Robert H Young

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Yolk sac tumor with a prominent polyvesicular vitelline pattern: a report of three cases
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 37:393-8. 2013
  2. doi request reprint The Warrens and other pioneering clinician pathologists of the Massachusetts General Hospital during its early years: an appreciation on the 200th anniversary of the hospital founding
    Robert H Young
    The James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Mod Pathol 24:1285-94. 2011
  3. ncbi request reprint A brief history of the pathology of the gonads
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mod Pathol 18:S3-S17. 2005
  4. ncbi request reprint The rich history of gynaecological pathology: brief notes on some of its personalities and their contributions
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Pathology 39:6-25. 2007
  5. doi request reprint Tumor-like lesions of the urinary bladder
    Robert H Young
    The James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Warren Building, Fruit Street, Boston, MA 2114, USA
    Mod Pathol 22:S37-52. 2009
  6. doi request reprint The history of British gynaecological pathology
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
    Histopathology 54:144-55. 2009
  7. ncbi request reprint Neoplasms of the fallopian tube and broad ligament: a selective survey including historical perspective and emphasising recent developments
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Pathology 39:112-24. 2007
  8. ncbi request reprint From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II
    Robert H Young
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Adv Anat Pathol 14:149-77. 2007
  9. ncbi request reprint Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems
    Robert H Young
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
    Mod Pathol 18:S81-98. 2005
  10. doi request reprint A close surgical margin after radical prostatectomy is an independent predictor of recurrence
    Jian Lu
    Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Urol 188:91-7. 2012

Detail Information

Publications98

  1. doi request reprint Yolk sac tumor with a prominent polyvesicular vitelline pattern: a report of three cases
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 37:393-8. 2013
    ..The good long-term outcome in 2 cases supports prior evidence that suggests that the natural history of this form of YST may be more indolent than conventional forms of the tumor...
  2. doi request reprint The Warrens and other pioneering clinician pathologists of the Massachusetts General Hospital during its early years: an appreciation on the 200th anniversary of the hospital founding
    Robert H Young
    The James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Mod Pathol 24:1285-94. 2011
    ....
  3. ncbi request reprint A brief history of the pathology of the gonads
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mod Pathol 18:S3-S17. 2005
    ..All the above have left a rich legacy which those who follow in their path will be challenged to equal...
  4. ncbi request reprint The rich history of gynaecological pathology: brief notes on some of its personalities and their contributions
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Pathology 39:6-25. 2007
    ..Willis, Hazel (Mansell) Gore, Robert Barter, Harold Attwood, Andrew Ostör (the last two also noted historians), Denys Fortune, Alan Ng, and Peter Russell...
  5. doi request reprint Tumor-like lesions of the urinary bladder
    Robert H Young
    The James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Warren Building, Fruit Street, Boston, MA 2114, USA
    Mod Pathol 22:S37-52. 2009
    ..The morphologic spectrum is explored and it is recommended that the two categories be retained...
  6. doi request reprint The history of British gynaecological pathology
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
    Histopathology 54:144-55. 2009
    ..Additionally, his countless entertaining and instructive lectures throughout the world represented a remarkable educational experience...
  7. ncbi request reprint Neoplasms of the fallopian tube and broad ligament: a selective survey including historical perspective and emphasising recent developments
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Pathology 39:112-24. 2007
    ..Brief consideration then follows of certain other tubal and paratubal neoplasms including those of the broad ligament, emphasising issues in differential diagnosis...
  8. ncbi request reprint From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II
    Robert H Young
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Adv Anat Pathol 14:149-77. 2007
    ....
  9. ncbi request reprint Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems
    Robert H Young
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
    Mod Pathol 18:S81-98. 2005
    ....
  10. doi request reprint A close surgical margin after radical prostatectomy is an independent predictor of recurrence
    Jian Lu
    Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Urol 188:91-7. 2012
    ..However, this recommendation remains controversial and relies on limited evidence. We evaluated the impact of close surgical margins on the long-term risk of biochemical recurrence after radical prostatectomy...
  11. ncbi request reprint Primary endometrioid stromal sarcoma of the ovary: a clinicopathologic study of 27 cases with morphologic and behavioral features similar to those of uterine low-grade endometrial stromal sarcoma
    Esther Oliva
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA Viollier Weintraub Laboratory, Pathology Department, Geneva, Switzerland
    Am J Surg Pathol 38:305-15. 2014
    ..When a primary ovarian origin is determined, the differential diagnosis is most often with a sex cord-stromal tumor, particularly a granulosa cell tumor because of a diffuse growth of cells with scant cytoplasm...
  12. ncbi request reprint Mixed tumors of the vagina: an immunohistochemical study of 13 cases with emphasis on the cell of origin and potential aid in differential diagnosis
    Esther Oliva
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Mod Pathol 17:1243-50. 2004
    ..MTsV are positive for h-Caldesmon and CD10, two markers that have been used in gynecologic pathology primarily to aid in establishing the smooth muscle or endometrial stromal phenotype of a neoplasm...
  13. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 21-2004. A 63-year-old man with metastatic prostate carcinoma refractory to hormone therapy
    Donald S Kaufman
    Division of Medical Oncology, Department of Medicine, Massachusetts General Hospital, USA
    N Engl J Med 351:171-8. 2004
  14. ncbi request reprint Case records of the Massachusetts General Hospital. Case 18-2007. A 54-year-old man with early-stage prostate cancer
    Donald S Kaufman
    Department of Hematology Oncology, Massachusetts General Hospital, USA
    N Engl J Med 356:2515-20. 2007
  15. doi request reprint Smaller prostate gland size and older age predict Gleason score upgrading
    Boris Gershman
    Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Urol Oncol 31:1033-7. 2013
    ..Gleason score is important for prostate cancer (CaP) risk stratification and prognostication but has a significant rate of upgrading. We examined the effect of prostate size and age on upgrading of Gleason 6 CaP...
  16. doi request reprint Architectural heterogeneity and cribriform pattern predict adverse clinical outcome for Gleason grade 4 prostatic adenocarcinoma
    Fei Dong
    Departments of Pathology Urology, Massachusetts General Hospital, Boston, MA Department of Pathology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
    Am J Surg Pathol 37:1855-61. 2013
    ..29-24.5; P=0.02). These results suggest that the morphologic subclassification of distinct Gleason grade 4 architectural patterns provides prognostic information beyond the current Gleason classification system. ..
  17. doi request reprint Papillary proliferation of the endometrium: a clinicopathologic study of 59 cases of simple and complex papillae without cytologic atypia
    Philip P C Ip
    Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Am J Surg Pathol 37:167-77. 2013
    ..As the distinction between simple and complex PPE may be difficult in small endometrial aspirational samples, consideration for curettage should be given to ascertain whether the lesion has been completely removed...
  18. ncbi request reprint Clear cell papillary cystadenoma of the epididymis and mesosalpinx: immunohistochemical differentiation from metastatic clear cell renal cell carcinoma
    Hakan Aydin
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 29:520-3. 2005
    ..Our findings indicate that, in cases where there is uncertainty about the histologic diagnosis of clear cell papillary cystadenoma, the above immunohistochemical panel helps to rule out metastatic renal cell carcinoma...
  19. ncbi request reprint Primary endometrioid adenocarcinoma of the vagina: a clinicopathologic study of 18 cases
    Paul N Staats
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 31:1490-501. 2007
    ..The prognosis seems to be good in low-stage patients, with 11 patients alive and well and 2 alive with recurrent disease...
  20. ncbi request reprint Ovarian metastases of appendiceal tumors with goblet cell carcinoidlike and signet ring cell patterns: a report of 30 cases
    Alexandra C Hristov
    Department of Pathology, The Johns Hopkins University School of Medicine and Hospital, 401 N Broadway, Baltimore, MD 21231, USA
    Am J Surg Pathol 31:1502-11. 2007
    ..In cases in which the primary tumor is not already evident, their "goblet cell carcinoidlike" patterns should direct attention to the appendix as a possible source...
  21. ncbi request reprint Appendiceal or cecal endometriosis with intestinal metaplasia: a potential mimic of appendiceal mucinous neoplasms
    Joseph Misdraji
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA Hospital Pathology Associates, Virginia Piper Cancer Institute, Minneapolis, MN Department of Pathology, University of British Columbia, BC, Canada
    Am J Surg Pathol 38:698-705. 2014
    ..6 y). Endometriosis with intestinal metaplasia is a rare phenomenon that, when it occurs in the appendix or cecum, may lead to misdiagnosis as a low-grade appendiceal mucinous neoplasm or mucinous carcinoma. ..
  22. ncbi request reprint From krukenberg to today: the ever present problems posed by metastatic tumors in the ovary: part I. Historical perspective, general principles, mucinous tumors including the krukenberg tumor
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Adv Anat Pathol 13:205-27. 2006
    ..Other mucinous tumors that commonly simulate closely metastatic neoplasms, include those from the pancreas in particular, but also diverse other sites, are then reviewed...
  23. ncbi request reprint Ovarian metastases of intestinal-type gastric carcinoma: A clinicopathologic study of 4 cases with contrasting features to those of the Krukenberg tumor
    Melinda F Lerwill
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 30:1382-8. 2006
    ....
  24. ncbi request reprint Case records of the Massachusetts General Hospital. Case 6-2007. A 28-year-old man with a mass in the testis
    Donald S Kaufman
    Department of Hematology Oncology, Massachusetts General Hospital, USA
    N Engl J Med 356:842-9. 2007
  25. ncbi request reprint Smooth muscle tumors of the ovary: a clinicopathologic study of 54 cases emphasizing prognostic criteria, histologic variants, and differential diagnosis
    Melinda F Lerwill
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital and the Department of Pathology, Harvard Medical School, Boston, MA 021114, USA
    Am J Surg Pathol 28:1436-51. 2004
    ..The main tumors in the differential diagnosis are those in the fibroma/thecoma category, spindle cell carcinomas, and metastatic gastrointestinal stromal tumors...
  26. doi request reprint Impact on the clinical outcome of prostate cancer by the 2005 international society of urological pathology modified Gleason grading system
    Fei Dong
    Department of Pathology, Biostatistics Center, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 36:838-43. 2012
    ..These results validate the prognostic value of the modified Gleason grading system and suggest that the recognition of an intermediate-risk histological pattern may be useful in the prognosis of patients with prostate cancer...
  27. ncbi request reprint Seminoma with tubular, microcystic, and related patterns: a study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor
    Thomas M Ulbright
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202 5280, USA
    Am J Surg Pathol 29:500-5. 2005
    ..The edema and paucity of lymphocytes may suggest spermatocytic seminoma, but the varied cell types of that neoplasm are absent...
  28. doi request reprint Solid pseudopapillary neoplasm of the ovary: a report of 3 primary ovarian tumors resembling those of the pancreas
    Vikram Deshpande
    Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Am J Surg Pathol 34:1514-20. 2010
    ..The morphologic and immunohistochemical similarity to pancreatic solid pseudopapillary neoplasm facilitates the accurate diagnosis of this rare ovarian neoplasm...
  29. doi request reprint Primary ovarian mucinous cystic tumor with prominent theca cell proliferation and focal granulosa cell tumor in its stroma: case report, literature review, and comparison with Sertoli-Leydig cell tumor with heterologous elements
    Paul N Staats
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Int J Gynecol Pathol 29:228-33. 2010
    ....
  30. doi request reprint Ruptured appendiceal diverticula mimicking low-grade appendiceal mucinous neoplasms
    Maylee Hsu
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 33:1515-21. 2009
    ..Failure to distinguish this process from a mucosal neoplasm with rupture may result in unnecessary therapy and cause the patient undue alarm...
  31. ncbi request reprint Autoimplants in serous borderline tumors of the ovary: a clinicopathologic study of 30 cases of a process to be distinguished from serous adenocarcinoma
    Sarah E Rollins
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 30:457-62. 2006
    ....
  32. ncbi request reprint CD10 expression in pure stromal and sex cord-stromal tumors of the ovary: an immunohistochemical analysis of 101 cases
    Esther Oliva
    Pathology Department, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Gynecol Pathol 26:359-67. 2007
    ..CD10 may play a useful role in aiding the differential between endometrial stromal tumors in the ovary and SCST and stromal tumors...
  33. doi request reprint Wolffian tumor of the ovary with a prominent spindle cell component: report of a case with brief discussion of unusual problems in differential diagnosis, and literature review
    - Fanghong Li
    Department of Pathology, Monmouth Medical Center, Long Branch, New Jersey 07740, USA
    Int J Surg Pathol 16:222-5. 2008
    ..Without further therapy, the patient was alive without disease 7 months after surgery. This case demonstrates the heterogeneity of Wolffian tumor of the ovary and shows how crucial sampling is in arriving at the correct diagnosis...
  34. doi request reprint Testicular tumors--some new and a few perennial problems
    Robert H Young
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Pathol Lab Med 132:548-64. 2008
    ..Finally, a few comments are made on the common paratesticular neoplasm, the adenomatoid tumor, highlighting its varied patterns and recent description of some of the issues that may arise when they undergo total or subtotal infarction...
  35. ncbi request reprint Endometrioid neoplasms with clear cells: a report of 21 cases in which the alteration is not of typical secretory type
    Elvio G Silva
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 31:1203-8. 2007
    ..There are prognostic and therapeutic implications in the distinction with clear cell carcinoma...
  36. ncbi request reprint Mesodermal adenosarcoma of the testis
    Ranleigh L Fleshman
    Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Am J Surg Pathol 29:420-3. 2005
    ..It was immunoreactive for muscle specific actin, CD10, and to a lesser degree, desmin. This case expands the known sites where mesodermal adenosarcoma may occur. The histogenesis is speculative, but possible options are discussed...
  37. ncbi request reprint Basal cell proliferations of the prostate other than usual basal cell hyperplasia: a clinicopathologic study of 23 cases, including four carcinomas, with a proposed classification
    Jesse K McKenney
    Department of Pathology, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Surg Pathol 28:1289-98. 2004
    ..This study suggests that adenoid cystic carcinomas are biologically indolent following prostatectomy but have a low risk of distant metastasis...
  38. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 34-2004. A 45-year-old man with recurrent pain in the right flank and hematuria
    Douglas M Dahl
    Department of Urology, Massachusetts General Hospital, USA
    N Engl J Med 351:2102-10. 2004
  39. ncbi request reprint Primary intestinal-type glandular lesions of the vagina: clinical, pathologic, and immunohistochemical features of 14 cases ranging from benign polyp to adenoma to adenocarcinoma
    Paul N Staats
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland Department of Pathology, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada
    Am J Surg Pathol 38:593-603. 2014
    ..The pertinent literature is reviewed, and the potential origin and differential diagnosis of these lesions are discussed. ..
  40. ncbi request reprint Sertoli cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 54 cases
    Esther Oliva
    James Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 29:143-56. 2005
    ..The tumors typically occur in young females, sometimes children who typically present with sexual precocity, and occasional patients have Peutz-Jeghers syndrome...
  41. ncbi request reprint Mucinous borderline ovarian tumors: points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior
    Brigitte M Ronnett
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Hum Pathol 35:949-60. 2004
    ..Improved classification of these mucinous tumors has clarifed the behavior of true M-BOTs by excluding these simulators from the M-BOT category...
  42. ncbi request reprint Primary mucinous tumors of the testis and paratestis: a report of nine cases
    Thomas M Ulbright
    Department of Pathology, Indiana University School of Medicine, Indianapolis, 46202 5280, USA
    Am J Surg Pathol 27:1221-8. 2003
    ..Clinical features are important to exclude metastasis, particularly in cases of carcinoma and, to a lesser extent, in tumors of borderline type...
  43. ncbi request reprint Endometrial stromal nodules and endometrial stromal tumors with limited infiltration: a clinicopathologic study of 50 cases
    Adriana Dionigi
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Surg Pathol 26:567-81. 2002
    ....
  44. ncbi request reprint History of gynecological pathology: XVII. Dr. Lars Santesson
    Robert E Scully
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Int J Gynecol Pathol 24:93-9. 2005
  45. ncbi request reprint Mesodermal (müllerian) adenosarcoma of the ovary: a clinicopathologic analysis of 40 cases and a review of the literature
    John H Eichhorn
    James Homer Wright Pathology Laboratories of the Massachussetts General Hospital and the Department of Phatology, Harvard Medical School, Boston, Massachussetts 02114, USA
    Am J Surg Pathol 26:1243-58. 2002
    ..Ovarian adenosarcomas have a worse prognosis than uterine adenosarcomas, presumably because of the greater ease of peritoneal spread. Many of the tumors caused problems in differential diagnosis...
  46. ncbi request reprint Gastrointestinal stromal tumors metastatic to the ovary: a report of five cases
    Julie A Irving
    James Homer Wright Pathology Laboratories of Massachusetts General Hospital and Department of Pathology, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 29:920-6. 2005
    ....
  47. ncbi request reprint Endometrial endometrioid adenocarcinoma with a deceptive pattern of spread to the uterine cervix: a manifestation of stage IIb endometrial carcinoma liable to be misinterpreted as an independent carcinoma or a benign lesion
    Rosemary Tambouret
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 27:1080-8. 2003
    ..It is important for both therapeutic and prognostic reasons that the cervical abnormality is not misinterpreted as a benign or malignant primary endocervical glandular process...
  48. ncbi request reprint Classical Hodgkin's lymphoma presenting as a testicular mass: report of a case
    Rania M Seliem
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital and the Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Int J Surg Pathol 15:207-12. 2007
    ..We report the case of a 52-year-old man who presented with a left testicular mass; orchiectomy revealed morphologic and immunophenotypic features typical of classical Hodgkin's lymphoma, nodular sclerosis type...
  49. ncbi request reprint An immunohistochemical analysis of endometrial stromal and smooth muscle tumors of the uterus: a study of 54 cases emphasizing the importance of using a panel because of overlap in immunoreactivity for individual antibodies
    Esther Oliva
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Surg Pathol 26:403-12. 2002
    ..8) CD34, CD99, and keratin have no or minimal role in this area, but keratin positivity in smooth muscle tumors should not lead to their confusion with epithelial tumors...
  50. ncbi request reprint The distinction between primary and metastatic mucinous carcinomas of the ovary: gross and histologic findings in 50 cases
    Kenneth R Lee
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 27:281-92. 2003
    ..Careful gross evaluation is also important with special attention paid to the external surface of the ovarian tumor(s) to detect abnormalities that have the features of surface implants on microscopic evaluation...
  51. ncbi request reprint Leydig cell tumors of the testis with unusual features: adipose differentiation, calcification with ossification, and spindle-shaped tumor cells
    Thomas M Ulbright
    Department of Pathology, Indiana University School of Medicine, Indianapolis 46202, USA
    Am J Surg Pathol 26:1424-33. 2002
    ....
  52. ncbi request reprint Krukenberg tumors of the ovary: a clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations
    Takako Kiyokawa
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital and the Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 30:277-99. 2006
    ....
  53. ncbi request reprint Potential utility of uroplakin III, thrombomodulin, high molecular weight cytokeratin, and cytokeratin 20 in noninvasive, invasive, and metastatic urothelial (transitional cell) carcinomas
    Douglas C Parker
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Surg Pathol 27:1-10. 2003
    ..The results of the study indicate a role for an antibody panel that includes UROIII, THR, HMWCK, and CK20 in the diagnosis of urothelial tumors...
  54. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 3-2004. A 57-year-old man with invasive transitional-cell carcinoma of the bladder
    Donald S Kaufman
    Division of Hematology Oncology, Massachusetts General Hospital, USA
    N Engl J Med 350:394-402. 2004
  55. ncbi request reprint Hepatocyte paraffin 1 antibody does not distinguish primary ovarian tumors with hepatoid differentiation from metastatic hepatocellular carcinoma
    Martha B Pitman
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Int J Gynecol Pathol 23:58-64. 2004
    ..Hepatocyte paraffin 1, however, is not useful in distinguishing metastatic hepatocellular carcinoma from primary ovarian hepatoid carcinoma or hepatoid yolk sac tumor...
  56. ncbi request reprint Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases
    Joseph Misdraji
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 27:1089-103. 2003
    ....
  57. doi request reprint Metastatic carcinoma to the testis: a clinicopathologic analysis of 26 nonincidental cases with emphasis on deceptive features
    Thomas M Ulbright
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Surg Pathol 32:1683-93. 2008
    ..Clues to the likely primary site can usually be gleaned from the pathologic findings...
  58. doi request reprint Viral-type orchitis: a potential mimic of testicular neoplasia
    Kristina M Braaten
    James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 33:1477-84. 2009
    ..In the rare instance in which a testicular specimen with orchitis is submitted for pathologic evaluation, diagnosis may be difficult. Familiarity with the pathologic changes characteristic of orchitis will help avoid misdiagnosis...
  59. ncbi request reprint Transitional cell carcinoma of the ovary: a morphologic study of 100 cases with emphasis on differential diagnosis
    John H Eichhorn
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 28:453-63. 2004
    ..Recognition of these features will lead to a more consistent diagnosis of this tumor and aid in determining whether it has distinctive clinical features, particularly with regard to its behavior...
  60. ncbi request reprint Arias-Stella reaction of the endocervix: a report of 18 cases with emphasis on its varied histology and differential diagnosis
    Marisa R Nucci
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Surg Pathol 28:608-12. 2004
    ....
  61. ncbi request reprint Intratubular large cell hyalinizing sertoli cell neoplasia of the testis: a report of 8 cases of a distinctive lesion of the Peutz-Jeghers syndrome
    Thomas M Ulbright
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Surg Pathol 31:827-35. 2007
    ..Orchiectomy is indicated when there is evidence of an invasive tumor and may be necessary to control hormonal manifestations...
  62. ncbi request reprint Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Semin Diagn Pathol 21:134-50. 2004
    ..In yet other cases the tumors may present clinically as incidentally discovered mucinous aggregates within hernia sac specimens or as a scrotal mass...
  63. ncbi request reprint Primary epithelial neoplasms and other epithelial lesions of the appendix (excluding carcinoid tumors)
    Joseph Misdraji
    James Homer Wright Pathology Laboratories, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Semin Diagn Pathol 21:120-33. 2004
    ..Retention cysts, hyperplastic polyps, and diffuse mucosal hyperplasia, although not necessarily neoplastic, are reviewed here as they may enter into the differential diagnosis of appendiceal mucinous neoplasms...
  64. ncbi request reprint Krukenberg tumor of renal pelvic origin: report of a case with selected comments on ovarian tumors metastatic from the urinary tract
    Julie A Irving
    Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada, and the Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Int J Gynecol Pathol 25:147-50. 2006
    ..This unique case reinforces that tumors with signet-ring cell morphology have a propensity to metastasize to the ovary, and indicates that renal pelvic carcinoma rarely may be the source of Krukenberg tumors...
  65. ncbi request reprint Howard Atwood Kelly, Elizabeth Hurdon, and their great work: "The vermiform appendix and its diseases"
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Semin Diagn Pathol 21:77-85. 2004
  66. ncbi request reprint Analysis of alpha-methylacyl-CoA racemase (P504S) expression in high-grade prostatic intraepithelial neoplasia
    Chin Lee Wu
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Hum Pathol 35:1008-13. 2004
    ..This study provides additional evidence to link high-grade PIN as a precursor lesion to prostatic adenocarcinoma...
  67. doi request reprint The risk of squamous cell carcinoma in persistent vulvar ulcers
    Ryan J Spencer
    Department of Obstetrics and Gynecology, Massachusetts General Hospital, Yawkey Center, Boston, MA 02114, USA
    Menopause 18:1067-71. 2011
    ..This study reports on pathologic discrepancies between office biopsy and subsequent wide local excision for nonhealing vulvar ulcers...
  68. ncbi request reprint Clear cell carcinoma of the urinary bladder: a report and comparison of four tumors of mullerian origin and nine of probable urothelial origin with discussion of histogenesis and diagnostic problems
    Esther Oliva
    James Homer Wright Pathology Laboratories of the Massachusetts General Hospital, Harvard Medical School, Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 26:190-7. 2002
    ....
  69. pmc Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations
    David C Wilbur
    Department of Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
    Arch Pathol Lab Med 133:1949-53. 2009
    ..Before implementation, technical issues, pathologist adaptability, and morphologic pitfalls must be well characterized...
  70. pmc Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance
    Katia Meirelles
    Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:2358-63. 2012
    ..These results suggest that chemotherapeutics may be stimulative to cancer stem cells and that selective inhibition of these cells by treating with MIS or targeting LIN28 should be considered in the development of therapeutics...
  71. ncbi request reprint Luteinized thecomas (thecomatosis) of the type typically associated with sclerosing peritonitis: a clinical, histopathologic, and immunohistochemical analysis of 27 cases
    Paul N Staats
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 32:1273-90. 2008
    ..We have documented for the first time that sclerosing peritonitis is not invariably associated with the distinctive ovarian pathology present in these cases...
  72. ncbi request reprint Dusting off another shelf: further comments on classic gynecologic pathology books of yesteryear
    Robert H Young
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Gynecol Pathol 24:100-10. 2005
    ..Teilum's interest in comparative pathology is evident in the pages, his linking of the famous Schiller-Duval bodies with the endodermal sinuses of the rat placenta, being the most notable example...
  73. ncbi request reprint Extrauterine lesions of intermediate trophoblast
    Rebecca N Baergen
    New York Presbyterian Hospital, Department of Pathology, New York, NY 10021, USA
    Int J Gynecol Pathol 22:362-7. 2003
    ..Follow-up, available on two of the three patients with PSTT, was uneventful at 6 and 12 years, but study of additional cases is necessary to reliably determine the behavior of extrauterine PSTTs...
  74. doi request reprint Seminoma with conspicuous signet ring cells: a rare, previously uncharacterized morphologic variant
    Thomas M Ulbright
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Surg Pathol 32:1175-81. 2008
    ..The description of this phenomenon expands the known morphologic spectrum of the most common testicular neoplasm...
  75. ncbi request reprint James Homer Wright: a biography of the enigmatic creator of the Wright stain on the occasion of its centennial
    Robert E Lee
    Department of Pathology, University of Pittsburgh, PA, USA
    Am J Surg Pathol 26:88-96. 2002
    ....
  76. ncbi request reprint Seminomas with exclusive intertubular growth: a report of 12 clinically and grossly inconspicuous tumors
    John D Henley
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202 5280, USA
    Am J Surg Pathol 28:1163-8. 2004
    ..In pure form, intertubular seminoma is both clinically and pathologically inconspicuous and may be misdiagnosed as atrophy, scar, or orchitis...
  77. ncbi request reprint Epithelioid endometrial and endometrioid stromal tumors: a report of four cases emphasizing their distinction from epithelioid smooth muscle tumors and other oxyphilic uterine and extrauterine tumors
    Esther Oliva
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Int J Gynecol Pathol 21:48-55. 2002
    ..Immunohistochemical evaluation may potentially provide major aid in diagnosis...
  78. doi request reprint Acinar cell carcinoma of the pancreas metastatic to the ovary: a report of 4 cases
    Efsevia Vakiani
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Am J Surg Pathol 32:1540-5. 2008
    ....
  79. ncbi request reprint Ovarian teratomas with florid benign vascular proliferation: a distinctive finding associated with the neural component of teratomas that may be confused with a vascular neoplasm
    Patricia M Baker
    Department of Pathology, Health Sciences Center, University of Manitoba, Winnipeg, Manitoba, Canada
    Int J Gynecol Pathol 21:16-21. 2002
    ..Recognition of this proliferation as a benign secondary one is important to avoid misdiagnosis of a vascular neoplasm or an immature teratoma, as happened in one of our cases...
  80. ncbi request reprint Malignant Sertoli cell tumors of the testis: a study of 13 examples of a neoplasm frequently misinterpreted as seminoma
    John D Henley
    Departments of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Surg Pathol 26:541-50. 2002
    ....
  81. ncbi request reprint Malignant peritoneal mesothelioma in women: a study of 75 cases with emphasis on their morphologic spectrum and differential diagnosis
    Patricia M Baker
    Department of Pathology, Health Sciences Center, University of Manitoba, Winnipeg, Canada
    Am J Clin Pathol 123:724-37. 2005
    ..Histochemistry, immunohistochemistry, and electron microscopy may provide important aid, particularly when tissue is limited, but should be needed only occasionally...
  82. ncbi request reprint Unusual epithelial and stromal changes in myoinvasive endometrioid adenocarcinoma: a study of their frequency, associated diagnostic problems, and prognostic significance
    Shawn K Murray
    QEII Health Sciences Center, Department of Pathology, Halifax, Nova Scotia, Canada
    Int J Gynecol Pathol 22:324-33. 2003
    ..A lymphocytic stromal reaction is associated with a favorable effect on prognosis and is less often accompanied by the distinctive morphologic changes (MELF) highlighted herein...
  83. ncbi request reprint Skeletal muscle-like and rhabdoid cells in uterine leiomyomas
    Robin L Parker
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, Alberta, Canada
    Int J Gynecol Pathol 24:319-25. 2005
    ..An association with leiomyomas with bizarre nuclei also was suggested...
  84. ncbi request reprint Placental site trophoblastic tumor: A study of 55 cases and review of the literature emphasizing factors of prognostic significance
    Rebecca N Baergen
    New York Presbyterian Hospital Weill Cornell Medical Center, 520 East 70th Street, Starr 1002, New York, NY 10021, USA
    Gynecol Oncol 100:511-20. 2006
    ..The placental site trophoblastic tumor is a rare form of gestational trophoblastic disease. Fifteen percent of reported cases have been fatal, but predicting behavior in individual patients has been challenging...
  85. ncbi request reprint Ovarian serous cystadenoma with associated genital rhabdomyoma
    Kristina Braaten
    Hum Pathol 36:1240-1. 2005
  86. ncbi request reprint Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Semin Diagn Pathol 22:3-32. 2005
    ....
  87. ncbi request reprint Use of histone deacetylase 8 (HDAC8), a new marker of smooth muscle differentiation, in the classification of mesenchymal tumors of the uterus
    Laurence de Leval
    Department of Pathology, Center for Experimental Cancer Research, University of Liege, Liege, Belgium
    Am J Surg Pathol 30:319-27. 2006
    ..Thus, HDAC8 detection may be useful in helping the differential diagnosis of uterine mesenchymal tumors...
  88. ncbi request reprint Paraganglioma of the ovary: report of three cases of a rare ovarian neoplasm, including two exhibiting inhibin positivity
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, Northern Ireland
    Am J Surg Pathol 30:600-5. 2006
    ..Possible theories of histogenesis of primary ovarian paraganglioma include an origin from extra-adrenal paraganglia in the region of the ovary or unidirectional differentiation within a teratoma...
  89. ncbi request reprint Primary malignant melanoma of the ovary: a report of 9 definite or probable cases with emphasis on their morphologic diversity and mimicry of other primary and secondary ovarian neoplasms
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Int J Gynecol Pathol 25:321-9. 2006
    ..This is an area where electron microscopy can still also contribute useful information...
  90. ncbi request reprint Polypoid endometriosis: a clinicopathologic analysis of 24 cases and a review of the literature
    Robin L Parker
    Department of Pathology and Laboratory Medicine, University of Calgary, Calgary Laboratory Services, Calgary, Alberta, Canada
    Am J Surg Pathol 28:285-97. 2004
    ..The main lesion in the differential is a müllerian (mesodermal) adenosarcoma...
  91. ncbi request reprint Tubulo-squamous polyp: a report of ten cases of a distinctive hitherto uncharacterized vaginal polyp
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Am J Surg Pathol 31:1013-9. 2007
    ....
  92. ncbi request reprint Non-endometrioid carcinomas of the uterine corpus: a review of their pathology with emphasis on recent advances and problematic aspects
    Philip B Clement
    Department of Pathology, Vancouver General Hospital and Health Science Centre and the University of Columbia, Vancouver, British Columbia, Canada
    Adv Anat Pathol 11:117-42. 2004
    ..7) The spectrum of reactive epithelial changes and other non-neoplastic abnormalities that may mimic serous or clear cell carcinoma...
  93. ncbi request reprint Ovarian sertoli-leydig cell tumors with pseudoendometrioid tubules (pseudoendometrioid sertoli-leydig cell tumors)
    W Glenn McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Am J Surg Pathol 31:592-7. 2007
    ..The presence of more typical Sertoli cell elements and Leydig cells, an absence of squamous elements, endometriosis or associated adenofibroma, and the characteristic immunophenotype assist in diagnosis...
  94. doi request reprint Anaplastic carcinoma in mucinous ovarian tumors: a clinicopathologic study of 34 cases emphasizing the crucial impact of stage on prognosis, their histologic spectrum, and overlap with sarcomalike mural nodules
    Claudia Provenza
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Am J Surg Pathol 32:383-9. 2008
    ..These foci/nodules may exhibit rhabdoid, sarcomatoid (spindle cell), or pleomorphic features...
  95. doi request reprint Granulosa cell tumors of the ovary with a pseudopapillary pattern: a study of 14 cases of an unusual morphologic variant emphasizing their distinction from transitional cell neoplasms and other papillary ovarian tumors
    Julie A Irving
    Department of Laboratory Medicine, Royal Jubilee Hospital, Victoria, Canada
    Am J Surg Pathol 32:581-6. 2008
    ..This phenomenon seems to be related to the cystic change that is a feature of many granulosa cell tumors...
  96. ncbi request reprint Immunoprofile of ovarian tumors with putative transitional cell (urothelial) differentiation using novel urothelial markers: histogenetic and diagnostic implications
    Sanjay Logani
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Surg Pathol 27:1434-41. 2003
    ..They also indicate that the morphologic similarity between TCC-O and TCC-B does not indicate any histogenic similarity and, as others have noted, TCC-O is a variant morphology in the spectrum of surface epithelial carcinomas...
  97. ncbi request reprint Ovarian mature cystic teratoma with florid vascular proliferation and Wagner-Meissner--like corpuscles
    Giovanni Fellegara
    Centro Consulenze Anatomia Patologica Oncologica, Centro Diagnostico Italiano, Milano, Italy
    Int J Surg Pathol 16:320-3. 2008
    ..The Wagner-Meissner-like corpuscles are viewed as evidence of a specialized type of differentiation of this neural component. To the best of our knowledge, they had not been previously reported in this setting...
  98. ncbi request reprint Lung carcinoma metastatic to the ovary: a clinicopathologic study of 32 cases emphasizing their morphologic spectrum and problems in differential diagnosis
    Julie A Irving
    Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada
    Am J Surg Pathol 29:997-1006. 2005
    ..The differential diagnosis with the primary ovarian tumors most often meriting consideration, including unusual variants of surface epithelial tumors, is discussed...