BRIAN ZABEL

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 174:244-51. 2005
  2. ncbi Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 280:34661-6. 2005
  3. ncbi Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 205:2207-20. 2008
  4. ncbi RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 103:2659-64. 2006
  5. ncbi Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Exp Hematol 34:1106-14. 2006
  6. ncbi Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease
    Kareem L Graham
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 183:6717-23. 2009
  7. ncbi Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets
    Xiao Yan Du
    Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Biol Chem 284:751-8. 2009
  8. ncbi Chemoattractants, extracellular proteases, and the integrated host defense response
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Exp Hematol 34:1021-32. 2006
  9. ncbi Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism
    Kerry B Goralski
    Department of Pharmacology and College of Pharmacy, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Biol Chem 282:28175-88. 2007
  10. ncbi Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin
    Paulina Kulig
    Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Ulica Gronostajowa 7, 30 387 Krakow, Poland
    J Immunol 178:3713-20. 2007

Research Grants

  1. Molecular and Functional Characterization of Chemerin Receptors
    BRIAN ZABEL; Fiscal Year: 2009
  2. Molecular and Functional Characterization of Chemerin Receptors
    Brian A Zabel; Fiscal Year: 2010
  3. Molecular and Functional Characterization of Chemerin Receptors
    Brian A Zabel; Fiscal Year: 2010

Collaborators

Detail Information

Publications10

  1. ncbi Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 174:244-51. 2005
    ....
  2. ncbi Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 280:34661-6. 2005
    ....
  3. ncbi Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 205:2207-20. 2008
    ..Rather, CCRL2 is able to bind the chemoattractant and increase local concentrations of bioactive chemerin, thus providing a link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1...
  4. ncbi RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells
    Janet Kalesnikoff
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 103:2659-64. 2006
    ..Thus, RabGEF1 plays a critical role in the regulation of SCF/c-Kit-mediated signaling events and biological responses in mast cells...
  5. ncbi Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Exp Hematol 34:1106-14. 2006
    ..We examined the regulation of mCMKLR1 expression by exposure to toll-like receptor (TLR) ligands and cytokines. Finally, we evaluated ex vivo human ascites macrophages for huCMKLR1 expression and chemerin responsiveness...
  6. ncbi Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease
    Kareem L Graham
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 183:6717-23. 2009
    ..The results imply involvement of CMKLR1 in both the induction and effector phases of disease. We conclude that CMKLR1 participates in the inflammatory mechanisms of EAE and represents a potential therapeutic target in multiple sclerosis...
  7. ncbi Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets
    Xiao Yan Du
    Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Biol Chem 284:751-8. 2009
    ....
  8. ncbi Chemoattractants, extracellular proteases, and the integrated host defense response
    Brian A Zabel
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
    Exp Hematol 34:1021-32. 2006
    ....
  9. ncbi Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism
    Kerry B Goralski
    Department of Pharmacology and College of Pharmacy, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Biol Chem 282:28175-88. 2007
    ..We conclude that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism...
  10. ncbi Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin
    Paulina Kulig
    Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Ulica Gronostajowa 7, 30 387 Krakow, Poland
    J Immunol 178:3713-20. 2007
    ..SspB may help direct the recruitment of specialized host cells, including immunoregulatory pDC and/or macrophages, contributing to the ability of S. aureus to elicit and maintain a chronic inflammatory state...

Research Grants3

  1. Molecular and Functional Characterization of Chemerin Receptors
    BRIAN ZABEL; Fiscal Year: 2009
    ....
  2. Molecular and Functional Characterization of Chemerin Receptors
    Brian A Zabel; Fiscal Year: 2010
    ....
  3. Molecular and Functional Characterization of Chemerin Receptors
    Brian A Zabel; Fiscal Year: 2010
    ....