Genomes and Genes
Organization: Mayo Clinic
- Hemorrhagic colitis as a presenting feature of Wegener granulomatosisQi Qian
Department of Medicine, Division of Nephrology, Rochester, MN 55905, USA
J Gastrointestin Liver Dis 19:445-7. 2010..This case represents the first known example of colitis as an initial presentation of WG without confounding etiologic factors. Hemorrhagic colitis, although uncommon, may be the major presenting feature of WG...
- New techniques for the quantification of fibromyalgia and myofascial painJeffrey R Basford
Department of Physical Medicine and Rehabilitation, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Curr Pain Headache Rep 13:376-8. 2009..This review focuses on myofascial pain with an emphasis on the growing capability of MRI, microanalytic techniques, and ultrasonography to assess, quantitate, and even visualize the characteristics of these stigmatic lesions...
- Robotic adnexectomy compared with laparoscopy for adnexal massJavier F Magrina
Department of Gynecology, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA
Obstet Gynecol 114:581-4. 2009..To evaluate whether the application of robotic technology in the performance of adnexectomy resulted in benefits for the patient when compared with patients operated by laparoscopy...
- In vivo toxicity studies of europium hydroxide nanorods in miceChitta Ranjan Patra
Department of Biochemistry and Molecular Biology, 200 First Street S W, Guggenheim 1321A, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, MN 55905, USA
Toxicol Appl Pharmacol 240:88-98. 2009..Histological examination of nanorod-treated vital organs (liver, kidney, spleen and lungs) showed no or only mild histological changes that indicate mild toxicity at the higher dose of nanorods...
- Quality: the Mayo Clinic approachStephen J Swensen
Department of Radiology, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA
Am J Med Qual 24:428-40. 2009..The Mayo Clinic experience has led to a greater understanding of the leadership commitment, organizational challenges, and the ..
- Stem cells and society: an undergraduate course exploring the intersections among science, religion, and lawChris Pierret
University of Missouri, Columbia, MO 65211, USA
CBE Life Sci Educ 8:79-87. 2009..In the Stem Cells and Society course, students are challenged to develop and clarify their own personal positions concerning embryonic stem cell research. These positions are grounded in science, religion or personal philosophy, and law...
- Immediate versus delayed zoledronic acid for prevention of bone loss in postmenopausal women with breast cancer starting letrozole after tamoxifen-N03CCStephanie L Hines
Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
Breast Cancer Res Treat 117:603-9. 2009..Patients in the upfront arm were slightly more likely to report limb edema, fatigue, fever, nausea and jaw osteonecrosis(1%). Upfront zoledronic acid prevents bone loss in postmenopausal women with BC starting letrozole after tamoxifen...
- Long-term effects of bilateral oophorectomy on brain aging: unanswered questions from the Mayo Clinic Cohort Study of Oophorectomy and AgingWalter A Rocca
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Womens Health (Lond Engl) 5:39-48. 2009In the Mayo Clinic Cohort Study of Oophorectomy and Aging, women who had both ovaries removed before reaching natural menopause experienced a long-term increased risk of parkinsonism, cognitive impairment or dementia, and depressive and ..
- Phase III randomized, placebo-controlled, double-blind trial of risedronate for the prevention of bone loss in premenopausal women undergoing chemotherapy for primary breast cancerStephanie L Hines
Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
J Clin Oncol 27:1047-53. 2009..Risedronate prevents bone loss in postmenopausal women. The purpose of this study was to determine whether risedronate prevents bone loss in premenopausal women undergoing chemotherapy for breast cancer...
- Endovenous ablation of the saphenous veinManju Kalra
Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
Perspect Vasc Surg Endovasc Ther 20:371-80. 2008....
- Mental illness in young adults who had strabismus as childrenBrian G Mohney
Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
Pediatrics 122:1033-8. 2008..We investigated the prevalence and types of psychiatric disorders diagnosed by early adulthood among patients who had common forms of strabismus as children...
- New generation of electro-anatomic mapping: full intracardiac ultrasound image integrationDouglas L Packer
Cardiac Translational Electrophysiology Laboratory, Saint Marys Hospital Complex, Mayo Clinic and Foundation, 2 416 Alfred Building, Rochester, MN 55902, USA
Europace 10:iii35-41. 2008....
- Assessment of functional effects of unclassified genetic variantsFergus J Couch
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
Hum Mutat 29:1314-26. 2008....
- Embolic protection devices in patients with renal artery stenosis with chronic renal insufficiency: a clinical studySanjay Misra
Department of Radiology, Mayo Clinic College of Medicine, 200 First Street Southwest, Alfred 6460, Rochester, MN 55902, USA
J Vasc Interv Radiol 19:1639-45. 2008..To present clinical outcomes with the use of embolic protection devices (EPDs) and renal artery stents in patients with chronic renal insufficiency (CRI) and renal artery stenosis (RAS)...
- Excess lead in the neural retina in age-related macular degenerationJay C Erie
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
Am J Ophthalmol 148:890-4. 2009..To measure lead and cadmium in retinal tissues of human donor eyes with and without age-related macular degeneration (AMD)...
- Proton beam radiotherapy versus three-dimensional conformal stereotactic body radiotherapy in primary peripheral, early-stage non-small-cell lung carcinoma: a comparative dosimetric analysisO Kenneth Macdonald
Department of Radiation Oncology, Mayo Clinic, 200 1st Street S W, Rochester, MN 55905, USA
Int J Radiat Oncol Biol Phys 75:950-8. 2009..We analyzed the dosimetric differences between PT and SBRT in treating primary peripheral early-stage non-small-cell lung cancer...
- Influence of endogenous angiotensin II on control of sympathetic nerve activity in human dehydrationJ A Rabbitts
Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA
J Physiol 587:5441-9. 2009..The sensitivity of baroreflex control of MSNA was unchanged during DEH compared to EUH. We conclude that endogenous increases in AngII during DEH contribute to DEH-associated sympathoexcitation...
- Flexible endoscopic management of Zenker diverticulum: the Mayo Clinic experienceDavid J Case
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA
Mayo Clin Proc 85:719-22. 2010..To describe the outcome of patients undergoing flexible endoscopic therapy for symptomatic Zenker diverticulum...
- Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunityInna G Ovsyannikova
Vaccine Research Group, Mayo Clinic, Rochester, Minnesota, United States of America
PLoS ONE 5:e11806. 2010..Apart from HLA, little is known about the effect of this extended genetic region on HLA haplotypic backgrounds as applied to immune responses...
- Prospective comparison of posterior fossa exploration and stereotactic radiosurgery dorsal root entry zone target as primary surgery for patients with idiopathic trigeminal neuralgiaBruce E Pollock
Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Neurosurgery 67:633-8; discussion 638-9. 2010..Trigeminal neuralgia (TN) is the most common facial pain syndrome, with an incidence of approximately 27 per 100,000 patient-years...
- Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiencySanjay Misra
Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Alfred 6460, Rochester, MN 55905, USA
J Vasc Interv Radiol 21:1255-61. 2010....
- Diagnostic accuracy of the TIMI risk score in patients with chest pain in the emergency department: a meta-analysisErik P Hess
Department of Emergency Medicine, Division of Emergency Medicine Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
CMAJ 182:1039-44. 2010..We sought to expand the clinical application of the TIMI risk score by assessing its prognostic accuracy in patients in the emergency department with potential acute coronary syndromes...
- Evaluation and management of pain in autosomal dominant polycystic kidney diseaseMarie C Hogan
Department of Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
Adv Chronic Kidney Dis 17:e1-e16. 2010..A small fraction of patients have disabling chronic pain. In this review, we discuss the etiologies of pain in ADPKD; review how ADPKD patients should be assessed; and discuss medical, surgical, and other management options...
- Caudate atrophy on MRI is a characteristic feature of FTLD-FUSK A Josephs
Department of Neurology Behavioral Neurology, Mayo Clinic, Rochester, MN 55905, USA
Eur J Neurol 17:969-75. 2010..We have observed severe caudate atrophy at autopsy in FTLD-FUS, and hence, we aimed to determine whether caudate atrophy on MRI is a feature that can distinguish FTLD-FUS from FTLD-TDP and FTLD-TAU...
- Cardiovascular pseudoneoplasmsDylan V Miller
Mayo Clinic, Rochester, MN 55901, USA
Arch Pathol Lab Med 134:362-8. 2010..Mass-forming reactive and pseudoneoplastic growths are less common, but recognizing and distinguishing these lesions from the neoplasms they resemble is critical to appropriate patient care...
- Stem cell transplantation in multiple myeloma: impact of response failure with thalidomide or lenalidomide inductionMorie A Gertz
Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
Blood 115:2348-53; quiz 2560. 2010..5 vs 30.4 months) and a shorter progression-free survival (22.1 vs 13.1 months; P < .001). Absence of a response to induction therapy with thalidomide or lenalidomide predicts a poorer outcome after high-dose therapy...
- Combination cytokine therapy inhibits tumor growth by generation of tumor-specific T-cell responses in a murine melanoma modelAmer N Kalaaji
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA
Cytokine 49:287-93. 2010..These results support potential clinical trials of the low-dose cytokine combination as adjuvant therapy for melanoma...
- Revised TN categorization for colon cancer based on national survival outcomes dataLeonard L Gunderson
Mayo Clinic Cancer Center Scottsdale, Radiation Oncology, 13400 East Shea Blvd, Scottsdale, AZ 85259, USA
J Clin Oncol 28:264-71. 2010..The AJCC Hindgut Taskforce sought population-based validation that depth of invasion and nodal status interact to affect survival...
- Beyond trastuzumab: small molecule tyrosine kinase inhibitors in HER-2-positive breast cancerVivek Roy
Mayo Clinic, Jacksonville, Florida 32224, USA
Oncologist 14:1061-9. 2009..In this article we summarize selected HER-2 TKIs approved for clinical use or in development for which clinical data are available...
- At the cutting edge of the impossible: a tribute to Vladimir P. DemikhovIgor E Konstantinov
Department of Cardiac Surgery, Royal Children s Hospital, Parkville, Victoria 3052, Australia
Tex Heart Inst J 36:453-8. 2009..Ironically, his transplantation of a dog's head drew more publicity than did his pioneering thoracic surgical accomplishments, and he became an easy target for criticism. An account of Demikhov's life and work is presented herein...
- Peroxisome proliferator-activated receptor gamma down-regulates follistatin in intestinal epithelial cells through SP1Brian M Necela
Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
J Biol Chem 283:29784-94. 2008..Collectively, our data indicate that repression of Sp1 transcriptional activity by PPARgamma is the underlying mechanism responsible for PPARgamma-mediated regulation of follistatin expression...
- Monitoring the reaction of carbachol with acetylcholinesterase by thioflavin T fluorescence and acetylthiocholine hydrolysisTerrone L Rosenberry
Mayo Clinic College of Medicine, Departments of Neuroscience and Pharmacology, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Chem Biol Interact 175:235-41. 2008..These fluorescence changes allow not only the monitoring of the course of the carbamoylation reaction but also the determination of carbachol affinities for the A- and P-sites...
- Automated polyp measurement with CT colonography: preliminary observations in a phantom colon modelJoel G Fletcher
Department of Radiology, Mayo Clinic, 200 First St SW, Mayo E 2, Rochester, MN 55905, USA
AJR Am J Roentgenol 188:945-52. 2007..The purpose of this study was to evaluate the accuracy and precision of polyp measurements obtained with an automated tool in a colon phantom containing polyps of multiple sizes, morphologic types, and locations...
- Journal reporting of medical errors: the wisdom of Solomon, the bravery of Achilles, and the foolishness of PanJoseph G Murphy
Section of Scientific Publications, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Chest 131:890-6. 2007..We propose a model for confidential error communication and describe US legislation designed to improve patient safety and establish nationwide programs for error disclosure and analysis...
- Meta-analyses in vaccinologyRobert M Jacobson
Vaccine Research Group, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905 0001, United States
Vaccine 25:3153-9. 2007....
- Diagnosis and treatment of neuromyelitis opticaDean M Wingerchuk
Mayo Clinic College of Medicine, Scottsdale, Arizona 85259, USA
Neurologist 13:2-11. 2007..Several clinical, laboratory, and neuroimaging characteristics may accurately distinguish NMO from MS early in the disease course...
- New humanized HLA-DR4-transgenic mice that mimic the sex bias of rheumatoid arthritisVeena Taneja
Mayo Clinic, Rochester, Minnesota 55905, USA
Arthritis Rheum 56:69-78. 2007..We used DRB1*0401-transgenic mice to understand the role of DR4 in susceptibility and sex bias in RA...
- Coated glass and vicryl microfibers as artificial axonsCharles L Howe
Department of Neuroscience and Neurology, Mayo Clinic College of Medicine, Rochester, Minn, USA
Cells Tissues Organs 183:180-94. 2006....
- The importance of base curve in the design of minus iseikonic lensesWilliam L Brown
Division of Optometry, Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
Optom Vis Sci 83:850-6. 2006..Steeper base curves are required to increase the optical "leverage" of increasing center thickness...
- Can complementary and alternative medicine clinical cancer research be successfully accomplished? The Mayo Clinic-North Central Cancer Treatment Group experienceDebra L Barton
Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Soc Integr Oncol 4:143-52. 2006..Trials using complementary therapies for both symptom management and cancer treatment done by the Mayo Clinic and the North Central Cancer Treatment Group are reviewed...
- Removal of pelvic leiomyomata and endometriosis five years after supracervical hysterectomyWesley S Hilger
Division of Gynecologic Surgery, Mayo Clinic, Scottsdale, AZ 85259, USA
Obstet Gynecol 108:772-4. 2006..The number of laparoscopic supracervical hysterectomies performed has increased, yet the benefits and consequences are not well understood...
- Treatment of the primary hyperoxalurias: a new chapterD Milliner
Mayo Clinic Hyperoxaluria Center, Rochester, Minnesota 55905, USA
Kidney Int 70:1198-200. 2006..Oxalobacter formigenes is a promising new therapy with potential to induce secretion of oxalate into the intestinal lumen, where it can be degraded by the bacteria...
- Two different perspectives in the management of pT3 and/or margin-positive prostate cancer after radical prostatectomyRichard Choo
Department of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA
BJU Int 98:773-6. 2006
- Advances in endoscopic imaging of Barrett's esophagusMichael B Wallace
Mayo Clinic, Jacksonville, FL 32224, USA
Gastroenterology 131:699-700. 2006
- Molecular mechanisms mediating inhibition of human large conductance Ca2+-activated K+ channels by high glucoseTong Lu
Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
Circ Res 99:607-16. 2006..This may represent an important fundamental mechanism that contributes to the impairment of vasodilation in diabetes...
- Effects of CT irradiation on implantable cardiac rhythm management devicesCynthia H McCollough
Department of Radiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
Radiology 243:766-74. 2007..To prospectively measure the response of a variety of models of implantable cardiac rhythm management devices (ICRMDs) to the radiation delivered by computed tomography (CT), for both maximum and typical dose levels...
- Prevalence and risk factors for gallbladder neoplasia in patients with primary sclerosing cholangitis: evidence for a metaplasia-dysplasia-carcinoma sequenceJason T Lewis
Division of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
Am J Surg Pathol 31:907-13. 2007..The strong correlation between gallbladder dysplasia/adenocarcinoma and bile duct dysplasia/CC supports the concept of a neoplastic "field effect" along the intrahepatic and extrahepatic biliary tract in PSC...
- Retrospective analysis of outcomes after stapedotomy with implantation of a self-crimping Nitinol stapes prosthesisAbraham J Sorom
Department of Otolaryngology Head and Neck Surgery, Mayo Clinic, Rochester, MN 55905, USA
Otolaryngol Head Neck Surg 137:65-9. 2007..To review hearing results after implantation of a self-crimping stapes prosthesis...
- Use of a palliative care order set to improve resident comfort with symptom management in palliative careB R Jarabek
Internal Medicine Residency Programme, Mayo Clinic, Rochester, MN 55905, USA
Palliat Med 22:343-9. 2008..0001), which significantly surpassed the 48% of second-year residents who reported being comfortable (P = 0.002). Introducing a palliative care order set improves resident comfort with symptom management in dying patients...
- A comprehensive approach to management of ventricular arrhythmiasFred Kusumoto
Department of Medicine, Mayo Clinic School of Medicine, Jacksonville, FL 32224, USA
Cardiol Clin 26:481-96, vii. 2008..A fourth case asks whether data from implantable cardioverter defibrillator (ICD) trials can be extrapolated to older patients, and the fifth case discusses management of recurrent ventricular arrhythmias in a patient with an ICD...
- One- and two-locus models for mapping rheumatoid arthritis-susceptibility genes on chromosome 6Daniel J Schaid
Division of Biostatistics, Harwick 7, Mayo Clinic, 200 First Street Southwest, Rochester, Minnesota 55905, USA
BMC Proc 1:S103. 2007..7-69.6 cM, providing evidence for a second rheumatoid arthritis susceptibility locus on chromosome 6...
- Strength, physical activity, and fasciculations in patients with ALSFarrah J Mateen
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
Amyotroph Lateral Scler 9:120-1. 2008..05) and limb atrophy (p>0.05). No prediction of disease duration could be made based on fasciculation frequency alone. Fasciculations therefore appear to have diagnostic, but not prognostic, utility in the care of people with ALS...
- Computer-assisted volumetric analysis compared with ABC/2 method for assessing warfarin-related intracranial hemorrhage volumesWilliam D Freeman
Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
Neurocrit Care 9:307-12. 2008..We compared 2 methods of measuring ICH volume in patients with warfarin-related ICH...
- Treatment of aggressive angiomyxoma with aromatase inhibitor prior to surgical resectionD L Giles
Department of Gynecologic Surgery, Mayo Clinic, Scottsdale, Arizona, USA
Int J Gynecol Cancer 18:375-9. 2008..We present the first case of a postmenopausal woman treated with an aromatase inhibitor to shrink the size of tumor prior to surgical resection...
- Genetic factors affecting the occurrence, clinical phenotype, and outcome of autoimmune hepatitisAlbert J Czaja
Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Clin Gastroenterol Hepatol 6:379-88. 2008..These lessons may be applicable to autoimmune disease in general...
- Liver disease in pregnancyJ Eileen Hay
Division of Gastroenterology and Hepatology, The Mayo Clinic, Rochester, MN, USA
Hepatology 47:1067-76. 2008..Early diagnosis and immediate delivery are essential for maternal and fetal survival...
- JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trialsA Pardanani
Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
Leukemia 22:23-30. 2008..for initial Phase I studies? Should JAK2V617F-negative MPD patients be included in the initial studies? What are the likely consequences of 'off-target' JAK3 and wild-type JAK2 inhibition? How should treatment responses be monitored?..
- Reoperation for sella haematoma after pituitary surgeryJohn L D Atkinson
Department of Neurological Surgery, Mayo Clinic, Rochester, MN 55905, USA
Clin Endocrinol (Oxf) 68:413-5. 2008..We retrospectively reviewed a large pituitary surgical series to determine the incidence and associated factors of this complication...
- Strong evidence of a genetic determinant for mammographic density, a major risk factor for breast cancerCeline M Vachon
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Cancer Res 67:8412-8. 2007..4 cM). The putative locus on chromosome 5p is likely to account for up to 22% of variation in MD. Hence, 1 or more of the 45 candidate genes in this region could explain a large proportion of MD and, potentially, breast cancer...
- Reduction of the false-positive rate in newborn screening by implementation of MS/MS-based second-tier tests: the Mayo Clinic experience (2004-2007)D Matern
Biochemical Genetics Laboratory, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Inherit Metab Dis 30:585-92. 2007..09%, a positive predictive value of 41%, and a positive detection rate of 1 affected case in 1672 babies screened...
- A plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms?G E Smith
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 69:133-9. 2007..To compare logistic and bilogistic models to describe the pattern of cognitive decline in the preclinical phase of Alzheimer disease (AD)...
- Left atrial volume predicts the risk of atrial fibrillation after cardiac surgery: a prospective studyMartin Osranek
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA
J Am Coll Cardiol 48:779-86. 2006..This study sought to identify preoperative predictors of postoperative atrial fibrillation (POAF) among patients undergoing cardiac surgery...
- Pharmacogenomics of Gastric Function & Weight in ObesityMichael Camilleri; Fiscal Year: 2007..It will also identify physiological and genetic factors that predict therapeutic success in the treatment of obesity with sibutramine. ..
- ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBSMichael Camilleri; Fiscal Year: 2007..abstract_text> ..
- ALPHA 2 ADRENERGIC CONTROL IN IRRITABLE BOWEL SYNDROMEMichael Camilleri; Fiscal Year: 2007..Candidate was recognized as Outstanding Mentor, Dept of Medicine, Mayo Clinic Rochester (Chair: Nicholas F. LaRusso, M.D.) in 2002. 2...
- ALPHA 2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBSMichael Camilleri; Fiscal Year: 2001....
- Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory FunctionsMICHAEL L CAMILLERI; Fiscal Year: 2010..The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
- Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory FunctionsMichael Camilleri; Fiscal Year: 2009..The studies will also provide further understanding of the potential of medications like medical marijuana on stomach function that may be relevant to appetite control. ..
- Pharmacogenomics of Gastric Function & Weight in ObesityMICHAEL L CAMILLERI; Fiscal Year: 2010....
- THE AGING GH AXIS IN POSTMENOPAUSAL WOMENJohannes Veldhuis; Fiscal Year: 2005..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
- ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXISJohannes Veldhuis; Fiscal Year: 2005....
- ACTIONS OF TESTOSTERONE ON THE AGING MALE GH AXISJohannes Veldhuis; Fiscal Year: 2007..g., for urological cancers) that markedly reduce male hormone concentrations. ..
- Novel Active Repressor Model of Human LDL-Receptor RegulationJohannes Veldhuis; Fiscal Year: 2007..If so, targeting this gene product could potentially shift cholesterol accumulation away from arteries toward the liver. This would represent a new treatment approach for patients with atherosclerotic disease. ..
- Age-Dependent Estrogen-Independent Mechanism of Hyposomatotropism in WomenJohannes D Veldhuis; Fiscal Year: 2010..Therefore, this proposal seeks to unravel fundamental mechanisms that control the production of the major trophic hormones GH and IGF-I, which maintain bone and muscle mass, reduce abdominal fat and enhance quality of life. ..
- Aging Systems in Geriatrics: the Male Gonadal AxisJohannes D Veldhuis; Fiscal Year: 2010..Why or how the decline occurs is not known. This grant studies mechanisms in the brain, pituitary (master) gland and testis (male gonad), which begin to fail in aging men under stress. ..
- Ensemble Control of ACTH Secretion: Impact of GenderJohannes D Veldhuis; Fiscal Year: 2010..The goal is to unveil new ways to detect, prevent and treat abnormal stress-adaptive responses in aging, illness and disease. ..
- Age-Dependent Estrogen-Independent Mechanism of Hyposomatotropism in WomenJohannes Veldhuis; Fiscal Year: 2007..Therefore, this proposal seeks to unravel fundamental mechanisms that control the production of the major trophic hormones GH and IGF-I, which maintain bone and muscle mass, reduce abdominal fat and enhance quality of life. ..
- Ensemble Control of ACTH Secretion: Impact of GenderJohannes Veldhuis; Fiscal Year: 2007..The goal is to unveil new ways to detect, prevent and treat abnormal stress-adaptive responses in aging, illness and disease. ..
- Ensemble Disruption of the GnRH-LH-Testosterone AxisJohannes Veldhuis; Fiscal Year: 2007..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
- Ensemble Control of ACTH Secretion: Impact of GenderJohannes Veldhuis; Fiscal Year: 2009..The goal is to unveil new ways to detect, prevent and treat abnormal stress-adaptive responses in aging, illness and disease. ..
- ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLESJohannes Veldhuis; Fiscal Year: 1990..Accordingly, these investigations are likely to contribute to new approaches to fertility regulation in the human, domestic animal or endangered wild species...
- ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLESJohannes Veldhuis; Fiscal Year: 1993..The preceding studies should contribute important new insights into and further developments in fertility regulation in man, domestic animals, and endangered wild species...
- ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLESJohannes Veldhuis; Fiscal Year: 2001....
- AGING GH AXIS IN POSTMENOPAUSAL WOMENJohannes Veldhuis; Fiscal Year: 2000..Such knowledge has significant clinical implications to rational estrogen-replacement strategies in older women with estrogen-deficiency states and physical frailty accompanied by relative hyposomatotropism. ..