Motojiro Yoshihara

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc A large-scale behavioral screen to identify neurons controlling motor programs in the Drosophila brain
    Thomas F Flood
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts
    G3 (Bethesda) 3:1629-37. 2013
  2. ncbi request reprint Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release
    Motojiro Yoshihara
    Picower Center for Learning and Memory, Cambridge, MA, USA
    Neuron 36:897-908. 2002
  3. ncbi request reprint Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 310:858-63. 2005
  4. ncbi request reprint The synaptotagmins: calcium sensors for vesicular trafficking
    Motojiro Yoshihara
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuroscientist 10:566-74. 2004
  5. pmc Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment
    Bill Adolfsen
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Cell Biol 166:249-60. 2004
  6. pmc Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:14869-74. 2010
  7. ncbi request reprint Presynaptic N-type calcium channels regulate synaptic growth
    Gabrielle E Rieckhof
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 278:41099-108. 2003
  8. ncbi request reprint Is synaptotagmin the calcium sensor?
    Motojiro Yoshihara
    Picower Center for Learning and Memory and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Neurobiol 13:315-23. 2003
  9. pmc Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease
    Wyan Ching Mimi Lee
    Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:3224-9. 2004
  10. ncbi request reprint GETDB, a database compiling expression patterns and molecular locations of a collection of Gal4 enhancer traps
    Shigeo Hayashi
    National Institute of Genetics, Mishima, Shizuoka ken, Japan
    Genesis 34:58-61. 2002

Collaborators

Detail Information

Publications10

  1. pmc A large-scale behavioral screen to identify neurons controlling motor programs in the Drosophila brain
    Thomas F Flood
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts
    G3 (Bethesda) 3:1629-37. 2013
    ..Through follow-up studies starting from this screen, we expect to find key components of the neural circuits underlying specific behaviors, thus providing a new avenue for their functional analysis. ..
  2. ncbi request reprint Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release
    Motojiro Yoshihara
    Picower Center for Learning and Memory, Cambridge, MA, USA
    Neuron 36:897-908. 2002
    ..These results indicate that synaptotagmin is the major Ca(2+) sensor for evoked release and functions to trigger synchronous fusion in response to Ca(2+), while suppressing asynchronous release...
  3. ncbi request reprint Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 310:858-63. 2005
    ..Postsynaptic Ca2+ influx also stimulates local synaptic differentiation and growth through Syt 4-mediated retrograde signals in a synapse-specific manner...
  4. ncbi request reprint The synaptotagmins: calcium sensors for vesicular trafficking
    Motojiro Yoshihara
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuroscientist 10:566-74. 2004
    ..This suggests an intriguing possibility that syt 4 may mediate a postsynaptic vesicle trafficking pathway, providing a molecular basis for an evolutionarily conserved bidirectional vesicular trafficking communication system at synapses...
  5. pmc Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment
    Bill Adolfsen
    The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Cell Biol 166:249-60. 2004
    ..In addition, the identification of a postsynaptic synaptotagmin suggests calcium-dependent membrane-trafficking functions on both sides of the synapse...
  6. pmc Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1
    Motojiro Yoshihara
    Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:14869-74. 2010
    ..These results suggest that the tandem C2 domains of Syt 1 play independent roles in neurotransmission, as Ca(2+) binding to C2A suppresses asynchronous release, whereas Ca(2+) binding to C2B mediates synchronous fusion...
  7. ncbi request reprint Presynaptic N-type calcium channels regulate synaptic growth
    Gabrielle E Rieckhof
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 278:41099-108. 2003
    ..Linking presynaptic voltage-gated calcium entry to downstream calcium-sensitive synaptic growth regulators provides an efficient activity-dependent mechanism for modifying synaptic strength...
  8. ncbi request reprint Is synaptotagmin the calcium sensor?
    Motojiro Yoshihara
    Picower Center for Learning and Memory and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Neurobiol 13:315-23. 2003
    ..Biochemical and genetic studies suggest that lipid and SNARE interactions underlie synaptotagmin's ability to mediate the incredible speed of vesicle fusion that is the hallmark of fast synaptic transmission...
  9. pmc Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease
    Wyan Ching Mimi Lee
    Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:3224-9. 2004
    ..Our findings indicate that nonnuclear events induced by cytoplasmic huntingtin aggregation play a central role in the progressive neurodegeneration observed in Huntington's disease...
  10. ncbi request reprint GETDB, a database compiling expression patterns and molecular locations of a collection of Gal4 enhancer traps
    Shigeo Hayashi
    National Institute of Genetics, Mishima, Shizuoka ken, Japan
    Genesis 34:58-61. 2002