Research Topics
| A ZietmanSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
The case for neoadjuvant androgen suppression before radiation therapyA L Zietman
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Mol Urol 4:203-8;discussion 215. 2000..It cannot be assumed that the same advantage will hold with brachytherapy...
Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trialAnthony L Zietman
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
JAMA 294:1233-9. 2005..Clinically localized prostate cancer is very prevalent among US men, but recurrence after treatment with conventional radiation therapy is common...
PSA bounces after neoadjuvant androgen deprivation and external beam radiation: impact on definitions of failureAnthony L Zietman
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 62:714-8. 2005..To determine the characteristics of prostate specific antigen (PSA) bounces after external beam radiation therapy (EBRT) with neoadjuvant androgen deprivation and their impact on definitions of biochemical failure...
Organ conservation in invasive bladder cancer by transurethral resection, chemotherapy and radiation: results of a urodynamic and quality of life study on long-term survivorsAnthony L Zietman
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox 302, Boston, MA 02114, USA
J Urol 170:1772-6. 2003..Concern exists about the function of the retained bladder after such therapy...
Active surveillance: a safe, low-cost prognostic test for prostate cancerAnthony Zietman
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
BJU Int 101:1059-60. 2008
A clinical approach to technology assessment: how do we and how should we choose the right treatment?Anthony Zietman
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Semin Radiat Oncol 22:11-7. 2012..We also discuss the role that independent bodies may have in determining whether or not a new device is not only safe but also adds to the medical landscape in a way that justifies its cost...
The future of radiation oncology: the evolution, diversification, and survival of the specialtyAnthony Zietman
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Semin Radiat Oncol 18:207-13. 2008..This article discusses these threats to the field and examines strategies by which we may evolve, diversify, and thrive...
Localized prostate cancer: brachytherapyAnthony L Zietman
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston 02114, USA
Curr Treat Options Oncol 3:429-36. 2002..Their use remains investigational. Therefore, prostate brachytherapy remains a reasonable option for men with early stage disease, but there remain unanswered questions regarding long-term efficacy and morbidity...
Neoadjuvant androgen suppression and external beam radiation therapyAnthony L Zietman
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
Front Radiat Ther Oncol 36:87-98. 2002
The Patterns of Care Survey of radiation therapy in localized prostate cancer: similarities between the practice nationally and in minority-rich areasA Zietman
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 50:75-80. 2001..This study was designed to determine whether the stage of presentation and the quality of radiation treatment delivered are comparable between Caucasian and minority patients nationally and within minority-rich areas...
Freedom from castration: an alternative end point for men with localized prostate cancer treated by external beam radiation therapyAnthony Zietman
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 53:1152-9. 2002..This study was designed to determine what proportion of men require subsequent ADT if their localized prostate cancer is first treated by radiation...
Randomized trial comparing conventional-dose with high-dose conformal radiation therapy in early-stage adenocarcinoma of the prostate: long-term results from proton radiation oncology group/american college of radiology 95-09Anthony L Zietman
Department of Radiation Oncology, Cox 3, Massachusetts General Hospital, Boston MA 02114, USA
J Clin Oncol 28:1106-11. 2010..This was achieved without an increase in grade >/= 3 late urinary or rectal morbidity...
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 21-2004. A 63-year-old man with metastatic prostate carcinoma refractory to hormone therapyDonald S Kaufman
Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital, USA
N Engl J Med 351:171-8. 2004
Long-term multi-institutional analysis of stage T1-T2 prostate cancer treated with radiotherapy in the PSA eraDeborah A Kuban
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Int J Radiat Oncol Biol Phys 57:915-28. 2003..To report the long-term outcome for patients with Stage T1-T2 adenocarcinoma of the prostate definitively irradiated in the prostate-specific antigen (PSA) era...
Radiation, chemotherapy and transurethral surgery: an organ-sparing alternative to the radical cystectomyAnthony L Zietman
Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
Front Radiat Ther Oncol 36:131-46. 2002
Changing trends in national practice for external beam radiotherapy for clinically localized prostate cancer: 1999 Patterns of Care survey for prostate cancerMichael J Zelefsky
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Int J Radiat Oncol Biol Phys 59:1053-61. 2004..To report changing trends in external beam radiotherapy (EBRT) delivery practice for clinically localized prostate cancer as determined from the 1999 survey from the American College of Radiology National Patterns of Care Study...
Nadir prostate-specific antigen within 12 months after radiotherapy predicts biochemical and distant failureMichael E Ray
Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0010, USA
Urology 68:1257-62. 2006..To determine whether nadir prostate-specific antigen (PSA) levels within 12 months (nadir PSA12) after completion of radiotherapy (RT) can be used as an early marker of recurrence risk...
The results of concurrent chemo-radiotherapy for recurrence after treatment with bacillus Calmette-Guérin for non-muscle-invasive bladder cancer: is immediate cystectomy always necessary?Jennifer Y Wo
Harvard Radiation Oncology Programm, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
BJU Int 104:179-83. 2009....
RTOG 97-06: initial report of a phase I-II trial of selective bladder conservation using TURBT, twice-daily accelerated irradiation sensitized with cisplatin, and adjuvant MCV combination chemotherapyMichael P Hagan
Medical College of Virginia Hospitals, Richmond, VA 23298 0058, USA
Int J Radiat Oncol Biol Phys 57:665-72. 2003..With only 45% of patients completing three cycles of MCV, this form of adjuvant chemotherapy appears to be poorly tolerated by most patients...
Development of RTOG consensus guidelines for the definition of the clinical target volume for postoperative conformal radiation therapy for prostate cancerJeff M Michalski
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 76:361-8. 2010..To define a prostate fossa clinical target volume (PF-CTV) for Radiation Therapy Oncology Group (RTOG) trials using postoperative radiotherapy for prostate cancer...
Management of complications of prostate cancer treatmentM Dror Michaelson
Division of Hematology Oncology, Massachusetts General Hospital, Boston, MA, USA
CA Cancer J Clin 58:196-213. 2008..Ongoing and planned clinical trials will continue to address strategies to prevent treatment-related side effects and improve quality of life for men with prostate cancer...
Case records of the Massachusetts General Hospital. Case 18-2007. A 54-year-old man with early-stage prostate cancerDonald S Kaufman
Department of Hematology-Oncology, Massachusetts General Hospital, USA
N Engl J Med 356:2515-20. 2007
High-dose external beam radiation for localized prostate cancer: current status and future challengesPaul L Nguyen
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Cancer J 13:295-301. 2007....
Bladder preservation: optimizing radiotherapy and integrated treatment strategiesRaymond H Mak
Department of Radiation, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
BJU Int 102:1345-53. 2008..Future work will continue to refine the bladder-preserving approach to improve survival and local control...
Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapyRobert W Ross
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA 02114, USA
Clin Imaging 33:301-5. 2009..Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria...
Comparison of biochemical failure definitions for permanent prostate brachytherapyDeborah A Kuban
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 65:1487-93. 2006..To assess prostate-specific antigen (PSA) failure definitions for patients with Stage T1-T2 prostate cancer treated by permanent prostate brachytherapy...
PSA nadir predicts biochemical and distant failures after external beam radiotherapy for prostate cancer: a multi-institutional analysisMichael E Ray
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
Int J Radiat Oncol Biol Phys 64:1140-50. 2006....
Salvage radiotherapy after radical prostatectomy for prostate adenocarcinoma: analysis of efficacy and prognostic factorsAshish K Chawla
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Urology 59:726-31. 2002..Those with favorable biochemical and pathologic tumor features are most likely to remain disease free...
Selective bladder preservation by trimodality therapy for patients with muscularis propria-invasive bladder cancer and who are cystectomy candidates--the Massachusetts General Hospital and Radiation Therapy Oncology Group experiencesWilliam U Shipley
Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02138, USA
Semin Radiat Oncol 15:36-41. 2005..This preserves the urinary diversion options open to the surgeon as well as brings forward the time to a salvage procedure should it be needed...
Dose escalation in localized prostate cancer: make no assumptionsAnthony L Zietman
Int J Radiat Oncol Biol Phys 54:635-6. 2002
Mapping of nodal disease in locally advanced prostate cancer: rethinking the clinical target volume for pelvic nodal irradiation based on vascular rather than bony anatomyHelen A Shih
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
Int J Radiat Oncol Biol Phys 63:1262-9. 2005..quot; We employed a novel magnetic resonance lymphangiographic technique to highlight the likely sites of occult nodal metastasis from prostate cancer...
Changes in body composition during androgen deprivation therapy for prostate cancerMatthew R Smith
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 87:599-603. 2002..Increased fatness resulted primarily from accumulation of sc rather than intraabdominal adipose tissue...
Influence of follow-up bias on PSA failure after external beam radiotherapy for localized prostate cancer: results from a 10-year cohort analysisJohn J Coen
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Int J Radiat Oncol Biol Phys 57:621-8. 2003..To estimate the biases inherent in prostate cancer outcome that arise from different failure end points and variations in follow-up time and intensity using a cohort of men with long follow-up...
Why does androgen deprivation enhance the results of radiation therapy?Jennifer Y Wo
Harvard Radiation Oncology Program, Boston, MA 02114, USA
Urol Oncol 26:522-9. 2008..There are ongoing clinical trials that will hopefully better define patient populations that will benefit from hormonal deprivation therapy...
Phase I-II RTOG study (99-06) of patients with muscle-invasive bladder cancer undergoing transurethral surgery, paclitaxel, cisplatin, and twice-daily radiotherapy followed by selective bladder preservation or radical cystectomy and adjuvant chemotherapyDonald S Kaufman
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Urology 73:833-7. 2009..To evaluate the safety, tolerance, protocol completion rate, tumor response rate, and patient survival of chemoradiotherapy for patients with muscle-invasive operable bladder cancer...
Bladder-sparing approaches to invasive diseaseJason A Efstathiou
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Cox 3, Boston, MA 02114, USA
World J Urol 24:517-29. 2006..Future work will continue to optimize the bladder-sparing regimen while limiting toxicity...
Proton radiation for localized prostate cancerJohn J Coen
Massachusetts General Hospital, Department of Radiation Oncology, Harvard Medical School, 100 Blossom Street, Boston, MA 02114 2617, USA
Nat Rev Urol 6:324-30. 2009..This technique would be particularly well suited to partial prostate 'boosts', hypofractionation regimens and stereotactic delivery of radiation, all new approaches to prostate cancer that are being investigated...
Life, liberty, and the pursuit of protons: an evidence-based review of the role of particle therapy in the treatment of prostate cancerJason A Efstathiou
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Cancer J 15:312-8. 2009....
Rectal dose-volume histogram parameters are associated with long-term patient-reported gastrointestinal quality of life after conventional and high-dose radiation for prostate cancer: a subgroup analysis of a randomized trialPaul L Nguyen
Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Int J Radiat Oncol Biol Phys 78:1081-5. 2010..2 GyE) or high-dose (79.2 GyE) radiation for prostate cancer...
Patient-reported long-term outcomes after conventional and high-dose combined proton and photon radiation for early prostate cancerJames A Talcott
Center for Outcomes Research, MGH Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA
JAMA 303:1046-53. 2010..Increased radiation doses improve prostate cancer control but also increase toxicity to adjacent normal tissue. Proton radiation may attenuate adverse effects...
Radical radiation for localized prostate cancer: local persistence of disease results in a late wave of metastasesJohn J Coen
Department of Radiation Oncology, Massachusetts General Hospital, 100 Blossom Street, Cox 3, Boston, MA 02114, USA
J Clin Oncol 20:3199-205. 2002..To assess whether failure to maintain local control (LC) of prostate cancer after radiation therapy results in a higher incidence of distant metastasis (DM)...
Radiotherapy treatment of early-stage prostate cancer with IMRT and protons: a treatment planning comparisonAlexei Trofimov
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 69:444-53. 2007..To compare intensity-modulated photon radiotherapy (IMRT) with three-dimensional conformal proton therapy (3D-CPT) for early-stage prostate cancer, and explore the potential utility of intensity-modulated proton therapy (IMPT)...
Body mass index and prostate-specific antigen failure following brachytherapy for localized prostate cancerJason A Efstathiou
Department of Radiation Oncology, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 71:1302-8. 2008..We investigated whether BMI is associated with PSA failure in men treated with brachytherapy for clinically localized prostate cancer...
External beam radiation treatment for rectal cancer is associated with a decrease in subsequent prostate cancer diagnosisKaren E Hoffman
Harvard Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts, USA
Cancer 112:943-9. 2008..The effect of this incidental exposure on subsequent prostate cancer diagnosis was investigated using the Surveillance, Epidemiology, and End Results (SEER) cancer registry...
Multi-institutional analysis of long-term outcome for stages T1-T2 prostate cancer treated with permanent seed implantationMichael J Zelefsky
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Int J Radiat Oncol Biol Phys 67:327-33. 2007..To assess long-term prostate-specific antigen (PSA) outcome after permanent prostate brachytherapy (BT) and identify predictors of improved disease-free survival...
Association of statin use with improved local control in patients treated with selective bladder preservation for muscle-invasive bladder cancerHenry K Tsai
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Urology 68:1188-92. 2006..To assess whether statin use improves local control (LC) in patients undergoing organ-preserving trimodality therapy for muscle-invasive bladder cancer...
Prostatectomy or watchful waiting in prostate cancerJohn J Coen
N Engl J Med 348:170-1; author reply 170-1. 2003
Biochemical and clinical significance of the posttreatment prostate-specific antigen bounce for prostate cancer patients treated with external beam radiation therapy alone: a multiinstitutional pooled analysisEric M Horwitz
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
Cancer 107:1496-502. 2006....
Metabolic changes during gonadotropin-releasing hormone agonist therapy for prostate cancer: differences from the classic metabolic syndromeMatthew R Smith
Department of Hematology Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Cancer 112:2188-94. 2008..To the authors' knowledge, however, less is known regarding the effects of GnRH agonists on other attributes of the metabolic syndrome...
Proton-beam vs intensity-modulated radiation therapy. Which is best for treating prostate cancer?Paul L Nguyen
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, MA 02114, USA
Oncology (Williston Park) 22:748-54; discussion 754, 757. 2008..In this article, we review the current status of the evidence supporting the use of protons in prostate cancer and discuss the active controversies that surround this modality...
The Titanic and the Iceberg: prostate proton therapy and health care economicsAnthony L Zietman
J Clin Oncol 25:3565-6. 2007
Increasing external beam dose for T1-T2 prostate cancer: effect on risk groupsHoward D Thames
Department of Biostatistics and Applied Mathematics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, and Department of Radiation Oncology, William Beaumont Hospital, Deroit, MI, USA
Int J Radiat Oncol Biol Phys 65:975-81. 2006....
Correction: Inaccurate analysis and results in a study of radiation therapy in adenocarcinoma of the prostateAnthony L Zietman
JAMA 299:898-9. 2008
Definitions of biochemical failure that best predict clinical failure in patients with prostate cancer treated with external beam radiation alone: a multi-institutional pooled analysisEric M Horwitz
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 2497, USA
J Urol 173:797-802. 2005..In this report we determined the sensitivity and specificity of several BF definitions using distant failure (DF) alone or clinical failure (CF), defined as local failure (LF) and/or DF...
Bicalutamide monotherapy versus leuprolide monotherapy for prostate cancer: effects on bone mineral density and body compositionMatthew R Smith
Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Oncol 22:2546-53. 2004..Less is known about the effects of bicalutamide monotherapy on bone mineral density and body composition...
Newer imaging modalities to assist with target localization in the radiation treatment of prostate cancer and possible lymph node metastasesSubhash S John
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 71:S43-7. 2008..The concepts of biologic target volume, real target volume, and multidimensional conformal radiotherapy are being explored...
Benchmarks achieved in the delivery of radiation therapy for muscle-invasive bladder cancerJohn J Coen
Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Urol Oncol 25:76-84. 2007..Radiation is a very effective palliative agent for patients with locally advanced or metastatic disease. It can palliate bleeding and pain for patients with local progression or alleviate pain from bony metastases...
Long-term durability of PSA failure-free survival after radiotherapy for localized prostate cancerTorunn I Yock
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 54:420-6. 2002..The hazard rates of biochemical progression in the 6-10 years after treatment are low and are comparable to those published for prostatectomy series...
Case records of the Massachusetts General Medicine. Weekly clinicopathological exercises. Case 9-2003. An 18-year-old man with back and leg pain and a nondiagnostic biopsy specimenAlison M Friedmann
Department of Pediatric Hematology/Oncology, Massachusetts General Hospital, Boston, USA
N Engl J Med 348:1150-8. 2003
Adenovirus-mediated inhibition of survivin expression sensitizes human prostate cancer cells to paclitaxel in vitro and in vivoMin Zhang
Department of Radiation Oncology, Massachusetts General Hospital/Harvard Medical School Boston, Massachusetts 02114, USA
Prostate 64:293-302. 2005..CONCLUSIONS: Survivin mediates paclitaxel-resistance in prostate cancer cells. The inhibition of Survivin sensitizes prostate cancer cells to paclitaxel-induced apoptosis through a caspase-dependant mechanism in vitro and in vivo...
