    ..Exercise should not be overlooked as an important therapeutic strategy...
  10. pmc Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson's disease
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 15:721-7. 2009
    ..Although sporadic PD is also associated with mitochondrial dysfunction, Lewy neurodegeneration represents a more pervasive disorder with perhaps a second, or different primary mechanism...
  11. ncbi request reprint Parkinson's disease: is the initial treatment established?
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Curr Neurol Neurosci Rep 3:289-95. 2003
    ..Carbidopa/levodopa, pramipexole, and ropinirole are all appropriate first choices in the treatment of PD...
  12. ncbi request reprint Challenging conventional wisdom: the etiologic role of dopamine oxidative stress in Parkinson's disease
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 20:271-82. 2005
    ..Although the clinical and therapeutic importance of the nigrostriatal dopaminergic system is undeniable, PD neuropathology is much more widespread...
  13. ncbi request reprint Slowing Parkinson's disease progression: recent dopamine agonist trials
    J Eric Ahlskog
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 60:381-9. 2003
    ..To date, there is no compelling evidence favoring dopamine agonists over levodopa; either is an appropriate choice for initial treatment of PD...
  14. ncbi request reprint Risk of cognitive impairment or dementia in relatives of patients with Parkinson disease
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 64:1458-64. 2007
    ..The evidence for increased risk of dementia in relatives of patients with Parkinson disease (PD) remains conflicting...
  15. doi request reprint Neuropathology of non-motor features of Parkinson disease
    Dennis W Dickson
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Parkinsonism Relat Disord 15:S1-5. 2009
    ....
  16. ncbi request reprint Risk of cancer after the diagnosis of Parkinson's disease: a historical cohort study
    Alexis Elbaz
    Departments of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Mov Disord 20:719-25. 2005
    ..Among PD patients, there was no relation between the risk of cancer and the cumulative dose of levodopa received or the use of other PD medications...
  17. ncbi request reprint Increased risk of essential tremor in first-degree relatives of patients with Parkinson's disease
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mov Disord 22:1607-14. 2007
    ..These findings suggest that PD and ET may share familial susceptibility factors...
  18. doi request reprint Incidence of dementia with Lewy bodies and Parkinson disease dementia
    Rodolfo Savica
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota2Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota
    JAMA Neurol 70:1396-402. 2013
    ..Epidemiologic data on dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD) remain limited in the United States and worldwide. These data are essential to guide research and clinical or public health interventions...
  19. ncbi request reprint Complex segregation analysis of Parkinson's disease: The Mayo Clinic Family Study
    Shannon K McDonnell
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Neurol 59:788-95. 2006
    ..To conduct complex segregation analyses of Parkinson's disease (PD)...
  20. pmc Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease
    Roberta Frigerio
    Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55902, USA
    Arch Neurol 66:1114-9. 2009
    ..To explore whether associations of potential risk factors for incidental Lewy body disease (iLBD) are similar to those for Parkinson disease (PD)...
  21. doi request reprint Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease
    Hiroshige Fujishiro
    Department of Pathology Neuropathology, Mayo Clinic, Jacksonville, Florida, USA
    Mov Disord 23:1085-92. 2008
    ..42, P < 0.05). This study demonstrates that cardiac sympathetic degeneration and alpha-synuclein pathology is present in presymptomatic phase of PD, and that both increase with disease duration and severity...
  22. doi request reprint Psychogenic tremor: long-term prognosis in patients with electrophysiologically confirmed disease
    Andrew McKeon
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Mov Disord 24:72-6. 2009
    ..037). Physiologically-confirmed psychogenic tremor carries a poor prognosis, with unremitting or worse tremor persisting 3-years after diagnosis in most...
  23. doi request reprint Incidental Lewy body disease and preclinical Parkinson disease
    Anthony DelleDonne
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Arch Neurol 65:1074-80. 2008
    ..The significance of Lewy bodies detected at autopsy in the brains of clinically normal individuals is uncertain but may represent preclinical Parkinson disease (PD)...
  24. ncbi request reprint Number of children and risk of Parkinson's disease
    Roberta Frigerio
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mov Disord 22:632-9. 2007
    ..The independent replication in two distinct populations and using different epidemiologic study designs may suggest a link between the number of children and PD restricted to men...
  25. ncbi request reprint Chemical exposures and Parkinson's disease: a population-based case-control study
    Roberta Frigerio
    Division of Epidemiology, Department of Health Sciences Research, Mayo College of Medicine, Rochester, Minnesota 55905, USA
    Mov Disord 21:1688-92. 2006
    ..This population-based study suggests a link between pesticides use and PD that is restricted to men. Pesticides may interact with other genetic or nongenetic factors that are different in men and women...
  26. pmc Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies?
    Roberta Frigerio
    Department of Neurology, Mayo Clinic, Rochester, MN, United States
    Neurobiol Aging 32:857-63. 2011
    ....
  27. ncbi request reprint Whole-body tremulousness: isolated generalized polymyoclonus
    Andrew McKeon
    Department of Neurology, Gonda 8 South, Mayo Clinic, 200 First St SW, Rochester, MN 55902, USA
    Arch Neurol 64:1318-22. 2007
    ..Acquired generalized repetitive myoclonus may be mistaken for tremor. Distinguishing myoclonus has etiologic and therapeutic implications...
  28. ncbi request reprint The Mayo Clinic family study of Parkinson's disease: study design, instruments, and sample characteristics
    Walter A Rocca
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minn, USA
    Neuroepidemiology 24:151-67. 2005
    ..Finally, we studied a group of 625 spouses of either cases or controls. Relatives with PD or other neurodegenerative diseases were ascertained using the family study method...
  29. doi request reprint Parkinsonism and dropped head: dystonia, myopathy or both?
    Rodolfo Savica
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 18:30-4. 2012
    ..The substrate for DHS is controversial, with some concluding that the cause is myopathic and others, exclusively dystonic. We report our clinical series of DHS arising in the setting of parkinsonism...
  30. doi request reprint Deep brain stimulation in benign tremulous parkinsonism
    Rodolfo Savica
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 68:1033-6. 2011
    ..This disorder has an uncertain pathophysiologic relationship to idiopathic Parkinson disease. Deep brain stimulation (DBS) should be efficacious for this condition, but there is no previously published experience...
  31. ncbi request reprint Orthostatic myoclonus: a contributor to gait decline in selected elderly
    Graham A Glass
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neurology 68:1826-30. 2007
    ..We encountered 15 patients with a newly recognized clinical phenomenon that we term orthostatic myoclonus. We conducted a retrospective chart review to better understand the clinical context and importance of this phenomenon...
  32. pmc Anxious personality predicts an increased risk of Parkinson's disease
    James H Bower
    Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 25:2105-13. 2010
    ..Our long-term historical cohort study suggests that an anxious personality trait may predict an increased risk of PD developing many years later...
  33. pmc Limb immobilization and corticobasal syndrome
    Jonathan Graff-Radford
    Department of Neurology, Behavioral Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 18:1097-9. 2012
    ..Recently, we evaluated two patients with corticobasal syndrome (CBS) who reported symptom onset after limb immobilization. Our objective was to investigate the association between trauma, immobilization and CBS...
  34. pmc Metabolic markers or conditions preceding Parkinson's disease: a case-control study
    Rodolfo Savica
    Department of Neurology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Mov Disord 27:974-9. 2012
    ..77; 95% CI, 0.37-1.57; P = .47). Our study, based on historical information from a records-linkage system, does not support an association between BMI, cholesterol level, hypertension, or diabetes mellitus with later development of PD...
  35. ncbi request reprint Levodopa-associated dyskinesia risk among Parkinson disease patients in Olmsted County, Minnesota, 1976-1990
    Jay A Van Gerpen
    Department of Neurology, Ochsner Clinic, New Orleans, LA, USA
    Arch Neurol 63:205-9. 2006
    ..The threat of levodopa-induced dyskinesias often influences early treatment decisions in those with Parkinson disease...
  36. pmc Rapidly progressive neurodegenerative dementias
    Keith A Josephs
    Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 66:201-7. 2009
    ..Neurodegenerative dementias are typically characterized by an insidious onset and a relatively slowly progressive course. Less common are patients with a rapidly progressive course to death...
  37. ncbi request reprint Familial aggregation of Parkinson's disease: The Mayo Clinic family study
    Walter A Rocca
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Ann Neurol 56:495-502. 2004
    ..62; 95% confidence interval, 1.66-4.15), whereas relatives of probands with later onset had no increased risk. The relative risk decreased when the incidence of all types of parkinsonism was considered...
  38. ncbi request reprint Interaction of alpha-synuclein and tau genotypes in Parkinson's disease
    Catherine E Mamah
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Ann Neurol 57:439-43. 2005
    ..These findings are consistent with in vitro experiments that revealed tau-mediated fibrillization of alpha-synuclein protein at low concentrations (dose threshold effect)...
  39. pmc Incidence and pathology of synucleinopathies and tauopathies related to parkinsonism
    Rodolfo Savica
    Division of Epidemiology, Department of Health Science Research, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    JAMA Neurol 70:859-66. 2013
    ..The frequency and distribution of synucleinopathies and tauopathies manifesting with parkinsonism in the general population are poorly understood, thus affecting health care planning and research...
  40. doi request reprint Risk factors for dementia with Lewy bodies: a case-control study
    Brendon P Boot
    Department of Neurology, Mayo Clinic College of Medicine, Rochester MN, Scottsdale, AZ, USA
    Neurology 81:833-40. 2013
    ..To determine the risk factors associated with dementia with Lewy bodies (DLB)...
  41. doi request reprint Stiff-man syndrome and variants: clinical course, treatments, and outcomes
    Andrew McKeon
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 69:230-8. 2012
    ..Little information is available about the incidence of stiff-man syndrome (SMS) (the classic form or its variants) or about long-term treatment responses and outcomes...
  42. ncbi request reprint The Mayo Clinic cohort study of personality and aging: design and sampling, reliability and validity of instruments, and baseline description
    Walter A Rocca
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Neuroepidemiology 26:119-29. 2006
    ..68, p < 0.0001). This newly established historical cohort study provides opportunities to test hypotheses regarding the link between personality and aging, aging-related diseases, and overall mortality...
  43. ncbi request reprint UCHL1 is associated with Parkinson's disease: a case-unaffected sibling and case-unrelated control study
    Maurizio Facheris
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurosci Lett 381:131-4. 2005
    ..Analyses confirmed a significant inverse association of the UCHL1 S18Y polymorphism with PD overall (OR=0.18, 95% CI=0.05-0.64, p=0.002, recessive model) and in several strata...
  44. ncbi request reprint Levodopa-dyskinesia incidence by age of Parkinson's disease onset
    Neeraj Kumar
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 20:342-4. 2005
    ..With onset from 40 to 59 years of age, the incidence was higher at 50%. These incidence data may overestimate the functional importance, because patients with minimal or reversible dyskinesias were counted...
  45. ncbi request reprint Pathological hypersexuality predominantly linked to adjuvant dopamine agonist therapy in Parkinson's disease and multiple system atrophy
    Kevin J Klos
    Department of Neurology, Division of Movement Disorders, Mayo Clinic, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 11:381-6. 2005
    ..A systematic literature review of pathological hypersexuality in PD revealed similar medication histories; combining these cases with our series, 26 of 29 patients (90%) were on adjuvant dopamine agonists...
  46. pmc Beyond Parkinson disease: amyotrophic lateral sclerosis and the axon guidance pathway
    Timothy G Lesnick
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
    PLoS ONE 3:e1449. 2008
    ..We also demonstrated that several axon guidance pathway genes represented by SNPs within our final models were differentially expressed in PD...
  47. ncbi request reprint Acquired hypocupremia after gastric surgery
    Neeraj Kumar
    Department of Neuroogy, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 2:1074-9. 2004
    ..Acquired copper deficiency is not a well-recognized complication of gastric surgery. In Menke's disease a defect in enterocyte transport of absorbed copper results in increased copper content in the duodenal mucosa and hypocupremia...
  48. ncbi request reprint Survival study of Parkinson disease in Olmsted County, Minnesota
    Alexis Elbaz
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Arch Neurol 60:91-6. 2003
    ..To compare survival in incident cases of Parkinson disease (PD) with survival in subjects free of PD from the general population...
  49. doi request reprint When does Parkinson disease start?
    Rodolfo Savica
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 67:798-801. 2010
    ..Recognition of a nonmotor preclinical phase spanning 20 or more years should guide the search for predictive biomarkers and the identification of risk or protective factors for Parkinson disease...
  50. pmc A genomic pathway approach to a complex disease: axon guidance and Parkinson disease
    Timothy G Lesnick
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS Genet 3:e98. 2007
    ..This genomic pathway approach may also offer insights into other complex diseases such as Alzheimer disease, diabetes mellitus, nicotine and alcohol dependence, and several cancers...
  51. pmc Autoimmune chorea in adults
    Orna O'Toole
    Department of Neurology, Mayo Clinic, College of Medicine, Rochester, MN, USA
    Neurology 80:1133-44. 2013
    ..To determine the characteristics of adult-onset autoimmune chorea, and compare paraneoplastic and idiopathic subgroups...
  52. doi request reprint Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility?
    Joanna M Biernacka
    Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55095, USA
    Parkinsonism Relat Disord 17:730-6. 2011
    ..Here we investigated the association of PD with interactions between variants of these genes...
  53. pmc Autopsy confirmed multiple system atrophy cases: Mayo experience and role of autonomic function tests
    Valeria Iodice
    Neurovascular and Autonomic Medicine Unit, Imperial College London, UK
    J Neurol Neurosurg Psychiatry 83:453-9. 2012
    ..Published autopsy confirmed cases have provided reasonable neurological characterisation but have lacked adequate autonomic function testing...
  54. doi request reprint The spectrum of disorders presenting as adult-onset focal lower extremity dystonia
    Andrew McKeon
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Parkinsonism Relat Disord 14:613-9. 2008
    ..Uncommonly, adult-onset dystonia is confined to one lower extremity. We sought to characterize the clinical spectrum associated with the presenting phenotype of lower limb dystonia including foot torsion...
  55. pmc Prospective differentiation of multiple system atrophy from Parkinson disease, with and without autonomic failure
    Axel Lipp
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 66:742-50. 2009
    ....
  56. doi request reprint Reversible extralimbic paraneoplastic encephalopathies with large abnormalities on magnetic resonance images
    Andrew McKeon
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 66:268-71. 2009
    ..To describe reversible extralimbic paraneoplastic encephalopathies with large, lobar lesions on magnetic resonance imaging (MRI)...
  57. doi request reprint Dopamine agonists and Othello's syndrome
    Jonathan Graff-Radford
    Department of Neurology, Mayo Clinic, 200 1st Street SW Rochester, MN 55905, USA
    Parkinsonism Relat Disord 16:680-2. 2010
    ..Othello's syndrome (OS) is a delusion of infidelity. We describe seven cases of OS in Parkinson's disease (iPD) patients using dopamine agonists...
  58. ncbi request reprint Increased risk of depressive and anxiety disorders in relatives of patients with Parkinson disease
    Gennarina Arabia
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Arch Gen Psychiatry 64:1385-92. 2007
    ..Relatives of patients with Parkinson disease (PD) have an increased risk of PD and other neurologic disorders; however, their risk of psychiatric disorders remains uncertain...
  59. pmc Risk factors for Parkinson's disease may differ in men and women: an exploratory study
    Rodolfo Savica
    Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Horm Behav 63:308-14. 2013
    ..By contrast, in women, anemia was the most important factor and we observed a suggestive synergistic interaction between anemia and higher education. Risk factors for PD and their interactions may differ in men and women...
  60. doi request reprint Genetic susceptibility loci, environmental exposures, and Parkinson's disease: a case-control study of gene-environment interactions
    Sun Ju Chung
    Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Parkinsonism Relat Disord 19:595-9. 2013
    ..Here we investigated the interactions between SNPs in those three susceptibility genes and environmental exposures (pesticides application, tobacco smoking, coffee drinking, and alcohol drinking) also associated with PD susceptibility...
  61. ncbi request reprint Nonfatal cancer preceding Parkinson's disease: a case-control study
    Alexis Elbaz
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Epidemiology 13:157-64. 2002
    ..We conducted a population-based case-control study to investigate the association of Parkinson's disease (PD) with preceding nonfatal cancer...
  62. pmc Frequency of new-onset pathologic compulsive gambling or hypersexuality after drug treatment of idiopathic Parkinson disease
    J Michael Bostwick
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:310-6. 2009
    ..To determine the frequency of new-onset compulsive gambling or hypersexuality among regional patients with Parkinson disease (PD), ascertaining the relationship of these behaviors to PD drug use...
  63. doi request reprint Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease
    Dennis W Dickson
    Neuropathology Laboratory, Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Acta Neuropathol 115:437-44. 2008
    ..The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology...
  64. ncbi request reprint Clinical features and survival of 3R and 4R tauopathies presenting as behavioral variant frontotemporal dementia
    William T Hu
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Alzheimer Dis Assoc Disord 21:S39-43. 2007
    ..In summary, survival in 4R tauopathies seemed independent of the presenting clinical phenotype, and there may be subtle clinical differences between bv-FTD patients with 3R and 4R tauopathies...
  65. ncbi request reprint Copper deficiency myelopathy produces a clinical picture like subacute combined degeneration
    Neeraj Kumar
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 63:33-9. 2004
    ..Copper deficiency in ruminants is known to cause an ataxic myelopathy. Copper deficiency as a cause of progressive myelopathy in adults is underrecognized...
  66. pmc Focal brain atrophy in gastric bypass patients with cognitive complaints
    Jonathan Graff-Radford
    Department of Neurology Behavioral Neurology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    J Clin Neurosci 18:1671-6. 2011
    ..Patients with cognitive complaints after gastric bypass surgery may have focal thalamic brain atrophy that could result in cognitive impairment...
  67. pmc High school football and risk of neurodegeneration: a community-based study
    Rodolfo Savica
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 87:335-40. 2012
    ..To assess whether high school football played between 1946 and 1956, when headgear was less protective than today, was associated with development of neurodegenerative diseases later in life...
  68. ncbi request reprint Pathological gambling caused by drugs used to treat Parkinson disease
    M Leann Dodd
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 62:1377-81. 2005
    ..Pathological gambling is a rare potential complication related to treatment of Parkinson disease (PD). However, the etiology of this behavior is poorly understood...
  69. ncbi request reprint Neurologic spectrum of chronic liver failure and basal ganglia T1 hyperintensity on magnetic resonance imaging: probable manganese neurotoxicity
    Kevin J Klos
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 62:1385-90. 2005
    ..The magnetic resonance imaging signal changes are characteristic of manganese accumulation, which has been neuropathologically confirmed. Manganese neurotoxicity may result in additional neurologic findings besides parkinsonism...
  70. doi request reprint Psychogenic tremor occurring after deep brain stimulation surgery for essential tremor
    Andrew McKeon
    Department of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA
    Neurology 70:1498-9. 2008
  71. ncbi request reprint Imaging features of copper deficiency myelopathy: a study of 25 cases
    Neeraj Kumar
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neuroradiology 48:78-83. 2006
    ..Neuroradiologists should consider this possibility when a long segment of symmetric dorsal spinal cord T2-hyperintensity is identified...
  72. ncbi request reprint Risk tables for parkinsonism and Parkinson's disease
    Alexis Elbaz
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    J Clin Epidemiol 55:25-31. 2002
    ..Lifetime risk estimates are useful in clinical practice, epidemiologic research, and public health...
  73. ncbi request reprint "Myelodysplasia," myeloneuropathy, and copper deficiency
    Neeraj Kumar
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Mayo Clin Proc 80:943-6. 2005
    ..The hematologic picture can resemble sideroblastic anemia or myelodysplastic syndrome. Hyperzincemia can be an accompanying abnormality even without exogenous zinc ingestion. The reason for the copper deficiency may not be evident...
  74. ncbi request reprint Myelopathy due to copper deficiency
    Neeraj Kumar
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 61:273-4. 2003
  75. pmc Normal pressure hydrocephalus: how often does the diagnosis hold water?
    Bryan T Klassen
    Department of Neurology, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 77:1119-25. 2011
    ..To determine our community's incidence of clinically suspected normal pressure hydrocephalus (NPH), the rate of shunting for NPH, and short- and long-term outcomes of shunting...
  76. ncbi request reprint Myelopathy due to copper deficiency following gastrointestinal surgery
    Neeraj Kumar
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    Arch Neurol 60:1782-5. 2003
    ..The neurological consequences of acquired copper deficiency in humans are not well described...
  77. ncbi request reprint Chorea as a manifestation of spontaneous CSF leak
    Bahram Mokri
    Department of Neurology, E8A, Mayo Clinic College of Medicine, 200 First Street S W, Rochester, MN 55905, USA
    Neurology 67:1490-1. 2006
    ..CSF pressure was low. CT myelography documented CSF leak at the cervicothoracic junction. Targeted epidural blood patch led to resolution of symptoms, including complete disappearance of choreiform movements...
  78. ncbi request reprint Syndrome resembling PSP after surgical repair of ascending aorta dissection or aneurysm
    Bahram Mokri
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 62:971-3. 2004
    ..The latent and progressive phase closely resembled a progressive supranuclear palsy phenotype. The disorder may prove to be self-limiting but leaves the patients with considerable neurologic deficits...
  79. ncbi request reprint Copper deficiency myelopathy
    Neeraj Kumar
    Department of Neurology, Mayo Clinic, Mayo Foundation, Rochester, Minn, USA
    Arch Neurol 61:762-6. 2004
    ..Myelopathy due to acquired copper deficiency is not a well-recognized entity in humans, although myelopathy due to copper deficiency is well documented in some animal species...
  80. ncbi request reprint Selective peripheral denervation for the treatment of intractable spasmodic torticollis: experience with 168 patients at the Mayo Clinic
    Aaron A Cohen-Gadol
    Department of Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    J Neurosurg 98:1247-54. 2003
    ..The authors assessed preoperative factors to determine which, if any, correlated with outcomes in patients with torticollis who had undergone this procedure...
  81. ncbi request reprint Respiratory insufficiency as the primary presenting symptom of multiple-system atrophy
    Graham A Glass
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Neurol 63:978-81. 2006
    ..We have encountered cases where these were presenting symptoms, with the diagnosis of MSA being initially unrecognized...
  82. ncbi request reprint Glutamic acid decarboxylase autoimmunity with brainstem, extrapyramidal, and spinal cord dysfunction
    Sean J Pittock
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 81:1207-14. 2006
    ..To describe novel neurological manifestations associated with glutamic acid decarboxylase (GAD65) autoimmunity...
  83. ncbi request reprint Antiphospholipid antibody-associated chorea
    Nicole M Orzechowski
    Division of Rheumatology, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Rheumatol 35:2165-70. 2008
    ..To describe the clinical features, treatment, and outcomes of patients with antiphospholipid antibody (aPL)-associated chorea...
  84. ncbi request reprint Neuropathology of primary restless leg syndrome: absence of specific tau- and alpha-synuclein pathology
    Sean J Pittock
    Department of Neurology Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 19:695-9. 2004
    ..The absence of diagnostic microscopic brain or spinal cord pathology suggests that the pathologic substrate may be neurochemical or receptor based...
  85. ncbi request reprint MRI correlates of alien leg-like phenomenon in corticobasal degeneration
    William T Hu
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Mov Disord 20:870-3. 2005
    ..The MRI brain scan in both had unique focal abnormalities in the corresponding leg area of the homunculus that may be the substrate for the alien limb features...
  86. ncbi request reprint Brain imaging to assess the effects of dopamine agonists on progression of Parkinson disease
    J Eric Ahlskog
    JAMA 288:311; author reply 312-3. 2002
  87. ncbi request reprint Myelopolyneuropathy due to copper deficiency or zinc excess?
    Neeraj Kumar
    Arch Neurol 61:604-5; author reply 605. 2004
  88. ncbi request reprint Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response
    Hulya Apaydin
    Department of Neurology, Istambul University, Cerrahpasa Medical School, Turkey
    Arch Neurol 59:102-12. 2002
    ..To investigate the neuropathologic substrate for dementia occurring late in Parkinson disease (PD)...
  89. ncbi request reprint I can't get no satisfaction: still no neuroprotection for Parkinson disease
    J Eric Ahlskog
    Neurology 69:1476-7. 2007